{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:01:46Z","timestamp":1787068906667,"version":"build-2736575974"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI131975"],"award-info":[{"award-number":["R01AI131975"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P01AI120756"],"award-info":[{"award-number":["P01AI120756"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U01AI136677"],"award-info":[{"award-number":["U01AI136677"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P30 AI064518"],"award-info":[{"award-number":["P30 AI064518"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P01AI162242"],"award-info":[{"award-number":["P01AI162242"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunogenetics"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s00251-022-01272-7","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T03:06:27Z","timestamp":1659063987000},"page":"1-16","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Functional consequences of allotypic polymorphisms in human immunoglobulin G subclasses"],"prefix":"10.1007","volume":"75","author":[{"given":"Andrew R.","family":"Crowley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone I.","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Tuyishime","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Jennewein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith J.","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galit","family":"Alter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4253-3476","authenticated-orcid":false,"given":"Margaret E.","family":"Ackerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"1272_CR1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jim.2010.12.016","volume":"366","author":"ME Ackerman","year":"2011","unstructured":"Ackerman ME, Moldt B, Wyatt RT, Dugast AS, McAndrew E, Tsoukas S et al (2011) A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples. J Immunol Methods 366:8\u201319","journal-title":"J Immunol Methods"},{"key":"1272_CR2","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1172\/JCI111909","volume":"75","author":"DM Ambrosino","year":"1985","unstructured":"Ambrosino DM, Schiffman G, Gotschlich EC, Schur PH, Rosenberg GA, DeLange GG et al (1985) Correlation between G2m(n) immunoglobulin allotype and human antibody response and susceptibility to polysaccharide encapsulated bacteria. J Clin Invest 75:1935\u20131942","journal-title":"J Clin Invest"},{"key":"1272_CR3","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/j.1365-3024.1981.tb00383.x","volume":"3","author":"C Auriault","year":"1981","unstructured":"Auriault C, Ouaissi MA, Torpier G, Eisen H, Capron A (1981) Proteolytic cleavage of IgG bound to the Fc receptor of Schistosoma mansoni schistosomula. Parasite Immunol 3:33\u201344","journal-title":"Parasite Immunol"},{"key":"1272_CR4","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1002\/1521-4141(200009)30:9<2540::AID-IMMU2540>3.0.CO;2-S","volume":"30","author":"A Atherton","year":"2000","unstructured":"Atherton A, Armour KL, Bell S, Minson AC, Clark MR (2000) The herpes simplex virus type 1 Fc receptor discriminates between IgG1 allotypes. Eur J Immunol 30:2540\u20132547","journal-title":"Eur J Immunol"},{"key":"1272_CR5","doi-asserted-by":"publisher","first-page":"969","DOI":"10.4049\/jimmunol.133.2.969","volume":"133","author":"L Bjorck","year":"1984","unstructured":"Bjorck L, Kronvall G (1984) Purification and some properties of streptococcal protein G, a novel IgG-binding reagent. J Immunol 133:969\u2013974","journal-title":"J Immunol"},{"key":"1272_CR6","doi-asserted-by":"publisher","first-page":"915","DOI":"10.4161\/mabs.28808","volume":"6","author":"AW Boesch","year":"2014","unstructured":"Boesch AW, Brown EP, Cheng HD, Ofori MO, Normandin E, Nigrovic PA et al (2014) Highly parallel characterization of IgG Fc binding interactions. MAbs 6:915\u2013927","journal-title":"MAbs"},{"key":"1272_CR7","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.jim.2012.09.007","volume":"386","author":"EP Brown","year":"2012","unstructured":"Brown EP, Licht AF, Dugast