{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:15:22Z","timestamp":1790900122333,"version":"4.1.0"},"reference-count":109,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,7,16]],"date-time":"2009-07-16T00:00:00Z","timestamp":1247702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1007\/s00253-009-2107-4","type":"journal-article","created":{"date-parts":[[2009,7,15]],"date-time":"2009-07-15T07:31:05Z","timestamp":1247643065000},"page":"417-428","source":"Crossref","is-referenced-by-count":35,"title":["Biosynthesis, biotechnological production, and application of teicoplanin: current state and perspectives"],"prefix":"10.1007","volume":"84","author":[{"given":"Hyung-Moo","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marimuthu","family":"Jeya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Yong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Jung","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raushan","family":"Kumar Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Wang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Kul","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,7,16]]},"reference":[{"key":"2107_CR1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1517\/13543784.14.2.117","volume":"14","author":"MN Alekshun","year":"2005","unstructured":"Alekshun MN (2005) New advances in antibiotic development and discovery. Expert Opin Investig Drugs 14:117\u2013134","journal-title":"Expert Opin Investig Drugs"},{"key":"2107_CR2","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1128\/AAC.37.8.1563","volume":"37","author":"M Arthur","year":"1993","unstructured":"Arthur M, Courvalin P (1993) Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother 37:1563\u20131571","journal-title":"Antimicrob Agents Chemother"},{"key":"2107_CR3","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1046\/j.1365-2958.1996.00617.x","volume":"21","author":"M Arthur","year":"1996","unstructured":"Arthur M, Depardieu F, Reynolds P, Courvalin P (1996a) Quantitative analysis of the metabolism of soluble cytoplasmic peptidoglycan precursors of glycopeptide-resistant enterococci. Mol Microbiol 21:33\u201344","journal-title":"Mol Microbiol"},{"key":"2107_CR4","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/0966-842X(96)10063-9","volume":"4","author":"M Arthur","year":"1996","unstructured":"Arthur M, Reynolds P, Courvalin P (1996b) Glycopeptide resistance in enterococci. Trends Microbiol 4:401\u2013407","journal-title":"Trends Microbiol"},{"key":"2107_CR5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0163-4453(96)80003-X","volume":"32","author":"M Arthur","year":"1996","unstructured":"Arthur M, Reynolds PE, Depardieu F, Evers S, Dutka-Malen S, Quintiliani R Jr, Courvalin P (1996c) Mechanisms of glycopeptide resistance in enterococci. J Infect 32:11\u201316","journal-title":"J Infect"},{"key":"2107_CR6","unstructured":"Assi F, Lancini G, Gianantonio A (1986) Method for selectively increasing the ration of single major components of teicoplanin A2 complex. European Patent 0204179A1"},{"key":"2107_CR7","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1038\/nbt1265","volume":"24","author":"RH Baltz","year":"2006","unstructured":"Baltz RH (2006) Molecular engineering approaches to peptide, polyketide and other antibiotics. Nat Biotechnol 24:1533\u20131540","journal-title":"Nat Biotechnol"},{"key":"2107_CR8","doi-asserted-by":"publisher","first-page":"4895","DOI":"10.1021\/ja00329a044","volume":"106","author":"JCJ Barna","year":"1984","unstructured":"Barna JCJ, Williams DH, Stone DJM, Leung TWC, Doddrell DM (1984) Structure elucidation of the teicoplanin antibiotics. J Am Chem Soc 106:4895\u20134902","journal-title":"J Am Chem Soc"},{"key":"2107_CR9","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1128\/AAC.39.3.781","volume":"39","author":"DA Beauregard","year":"1995","unstructured":"Beauregard DA, Williams DH, Gwynn MN, Knowles DJ (1995) Dimerization and membrane anchors in extracellular targeting of vancomycin group antibiotics. Antimicrob Agents Chemother 39:781\u2013785","journal-title":"Antimicrob Agents Chemother"},{"key":"2107_CR10","doi-asserted-by":"publisher","first-page":"773","DOI":"10.7164\/antibiotics.56.773","volume":"56","author":"F Beltrametti","year":"2003","unstructured":"Beltrametti F, Lazzarini A, Brunati C, Marazzi A, Jovetic S, Selva E, Marinelli F (2003) Production and characterization of monochlorinated and dechlorinated A40926 derivatives. J Antibiot (Tokyo) 56:773\u2013782","journal-title":"J Antibiot (Tokyo)"},{"key":"2107_CR11","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1128\/AAC.01071-06","volume":"51","author":"F Beltrametti","year":"2007","unstructured":"Beltrametti F, Consolandi A, Carrano L, Bagatin F, Rossi R, Leoni L, Zennaro E, Selva E, Marinelli F (2007) Resistance to glycopeptide antibiotics in the teicoplanin producer is mediated by van gene homologue expression directing the synthesis of a modified cell wall peptidoglycan. Antimicrob Agents Chemother 51:1135\u20131141","journal-title":"Antimicrob Agents Chemother"},{"key":"2107_CR12","doi-asserted-by":"publisher","first-page":"4688","DOI":"10.1002\/1521-3773(20011217)40:24<4688::AID-ANIE4688>3.0.CO;2-M","volume":"40","author":"D Bischoff","year":"2001","unstructured":"Bischoff D, Pelzer S, Bister B, Nicholson GJ, Stockert S, Schirle M, Wohlleben W, Jung G, Sussmuth RD (2001) The Biosynthesis of Vancomycin-Type Glycopeptide Antibiotics-The Order of the Cyclization Steps This work was supported by the Deutsche Forschungsgemeinschaft (SFB 323) and by a grant of the EU (MEGATOP, QLK3-1999-00650). R. D. S. gratefully acknowledges the support of a Feodor-Lynen Fellowship granted by the Alexander-von-Humboldt Stiftung. We thank Corina Bihlmaier and Volker Pfeifer for help with transformation and Southern hybridization, J. A. Moss (La Jolla (USA)) for critical comments on the manuscript and Prof. Dr. M. E. Maier and Prof. Dr. H.