{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:56:56Z","timestamp":1793797016060,"version":"4.6.1"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,9,14]],"date-time":"2011-09-14T00:00:00Z","timestamp":1315958400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1007\/s00253-011-3569-8","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T06:44:28Z","timestamp":1315896268000},"page":"601-611","source":"Crossref","is-referenced-by-count":35,"title":["Trypsin promotes efficient influenza vaccine production in MDCK cells by interfering with the antiviral host response"],"prefix":"10.1007","volume":"93","author":[{"given":"Claudius","family":"Seitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Isken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Heynisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Rettkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Frensing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Reichl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,9,14]]},"reference":[{"issue":"3","key":"3569_CR1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1128\/JVI.47.3.626-630.1983","volume":"47","author":"H Arnheiter","year":"1983","unstructured":"Arnheiter H, Haller O (1983) Mx gene control of interferon action: different kinetics of the antiviral state against influenza virus and vesicular stomatitis virus. J Virol 47(3):626\u2013630","journal-title":"J Virol"},{"issue":"11","key":"3569_CR2","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.2165\/00003495-200868110-00002","volume":"68","author":"JM Audsley","year":"2008","unstructured":"Audsley JM, Tannock GA (2008) Cell-based influenza vaccines: progress to date. Drugs 68(11):1483\u20131491","journal-title":"Drugs"},{"issue":"3","key":"3569_CR3","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1128\/JVI.74.3.1513-1523.2000","volume":"74","author":"S Balachandran","year":"2000","unstructured":"Balachandran S, Roberts PC, Kipperman T, Bhalla KN, Compans RW, Archer DR, Barber GN (2000) Alpha\/beta interferons potentiate virus-induced apoptosis through activation of the FADD\/caspase-8 death signaling pathway. J Virol 74(3):1513\u20131523","journal-title":"J Virol"},{"issue":"Suppl 4","key":"3569_CR4","doi-asserted-by":"crossref","first-page":"D5","DOI":"10.1016\/j.vaccine.2008.05.076","volume":"26","author":"RB Couch","year":"2008","unstructured":"Couch RB (2008) Seasonal inactivated influenza virus vaccines. Vaccine 26(Suppl 4):D5\u2013D9","journal-title":"Vaccine"},{"issue":"6","key":"3569_CR5","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1586\/erv.09.31","volume":"8","author":"A Doroshenko","year":"2009","unstructured":"Doroshenko A, Halperin SA (2009) Trivalent MDCK cell culture-derived influenza vaccine Optaflu (Novartis Vaccines). Expert Rev Vaccines 8(6):679\u2013688","journal-title":"Expert Rev Vaccines"},{"issue":"8","key":"3569_CR6","doi-asserted-by":"crossref","first-page":"6437","DOI":"10.1128\/JVI.72.8.6437-6441.1998","volume":"72","author":"A Egorov","year":"1998","unstructured":"Egorov A, Brandt S, Sereinig S, Romanova J, Ferko B, Katinger D, Grassauer A, Alexandrova G, Katinger H, Muster T (1998) Transfectant influenza A viruses with long deletions in the NS1 protein grow efficiently in Vero cells. J Virol 72(8):6437\u20136441","journal-title":"J Virol"},{"key":"3569_CR7","doi-asserted-by":"crossref","unstructured":"Frensing T, Seitz C, Heynisch B, Patzina C, Kochs, G, Reichl, U (2011) Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cells. Vaccine 29:7125\u20137129","DOI":"10.1016\/j.vaccine.2011.05.069"},{"issue":"2","key":"3569_CR8","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1006\/viro.1998.9508","volume":"252","author":"A Garc\u00eda-Sastre","year":"1998","unstructured":"Garc\u00eda-Sastre A, Egorov A, Matassov D, Brandt S, Levy DE, Durbin JE, Palese P, Muster T (1998) Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virology 252(2):324\u2013330","journal-title":"Virology"},{"issue":"4","key":"3569_CR9","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1128\/AEM.16.4.588-594.1968","volume":"16","author":"CR Gaush","year":"1968","unstructured":"Gaush CR, Smith TF (1968) Replication and plaque assay of influenza virus in an established line of canine kidney cells. Appl Microbiol 16(4):588\u2013594","journal-title":"Appl Microbiol"},{"issue":"12","key":"3569_CR10","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1586\/erv.09.128","volume":"8","author":"Y Genzel","year":"2009","unstructured":"Genzel Y, Reichl U (2009) Continuous cell