{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:33:30Z","timestamp":1790332410191,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1007\/s00253-008-1459-5","type":"journal-article","created":{"date-parts":[[2008,4,14]],"date-time":"2008-04-14T09:20:44Z","timestamp":1208164844000},"source":"Crossref","is-referenced-by-count":43,"title":["Identification of fungal metabolites of anticonvulsant drug carbamazepine"],"prefix":"10.1007","volume":"79","author":[{"given":"Su-Il","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo-Young","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hor-Gil","family":"Hur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,6,1]]},"reference":[{"key":"1459_CR1","first-page":"169","volume":"63","author":"R Azerad","year":"1999","unstructured":"Azerad R (1999) Microbial models for drug metabolism. Adv Biochem Eng Biotech 63:169\u2013218","journal-title":"Adv Biochem Eng Biotech"},{"key":"1459_CR2","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1021\/es050991m","volume":"40","author":"S Castiglioni","year":"2006","unstructured":"Castiglioni S, Bagnati R, Fanelli R, Pomati F, Calamari D, Zuccato E (2006) Removal of pharmaceuticals in sewage treatment plants in Italy. Environ Sci Technol 40:357\u2013363","journal-title":"Environ Sci Technol"},{"key":"1459_CR3","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1080\/004982599238353","volume":"29","author":"BTJ Duhart","year":"1999","unstructured":"Duhart BTJ, Zhang D, Deck J, Freeman JP, Cerniglia CE (1999) Biotransformation of protriptyline by filamentous fungi and yeasts. Xenobiotica 29:733\u2013746","journal-title":"Xenobiotica"},{"key":"1459_CR4","first-page":"499","volume-title":"Antiepiletic drugs","author":"JW Faigle","year":"1989","unstructured":"Faigle JW, Feldmann KF (1989) Carbamazepine. Chemistry and biotransformation. In: Levy R, Mattson R, Meldrum BS, Penry JK, Dreifuss FE (eds) Antiepiletic drugs. 3rd edn. Raven, New York, pp 499\u2013513","edition":"3"},{"key":"1459_CR5","first-page":"499","volume-title":"Antiepiletic drugs","author":"JW Faigle","year":"1995","unstructured":"Faigle JW, Feldmann KF (1995) Carbamazepine. Chemistry and biotransformation. In: Levy R, Mattson R, Meldrum BS (eds) Antiepiletic drugs. 4th edn. Raven, New York, pp 499\u2013513","edition":"4"},{"key":"1459_CR6","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1897\/05-193R.1","volume":"25","author":"GH Han","year":"2006","unstructured":"Han GH, Hur HG, Kim SD (2006) Ecotoxicological risk of pharmaceuticals from wastewater treatment plants in Korea: occurrence and toxicity to Daphnia magna. Environ Toxicol Chem 25:265\u2013271","journal-title":"Environ Toxicol Chem"},{"key":"1459_CR7","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/jps.2600700209","volume":"70","author":"CD Hufford","year":"1981","unstructured":"Hufford CD, Capiton GA, Clark AM, Baker JK (1981) Metabolism of imipramine by microorganisms. J Pharma Sci 70:151\u2013155","journal-title":"J Pharma Sci"},{"key":"1459_CR8","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1016\/0006-2952(94)90071-X","volume":"47","author":"BM Kerr","year":"1994","unstructured":"Kerr BM, Thummel KE, Wurden CJ, Klein SM, Kroetz DL, Gonzalez FL, Levy RH (1994) Human liver carbamazepine metabolism: role of CYP3A4 and CYP2C8 in 10,11-epoxide formation. Biochem Pharmacol 47:1969\u20131979","journal-title":"Biochem Pharmacol"},{"key":"1459_CR9","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1271\/bbb.57.1589","volume":"57","author":"M Kittelmann","year":"1993","unstructured":"Kittelmann M, Lattmann R, Ghisalba O (1993) Preparation of 10,11-epoxy-carbamazepine and 10,11-dihydro-10-hydroxy-carbamazepine by microbial epoxidation and hydroxylation. Biosci Biotechnol Biochem 57:1589\u20131590","journal-title":"Biosci Biotechnol Biochem"},{"key":"1459_CR10","first-page":"1018","volume":"278","author":"NR Kitteringham","year":"1996","unstructured":"Kitteringham NR, Davis C, Howard N, Pirmohamed M, Park BK (1996) Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: studies with cis-stilbene oxide, carbamazepine 10,11-epoxide and naphthalene. J Pharmacol Exp Ther 278:1018\u20131027","journal-title":"J Pharmacol Exp Ther"},{"key":"1459_CR11","first-page":"1","volume":"10","author":"K Lertratanangkoon","year":"1982","unstructured":"Lertratanangkoon K, Horning MG (1982) Metabolism of carbamazepine. Drug Metab Dispos 10:1\u201310","journal-title":"Drug Metab