-P. Fiedler (Tubingen) for generous support. Angew Chem Int Ed Engl 40:4688\u20134691","journal-title":"Angew Chem Int Ed Engl"},{"key":"2107_CR13","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/cbic.200300619","volume":"4","author":"B Bister","year":"2003","unstructured":"Bister B, Bischoff D, Nicholson GJ, Stockert S, Wink J, Brunati C, Donadio S, Pelzer S, Wohlleben W, Sussmuth RD (2003) Bromobalhimycin and chlorobromobalhimycins\u2014illuminating the potential of halogenases in glycopeptide antibiotic biosyntheses. Chembiochem 4:658\u2013662","journal-title":"Chembiochem"},{"key":"2107_CR14","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/med.1014","volume":"21","author":"DL Boger","year":"2001","unstructured":"Boger DL (2001) Vancomycin, teicoplanin, and ramoplanin: synthetic and mechanistic studies. Med Res Rev 21:356\u2013381","journal-title":"Med Res Rev"},{"key":"2107_CR15","doi-asserted-by":"publisher","first-page":"615","DOI":"10.7164\/antibiotics.37.615","volume":"37","author":"A Borghi","year":"1984","unstructured":"Borghi A, Coronelli C, Faniuolo L, Allievi G, Pallanza R, Gallo GG (1984) Teichomycins, new antibiotics from Actinoplanes teichomyceticus nov. sp. IV. Separation and characterization of the components of teichomycin (teicoplanin). J Antibiot (Tokyo) 37:615\u2013620","journal-title":"J Antibiot (Tokyo)"},{"key":"2107_CR16","doi-asserted-by":"publisher","first-page":"361","DOI":"10.7164\/antibiotics.42.361","volume":"42","author":"A Borghi","year":"1989","unstructured":"Borghi A, Antonini P, Zanol M, Ferrari P, Zerilli LF, Lancini GC (1989) Isolation and structure determination of two new analogs of teicoplanin, a glycopeptide antibiotic. J Antibiot (Tokyo) 42:361\u2013366","journal-title":"J Antibiot (Tokyo)"},{"key":"2107_CR17","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1099\/00221287-137-3-587","volume":"137","author":"A Borghi","year":"1991","unstructured":"Borghi A, Edwards D, Zerilli LF, Lancini GC (1991) Factors affecting the normal and branched-chain acyl moieties of teicoplanin components produced by Actinoplanes teichomyceticus. J Gen Microbiol 137:587\u2013592","journal-title":"J Gen Microbiol"},{"key":"2107_CR18","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/ja.2005.63","volume":"58","author":"M Brunati","year":"2005","unstructured":"Brunati M, Bava A, Marinelli F, Lancini G (2005) Influence of leucine and valine on ramoplanin production by Actinoplanes sp. ATCC 33076. J Antibiot (Tokyo) 58:473\u2013478","journal-title":"J Antibiot (Tokyo)"},{"key":"2107_CR19","doi-asserted-by":"publisher","first-page":"10408","DOI":"10.1021\/bi00107a007","volume":"30","author":"TD Bugg","year":"1991","unstructured":"Bugg TD, Wright GD, Dutka-Malen S, Arthur M, Courvalin P, Walsh CT (1991) Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. Biochemistry 30:10408\u201310415","journal-title":"Biochemistry"},{"key":"2107_CR20","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.mib.2004.08.013","volume":"7","author":"K Bush","year":"2004","unstructured":"Bush K, Macielag M, Weidner-Wells M (2004) Taking inventory: antibacterial agents currently at or beyond Phase 1. Curr Opin Microbiol 7:466\u2013476","journal-title":"Curr Opin Microbiol"},{"key":"2107_CR21","doi-asserted-by":"publisher","first-page":"449","DOI":"10.2165\/00003495-199040030-00007","volume":"40","author":"DM Campoli-Richards","year":"1990","unstructured":"Campoli-Richards DM, Brogden RN, Faulds D (1990) Teicoplanin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential. Drugs 40:449\u2013486","journal-title":"Drugs"},{"key":"2107_CR22","doi-asserted-by":"publisher","first-page":"3652","DOI":"10.1128\/JCM.38.10.3652-3655.2000","volume":"38","author":"DK Chen","year":"2000","unstructured":"Chen DK, Pearce L, McGeer A, Low DE, Willey BM (2000) Evaluation of D-xylose and 1% methyl-alpha-D-glucopyranoside fermentation tests for distinguishing Enterococcus gallinarum from Enterococcus faecium. J Clin Microbiol 38:3652\u20133655","journal-title":"J Clin Microbiol"},{"key":"2107_CR23","doi-asserted-by":"publisher","first-page":"8548","DOI":"10.1073\/pnas.151246498","volume":"98","author":"HT Chiu","year":"2001","unstructured":"Chiu HT, Hubbard BK, Shah AN, Eide J, Fredenburg RA, Walsh CT, Khosla C (2001) Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster. Proc Natl Acad Sci U S A 98:8548\u20138553","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2107_CR24","first-page":"1005","volume":"43","author":"A Cometti","year":"1988","unstructured":"Cometti A, Gallo GG, Kettenring J, Panzone GB, Tuan G, Zerilli LF (1988) Isolation and