AS, Choi I, Bailey-Kellogg C, Alter G et al (2012) High-throughput, multiplexed IgG subclassing of antigen-specific antibodies from clinical samples. J Immunol Methods 386:117\u2013123","journal-title":"J Immunol Methods"},{"key":"1272_CR8","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jim.2018.01.013","volume":"455","author":"EP Brown","year":"2018","unstructured":"Brown EP, Weiner JA, Lin S, Natarajan H, Normandin E, Barouch DH et al (2018) Optimization and qualification of an Fc array assay for assessments of antibodies against HIV-1\/SIV. J Immunol Methods 455:24\u201333","journal-title":"J Immunol Methods"},{"key":"1272_CR9","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jim.2017.01.010","volume":"443","author":"EP Brown","year":"2017","unstructured":"Brown EP, Dowell KG, Boesch AW, Normandin E, Mahan AE, Chu T et al (2017) Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles. J Immunol Methods 443:33\u201344","journal-title":"J Immunol Methods"},{"key":"1272_CR10","doi-asserted-by":"publisher","first-page":"3716","DOI":"10.1182\/blood-2008-09-179754","volume":"113","author":"P Bruhns","year":"2009","unstructured":"Bruhns P, Iannascoli B, England P, Mancardi DA, Fernandez N, Jorieux S et al (2009) Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses. Blood 113:3716\u20133725","journal-title":"Blood"},{"key":"1272_CR11","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.3389\/fimmu.2019.01161","volume":"10","author":"V Calonga-Solis","year":"2019","unstructured":"Calonga-Solis V, Malheiros D, Beltrame MH, Vargas LB, Dourado RM, Issler HC et al (2019) Unveiling the diversity of immunoglobulin heavy constant gamma (IGHG) gene segments in Brazilian populations reveals 28 novel alleles and evidence of gene conversion and natural selection. Front Immunol 10:1161","journal-title":"Front Immunol"},{"key":"1272_CR12","doi-asserted-by":"publisher","first-page":"6911","DOI":"10.1074\/jbc.274.11.6911","volume":"274","author":"TL Chapman","year":"1999","unstructured":"Chapman TL, You I, Joseph IM, Bjorkman PJ, Morrison SL, Raghavan M (1999) Characterization of the interaction between the herpes simplex virus type I Fc receptor and immunoglobulin G. J Biol Chem 274:6911\u20136919","journal-title":"J Biol Chem"},{"key":"1272_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008083","volume":"16","author":"TH Chu","year":"2020","unstructured":"Chu TH, Crowley AR, Backes I, Chang C, Tay M, Broge T et al (2020) Hinge length contributes to the phagocytic activity of HIV-specific IgG1 and IgG3 antibodies. PLoS Pathog 16:e1008083","journal-title":"PLoS Pathog"},{"key":"1272_CR14","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1034\/j.1600-051X.2003.00409.x","volume":"30","author":"HY Chung","year":"2003","unstructured":"Chung HY, Lu HC, Chen WL, Lu CT, Yang YH, Tsai CC (2003) Gm (23) allotypes and Fcgamma receptor genotypes as risk factors for various forms of periodontitis. J Clin Periodontol 30:954\u2013960","journal-title":"J Clin Periodontol"},{"key":"1272_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004131","volume":"10","author":"E Corrales-Aguilar","year":"2014","unstructured":"Corrales-Aguilar E, Trilling M, Hunold K, Fiedler M, Le VT, Reinhard H et al (2014) Human cytomegalovirus Fcgamma binding proteins gp34 and gp68 antagonize Fcgamma receptors I. II and III PLoS Pathog 10:e1004131","journal-title":"II and III PLoS Pathog"},{"key":"1272_CR16","doi-asserted-by":"publisher","first-page":"36964","DOI":"10.1038\/srep36964","volume":"6","author":"G Dekkers","year":"2016","unstructured":"Dekkers G, Plomp R, Koeleman CA, Visser R, von Horsten HH, Sandig V et al (2016) Multi-level glyco-engineering techniques to generate IgG with defined Fc-glycans. Sci Rep 6:36964","journal-title":"Sci Rep"},{"key":"1272_CR17","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1084\/jem.154.6.1732","volume":"154","author":"IK De Miranda-Santos","year":"1981","unstructured":"De Miranda-Santos IK, Campos-Neto A (1981) Receptor for immunoglobulin Fc on pathogenic but not on nonpathogenic protozoa of the Trypanosomatidae. J Exp