Dispos"},{"key":"1459_CR12","doi-asserted-by":"publisher","first-page":"5209","DOI":"10.1021\/es0484146","volume":"39","author":"D Loffler","year":"2005","unstructured":"Loffler D, Rombke J, Meller M, Ternes T (2005) Environmental fate of pharmaceuticals in water\/sediment systems. Environ Sci Technol 39:5209\u20135218","journal-title":"Environ Sci Technol"},{"key":"1459_CR13","first-page":"494","volume":"6","author":"RK Lynn","year":"1978","unstructured":"Lynn RK, Smith RG, Thompson RM, Deinzer ML, Griffin D, Gerber N (1978) Characterization of glucuronide metabolites of carbamazepine in human urine by gas chromatography and mass spectrometry. Drug Metab Dispos 6:494\u2013501","journal-title":"Drug Metab Dispos"},{"key":"1459_CR14","first-page":"275","volume":"25","author":"JL Maggs","year":"1997","unstructured":"Maggs JL, Pirmohamed M, Kitteringham NR, Park BK (1997) Characterization of the metabolites of carbamazepine in patient urine by liquid chromatography\/mass spectrometry. Drug Metab Dispos 25:275\u2013280","journal-title":"Drug Metab Dispos"},{"key":"1459_CR15","doi-asserted-by":"publisher","first-page":"3731","DOI":"10.1021\/ac030082k","volume":"75","author":"X Miao","year":"2003","unstructured":"Miao X, Metcalfe CD (2003) Determination of carbamazepine and its metabolites in aqueous samples using liquid chromatography\u2013electrospray tandem mass spectrometry. Anal Chem 75:3731\u20133738","journal-title":"Anal Chem"},{"key":"1459_CR16","first-page":"1157","volume":"27","author":"JD Moody","year":"1999","unstructured":"Moody JD, Freeman JP, Cerniglia CE (1999) Biotransformation of doxepin by Cunninghamella elegans. Drug Metab Dispos 27:1157\u20131164","journal-title":"Drug Metab Dispos"},{"key":"1459_CR17","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1177\/096032719801701204","volume":"17","author":"P Myllynen","year":"1998","unstructured":"Myllynen P, Pienimaki P, Raunio H, Vahakangas K (1998) Microsomal metabolism of carbamazepine and oxcarbamazepine in liver and placenta. Human Exp Toxicol 17:668\u2013676","journal-title":"Human Exp Toxicol"},{"key":"1459_CR18","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/S10267-005-0257-5","volume":"46","author":"Y Ogawa","year":"2005","unstructured":"Ogawa Y, Suda A, Kusama-Eguchi K, Watanabe K, Tokumasu S (2005) Interspecific groups of Umbelopsis ramanniana inferred from nucleotide sequences of nuclear rDNA transcribed spacer regions and sporangiospore morphology. Mycoscience 46:343\u2013351","journal-title":"Mycoscience"},{"key":"1459_CR19","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/j.1574-6968.1999.tb13723.x","volume":"177","author":"IA Parshikov","year":"1999","unstructured":"Parshikov IA, Freeman JP, Lay JO Jr, Beger RD, Williams AJ, Sutherland JB (1999) Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin by the fungus Mucor ramannianus. FEMS Microbiol Lett 177:131\u2013135","journal-title":"FEMS Microbiol Lett"},{"key":"1459_CR20","doi-asserted-by":"publisher","first-page":"2664","DOI":"10.1128\/AEM.66.6.2664-2667.2000","volume":"66","author":"IA Parshikov","year":"2000","unstructured":"Parshikov IA, Freeman JP, Lay JO Jr, Beger RD, Williams AJ, Sutherland JB (2000) Microbiological transformation of enrofloxacin by the fungus Mucor ramannianus. Appl Environ Microbiol 66:2664\u20132667","journal-title":"Appl Environ Microbiol"},{"key":"1459_CR21","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1080\/13880200500301597","volume":"43","author":"IA Parshikov","year":"2005","unstructured":"Parshikov IA, Miriyala B, Muraleedharan K, Illendula A, Avery M, Williams J (2005) Biocatalysis of the antimalarial artemisinin by Mucor ramannianus strains. Pharma Biol 43:579\u2013582","journal-title":"Pharma Biol"},{"key":"1459_CR22","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1080\/00498250110055479","volume":"31","author":"O Pelkonen","year":"2001","unstructured":"Pelkonen O, Myllynen P, Taavitsainen P, Boobis AR, Watts P, Lake BG, Price RJ, Renwick AB, Gomez-Lechon MJ, Castell JV, Ingelman-Sundberg M, Hidestrand M, Guillouzo A, Corcos L, Goldfarb PS, Lewis DF (2001) Carbamazepine: a \u2018blind\u2019 assessment of CVP-associated metabolism and interactions in human liver-derived in vitro systems. Xenobiotica 31:321\u2013343","journal-title":"Xenobiotica"},{"key":"1459_CR23","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s00244-004-0029-9","volume":"48","author":"J Seo","year":"2005","unstructured":"Seo J, Lee Y-G, Kim S-D, Cha C-J, Ahn J-H, Hur H-G (2005) Biodegradation of the insecticide N,N,-Diethyl-m-toluamide