structure determination of the main related substances of teicoplanin, a glycopeptide antibiotic. Farmaco [Sci] 43:1005\u20131018","journal-title":"Farmaco [Sci]"},{"key":"2107_CR25","first-page":"133","volume":"7","author":"A Corti","year":"1985","unstructured":"Corti A, Soffientini A, Cassani G (1985) Binding of the glycopeptide antibiotic teicoplanin to D-alanyl-D-alanine-agarose: the effect of micellar aggregates. J Appl Biochem 7:133\u2013137","journal-title":"J Appl Biochem"},{"key":"2107_CR26","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2165\/00003088-199835010-00005","volume":"35","author":"NW David","year":"1998","unstructured":"David NW, Joanne LR (1998) Community-based parenteral anti-infective therapy (CoPAT): pharmacokinetic and monitoring issues. Clin Pharmacokinet 35:65\u201377","journal-title":"Clin Pharmacokinet"},{"key":"2107_CR27","doi-asserted-by":"publisher","first-page":"9064","DOI":"10.1021\/ja026342h","volume":"124","author":"SD Dong","year":"2002","unstructured":"Dong SD, Oberthur M, Losey HC, Anderson JW, Eggert US, Peczuh MW, Walsh CT, Kahne D (2002) The structural basis for induction of VanB resistance. J Am Chem Soc 124:9064\u20139065","journal-title":"J Am Chem Soc"},{"key":"2107_CR28","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/BF00903781","volume":"32","author":"JL Doull","year":"1990","unstructured":"Doull JL, Vining LC (1990) Nutritional control of actinorhodin production by Streptomyces coelicolor A3(2): suppressive effects of nitrogen and phosphate. Appl Microbiol Biotechnol 32:449\u2013454","journal-title":"Appl Microbiol Biotechnol"},{"key":"2107_CR29","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1002\/(SICI)1521-3773(19990503)38:9<1172::AID-ANIE1172>3.0.CO;2-C","volume":"38","author":"H Dudley","year":"1999","unstructured":"Dudley H, Williams BB (1999) The vancomycin group of antibiotics and the fight against resistant bacteria. Angewandte Chemie International Edition 38:1172\u20131193","journal-title":"Angewandte Chemie International Edition"},{"key":"2107_CR30","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1006\/jtbi.1998.0809","volume":"195","author":"DA Evans","year":"1998","unstructured":"Evans DA, Klemer J, Kaattari SL (1998a) Heuristic models of the intermonomeric disulfide bonding process. J Theor Biol 195:505\u2013524","journal-title":"J Theor Biol"},{"key":"2107_CR31","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1002\/(SICI)1521-3773(19981016)37:19<2700::AID-ANIE2700>3.0.CO;2-P","volume":"37","author":"DA Evans","year":"1998","unstructured":"Evans DA, Wood MR, Trotter BW, Richardson TI, Barrow JC, Katz JL (1998b) Total syntheses of vancomycin and eremomycin aglycons. Angewandte Chemie International Edition 37:2700\u20132704","journal-title":"Angewandte Chemie International Edition"},{"key":"2107_CR32","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1089\/mdr.1996.2.219","volume":"2","author":"S Evers","year":"1996","unstructured":"Evers S, Quintiliani R Jr, Courvalin P (1996) Genetics of glycopeptide resistance in enterococci. Microb Drug Resist 2:219\u2013223","journal-title":"Microb Drug Resist"},{"key":"2107_CR33","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1128\/AAC.43.9.2161","volume":"43","author":"M Fines","year":"1999","unstructured":"Fines M, Perichon B, Reynolds P, Sahm DF, Courvalin P (1999) VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405. Antimicrob Agents Chemother 43:2161\u20132164","journal-title":"Antimicrob Agents Chemother"},{"key":"2107_CR34","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1126\/science.284.5413.507","volume":"284","author":"M Ge","year":"1999","unstructured":"Ge M, Chen Z, Onishi HR, Kohler J, Silver LL, Kerns R, Fukuzawa S, Thompson C, Kahne D (1999) Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala. Science 284:507\u2013511","journal-title":"Science"},{"issue":"Suppl 1","key":"2107_CR35","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1016\/S0924-8579(00)00300-9","volume":"16","author":"Y Gholizadeh","year":"2000","unstructured":"Gholizadeh Y, Courvalin P (2000) Acquired and intrinsic glycopeptide resistance in enterococci. Int J Antimicrob Agents 16(Suppl 1):S11\u2013S17","journal-title":"Int J Antimicrob Agents"},{"key":"2107_CR36","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1128\/AAC.34.5.899","volume":"34","author":"FW Goldstein","year":"1990","unstructured":"Goldstein FW, Coutrot A, Sieffer A, Acar JF (1990) Percentages and distributions of teicoplanin- and vancomycin-resistant strains among coagulase-negative staphylococci. Antimicrob Agents Chemother 34:899\u2013900","journal-title":"Antimicrob Agents Chemother"},{"key":"2107_CR37","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1007\/s10295-003-0024-6","volume":"30","author":"N Gunnarsson","year":"2003","unstructured":"Gunnarsson N, Bruheim P, Nielsen J (2003) Production of the glycopeptide antibiotic A40926 by Nonomuraea sp. ATCC 39727: influence of medium composition in batch fermentation. J Ind Microbiol Biotechnol 30:150\u2013156","journal-title":"J Ind Microbiol Biotechnol"},{"key":"2107_CR38","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.chembiol.2007.08.014","volume":"14","author":"B Hadatsch","year":"2007","unstructured":"Hadatsch B, Butz