Med 154:1732\u20131742","journal-title":"J Exp Med"},{"key":"1272_CR18","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.humimm.2011.12.008","volume":"73","author":"RN Deepe","year":"2012","unstructured":"Deepe RN, Kistner-Griffin E, Martin JN, Deeks SG, Pandey JP (2012) Epistatic interactions between Fc (GM) and FcgammaR genes and the host control of human immunodeficiency virus replication. Hum Immunol 73:263\u2013266","journal-title":"Hum Immunol"},{"key":"1272_CR19","doi-asserted-by":"crossref","unstructured":"De Vries RR, Khan PM, Bernini LF, Loghem EV, Van Rood JJ (1979)\u00a0Genetic control of survival in epidemics. J Immunogenet 6:271\u201387","DOI":"10.1111\/j.1744-313X.1979.tb00684.x"},{"key":"1272_CR20","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1002\/ajpa.10405","volume":"125","author":"JM Dugoujon","year":"2004","unstructured":"Dugoujon JM, Hazout S, Loirat F, Mourrieras B, Crouau-Roy B, Sanchez-Mazas A (2004) GM haplotype diversity of 82 populations over the world suggests a centrifugal model of human migrations. Am J Phys Anthropol 125:175\u2013192","journal-title":"Am J Phys Anthropol"},{"key":"1272_CR21","doi-asserted-by":"publisher","first-page":"740","DOI":"10.3389\/fimmu.2020.00740","volume":"11","author":"SW de Taeye","year":"2020","unstructured":"de Taeye SW, Bentlage AEH, Mebius MM, Meesters JI, Lissenberg-Thunnissen S, Falck D et al (2020) FcgammaR binding and ADCC activity of human IgG allotypes. Front Immunol 11:740","journal-title":"Front Immunol"},{"key":"1272_CR22","doi-asserted-by":"publisher","first-page":"7046","DOI":"10.1128\/jvi.65.12.7046-7050.1991","volume":"65","author":"G Dubin","year":"1991","unstructured":"Dubin G, Socolof E, Frank I, Friedman HM (1991) Herpes simplex virus type 1 Fc receptor protects infected cells from antibody-dependent cellular cytotoxicity. J Virol 65:7046\u20137050","journal-title":"J Virol"},{"key":"1272_CR23","doi-asserted-by":"crossref","unstructured":"Forsgren A and Sjoquist J (1966) \u201cProtein A\u201d from S. aureus. I. Pseudo-immune reaction with human gamma-globulin. J Immunol 97:822\u20137","DOI":"10.4049\/jimmunol.97.6.822"},{"key":"1272_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2019.07.002","volume":"473","author":"S Fischinger","year":"2019","unstructured":"Fischinger S, Fallon JK, Michell AR, Broge T, Suscovich TJ, Streeck H et al (2019) A high-throughput, bead-based, antigen-specific assay to assess the ability of antibodies to induce complement activation. J Immunol Methods 473:112630","journal-title":"J Immunol Methods"},{"key":"1272_CR25","doi-asserted-by":"publisher","first-page":"4479","DOI":"10.1128\/jvi.63.11.4479-4488.1989","volume":"63","author":"I Frank","year":"1989","unstructured":"Frank I, Friedman HM (1989) A novel function of the herpes simplex virus type 1 Fc receptor: participation in bipolar bridging of antiviral immunoglobulin G. J Virol 63:4479\u20134488","journal-title":"J Virol"},{"key":"1272_CR26","first-page":"473","volume":"56","author":"MA French","year":"1984","unstructured":"French MA, Harrison G (1984) Serum IgG subclass concentrations in healthy adults: a study using monoclonal antisera. Clin Exp Immunol 56:473\u2013475","journal-title":"Clin Exp Immunol"},{"key":"1272_CR27","first-page":"149","volume":"56","author":"GM Galbraith","year":"1984","unstructured":"Galbraith GM, Thiers BH, Pandey JP (1984) Gm allotype associated resistance and susceptibility to alopecia areata. Clin Exp Immunol 56:149\u2013152","journal-title":"Clin Exp Immunol"},{"key":"1272_CR28","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/j.1699-0463.1956.tb03392.x","volume":"39","author":"R Grubb","year":"1956","unstructured":"Grubb R (1956) Agglutination of erythrocytes coated with incomplete anti-Rh by certain rheumatoid arthritic sera and some other sera; the existence of human serum groups. Acta Pathol Microbiol Scand 39:195\u2013197","journal-title":"Acta Pathol Microbiol Scand"},{"key":"1272_CR29","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1093\/infdis\/157.6.1142","volume":"157","author":"DM