{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:54:34Z","timestamp":1790261674904,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1007\/s00253-008-1606-z","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T11:12:11Z","timestamp":1218539531000},"page":"263-273","source":"Crossref","is-referenced-by-count":67,"title":["TADH, the thermostable alcohol dehydrogenase from Thermus sp. ATN1: a versatile new biocatalyst for organic synthesis"],"prefix":"10.1007","volume":"81","author":[{"given":"Volker","family":"H\u00f6llrigl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Hollmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas C.","family":"Kleeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Buehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,11,1]]},"reference":[{"key":"1606_CR1","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) Rapid and sensitive method for quantitation of microgram quantities of protein utilizing principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"1606_CR2","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/anie.200300599","volume":"43","author":"M Breuer","year":"2004","unstructured":"Breuer M, Ditrich K, Habicher T, Hauer B, Kesseler M, St\u00fcrmer R, Zelinski T (2004) Industrial methods for the production of optically active intermediates. Angew Chem Int Ed 43:788\u2013824","journal-title":"Angew Chem Int Ed"},{"key":"1606_CR3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1042\/bj3160115","volume":"316","author":"DS Burdette","year":"1996","unstructured":"Burdette DS, Vieille C, Zeikus JG (1996) Cloning and expression of the gene encoding the Thermoanaerobacter ethanolicus 39E secondary-alcohol dehydrogenase and biochemical characterization of the enzyme. Biochem J 316:115\u2013122","journal-title":"Biochem J"},{"key":"1606_CR4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF02798431","volume":"14","author":"HK Chenault","year":"1987","unstructured":"Chenault HK, Whitesides GM (1987) Regeneration of nicotinamide cofactors for use in chemical synthesis. Appl Biochem Biotechnol 14:147\u2013197","journal-title":"Appl Biochem Biotechnol"},{"key":"1606_CR5","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/oxfordjournals.jbchem.a021441","volume":"120","author":"S D\u2019Auria","year":"1996","unstructured":"D\u2019Auria S, LaCara F, Nazzaro F, Vespa N, Rossi M (1996) A thermophilic alcohol dehydrogenase from Bacillus acidocaldarius not reactive towards ketones. J Biochem 120:498\u2013504","journal-title":"J Biochem"},{"key":"1606_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-18537-3","volume-title":"Biotransformations in organic chemistry","author":"K Faber","year":"2004","unstructured":"Faber K (2004) Biotransformations in organic chemistry. Springer, Berlin"},{"key":"1606_CR7","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1039\/p19950000967","volume":"1","author":"JM Fang","year":"1995","unstructured":"Fang JM, Lin CH, Bradshaw CW, Wong CH (1995) Enzymes in organic-synthesis\u2014oxidoreductions. J Chem Soc Perkin Trans 1:967\u2013978","journal-title":"J Chem Soc Perkin Trans"},{"key":"1606_CR8","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1002\/anie.200351089","volume":"42","author":"MV Filho","year":"2003","unstructured":"Filho MV, Stillger T, M\u00fcller M, Liese A, Wandrey C (2003) Is log P a convenient criterion to guide the choice of solvents for biphasic enzymatic reactions? Angew Chem Int Ed 42:2993\u20132996","journal-title":"Angew Chem Int Ed"},{"key":"1606_CR9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00253-007-1002-0","volume":"76","author":"K Goldberg","year":"2007","unstructured":"Goldberg K, Schroer K, L\u00fctz S, Liese A (2007) Biocatalytic ketone reduction\u2014a powerful tool for the production of chiral alcohols\u2014part I: processes with isolated enzymes. Appl Microbiol Biotechnol 76:237\u2013248","journal-title":"Appl