lines as a production system for influenza vaccines. Expert Rev Vaccines 8(12):1681\u20131692","journal-title":"Expert Rev Vaccines"},{"issue":"16","key":"3569_CR11","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1016\/j.vaccine.2006.01.019","volume":"24","author":"Y Genzel","year":"2006","unstructured":"Genzel Y, Fischer M, Reichl U (2006) Serum-free influenza virus production avoiding washing steps and medium exchange in large-scale microcarrier culture. Vaccine 24(16):3261\u20133272","journal-title":"Vaccine"},{"issue":"2","key":"3569_CR12","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00253-010-2742-9","volume":"88","author":"Y Genzel","year":"2010","unstructured":"Genzel Y, Dietzsch C, Rapp E, Schwarzer J, Reichl U (2010) MDCK and Vero cells for influenza virus vaccine production: a one-to-one comparison up to lab-scale bioreactor cultivation. Appl Microbiol Biotechnol 88(2):461\u2013475","journal-title":"Appl Microbiol Biotechnol"},{"issue":"16","key":"3569_CR13","doi-asserted-by":"crossref","first-page":"6806","DOI":"10.1073\/pnas.0701849104","volume":"104","author":"D Grimm","year":"2007","unstructured":"Grimm D, Staeheli P, Hufbauer M, Koerner I, Mart\u00ednez-Sobrido L, Sol\u00f3rzano A, Garc\u00eda-Sastre A, Haller O, Kochs G (2007) Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene. Proc Natl Acad Sci USA 104(16):6806\u20136811","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Pt 10","key":"3569_CR14","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1099\/vir.0.2008\/004606-0","volume":"89","author":"BG Hale","year":"2008","unstructured":"Hale BG, Randall RE, Ortin J, Jackson D (2008) The multifunctional NS1 protein of influenza A viruses. J Gen Virol 89(Pt 10):2359\u20132376","journal-title":"J Gen Virol"},{"key":"3569_CR15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2217\/fmb.09.108","volume":"5","author":"BG Hale","year":"2010","unstructured":"Hale BG, Albrecht RA, Garc\u00eda-Sastre A (2010) Innate immune evasion strategies of influenza viruses. Future Microbiol 5:23\u201341","journal-title":"Future Microbiol"},{"issue":"1","key":"3569_CR16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.20506\/rst.28.1.1867","volume":"28","author":"O Haller","year":"2009","unstructured":"Haller O, Staeheli P, Kochs G (2009) Protective role of interferon-induced Mx GTPases against influenza viruses. Rev Sci Tech 28(1):219\u2013231","journal-title":"Rev Sci Tech"},{"issue":"1","key":"3569_CR17","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.virol.2005.11.024","volume":"347","author":"A Hayman","year":"2006","unstructured":"Hayman A, Comely S, Lackenby A, Murphy S, McCauley J, Goodbourn S, Barclay W (2006) Variation in the ability of human influenza A viruses to induce and inhibit the IFN-beta pathway. Virology 347(1):52\u201364","journal-title":"Virology"},{"issue":"5","key":"3569_CR18","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1128\/JVI.01856-06","volume":"81","author":"A Hayman","year":"2007","unstructured":"Hayman A, Comely S, Lackenby A, Hartgroves LCS, Goodbourn S, McCauley JW, Barclay WS (2007) NS1 proteins of avian influenza A viruses can act as antagonists of the human alpha\/beta interferon response. J Virol 81(5):2318\u20132327","journal-title":"J Virol"},{"issue":"51","key":"3569_CR19","doi-asserted-by":"crossref","first-page":"8210","DOI":"10.1016\/j.vaccine.2010.07.076","volume":"28","author":"B Heynisch","year":"2010","unstructured":"Heynisch B, Frensing T, Heinze K, Seitz C, Genzel Y, Reichl U (2010) Differential activation of host cell signalling pathways through infection with two variants of influenza A\/Puerto Rico\/8\/34 (H1N1) in MDCK cells. Vaccine 28(51):8210\u20138218","journal-title":"Vaccine"},{"issue":"14","key":"3569_CR20","doi-asserted-by":"crossref","first-page":"7776","DOI":"10.1128\/JVI.00546-06","volume":"81","author":"D Holzinger","year":"2007","unstructured":"Holzinger D, Jorns C, Stertz S, Boisson-Dupuis S, Thimme R, Weidmann M, Casanova JL, Haller O, Kochs G (2007) Induction of MxA gene expression by influenza A virus requires type I or type III interferon signaling. J Virol 81(14):7776\u20137785","journal-title":"J Virol"},{"issue":"9","key":"3569_CR21","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nri1900","volume":"6","author":"K Honda","year":"2006","unstructured":"Honda K, Taniguchi T (2006) IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol 6(9):644\u2013658","journal-title":"Nat Rev Immunol"},{"issue":"45","key":"3569_CR22","doi-asserted-by":"crossref","first-page":"5736","DOI":"10.1016\/j.vaccine.2008.08.015","volume":"26","author":"AY