Granoff","year":"1988","unstructured":"Granoff DM, Suarez BK, Pandey JP, Shackelford PG (1988) Genes associated with the G2m(23) immunoglobulin allotype regulate the IgG subclass responses to Haemophilus influenzae type b polysaccharide vaccine. J Infect Dis 157:1142\u20131149","journal-title":"J Infect Dis"},{"key":"1272_CR30","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1111\/j.1699-0463.1956.tb05067.x","volume":"39","author":"R Grubb","year":"1956","unstructured":"Grubb R, Laurell AB (1956) Hereditary serological human serum groups. Acta Pathol Microbiol Scand 39:390\u2013398","journal-title":"Acta Pathol Microbiol Scand"},{"key":"1272_CR31","doi-asserted-by":"crossref","unstructured":"Hassan MS, Islam KB, Hammarstr\u00f6m L, Smith CI (1992)\u00a0Regulation of C gamma 3 expression. Role of switch in the allotype-associated variation of human serum IgG3 levels. J Immunol 148:2555\u201362","DOI":"10.4049\/jimmunol.148.8.2555"},{"key":"1272_CR32","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.1111\/trf.13812","volume":"56","author":"HL Howie","year":"2016","unstructured":"Howie HL, Delaney M, Wang X, Er LS, Vidarsson G, Stegmann TC et al (2016) Serological blind spots for variants of human IgG3 and IgG4 by a commonly used anti-immunoglobulin reagent. Transfusion 56:2953\u20132962","journal-title":"Transfusion"},{"key":"1272_CR33","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1128\/jvi.50.3.796-804.1984","volume":"50","author":"PJ Johansson","year":"1984","unstructured":"Johansson PJ, Hallberg T, Oxelius VA, Grubb A, Blomberg J (1984) Human immunoglobulin class and subclass specificity of Fc receptors induced by herpes simplex virus type 1. J Virol 50:796\u2013804","journal-title":"J Virol"},{"key":"1272_CR34","doi-asserted-by":"publisher","first-page":"722","DOI":"10.4049\/jimmunol.177.1.722","volume":"177","author":"G Jonsson","year":"2006","unstructured":"Jonsson G, Oxelius VA, Truedsson L, Braconier JH, Sturfelt G, Sjoholm AG (2006) Homozygosity for the IgG2 subclass allotype G2M(n) protects against severe infection in hereditary C2 deficiency. J Immunol 177:722\u2013728","journal-title":"J Immunol"},{"issue":"Pt 3","key":"1272_CR35","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1017\/S0031182000075119","volume":"106","author":"B Kalinna","year":"1993","unstructured":"Kalinna B, McManus DP (1993) An IgG (Fc gamma)-binding protein of Taenia crassiceps (Cestoda) exhibits sequence homology and antigenic similarity with schistosome paramyosin. Parasitology 106(Pt 3):289\u2013296","journal-title":"Parasitology"},{"key":"1272_CR36","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jim.2019.05.006","volume":"471","author":"CB Karsten","year":"2019","unstructured":"Karsten CB, Mehta N, Shin SA, Diefenbach TJ, Slein MD, Karpinski W et al (2019) A versatile high-throughput assay to characterize antibody-mediated neutrophil phagocytosis. J Immunol Methods 471:46\u201356","journal-title":"J Immunol Methods"},{"key":"1272_CR37","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/978-1-61779-842-9_34","volume":"882","author":"MP Lefranc","year":"2012","unstructured":"Lefranc MP, Lefranc G (2012) Human Gm, Km, and Am allotypes and their molecular characterization: a remarkable demonstration of polymorphism. Methods Mol Biol 882:635\u2013680","journal-title":"Methods Mol Biol"},{"key":"1272_CR38","doi-asserted-by":"publisher","first-page":"3238","DOI":"10.4049\/jimmunol.1003336","volume":"187","author":"AF Labrijn","year":"2011","unstructured":"Labrijn AF, Rispens T, Meesters J, Rose RJ, den Bleker TH, Loverix S et al (2011) Species-specific determinants in the IgG CH3 domain enable Fab-arm exchange by affecting the noncovalent CH3-CH3 interaction strength. J Immunol 187:3238\u20133246","journal-title":"J Immunol"},{"key":"1272_CR39","doi-asserted-by":"publisher","first-page":"4206","DOI":"10.1038\/s41467-019-12097-6","volume":"10","author":"X Liu","year":"2019","unstructured":"Liu X, Zhao Y, Shi H, Zhang Y, Yin X, Liu M et al (2019) Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility. Nat Commun 10:4206","journal-title":"Nat