D, Schmiederer T, Steudle J, Wohlleben W, Sussmuth R, Stegmann E (2007) The biosynthesis of teicoplanin-type glycopeptide antibiotics: assignment of p450 mono-oxygenases to side chain cyclizations of glycopeptide a47934. Chem Biol 14:1078\u20131089","journal-title":"Chem Biol"},{"key":"2107_CR39","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1128\/AAC.37.3.453","volume":"37","author":"RE Hancock","year":"1993","unstructured":"Hancock RE, Farmer SW (1993) Mechanism of uptake of deglucoteicoplanin amide derivatives across outer membranes of Escherichia coli and Pseudomonas aeruginosa. Antimicrob Agents Chemother 37:453\u2013456","journal-title":"Antimicrob Agents Chemother"},{"key":"2107_CR40","doi-asserted-by":"publisher","first-page":"6915","DOI":"10.1021\/ja00361a029","volume":"105","author":"CM Harris","year":"1983","unstructured":"Harris CM, Kopecka H, Harris TM (1983) Vancomycin: structure and transformation to CDP-I. J Am Chem Soc 105:6915\u20136922","journal-title":"J Am Chem Soc"},{"key":"2107_CR41","doi-asserted-by":"publisher","first-page":"40","DOI":"10.7164\/antibiotics.52.40","volume":"52","author":"A Heydorn","year":"1999","unstructured":"Heydorn A, Suhr-Jessen T, Nielsen J (1999) Growth and production kinetics of a teicoplanin producing strain of Actinoplanes teichomyceticus. J Antibiot (Tokyo) 52:40\u201344","journal-title":"J Antibiot (Tokyo)"},{"key":"2107_CR42","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/S1074-5521(00)00043-0","volume":"7","author":"B Hubbard","year":"2000","unstructured":"Hubbard B, Thomas M, Walsh C (2000) Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics. Chem Biol 7:931\u2013942","journal-title":"Chem Biol"},{"key":"2107_CR43","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00253-001-0872-9","volume":"58","author":"ZH Jin","year":"2002","unstructured":"Jin ZH, Wang MR, Cen PL (2002) Production of teicoplanin by valine analogue-resistant mutant strains of Actinoplanes teichomyceticus. Appl Microbiol Biotechnol 58:63\u201366","journal-title":"Appl Microbiol Biotechnol"},{"key":"2107_CR44","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00253-008-1530-2","volume":"80","author":"HM Jung","year":"2008","unstructured":"Jung HM, Kim SY, Prabhu P, Moon HJ, Kim IW, Lee JK (2008) Optimization of culture conditions and scale-up to plant scales for teicoplanin production by Actinoplanes teichomyceticus. Appl Microbiol Biotechnol 80:21\u201327","journal-title":"Appl Microbiol Biotechnol"},{"key":"2107_CR45","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1021\/cr030103a","volume":"105","author":"D Kahne","year":"2005","unstructured":"Kahne D, Leimkuhler C, Lu W, Walsh C (2005) Glycopeptide and lipoglycopeptide antibiotics. Chem Rev 105:425\u2013448","journal-title":"Chem Rev"},{"key":"2107_CR46","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1128\/AAC.39.7.1589","volume":"39","author":"MT Kenny","year":"1995","unstructured":"Kenny MT, Brackman MA, Dulworth JK (1995) In vitro activity of the semisynthetic glycopeptide amide MDL 63, 246. Antimicrob Agents Chemother 39:1589\u20131590","journal-title":"Antimicrob Agents Chemother"},{"key":"2107_CR47","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.chembiol.2005.12.003","volume":"13","author":"SS Lamb","year":"2006","unstructured":"Lamb SS, Patel T, Koteva KP, Wright GD (2006) Biosynthesis of sulfated glycopeptide antibiotics by using the sulfotransferase StaL. Chem Biol 13:171\u2013181","journal-title":"Chem Biol"},{"key":"2107_CR48","unstructured":"Lancini GC CB (1990) Glycopeptide antibiotics of the vancomycin group. In Kleinhauf H., Van Dohren H. (Eds), Walter de Gruyter. Berlin, p 159"},{"key":"2107_CR49","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1056\/NEJM198807213190307","volume":"319","author":"R Leclercq","year":"1988","unstructured":"Leclercq R, Derlot E, Duval J, Courvalin P (1988) Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium. N Engl J Med 319:157\u2013161","journal-title":"N Engl J Med"},{"key":"2107_CR50","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1023\/A:1022842203917","volume":"25","author":"JC Lee","year":"2003","unstructured":"Lee JC, Park HR, Park DJ, Son KH, Yoon KH, Kim YB, Kim CJ (2003) Production of teicoplanin by a mutant of Actinoplanes teicomyceticus. Biotechnol Lett 25:537\u2013540","journal-title":"Biotechnol Lett"},{"key":"2107_CR51","doi-asserted-by":"publisher","first-page":"20588","DOI":"10.1021\/jp0548117","volume":"109","author":"JG Lee","year":"2005","unstructured":"Lee JG, Sagui C, Roland C (2005) Quantum simulations of the structure and binding of glycopeptide antibiotic aglycons to cell wall analogues. J Phys Chem B 109:20588\u201320596","journal-title":"J Phys Chem B"},{"key":"2107_CR52","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1039\/b103548g","volume":"18","author":"T Li","year":"2001","unstructured":"Li T, Choroba O, Charles E, Sandercock A, Williams D, Spencer J (2001) Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics. Chem Commun 18:1752\u20131753","journal-title":"Chem Commun"},{"key":"2107_CR53","first-page":"107","volume":"11","author":"TLHF Li","year":"2004","unstructured":"Li TLHF, Haydock SF, Mironenko T, Leadlay PF, Spencer JB (2004) Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferase and the key acyltransferase. Chem Biol 11:107\u2013119","journal-title":"Chem Biol"},{"key":"2107_CR54","doi-asserted-by":"publisher","first-page":"4745","DOI":"10.1021\/bi010050w","volume":"40","author":"HC Losey","year":"2001","unstructured":"Losey HC, Peczuh MW, Chen Z, Eggert US, Dong SD, Pelczer I, Kahne D, Walsh CT (2001) Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides. Biochemistry 40:4745\u20134755","journal-title":"Biochemistry"},{"key":"2107_CR55","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/S1074-5521(02)00270-3","volume":"9","author":"HC Losey","year":"2002","unstructured":"Losey HC, Jiang J, Biggins JB, Oberthur M, Ye XY, Dong SD, Kahne D, Thorson JS, Walsh CT (2002) Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides. Chem Biol 9:1305\u20131314","journal-title":"Chem Biol"},{"key":"2107_CR56","doi-asserted-by":"publisher","first-page":"4581","DOI":"10.1021\/ja00090a006","volume":"116","author":"JP Mackay","year":"1994","unstructured":"Mackay JP, Gerhard U, Beauregard DA, Williams DH, Westwell MS, Searle MS (1994) Glycopeptide antibiotic activity and the possible role of dimerization: a model for biological signaling. J Am Chem Soc 116:4581\u20134590","journal-title":"J Am Chem Soc"},{"key":"2107_CR57","doi-asserted-by":"publisher","first-page":"988","DOI":"10.7164\/antibiotics.37.988","volume":"37","author":"A Malabarba","year":"1984","unstructured":"Malabarba A, Strazzolini P, Depaoli A, Landi M, Berti M, Cavalleri B (1984) Teicoplanin, antibiotics from Actinoplanes teichomyceticus nov. sp. VI. Chemical degradation: physico-chemical and biological properties of acid hydrolysis products. J Antibiot (Tokyo) 37:988\u2013999","journal-title":"J Antibiot (Tokyo)"},{"key":"2107_CR58","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/(SICI)1098-1128(199701)17:1<69::AID-MED3>3.0.CO;2-R","volume":"17","author":"A Malabarba","year":"1997","unstructured":"Malabarba A, Nicas TI, Thompson RC (1997) Structural modifications of glycopeptide antibiotics. Med Res Rev 17:69\u2013137","journal-title":"Med Res Rev"},{"key":"2107_CR59","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.1021\/cr960029e","volume":"97","author":"MA Marahiel","year":"1997","unstructured":"Marahiel MA, Stachelhaus T, Mootz HD (1997) Modular peptide synthetases involved in nonribosomal peptide synthesis. Chem Rev 97:2651\u20132674","journal-title":"Chem Rev"},{"key":"2107_CR60","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S0378-1097(97)00449-7","volume":"157","author":"CG Marshall","year":"1997","unstructured":"Marshall CG, Wright GD (1997) The glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009 has both D-alanyl-D-alanine and D-alanyl-D-lactate ligases. FEMS Microbiol Lett 157:295\u2013299","journal-title":"FEMS Microbiol Lett"},{"key":"2107_CR61","doi-asserted-by":"publisher","first-page":"5792","DOI":"10.1128\/JB.180.21.5792-5795.1998","volume":"180","author":"CG Marshall","year":"1998","unstructured":"Marshall CG, Wright GD (1998) DdlN from vancomycin-producing Amycolatopsis orientalis C329.2 is a VanA homologue with D-alanyl-D-lactate ligase activity. J Bacteriol 180:5792\u20135795","journal-title":"J Bacteriol"},{"key":"2107_CR62","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1128\/AAC.42.9.2215","volume":"42","author":"CG Marshall","year":"1998","unstructured":"Marshall CG, Lessard IA, Park I, Wright GD (1998) Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms. Antimicrob Agents Chemother 42:2215\u20132220","journal-title":"Antimicrob Agents Chemother"},{"key":"2107_CR63","doi-asserted-by":"publisher","first-page":"8485","DOI":"10.1021\/bi982843x","volume":"38","author":"CG Marshall","year":"1999","unstructured":"Marshall CG, Zolli M, Wright GD (1999) Molecular mechanism of VanHst, an alpha-ketoacid dehydrogenase required for glycopeptide antibiotic resistance from a glycopeptide producing organism. Biochemistry 38:8485\u20138491","journal-title":"Biochemistry"},{"key":"2107_CR64","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1002\/(SICI)1097-0290(19960220)49:4<412::AID-BIT8>3.0.CO;2-S","volume":"49","author":"JJ McIntyre","year":"1996","unstructured":"McIntyre JJ, Bull AT, Bunch AW (1996) Vancomycin production in batch and continuous culture. Biotechnol Bioeng 49:412\u2013420","journal-title":"Biotechnol Bioeng"},{"key":"2107_CR65","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/1439-7633(20020603)3:6<490::AID-CBIC490>3.0.CO;2-N","volume":"3","author":"HD Mootz","year":"2002","unstructured":"Mootz HD, Schwarzer D, Marahiel MA (2002) Ways of assembling complex natural products on modular nonribosomal peptide synthetases. Chembiochem 3:490\u2013504","journal-title":"Chembiochem"},{"key":"2107_CR66","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1056\/NEJM200003093421007","volume":"342","author":"BE Murray","year":"2000","unstructured":"Murray BE (2000) Vancomycin-resistant enterococcal infections. N Engl J Med 342:710\u2013721","journal-title":"N Engl J Med"},{"key":"2107_CR67","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1002\/(SICI)1521-3773(19990802)38:15<2096::AID-ANIE2096>3.0.CO;2-F","volume":"38","author":"KC Nicolaou","year":"1999","unstructured":"Nicolaou KC, Boddy CN, Brase S, Winssinger N (1999) Chemistry, biology, and