Microbiol Biotechnol"},{"key":"1606_CR10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/1357-2725(95)00138-7","volume":"28","author":"A Guagliardi","year":"1996","unstructured":"Guagliardi A, Martino M, Iaccarino I, DeRosa M, Rossi M, Bartolucci S (1996) Purification and characterization of the alcohol dehydrogenase from a novel strain of Bacillus stearothermophilus Growing at 70\u00b0C. Int J Biochem Cell Biol 28:239\u2013246","journal-title":"Int J Biochem Cell Biol"},{"key":"1606_CR11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0960-8524(03)00033-6","volume":"89","author":"GD Haki","year":"2003","unstructured":"Haki GD, Rakshit SK (2003) Developments in industrially important thermostable enzymes: a review. Bioresour Technol 89:17\u201334","journal-title":"Bioresour Technol"},{"key":"1606_CR12","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S0076-6879(84)04109-4","volume":"104","author":"MJ Heeb","year":"1984","unstructured":"Heeb MJ, Gabriel O (1984) Enzyme localization in gels. Methods Enzymol 104:416\u2013439","journal-title":"Methods Enzymol"},{"key":"1606_CR13","first-page":"736","volume":"32","author":"GTM Henehan","year":"1993","unstructured":"Henehan GTM, Oppenheimer NJ (1993) Horse liver alcohol dehydrogenase-catalyzed oxidation of aldehydes\u2014dismutation precedes net production of reduced nicotinamide adenine-dinucleotide. Biochemistry 32:736\u2013738","journal-title":"Biochemistry"},{"key":"1606_CR14","doi-asserted-by":"crossref","first-page":"12294","DOI":"10.1021\/bi00038a025","volume":"34","author":"GTM Henehan","year":"1995","unstructured":"Henehan GTM, Chang SH, Oppenheimer NJ (1995) Aldehyde dehydrogenase-activity of Drosophila-melanogaster alcohol-dehydrogenase\u2014burst kinetics at high pH and aldehyde dismutase activity at physiological pH. Biochem 34:12294\u201312301","journal-title":"Biochem"},{"key":"1606_CR15","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00253-007-1238-8","volume":"77","author":"M Hess","year":"2008","unstructured":"Hess M, Antranikian G (2008) Archaeal alcohol dehydrogenase active at increased temperatures and in the presence of organic solvents. Appl Microbiol Biotechnol 77:1003\u20131013","journal-title":"Appl Microbiol Biotechnol"},{"key":"1606_CR16","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S1389-1723(04)70191-7","volume":"97","author":"H Hirakawa","year":"2004","unstructured":"Hirakawa H, Kamiya N, Kawarabayashi Y, Nagamune T (2004) Properties of an alcohol dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix K1. J Biosci Bioeng 97:202\u2013206","journal-title":"J Biosci Bioeng"},{"key":"1606_CR17","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1016\/j.tetasy.2005.09.026","volume":"16","author":"F Hollmann","year":"2005","unstructured":"Hollmann F, Kleeb A, Otto K, Schmid A (2005) Coupled chemoenzymatic transfer hydrogenation catalysis for enantioselective reduction and oxidation reactions. Tetrahedron: Asymmetry 16:3512\u20133519","journal-title":"Tetrahedron: Asymmetry"},{"key":"1606_CR18","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/adsc.200700059","volume":"349","author":"V H\u00f6llrigl","year":"2007","unstructured":"H\u00f6llrigl V, Otto K, Schmid A (2007) Electroenzymatic asymmetric reduction of rac-3-methylcyclohexanone to (1S,3S)-3-methylcyclohexanol in organic\/aqueous media catalyzed by a thermophilic alcohol dehydrogenase. Adv Synth Catal 349:1337\u20131340","journal-title":"Adv Synth Catal"},{"key":"1606_CR19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1139\/v82-005","volume":"60","author":"JB Jones","year":"1982","unstructured":"Jones JB, Jakovac IJ (1982) A new cubic-space section model for predicting the specificity of horse liver alcohol dehydrogenase-catalyzed oxidoreductions. Can J Chem 60:19\u201328","journal-title":"Can J Chem"},{"key":"1606_CR20","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1021\/ja00261a026","volume":"108","author":"E Keinan","year":"1986","unstructured":"Keinan E, Hafeli EK, Seth KK, Lamed R (1986) Thermostable enzymes in organic synthesis. 