Commun"},{"key":"1272_CR40","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1074\/jbc.M311470200","volume":"279","author":"P Maillard","year":"2004","unstructured":"Maillard P, Lavergne JP, Siberil S, Faure G, Roohvand F, Petres S et al (2004) Fcgamma receptor-like activity of hepatitis C virus core protein. J Biol Chem 279:2430\u20132437","journal-title":"J Biol Chem"},{"key":"1272_CR41","doi-asserted-by":"crossref","unstructured":"McAndrew EG, Dugast AS, Licht AF, Eusebio JR, Alter G, Ackerman ME (2011)\u00a0Determining the phagocytic activity of clinical antibody samples. J Vis Exp e3588","DOI":"10.3791\/3588"},{"issue":"Pt 3","key":"1272_CR42","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1177\/000456329403100305","volume":"31","author":"J Miles","year":"1994","unstructured":"Miles J, Riches P (1994) The determination of IgG subclass concentrations in serum by enzyme-linked immunosorbent assay: establishment of age-related reference ranges for cord blood samples, children aged 5\u201313 years and adults. Ann Clin Biochem 31(Pt 3):245\u2013248","journal-title":"Ann Clin Biochem"},{"key":"1272_CR43","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.4049\/jimmunol.169.3.1379","volume":"169","author":"GR McLean","year":"2002","unstructured":"McLean GR, Torres M, Elguezabal N, Nakouzi A, Casadevall A (2002) Isotype can affect the fine specificity of an antibody for a polysaccharide antigen. J Immunol 169:1379\u20131386","journal-title":"J Immunol"},{"key":"1272_CR44","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.4049\/jimmunol.1500872","volume":"195","author":"M Moraru","year":"2015","unstructured":"Moraru M, Black LE, Muntasell A, Portero F, Lopez-Botet M, Reyburn HT et al (2015) NK cell and Ig interplay in defense against herpes simplex virus type 1: epistatic interaction of CD16A and IgG1 allotypes of variable affinities modulates antibody-dependent cellular cytotoxicity and susceptibility to clinical reactivation. J Immunol 195:1676\u20131684","journal-title":"J Immunol"},{"key":"1272_CR45","doi-asserted-by":"publisher","first-page":"3805","DOI":"10.1016\/j.molimm.2007.03.022","volume":"44","author":"AM Namboodiri","year":"2007","unstructured":"Namboodiri AM, Budkowska A, Nietert PJ, Pandey JP (2007) Fc gamma receptor-like hepatitis C virus core protein binds differentially to IgG of discordant Fc (GM) genotypes. Mol Immunol 44:3805\u20133808","journal-title":"Mol Immunol"},{"key":"1272_CR46","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1007\/s00705-011-0937-8","volume":"156","author":"AM Namboodiri","year":"2011","unstructured":"Namboodiri AM, Pandey JP (2011) The human cytomegalovirus TRL11\/IRL11-encoded FcgammaR binds differentially to allelic variants of immunoglobulin G1. Arch Virol 156:907\u2013910","journal-title":"Arch Virol"},{"key":"1272_CR47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003961","volume":"10","author":"B Ndjamen","year":"2014","unstructured":"Ndjamen B, Farley AH, Lee T, Fraser SE, Bjorkman PJ (2014) The herpes virus Fc receptor gE-gI mediates antibody bipolar bridging to clear viral antigens from the cell surface. PLoS Pathog 10:e1003961","journal-title":"PLoS Pathog"},{"key":"1272_CR48","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1093\/intimm\/dxg036","volume":"15","author":"M Oda","year":"2003","unstructured":"Oda M, Kozono H, Morii H, Azuma T (2003) Evidence of allosteric conformational changes in the antibody constant region upon antigen binding. Int Immunol 15:417\u2013426","journal-title":"Int Immunol"},{"key":"1272_CR49","doi-asserted-by":"crossref","unstructured":"Orlandi C, Deredge D, Ray K, Gohain N, Tolbert W, DeVico AL, Wintrode P, Pazgier M, Lewis GK\u00a0(2020) Antigen-induced allosteric changes in a human IgG1 Fc increase low-affinity Fcgamma receptor binding. Structure 28:516\u2013527e5","DOI":"10.1016\/j.str.2020.03.001"},{"key":"1272_CR50","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1159\/000335592","volume":"159","author":"VA Oxelius","year":"2012","unstructured":"Oxelius VA (2012) From genotypes of immunoglobulin constant heavy G