medicine of the glycopeptide antibiotics. Angew Chem Int Ed Engl 38:2096\u20132152","journal-title":"Angew Chem Int Ed Engl"},{"key":"2107_CR68","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/j.1552-4604.1988.tb05737.x","volume":"28","author":"F Parenti","year":"1988","unstructured":"Parenti F (1988) Glycopeptide antibiotics. J Clin Pharmacol 28:136\u2013140","journal-title":"J Clin Pharmacol"},{"key":"2107_CR69","doi-asserted-by":"publisher","first-page":"276","DOI":"10.7164\/antibiotics.31.276","volume":"31","author":"F Parenti","year":"1978","unstructured":"Parenti F, Beretta G, Berti M, Arioli V (1978) Teichomycins, new antibiotics from Actinoplanes teichomyceticus Nov. Sp. I. Description of the producer strain, fermentation studies and biological properties. J Antibiot (Tokyo) 31:276\u2013283","journal-title":"J Antibiot (Tokyo)"},{"issue":"Suppl 5","key":"2107_CR70","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1080\/1120009X.2000.11782312","volume":"12","author":"F Parenti","year":"2000","unstructured":"Parenti F, Schito GC, Courvalin P (2000) Teicoplanin chemistry and microbiology. J Chemother 12(Suppl 5):5\u201314","journal-title":"J Chemother"},{"key":"2107_CR71","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.chembiol.2006.01.008","volume":"13","author":"S Pelzer","year":"2006","unstructured":"Pelzer S, Dziarnowski A (2006) Sulfation: a new biocombinatorial tool. Chem Biol 13:113\u2013114","journal-title":"Chem Biol"},{"key":"2107_CR72","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1128\/AAC.43.7.1565","volume":"43","author":"S Pelzer","year":"1999","unstructured":"Pelzer S, Sussmuth R, Heckmann D, Recktenwald J, Huber P, Jung G, Wohlleben W (1999) Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908. Antimicrob Agents Chemother 43:1565\u20131573","journal-title":"Antimicrob Agents Chemother"},{"key":"2107_CR73","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1093\/jac\/11.1.94","volume":"11","author":"G Peters","year":"1983","unstructured":"Peters G, Pulverer G (1983) Antibacterial activity of teichomycin, a new glycopeptide antibiotic, in comparison to vancomycin. J Antimicrob Chemother 11:94\u201395","journal-title":"J Antimicrob Chemother"},{"key":"2107_CR74","doi-asserted-by":"publisher","first-page":"38370","DOI":"10.1074\/jbc.M106580200","volume":"276","author":"V Pfeifer","year":"2001","unstructured":"Pfeifer V, Nicholson G, Ries J, Recktenwald J, Schefer A, Shawky R, Schr\u00f6der J, Wohlleben W, Pelzer S (2001) A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3, 5-dihydroxyphenylglycine. J Biol Chem 276:38370\u201338377","journal-title":"J Biol Chem"},{"key":"2107_CR75","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1146\/annurev.pharmtox.42.091601.142813","volume":"42","author":"J Pootoolal","year":"2002","unstructured":"Pootoolal J, Neu J, Wright GD (2002a) Glycopeptide antibiotic resistance. Annu Rev Pharmacol Toxicol 42:381\u2013408","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2107_CR76","doi-asserted-by":"publisher","first-page":"8962","DOI":"10.1073\/pnas.102285099","volume":"99","author":"J Pootoolal","year":"2002","unstructured":"Pootoolal J, Thomas MG, Marshall CG, Neu JM, Hubbard BK, Walsh CT, Wright GD (2002b) Assembling the glycopeptide antibiotic scaffold: the biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009. Proc Natl Acad Sci U S A 99:8962\u20138967","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2107_CR77","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S1074-5521(02)00101-1","volume":"9","author":"O Puk","year":"2002","unstructured":"Puk O, Huber P, Bischoff D, Recktenwald J, Jung G, Sussmuth RD, van Pee KH, Wohlleben W, Pelzer S (2002) Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase\/perhydrolase. Chem Biol 9:225\u2013235","journal-title":"Chem Biol"},{"key":"2107_CR78","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1099\/00221287-148-4-1105","volume":"148","author":"J Recktenwald","year":"2002","unstructured":"Recktenwald J, Shawky R, Puk O, Pfennig F, Keller U, Wohlleben W, Pelzer S (2002) Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules. Microbiology 148:1105\u20131108","journal-title":"Microbiology"},{"key":"2107_CR79","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1007\/BF01967563","volume":"8","author":"PE Reynolds","year":"1989","unstructured":"Reynolds PE (1989) Structure, biochemistry and mechanism of action of glycopeptide antibiotics. Eur J Clin Microbiol Infect Dis 8:943\u2013950","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2107_CR80","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1128\/AAC.49.1.21-25.2005","volume":"49","author":"PE Reynolds","year":"2005","unstructured":"Reynolds PE, Courvalin P (2005) Vancomycin resistance in enterococci due to synthesis of precursors terminating in D-alanyl-D-serine. Antimicrob Agents Chemother 49:21\u201325","journal-title":"Antimicrob Agents Chemother"},{"key":"2107_CR81","doi-asserted-by":"publisher","first-page":"560","DOI":"10.7164\/antibiotics.51.560","volume":"51","author":"MJ Rodriguez","year":"1998","unstructured":"Rodriguez MJ, Snyder NJ, Zweifel MJ, Wilkie SC, Stack DR, Cooper RD, Nicas TI, Mullen DL, Butler TF, Thompson RC (1998) Novel glycopeptide antibiotics: N-alkylated derivatives