Hu","year":"2008","unstructured":"Hu AY, Weng TC, Tseng YF, Chen YS, Wu CH, Hsiao S, Chou AH, Chao HJ, Gu A, Wu SC, Chong P, Lee MS (2008) Microcarrier-based MDCK cell culture system for the production of influenza H5N1 vaccines. Vaccine 26(45):5736\u20135740","journal-title":"Vaccine"},{"issue":"22","key":"3569_CR23","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1016\/j.vaccine.2010.03.005","volume":"28","author":"AI Hussain","year":"2010","unstructured":"Hussain AI, Cordeiro M, Sevilla E, Liu J (2010) Comparison of egg and high yielding MDCK cell-derived live attenuated influenza virus for commercial production of trivalent influenza vaccine: in vitro cell susceptibility and influenza virus replication kinetics in permissive and semi-permissive cells. Vaccine 28(22):3848\u20133855","journal-title":"Vaccine"},{"key":"3569_CR24","unstructured":"Iglewicz B (2000) Robust scale estimators and confidence intervals for location. Understanding robust and exploratory data analysis. D. C. Hoaglin. New York, Wiley: 404\u2013432."},{"key":"3569_CR25","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/oxfordjournals.bmb.a069760","volume":"15","author":"A Isaacs","year":"1959","unstructured":"Isaacs A, Burke DC (1959) Viral interference and interferon. Br Med Bull 15:185\u2013188","journal-title":"Br Med Bull"},{"issue":"11","key":"3569_CR26","doi-asserted-by":"crossref","first-page":"e13927","DOI":"10.1371\/journal.pone.0013927","volume":"5","author":"D Jia","year":"2010","unstructured":"Jia D, Rahbar R, Chan RW, Lee SM, Chan MC, Wang BX, Baker DP, Sun B, Peiris JS, Nicholls JM, Fish EN (2010) Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling. PLoS One 5(11):e13927","journal-title":"PLoS One"},{"issue":"3","key":"3569_CR27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.biologicals.2007.10.002","volume":"36","author":"B Kalbfuss","year":"2008","unstructured":"Kalbfuss B, Knochlein A, Kr\u00f6ber T, Reichl U (2008) Monitoring influenza virus content in vaccine production: precise assays for the quantitation of hemagglutination and neuraminidase activity. Biologicals 36(3):145\u2013161","journal-title":"Biologicals"},{"issue":"Pt 3","key":"3569_CR28","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1099\/vir.0.006841-0","volume":"90","author":"T Kekarainen","year":"2009","unstructured":"Kekarainen T, Martinez-Guino L, Segales J (2009) Swine torque teno virus detection in pig commercial vaccines, enzymes for laboratory use and human drugs containing components of porcine origin. J Gen Virol 90(Pt 3):648\u2013653","journal-title":"J Gen Virol"},{"issue":"2","key":"3569_CR29","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/0042-6822(75)90284-6","volume":"68","author":"HD Klenk","year":"1975","unstructured":"Klenk HD, Rott R, Orlich M, Blodorn J (1975) Activation of influenza A viruses by trypsin treatment. Virology 68(2):426\u2013439","journal-title":"Virology"},{"issue":"4","key":"3569_CR30","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1128\/JVI.01718-06","volume":"81","author":"I Koerner","year":"2007","unstructured":"Koerner I, Kochs G, Kalinke U, Weiss S, Staeheli P (2007) Protective role of beta interferon in host defense against influenza A virus. J Virol 81(4):2025\u20132030","journal-title":"J Virol"},{"issue":"2","key":"3569_CR31","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/0042-6822(75)90285-8","volume":"68","author":"SG Lazarowitz","year":"1975","unstructured":"Lazarowitz SG, Choppin PW (1975) Enhancement of the infectivity of influenza A and B viruses by proteolytic cleavage of the hemagglutinin polypeptide. Virology 68(2):440\u2013454","journal-title":"Virology"},{"issue":"1","key":"3569_CR32","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0042-6822(73)90296-1","volume":"56","author":"SG Lazarowitz","year":"1973","unstructured":"Lazarowitz SG, Goldberg AR, Choppin PW (1973) Proteolytic cleavage by plasmin of the HA polypeptide of influenza virus: host cell activation of serum plasminogen. Virology 56(1):172\u2013180","journal-title":"Virology"},{"issue":"21","key":"3569_CR33","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1016\/j.vaccine.2010.03.029","volume":"28","author":"A Ru Le","year":"2010","unstructured":"Le Ru A, Jacob D, Transfiguracion J, Ansorge S, Henry O, Kamen AA (2010) Scalable production of influenza virus in HEK-293 cells for efficient vaccine manufacturing. Vaccine 