chains (Fcgamma) (GM) genes (IGHG) to phenotypes in childhood asthma. Int Arch Allergy Immunol 159:94\u2013102","journal-title":"Int Arch Allergy Immunol"},{"key":"1272_CR51","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1111\/j.1365-2222.2006.02602.x","volume":"36","author":"VA Oxelius","year":"2006","unstructured":"Oxelius VA, Braback L, Ahlstedt S, Bjorksten B (2006) Immunoglobulin constant heavy G chain genes as risk factors in childhood allergies. Clin Exp Allergy 36:1616\u20131624","journal-title":"Clin Exp Allergy"},{"key":"1272_CR52","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1126\/science.145.3635.928","volume":"145","author":"SH Polmar","year":"1964","unstructured":"Polmar SH, Steinberg AG (1964) Dependence of a Gm(B) antigen on the quaternary structure of human gamma globulin. Science 145:928\u2013929","journal-title":"Science"},{"key":"1272_CR53","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1007\/BF01958271","volume":"149","author":"A Plebani","year":"1989","unstructured":"Plebani A, Ugazio AG, Avanzini MA, Massimi P, Zonta L, Monafo V et al (1989) Serum IgG subclass concentrations in healthy subjects at different age: age normal percentile charts. Eur J Pediatr 149:164\u2013167","journal-title":"Eur J Pediatr"},{"key":"1272_CR54","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1007\/s00262-009-0709-4","volume":"58","author":"JP Pandey","year":"2009","unstructured":"Pandey JP, Nietert PJ, Klaamas K, Kurtenkov O (2009) A genetic variant of immunoglobulin gamma2 is strongly associated with immunity to mucin 1 in patients with breast cancer. Cancer Immunol Immunother 58:2025\u20132029","journal-title":"Cancer Immunol Immunother"},{"key":"1272_CR55","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jneuroim.2014.03.003","volume":"270","author":"JP Pandey","year":"2014","unstructured":"Pandey JP, Namboodiri AM (2014) Immunoglobulin GM and FcgammaRIIIa genotypes influence cytotoxicity of neuroblastoma cells. J Neuroimmunol 270:95\u201397","journal-title":"J Neuroimmunol"},{"key":"1272_CR56","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1016\/j.humimm.2013.08.280","volume":"74","author":"JP Pandey","year":"2013","unstructured":"Pandey JP, Kistner-Griffin E, Namboodiri AM, Black L, Jobim M (2013) Suggestive evidence that Fc variants of IgG2 and FcgammaRIIa loci interact to contribute to the risk of prostate cancer. Hum Immunol 74:1656\u20131658","journal-title":"Hum Immunol"},{"key":"1272_CR57","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1016\/j.humimm.2013.04.008","volume":"74","author":"JP Pandey","year":"2013","unstructured":"Pandey JP, Namboodiri AM, Kistner-Griffin E (2013) IgG and FcgammaR genotypes and humoral immunity to mucin 1 in prostate cancer. Hum Immunol 74:1030\u20131033","journal-title":"Hum Immunol"},{"key":"1272_CR58","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/1475-2875-9-229","volume":"9","author":"JP Pandey","year":"2010","unstructured":"Pandey JP, Morais CG, Fontes CJ, Braga EM (2010) Immunoglobulin GM 3 23 5,13,14 phenotype is strongly associated with IgG1 antibody responses to Plasmodium vivax vaccine candidate antigens PvMSP1-19 and PvAMA-1. Malar J 9:229","journal-title":"Malar J"},{"key":"1272_CR59","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.humimm.2015.09.005","volume":"76","author":"JP Pandey","year":"2015","unstructured":"Pandey JP, Namboodiri AM, Radwan FF, Nietert PJ (2015) The decoy Fcgamma receptor encoded by the cytomegalovirus UL119-UL118 gene has differential affinity to IgG proteins expressing different GM allotypes. Hum Immunol 76:591\u2013594","journal-title":"Hum Immunol"},{"key":"1272_CR60","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1093\/infdis\/jiu367","volume":"210","author":"JP Pandey","year":"2014","unstructured":"Pandey JP, Kistner-Griffin E, Radwan FF, Kaur N, Namboodiri AM, Black L et al (2014) Immunoglobulin genes influence the magnitude of humoral immunity to cytomegalovirus glycoprotein B. J Infect Dis 210:1823\u20131826","journal-title":"J Infect