2. asymmetric reduction of ketones with alcohol dehydrogenase from Thermoanaerobium brockii. J Am Chem Soc 108:162\u2013169","journal-title":"J Am Chem Soc"},{"key":"1606_CR21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/bit.20004","volume":"86","author":"B Kosjek","year":"2004","unstructured":"Kosjek B, Stampfer W, Pogorevc M, Goessler W, Faber K, Kroutil W (2004) Purification and characterization of a chemotolerant alcohol dehydrogenase applicable to coupled redox reactions. Biotechnol Bioeng 86:55\u201362","journal-title":"Biotechnol Bioeng"},{"key":"1606_CR22","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/0003-9861(82)90549-5","volume":"217","author":"LJ Kricka","year":"1982","unstructured":"Kricka LJ, Deluca M (1982) Effect of solvents on the catalytic activity of firefly luciferase. Arch Biochem Biophys 217:674\u2013681","journal-title":"Arch Biochem Biophys"},{"key":"1606_CR23","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.cbpa.2004.02.005","volume":"8","author":"W Kroutil","year":"2004","unstructured":"Kroutil W, Mang H, Edegger K, Faber K (2004) Recent advances in the biocatalytic reduction of ketones and oxidation of sec-alcohols. Curr Opin Chem Biol 8:120\u2013126","journal-title":"Curr Opin Chem Biol"},{"key":"1606_CR24","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli UK (1970) Cleavage of structural proteins during assembly of head of bacteriophage T4. Nature 227:680\u2013685","journal-title":"Nature"},{"key":"1606_CR25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1042\/bj1950183","volume":"195","author":"RJ Lamed","year":"1981","unstructured":"Lamed RJ, Zeikus JG (1981) Novel NADP-linked alcohol-aldehyde\/ketone oxidoreductase in thermophilic ethanologenic bacteria. Biochem J 195:183\u2013190","journal-title":"Biochem J"},{"key":"1606_CR26","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1021\/cr60274a001","volume":"71","author":"A Leo","year":"1971","unstructured":"Leo A, Hansch C, Elkins D (1971) Partition coefficients and their uses. Chem Rev 71:525\u2013616","journal-title":"Chem Rev"},{"key":"1606_CR27","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2174\/0929867013373390","volume":"8","author":"MD Leonida","year":"2001","unstructured":"Leonida MD (2001) Redox enzymes used in chiral syntheses coupled to coenzyme regeneration. Curr Med Chem 8:345\u2013369","journal-title":"Curr Med Chem"},{"key":"1606_CR28","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1128\/JB.181.4.1163-1170.1999","volume":"181","author":"KS Ma","year":"1999","unstructured":"Ma KS, Adams MWW (1999) An unusual oxygen-sensitive, iron- and zinc-containing alcohol dehydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus. J Bacteriol 181:1163\u20131170","journal-title":"J Bacteriol"},{"key":"1606_CR29","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1111\/j.1742-4658.2005.04561.x","volume":"272","author":"B Mee","year":"2005","unstructured":"Mee B, Kelleher D, Frias J, Malone R, Tipton KF, Henehan GTM, Windle HJ (2005) Characterization of cinnamyl alcohol dehydrogenase of Helicobacter pylori\u2014an aldehyde dismutating enzyme. FEBS J 272:1255\u20131264","journal-title":"FEBS J"},{"key":"1606_CR30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1357-2725(01)00109-1","volume":"34","author":"M Miroliaei","year":"2002","unstructured":"Miroliaei M, Nemat-Gorgani M (2002) Effect of organic solvents on stability and activity of two related alcohol dehydrogenases: a comparative study. Int J Biochem Cell Biol 34:169\u2013175","journal-title":"Int J Biochem Cell Biol"},{"key":"1606_CR31","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1016\/S0957-4166(03)00526-3","volume":"14","author":"K Nakamura","year":"2003","unstructured":"Nakamura