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Long noncoding RNA Maternally expressed gene 3 (lncRNA MEG3) and lncRNA Musculoaponeurotic fibrosarcoma oncogene family, protein G antisense 1 (MAFG-AS1) are regulators of microRNA (miRNA) 147-b, which is induced upon TLR stimulation. We included fifty BD patients, and fifty age and sex-matched controls. Real-time polymerase chain reaction (PCR) was used to measure the expression levels of serum lncRNA MEG3, lncRNA MAFG-AS1, and miRNA 147-b. LncRNA MEG3 and lncRNA MAFG-AS1 were significantly downregulated while miRNA 147-b was significantly upregulated in the BD patients' serum compared to the controls with <jats:italic>p<\/jats:italic>-value &lt;0.001. Receiver operation characteristics (ROC) curve analysis revealed that the three biomarkers can discriminate between BD and control subjects with 76%, 100%, and 70% sensitivity respectively, and 100% specificity for all of them. There was a lower expression level of lnc RNA MEG3 among patients who had new eye involvement in the last month in comparison to those without new eye involvement (<jats:italic>p<\/jats:italic>-value=0.017). So, LncRNA MEG3, lncRNA MAFG-AS1, and miRNA147-b are promising diagnostic markers and therapeutic targets for BD patients. LncRNA MEG3 can be used as a predictor for new BD ocular involvement.<\/jats:p>","DOI":"10.1007\/s00251-024-01346-8","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T04:02:04Z","timestamp":1720584124000},"page":"233-241","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A possible role of lncRNA MEG3 and lncRNA MAFG-AS1 on miRNA 147-b in the pathogenesis of Behcet\u2019s disease"],"prefix":"10.1007","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4452-4423","authenticated-orcid":false,"given":"Shimaa","family":"Abobakr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3031-3599","authenticated-orcid":false,"given":"Olfat","family":"Shaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2939-5611","authenticated-orcid":false,"given":"Mohamed Tharwat","family":"Hegazy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2012-8505","authenticated-orcid":false,"given":"Ayman Mohamed","family":"Hany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"issue":"1","key":"1346_CR1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s12094-023-03246-x","volume":"26","author":"M Ahmadi","year":"2023","unstructured":"Ahmadi M, Morshedzadeh F, Ghaderian S, Mousavi P, Habibipour L, Peymani M, Abbaszadegan M, Ghafouri-Fard S (2023) Carcinogenic roles of MAFG-AS1 in human cancers. 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