Dis"},{"key":"1272_CR61","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1093\/infdis\/jiv472","volume":"213","author":"JP Pandey","year":"2016","unstructured":"Pandey JP, Gao G, Namboodiri AM, Iwasaki M, Kasuga Y, Hamada GS et al (2016) Humoral immunity to cytomegalovirus glycoprotein B in patients with breast cancer and matched controls: contribution of immunoglobulin gamma, kappa, and Fcgamma receptor genes. J Infect Dis 213:611\u2013617","journal-title":"J Infect Dis"},{"key":"1272_CR62","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/j.1744-313X.1984.tb01051.x","volume":"11","author":"JP Pandey","year":"1984","unstructured":"Pandey JP, Baker CJ, Kasper DL, Fudenberg HH (1984) Two unlinked genetic loci interact to control the human immune response to type III group B streptococcal antigen. J Immunogenet 11:159\u2013163","journal-title":"J Immunogenet"},{"key":"1272_CR63","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/cyto.a.21084","volume":"79","author":"J Pollara","year":"2011","unstructured":"Pollara J, Hart L, Brewer F, Pickeral J, Packard BZ, Hoxie JA et al (2011) High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses. Cytometry A 79:603\u2013612","journal-title":"Cytometry A"},{"key":"1272_CR64","doi-asserted-by":"crossref","unstructured":"Recke A, Konitzer S, Lemcke S, Freitag M, Sommer NM, Abdelhady M, Amoli MM, Benoit S, El-Chennawy F, Eldarouti M, Eming R (2018)\u00a0The p.Arg435His variation of IgG3 with high affinity to FcRn is associated with susceptibility for pemphigus vulgaris-analysis of four different ethnic cohorts. Front Immunol 9:1788","DOI":"10.3389\/fimmu.2018.01788"},{"key":"1272_CR65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008064","volume":"15","author":"SI Richardson","year":"2019","unstructured":"Richardson SI, Lambson BE, Crowley AR, Bashirova A, Scheepers C, Garrett N et al (2019) IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody. PLoS Pathog 15:e1008064","journal-title":"PLoS Pathog"},{"key":"1272_CR66","first-page":"114","volume":"72","author":"C Rodriguez de Cuna","year":"1991","unstructured":"Rodriguez de Cuna C, Kierszenbaum F, Wirth JJ (1991) Binding of the specific ligand to Fc receptors on Trypanosoma cruzi increases the infective capacity of the parasite. Immunology 72:114\u2013120","journal-title":"Immunology"},{"key":"1272_CR67","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.molimm.2004.07.004","volume":"42","author":"T Sagawa","year":"2005","unstructured":"Sagawa T, Oda M, Morii H, Takizawa H, Kozono H, Azuma T (2005) Conformational changes in the antibody constant domains upon hapten-binding. Mol Immunol 42:9\u201318","journal-title":"Mol Immunol"},{"key":"1272_CR68","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.1016\/j.jaci.2009.09.046","volume":"125","author":"HW Schroeder Jr","year":"2010","unstructured":"Schroeder HW Jr, Cavacini L (2010) Structure and function of immunoglobulins. J Allergy Clin Immunol 125:S41-52","journal-title":"J Allergy Clin Immunol"},{"key":"1272_CR69","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.4049\/jimmunol.151.5.2529","volume":"151","author":"IJ Seppala","year":"1993","unstructured":"Seppala IJ, Sarvas H, Makela O (1993) Low concentrations of Gm allotypic subsets G3 mg and G1 mf in homozygotes and heterozygotes. J Immunol 151:2529\u20132537","journal-title":"J Immunol"},{"key":"1272_CR70","doi-asserted-by":"publisher","first-page":"3490","DOI":"10.1128\/JVI.01476-07","volume":"82","author":"ER Sprague","year":"2008","unstructured":"Sprague ER, Reinhard H, Cheung EJ, Farley AH, Trujillo RD, Hengel H et al (2008) The human cytomegalovirus Fc receptor gp68 binds the Fc CH2-CH3 interface of immunoglobulin G. J Virol 82:3490\u20133499","journal-title":"J Virol"},{"key":"1272_CR71","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/ncomms1608","volume":"2","author":"NM Stapleton","year":"2011","unstructured":"Stapleton NM, Andersen JT, Stemerding AM, Bjarnarson SP, Verheul RC, Gerritsen J et al (2011) Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential. Nat Commun 2:599","journal-title":"Nat