K, Yamanaka R, Matsuda T, Harada T (2003) Recent developments in asymmetric reduction of ketones with biocatalysts. Tetrahedron: Asymmetry 14:2659\u20132681","journal-title":"Tetrahedron: Asymmetry"},{"key":"1606_CR32","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/1097-0290(20001220)70:6<638::AID-BIT5>3.0.CO;2-#","volume":"70","author":"B Orlich","year":"2000","unstructured":"Orlich B, Berger H, Lade M, Schom\u00e4cker R (2000) Stability and activity of alcohol dehydrogenases in W\/O-microemulsions: enantioselective reduction including cofactor regeneration. Biotechnol Bioeng 70:638\u2013646","journal-title":"Biotechnol Bioeng"},{"key":"1606_CR33","volume-title":"Characterization of a thermostable alkane oxidising system. Biotechnology","author":"K Otto","year":"2001","unstructured":"Otto K (2001) Characterization of a thermostable alkane oxidising system. Biotechnology. Technical University Hamburg, Hamburg"},{"key":"1606_CR34","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1351\/pac196409010119","volume":"9","author":"V Prelog","year":"1964","unstructured":"Prelog V (1964) Specification of the stereospecificity of some oxido-reductases by diamond lattice sections. Pure Appl Chem 9:119\u2013130","journal-title":"Pure Appl Chem"},{"key":"1606_CR35","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0168-6445(03)00068-8","volume":"27","author":"H Radianingtyas","year":"2003","unstructured":"Radianingtyas H, Wright PC (2003) Alcohol dehydrogenases from thermophilic and hyperthermophilic archaea and bacteria. FEMS Microbiol Rev 27:593\u2013616","journal-title":"FEMS Microbiol Rev"},{"key":"1606_CR36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3109\/10408419409113545","volume":"20","author":"MF Reid","year":"1994","unstructured":"Reid MF, Fewson CA (1994) Molecular characterization of microbial alcohol dehydrogenases. Crit Rev Microbiol 20:13\u201356","journal-title":"Crit Rev Microbiol"},{"key":"1606_CR37","volume-title":"Molecular cloning: a laboratory manual","author":"J Sambrook","year":"2001","unstructured":"Sambrook J, Russell DW (2001) Molecular cloning: a laboratory manual. Cold Spring Laboratory, New York"},{"key":"1606_CR38","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1359-0294(00)00043-1","volume":"5","author":"G Savelli","year":"2000","unstructured":"Savelli G, Spreti N, Di Profio P (2000) Enzyme activity and stability control by amphiphilic self-organizing systems in aqueous solutions. Curr Opin Colloid Interface Sci 5:111\u2013117","journal-title":"Curr Opin Colloid Interface Sci"},{"key":"1606_CR39","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0958-1669(02)00336-1","volume":"13","author":"A Schmid","year":"2002","unstructured":"Schmid A, Hollmann F, Park JB, Buhler B (2002) The use of enzymes in the chemical industry in Europe. Curr Opin Biotechnol 13:359\u2013366","journal-title":"Curr Opin Biotechnol"},{"key":"1606_CR40","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1126\/science.1079237","volume":"299","author":"HE Schoemaker","year":"2003","unstructured":"Schoemaker HE, Mink D, Wubbolts MG (2003) Dispelling the myths\u2014biocatalysis in industrial synthesis. Science 299:1694\u20131697","journal-title":"Science"},{"key":"1606_CR41","doi-asserted-by":"crossref","first-page":"11186","DOI":"10.1021\/bi00092a031","volume":"32","author":"GL Shearer","year":"1993","unstructured":"Shearer GL, Kim KY, Lee KM, Wang CK, Plapp BV (1993) Alternative pathways and reactions of benzyl alcohol and benzaldehyde with horse liver alcohol-dehydrogenase. Biochem 32:11186\u201311194","journal-title":"Biochem"},{"key":"1606_CR42","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0958-1669(02)00360-9","volume":"13","author":"AJ Straathof","year":"2002","unstructured":"Straathof AJ, Panke S, Schmid A (2002) The production of fine chemicals by biotransformations. Curr Opin Biotechnol 