{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:50:29Z","timestamp":1790704229889,"version":"4.1.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunogenetics"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s00251-022-01289-y","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T13:04:20Z","timestamp":1670418260000},"page":"191-194","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["X-linked hyper-immunoglobulin M syndrome harboring a novel CD40-ligand gene mutation: a case report"],"prefix":"10.1007","volume":"75","author":[{"given":"Rahul","family":"Ramachandran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamini","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parminder","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5618-5655","authenticated-orcid":false,"given":"Abhishek","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"1289_CR1","doi-asserted-by":"crossref","unstructured":"Bajorath J, Chalupny NJ, Marken JS, Siadak AW, Skonier J, Gordon M, Hollenbaugh D, Noelle RJ et al (1995) Identification of residues on CD40 and its ligand which are critical for the receptor-ligand interaction. Biochem 34:1833\u201344","DOI":"10.1021\/bi00006a003"},{"key":"1289_CR2","first-page":"519","volume":"56","author":"A Etzioni","year":"2004","unstructured":"Etzioni A (2004) Ochs HD 2004 The hyper IgM syndrome\u2014an evolving story.\u00a0Pediatr\u00a0Res 56:519\u2013525","journal-title":"Res"},{"key":"1289_CR3","first-page":"256","volume":"56","author":"KC Gilmour","year":"2003","unstructured":"Gilmour KC, Walshe D, Heath S, Monaghan G, Loughlin S, Lester T, Norbury G, Cale CM (2003) Immunological and genetic analysis of 65 patients with a clinical suspicion of X linked hyper-IgM. Mol\u00a0Pathol 56:256","journal-title":"Pathol"},{"key":"1289_CR4","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/s10875-008-9171-x","volume":"28","author":"AA Jesus","year":"2008","unstructured":"Jesus AA, Duarte AJ, Oliveira JB (2008) Autoimmunity in hyper-IgM syndrome. J Clin Immunol 28:62\u201366","journal-title":"J Clin Immunol"},{"key":"1289_CR5","doi-asserted-by":"crossref","unstructured":"Karpusas M, Hsu YM, Wang JH, Thompson J, Lederman S, Chess L, Thomas D (1995) 2\u00a0\u00c5 crystal structure of an extracellular fragment of human CD40 ligand.\u00a0Structure 3:1031\u20139","DOI":"10.1016\/S0969-2126(01)00239-8"},{"key":"1289_CR6","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0022-3476(97)70123-9","volume":"131","author":"J Levy","year":"1997","unstructured":"Levy J, Espanol-Boren T, Thomas C, Fischer A, Tovo P, Bordigoni P, Resnick I, Fasth A et al (1997) Clinical spectrum of X-linked hyper-IgM syndrome. J Pediatr 131:47\u201354","journal-title":"J Pediatr"},{"key":"1289_CR7","doi-asserted-by":"publisher","first-page":"6550","DOI":"10.1073\/pnas.89.14.6550","volume":"89","author":"RJ Noelle","year":"1992","unstructured":"Noelle RJ, Roy M, Shepherd DM, Stamenkovic I, Ledbetter JA, Aruffo A (1992) A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc\u00a0Natl Acad Sci 89:6550\u20136554","journal-title":"Natl Acad Sci"},{"key":"1289_CR8","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1046\/j.1365-2249.2000.01142.x","volume":"120","author":"LD Notarangelo","year":"2000","unstructured":"Notarangelo LD, Hayward AR (2000) X-linked immunodeficiency with hyper-IgM (XHIM). Clin\u00a0Exp Immunol 120:399\u2013405","journal-title":"Exp Immunol"},{"key":"1289_CR9","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1007\/s12016-013-8378-7","volume":"46","author":"N Qamar","year":"2014","unstructured":"Qamar N, Fuleihan RL (2014) The hyper IgM syndromes.\u00a0Clin\u00a0Rev Allergy Immunol 46:120\u2013130","journal-title":"Rev Allergy Immunol"},{"key":"1289_CR10","doi-asserted-by":"crossref","unstructured":"Sarode AY, Jha MK, Zutshi S, Ghosh SK, Mahor H, Sarma U, Saha B (2020) residue-specific message encoding in CD40-ligand.\u00a0iScience 23:101441","DOI":"10.1016\/j.isci.2020.101441"},{"key":"1289_CR11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/jlb.67.1.2","volume":"67","author":"C van Kooten","year":"2000","unstructured":"van Kooten C, Banchereau J (2000) CD40-CD40 ligand. J Leukoc Biol 67:2\u201317","journal-title":"J Leukoc Biol"},{"key":"1289_CR12","doi-asserted-by":"crossref","unstructured":"Winkelstein JA, Marino MC, Ochs H, Fuleihan R, Scholl PR, Geha R, Stiehm ER, Conley ME (2003) The X-linked hyper-IgM syndrome: clinical and immunologic features of 79 patients.\u00a0Medicine 82:373\u201384","DOI":"10.1097\/01.md.0000100046.06009.b0"},{"key":"1289_CR13","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.1016\/j.jmb.2016.05.014","volume":"428","author":"AP Yamniuk","year":"2016","unstructured":"Yamniuk AP, Suri A, Krystek SR, Tamura J, Ramamurthy V, Kuhn R, Carroll K, Fleener C et al (2016) Functional antagonism of human CD40 achieved by targeting a unique species-specific epitope. J Mol Biol 428:2860\u20132879","journal-title":"J Mol Biol"}],"container-title":["Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00251-022-01289-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00251-022-01289-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00251-022-01289-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T06:03:17Z","timestamp":1679724197000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00251-022-01289-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,7]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["1289"],"URL":"https:\/\/doi.org\/10.1007\/s00251-022-01289-y","relation":{},"ISSN":["0093-7711","1432-1211"],"issn-type":[{"value":"0093-7711","type":"print"},{"value":"1432-1211","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,7]]},"assertion":[{"value":"31 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all individual participant included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}