Commun"},{"key":"1272_CR72","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1080\/19420862.2016.1218586","volume":"8","author":"GP Subedi","year":"2016","unstructured":"Subedi GP, Barb AW (2016) The immunoglobulin G1 N-glycan composition affects binding to each low affinity Fc gamma receptor. MAbs 8:1512\u20131524","journal-title":"MAbs"},{"key":"1272_CR73","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.4049\/jimmunol.174.4.2132","volume":"174","author":"M Torres","year":"2005","unstructured":"Torres M, May R, Scharff MD, Casadevall A (2005) Variable-region-identical antibodies differing in isotype demonstrate differences in fine specificity and idiotype. J Immunol 174:2132\u20132142","journal-title":"J Immunol"},{"key":"1272_CR74","doi-asserted-by":"crossref","unstructured":"Torres M, Fernandez-Fuentes N, Fiser A, Casadevall A (2007a) The immunoglobulin heavy chain constant region affects kinetic and thermodynamic parameters of antibody variable region interactions with antigen. J Biol Chem 282:13917\u201313927","DOI":"10.1074\/jbc.M700661200"},{"key":"1272_CR75","doi-asserted-by":"crossref","unstructured":"Torres M, Fernandez-Fuentes N, Fiser A, Casadevall A (2007b)\u00a0Exchanging murine and human immunoglobulin constant chains affects the kinetics and thermodynamics of antigen binding and chimeric antibody autoreactivity. PLoS One 2","DOI":"10.1371\/journal.pone.0001310"},{"key":"1272_CR76","doi-asserted-by":"crossref","unstructured":"Van Der Zee JS, van Swieten PE, Aalberse RC (1986)\u00a0Serologic aspects of IgG4 antibodies. II. IgG4 antibodies form small, nonprecipitating immune complexes due to functional monovalency. J Immunol 137:3566\u201371","DOI":"10.4049\/jimmunol.137.11.3566"},{"key":"1272_CR77","doi-asserted-by":"publisher","first-page":"520","DOI":"10.3389\/fimmu.2014.00520","volume":"5","author":"G Vidarsson","year":"2014","unstructured":"Vidarsson G, Dekkers G, Rispens T (2014) IgG subclasses and allotypes: from structure to effector functions. Front Immunol 5:520","journal-title":"Front Immunol"},{"key":"1272_CR78","first-page":"565","volume":"54","author":"D Wiger","year":"1985","unstructured":"Wiger D, Michaelsen TE (1985) Binding site and subclass specificity of the herpes simplex virus type 1-induced Fc receptor. Immunology 54:565\u2013572","journal-title":"Immunology"},{"key":"1272_CR79","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.ccell.2014.11.001","volume":"27","author":"AL White","year":"2015","unstructured":"White AL, Chan HT, French RR, Willoughby J, Mockridge CI, Roghanian A et al (2015) Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies. Cancer Cell 27:138\u2013148","journal-title":"Cancer Cell"},{"key":"1272_CR80","doi-asserted-by":"crossref","unstructured":"Wu C, Cai P, Chang Q, Hao L, Peng S, Sun X et al (2011) Mapping the binding between the tetraspanin molecule (Sjc23) of Schistosoma japonicum and human non-immune IgG. PLoS One 6","DOI":"10.1371\/journal.pone.0019112"},{"key":"1272_CR81","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1126\/science.1187659","volume":"329","author":"X Wu","year":"2010","unstructured":"Wu X, Yang ZY, Li Y, Hogerkorp CM, Schief WR, Seaman MS et al (2010) Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. Science 329:856\u2013861","journal-title":"Science"}],"container-title":["Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00251-022-01272-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00251-022-01272-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00251-022-01272-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T06:08:09Z","timestamp":1673849289000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00251-022-01272-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,29]]},"references-count":81,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["1272"],"URL":"https:\/\/doi.org\/10.1007\/s00251-022-01272-7","relation":{},"ISSN":["0093-7711","1432-1211"],"issn-type":[{"value":"0093-7711","type":"print"},{"value":"1432-1211","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,29]]},"assertion":[{"value":"2 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}