by fungi: identification and toxicity of metabolites. Arch Environ Contam Toxicol 48:323\u2013328","journal-title":"Arch Environ Contam Toxicol"},{"key":"1459_CR24","doi-asserted-by":"publisher","first-page":"163","DOI":"10.2166\/wst.2007.051","volume":"55","author":"J Seo","year":"2007","unstructured":"Seo J, Jeon J, Kim S-D, Kang S, Han J, Hur H-G (2007) Fungal biodegradation of carbofuran and carbofuran phenol by the fungus Mucor ramannianus: identification of metabolites. Water Sci Technol 55:163\u2013167","journal-title":"Water Sci Technol"},{"key":"1459_CR25","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1124\/jpet.104.073114","volume":"311","author":"AG Staines","year":"2004","unstructured":"Staines AG, Michael WHC, Burchell B (2004) N-Glucuronidation of carbamazepine in human tissues is mediated by UGT2B7. J Pharmacol Exp Ther 311:1131\u20131137","journal-title":"J Pharmacol Exp Ther"},{"key":"1459_CR26","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.1016\/S0043-1354(98)00099-2","volume":"32","author":"TA Ternes","year":"1998","unstructured":"Ternes TA (1998) Occurrence of drugs in German sewage treatment plants and rivers. Water Res 32:3245\u20133260","journal-title":"Water Res"},{"key":"1459_CR27","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1021\/es025834r","volume":"37","author":"C Tixier","year":"2003","unstructured":"Tixier C, Singer H, Oellers S, Muller SR (2003) Occurrence and fate of carbamazepine, clofibric acid, diclofenac, ibuprofen, ketoprofen and naproxen in surface waters. Environ Sci Technol 37:1061\u20131068","journal-title":"Environ Sci Technol"},{"key":"1459_CR28","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/BF00148169","volume":"12","author":"CR Valentine","year":"1996","unstructured":"Valentine CR, Valentine JL, Seng J, Leakey J, Casciano D (1996) The use of transgenic cell lines for evaluating toxic metabolites of carbamazepine. Cell Biol Toxicol 12:155\u2013165","journal-title":"Cell Biol Toxicol"},{"key":"1459_CR29","first-page":"1417","volume":"23","author":"D Zhang","year":"1995","unstructured":"Zhang D, Evans FE, Freeman JP, Duhart BJR, Cerniglia CE (1995) Biotransformation of amitriptyline by Cunninghamella elegans. Drug Metab Dispos 23:1417\u20131425","journal-title":"Drug Metab Dispos"},{"key":"1459_CR30","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0009-2797(96)03736-2","volume":"102","author":"D Zhang","year":"1996","unstructured":"Zhang D, Evans FE, Freeman JP, Yang Y, Deck J, Cerniglia CE (1996a) Formation of mammalian metabolites of cyclobenzaprine by the fungus, Cunninghamella elegans. Chem Biol Interactions 102:79\u201392","journal-title":"Chem Biol Interactions"},{"key":"1459_CR31","doi-asserted-by":"publisher","first-page":"3477","DOI":"10.1128\/AEM.62.9.3477-3479.1996","volume":"62","author":"D Zhang","year":"1996","unstructured":"Zhang D, Hansen EB, Deck JJR, Heinze TM, Sutherland JB, Cerniglia CE (1996b) Fungal biotransformation of the antihistamine azatadine by Cunninghamella elegans. Appl Environ Microbiol 62:3477\u20133479","journal-title":"Appl Environ Microbiol"},{"key":"1459_CR32","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/j.1574-6968.1996.tb08161.x","volume":"138","author":"D Zhang","year":"1996","unstructured":"Zhang D, Yifan Y, Leakey JEA, Cerniglia CE (1996c) Phase I and phase II enzymes produced by Cunninghamella elegans for the metabolism of xenobiotics. FEMS Micobiol Lett 138:221\u2013226","journal-title":"FEMS Micobiol Lett"},{"key":"1459_CR33","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1080\/004982597240622","volume":"27","author":"D Zhang","year":"1997","unstructured":"Zhang D, Hansen EB, Deck JJR, Heinze TM, Henderson A, Korfmacher WA, Cerniglia CE (1997) Fungal transformation of antihistamines: metabolism of cyproheptadine hydrochloride by Cunninghamella elegans. Xenobiotica 27:310\u2013315","journal-title":"Xenobiotica"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-008-1459-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00253-008-1459-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-008-1459-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-008-1459-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T03:04:04Z","timestamp":1580958244000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00253-008-1459-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["1459"],"URL":"https:\/\/doi.org\/10.1007\/s00253-008-1459-5","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]},"article-number":"663"}}