active against vancomycin-resistant enterococci. J Antibiot (Tokyo) 51:560\u2013569","journal-title":"J Antibiot (Tokyo)"},{"key":"2107_CR82","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1128\/AAC.34.11.2137","volume":"34","author":"KV Rolston","year":"1990","unstructured":"Rolston KV, Nguyen H, Messer M (1990) In vitro activity of LY264826, a new glycopeptide antibiotic, against gram-positive bacteria isolated from patients with cancer. Antimicrob Agents Chemother 34:2137\u20132141","journal-title":"Antimicrob Agents Chemother"},{"key":"2107_CR83","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1016\/S0969-2126(96)00156-6","volume":"4","author":"M Schafer","year":"1996","unstructured":"Schafer M, Schneider TR, Sheldrick GM (1996) Crystal structure of vancomycin. Structure\u00a04:1509\u20131515","journal-title":"Structure"},{"key":"2107_CR84","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.femsle.2004.09.017","volume":"240","author":"S Serina","year":"2004","unstructured":"Serina S, Radice F, Maffioli S, Donadio S, Sosio M (2004) Glycopeptide resistance determinants from the teicoplanin producer Actinoplanes teichomyceticus. FEMS Microbiol Lett 240:69\u201374","journal-title":"FEMS Microbiol Lett"},{"key":"2107_CR85","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/271223a0","volume":"271","author":"GM Sheldrick","year":"1978","unstructured":"Sheldrick GM, Jones PG, Kennard O, Williams DH, Smith GA (1978) Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine. Nature 271:223\u2013225","journal-title":"Nature"},{"key":"2107_CR86","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S1074-5521(97)90288-X","volume":"4","author":"PJ Solenberg","year":"1997","unstructured":"Solenberg PJ, Matsushima P, Stack DR, Wilkie SC, Thompson RC, Baltz RH (1997) Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis. Chem Biol 4:195\u2013202","journal-title":"Chem Biol"},{"key":"2107_CR87","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1128\/AAC.26.6.917","volume":"26","author":"S Somma","year":"1984","unstructured":"Somma S, Gastaldo L, Corti A (1984) Teicoplanin, a new antibiotic from Actinoplanes teichomyceticus nov. sp. Antimicrob Agents Chemother 26:917\u2013923","journal-title":"Antimicrob Agents Chemother"},{"key":"2107_CR88","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1271\/bbb.80143","volume":"72","author":"JM Song","year":"2008","unstructured":"Song JM, Park JT, Lee HS, Kang JH, Kang DJ (2008) Production of teicoplanin from Actinoplanes teichomyceticus ID9303 by adding proline. Biosci Biotechnol Biochem 72:1635\u20131637","journal-title":"Biosci Biotechnol Biochem"},{"key":"2107_CR89","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s10295-006-0124-1","volume":"33","author":"M Sosio","year":"2006","unstructured":"Sosio M, Donadio S (2006) Understanding and manipulating glycopeptide pathways: the example of the dalbavancin precursor A40926. J Ind Microbiol Biotechnol 33:569\u2013576","journal-title":"J Ind Microbiol Biotechnol"},{"key":"2107_CR90","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1023\/A:1010239717396","volume":"78","author":"M Sosio","year":"2000","unstructured":"Sosio M, Bianchi A, Bossi E, Donadio S (2000) Teicoplanin biosynthesis genes in Actinoplanes teichomyceticus. Antonie Van Leeuwenhoek 78:379\u2013384","journal-title":"Antonie Van Leeuwenhoek"},{"key":"2107_CR91","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/S1074-5521(03)00120-0","volume":"10","author":"M Sosio","year":"2003","unstructured":"Sosio M, Stinchi S, Beltrametti F, Lazzarini A, Donadio S (2003) The gene cluster for the biosynthesis of the glycopeptide antibiotic A40926 by nonomuraea species. Chem Biol 10:541\u2013549","journal-title":"Chem Biol"},{"key":"2107_CR92","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1099\/mic.0.26507-0","volume":"150","author":"M Sosio","year":"2004","unstructured":"Sosio M, Kloosterman H, Bianchi A, de Vreugd P, Dijkhuizen L, Donadio S (2004) Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus. Microbiology 150:95\u2013102","journal-title":"Microbiology"},{"key":"2107_CR93","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0924-8579(95)00004-R","volume":"5","author":"RC Spencer","year":"1995","unstructured":"Spencer RC, Goering R (1995) A critical review of the in-vitro activity of teicoplanin. Int J Antimicrob Agents 5:169\u2013177","journal-title":"Int J Antimicrob Agents"},{"key":"2107_CR94","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/cbic.200300620","volume":"5","author":"JS Thorson","year":"2004","unstructured":"Thorson JS, Barton WA, Hoffmeister D, Albermann C, Nikolov DB (2004) Structure-based enzyme engineering and its impact on in vitro glycorandomization. Chembiochem 5:16\u201325","journal-title":"Chembiochem"},{"key":"2107_CR95","first-page":"1670","volume":"7","author":"AW Truman","year":"2006","unstructured":"Truman AW, Robinson L, Spencer JB (2006) Identification of a deacetylase involved in the maturation of teicoplanin. Chem biochem 7:1670\u20131675","journal-title":"Chem biochem"},{"key":"2107_CR96","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0140-6736(88)91037-9","volume":"1","author":"AH Uttley","year":"1988","unstructured":"Uttley AH, Collins CH, Naidoo J, George RC (1988) Vancomycin-resistant enterococci. Lancet 1:57\u201358","journal-title":"Lancet"},{"key":"2107_CR97","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S1074-5521(98)90060-6","volume":"5","author":"AM Wageningen van","year":"1998","unstructured":"van Wageningen AM, Kirkpatrick PN, Williams DH, Harris BR, Kershaw JK, Lennard NJ, Jones M, Jones SJ, Solenberg PJ (1998) Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic. Chem Biol 5:155\u2013162","journal-title":"Chem Biol"},{"key":"2107_CR98","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1002\/bit.10137","volume":"77","author":"AG Vara","year":"2002","unstructured":"Vara AG, Hochkoepple A, Nielsen J, Villadsen J (2002) Production of teicoplanin by Actinoplanes teichomyceticus in continuous fermentation. Biotechnol Bioeng 77:589\u2013598","journal-title":"Biotechnol Bioeng"},{"key":"2107_CR99","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1128\/9781555817886","volume-title":"Antibiotics: actions, origins, resistance","author":"C Walsh","year":"2003","unstructured":"Walsh C (2003) Antibiotics: actions, origins, resistance . ASM, Washington, DC, p 340"},{"key":"2107_CR100","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S1074-5521(96)90079-4","volume":"3","author":"CT Walsh","year":"1996","unstructured":"Walsh CT, Fisher SL, Park IS, Prahalad M, Wu Z (1996) Bacterial resistance to vancomycin: five genes and one missing hydrogen bond tell the story. Chem Biol 3:21\u201328","journal-title":"Chem Biol"},{"key":"2107_CR101","doi-asserted-by":"publisher","first-page":"3425","DOI":"10.1021\/jm030257i","volume":"46","author":"C Walsh","year":"2003","unstructured":"Walsh C, Freel Meyers CL, Losey HC (2003) Antibiotic glycosyltransferases: antibiotic maturation and prospects for reprogramming. J Med Chem 46:3425\u20133436","journal-title":"J Med Chem"},{"issue":"Suppl","key":"2107_CR102","first-page":"77","volume":"21","author":"M Wang","year":"1996","unstructured":"Wang M, Ding H, Hu Y (1996) The action of arginine and valine in the biosynthesis of teicoplanin. Chin J Antibiot 21(Suppl):77\u201380","journal-title":"Chin J Antibiot"},{"key":"2107_CR103","doi-asserted-by":"publisher","first-page":"3383","DOI":"10.1002\/1521-3773(20020916)41:18<3383::AID-ANIE3383>3.0.CO;2-R","volume":"41","author":"S Weist","year":"2002","unstructured":"Weist S, Bister B, Puk O, Bischoff D, Pelzer S, Nicholson GJ, Wohlleben W, Jung G, Sussmuth RD (2002) Fluorobalhimycin\u2014a new chapter in glycopeptide antibiotic research. Angew Chem Int Ed Engl 41:3383\u20133385","journal-title":"Angew Chem Int Ed Engl"},{"key":"2107_CR104","doi-asserted-by":"publisher","first-page":"5942","DOI":"10.1021\/ja0499389","volume":"126","author":"S Weist","year":"2004","unstructured":"Weist S, Kittel C, Bischoff D, Bister B, Pfeifer V, Nicholson GJ, Wohlleben W, Sussmuth RD (2004) Mutasynthesis of glycopeptide antibiotics: variations of vancomycin's AB-ring amino acid 3, 5-dihydroxyphenylglycine. J Am Chem Soc 126:5942\u20135943","journal-title":"J Am Chem Soc"},{"key":"2107_CR105","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1056\/NEJMp048093","volume":"351","author":"RP Wenzel","year":"2004","unstructured":"Wenzel RP (2004) The antibiotic pipeline\u2014challenges, costs, and values. N Engl J Med 351:523\u2013526","journal-title":"N Engl J Med"},{"key":"2107_CR106","unstructured":"Wikipedia TFE (2009) Dalbavancin. In category: Drugs not assigned an ATC code. Wikimedia Foundation Inc. Available via DIALOG. <\nhttp:\/\/en.wikipedia.org\/wiki\/Dalbavancin\n\n>. Accessed 2 June 2009"},{"key":"2107_CR107","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1126\/science.280.5364.711","volume":"280","author":"DH Williams","year":"1998","unstructured":"Williams DH, Maguire AJ, Tsuzuki W, Westwell MS (1998) An analysis of the origins of a cooperative binding energy of dimerization. Science 280:711\u2013714","journal-title":"Science"},{"key":"2107_CR108","doi-asserted-by":"publisher","first-page":"6580","DOI":"10.1021\/ja00412a008","volume":"103","author":"MP Williamson","year":"1981","unstructured":"Williamson MP, Williams DH (1981) Structure revision of the antibiotic vancomycin. Use of nuclear Overhauser effect difference spectroscopy. J Am Chem Soc 103:6580\u20136585","journal-title":"J Am Chem Soc"},{"key":"2107_CR109","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/BF02276052","volume":"13","author":"AP Wilson","year":"1994","unstructured":"Wilson AP, Gruneberg RN (1994) Use of teicoplanin in community medicine. Eur J Clin Microbiol Infect Dis 13:701\u2013710","journal-title":"Eur J Clin Microbiol Infect Dis"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-009-2107-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00253-009-2107-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-009-2107-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-009-2107-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T12:23:33Z","timestamp":1583843013000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00253-009-2107-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,16]]},"references-count":109,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["2107"],"URL":"https:\/\/doi.org\/10.1007\/s00253-009-2107-4","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,16]]}}}