13:548\u2013556","journal-title":"Curr Opin Biotechnol"},{"key":"1606_CR43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0014-5793(96)00954-4","volume":"394","author":"S Svensson","year":"1996","unstructured":"Svensson S, Lundsj\u00f6 A, Cronholm T, H\u00f6\u00f6g JO (1996) Aldehyde dismutase activity of human liver alcohol dehydrogenase. FEBS Lett 394:217\u2013220","journal-title":"FEBS Lett"},{"key":"1606_CR44","doi-asserted-by":"crossref","first-page":"5231","DOI":"10.1128\/AEM.66.12.5231-5235.2000","volume":"66","author":"A Tani","year":"2000","unstructured":"Tani A, Sakai Y, Ishige T, Kato N (2000) Thermostable NADP+-dependent medium-chain alcohol dehydrogenase from Acinetobacter sp Strain M-1: purification and characterization and gene expression in Escherichia coli. Appl Environ Microb 66:5231\u20135235","journal-title":"Appl Environ Microb"},{"key":"1606_CR45","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1042\/bst0320290","volume":"32","author":"IN Taylor","year":"2004","unstructured":"Taylor IN, Brown RC, Bycroft M, King G, Littlechild JA, Lloyd MC, Praquin C, Toogood HS, Taylor SJC (2004) Application of thermophilic enzymes in commercial biotransformation processes. Biochem Soc Trans 32:290\u2013292","journal-title":"Biochem Soc Trans"},{"key":"1606_CR46","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1023\/A:1005476115349","volume":"21","author":"S Trivic","year":"1999","unstructured":"Trivic S, Leskova V, Winston GW (1999) Aldehyde dismutase activity of yeast alcohol dehydrogenase. Biotechnol Lett 21:231\u2013234","journal-title":"Biotechnol Lett"},{"key":"1606_CR47","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0958-1669(03)00094-6","volume":"14","author":"WA Donk van der","year":"2003","unstructured":"van der Donk WA, Zhao HM (2003) Recent developments in pyridine nucleotide regeneration. Curr Opin Biotechnol 14:421\u2013426","journal-title":"Curr Opin Biotechnol"},{"key":"1606_CR48","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1039\/b001039l","volume":"1","author":"K Velonia","year":"2000","unstructured":"Velonia K, Smonou I (2000) Dismutation of aldehydes catalyzed by alcohol dehydrogenases. J Chem Soc Perkin Trans 1:2283\u20132287","journal-title":"J Chem Soc Perkin Trans"},{"key":"1606_CR49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MMBR.65.1.1-43.2001","volume":"65","author":"C Vieille","year":"2001","unstructured":"Vieille C, Zeikus GJ (2001) Hyperthermophilic enzymes: sources, uses, and molecular mechanisms for thermostability. Microbiol Mol Biol Rev 65:1\u201343","journal-title":"Microbiol Mol Biol Rev"},{"key":"1606_CR50","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/b98911","volume-title":"Technology transfer in biotechnology","author":"R Wichmann","year":"2005","unstructured":"Wichmann R, Vasic-Racki D (2005) Cofactor regeneration at the lab scale. In: Kragl U (ed) Technology transfer in biotechnology. vol. 92. Springer, Berlin, pp 225\u2013260"},{"key":"1606_CR51","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S1096-4959(02)00051-9","volume":"132","author":"SY Yoon","year":"2002","unstructured":"Yoon SY, Noh HS, Kim EH, Kong KH (2002) The highly stable alcohol dehydrogenase of Thermomicrobium roseum: purification and molecular characterization. Comp Biochem Physiol B Biochem Mol Biol 132:415\u2013422","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-008-1606-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00253-008-1606-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-008-1606-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-008-1606-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T08:14:49Z","timestamp":1580976889000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00253-008-1606-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["1606"],"URL":"https:\/\/doi.org\/10.1007\/s00253-008-1606-z","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}