28(21):3661\u20133671","journal-title":"Vaccine"},{"issue":"14","key":"3569_CR34","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.1128\/JVI.00246-08","volume":"82","author":"F LeBouder","year":"2008","unstructured":"LeBouder F, Morello E, Rimmelzwaan GF, Bosse F, Pechoux C, Delmas B, Riteau B (2008) Annexin II incorporated into influenza virus particles supports virus replication by converting plasminogen into plasmin. J Virol 82(14):6820\u20136828","journal-title":"J Virol"},{"issue":"1","key":"3569_CR35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.antiviral.2008.01.004","volume":"78","author":"P Leyssen","year":"2008","unstructured":"Leyssen P, De Clercq E, Neyts J (2008) Molecular strategies to inhibit the replication of RNA viruses. Antiviral Res 78(1):9\u201325","journal-title":"Antiviral Res"},{"issue":"4","key":"3569_CR36","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jcv.2009.09.013","volume":"46","author":"IW Li","year":"2009","unstructured":"Li IW, Chan KH, To KW, Wong SS, Ho PL, Lau SK, Woo PC, Tsoi HW, Chan JF, Cheng VC, Zheng BJ, Chen H, Yuen KY (2009) Differential susceptibility of different cell lines to swine-origin influenza A H1N1, seasonal human influenza A H1N1, and avian influenza A H5N1 viruses. J Clin Virol 46(4):325\u2013330","journal-title":"J Clin Virol"},{"issue":"46","key":"3569_CR37","doi-asserted-by":"crossref","first-page":"6460","DOI":"10.1016\/j.vaccine.2009.06.024","volume":"27","author":"J Liu","year":"2009","unstructured":"Liu J, Shi X, Schwartz R, Kemble G (2009) Use of MDCK cells for production of live attenuated influenza vaccine. Vaccine 27(46):6460\u20136463","journal-title":"Vaccine"},{"issue":"52","key":"3569_CR38","doi-asserted-by":"crossref","first-page":"6852","DOI":"10.1016\/j.vaccine.2008.09.075","volume":"26","author":"K Makizumi","year":"2008","unstructured":"Makizumi K, Kimachi K, Fukada K, Nishimura T, Kudo Y, Goto S, Odagiri T, Tashiro M, Kino Y (2008) Timely production of A\/Fujian-like influenza vaccine matching the 2003\u20132004 epidemic strain may have been possible using Madin\u2013Darby canine kidney cells. Vaccine 26(52):6852\u20136858","journal-title":"Vaccine"},{"issue":"3","key":"3569_CR39","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1023\/A:1008160817560","volume":"34","author":"OW Merten","year":"2000","unstructured":"Merten OW (2000) Safety for vaccine(e)s. Cytotechnology 34(3):181\u2013183","journal-title":"Cytotechnology"},{"issue":"10","key":"3569_CR40","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1007\/s007050050428","volume":"143","author":"K Noma","year":"1998","unstructured":"Noma K, Kiyotani K, Kouchi H, Fujii Y, Egi Y, Tanaka K, Yoshida T (1998) Endogenous protease-dependent replication of human influenza viruses in two MDCK cell lines. Arch Virol 143(10):1893\u20131909","journal-title":"Arch Virol"},{"issue":"17\u201319","key":"3569_CR41","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1016\/S0264-410X(00)00508-9","volume":"19","author":"MG Pau","year":"2001","unstructured":"Pau MG, Ophorst C, Koldijk MH, Schouten G, Mehtali M, Uytdehaag F (2001) The human cell line PER.C6 provides a new manufacturing system for the production of influenza vaccines. Vaccine 19(17\u201319):2716\u20132721","journal-title":"Vaccine"},{"issue":"11","key":"3569_CR42","doi-asserted-by":"crossref","first-page":"e1000196","DOI":"10.1371\/journal.ppat.1000196","volume":"4","author":"EK Pauli","year":"2008","unstructured":"Pauli EK, Schmolke M, Wolff T, Viemann D, Roth J, Bode JG, Ludwig S (2008) Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression. PLoS Pathog 4(11):e1000196","journal-title":"PLoS Pathog"},{"issue":"4","key":"3569_CR43","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bpj.2009.10.049","volume":"98","author":"L Qiao","year":"2010","unstructured":"Qiao L, Phipps-Yonas H, Hartmann B, Moran TM, Sealfon SC, Hayot F (2010) Immune response modeling of interferon beta-pretreated influenza virus-infected human dendritic cells. Biophys J 98(4):505\u2013514","journal-title":"Biophys J"},{"key":"3569_CR44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/vir.0.83391-0","volume":"89","author":"RE Randall","year":"2008","unstructured":"Randall RE, Goodbourn S (2008) Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol 89:1\u201347","journal-title":"J Gen Virol"},{"issue":"9","key":"3569_CR45","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1089\/jir.2009.0068","volume":"29","author":"M Rieder","year":"2009","unstructured":"Rieder M, Conzelmann KK (2009) Rhabdovirus evasion of the interferon system. J Interferon Cytokine Res 29(9):499\u2013509","journal-title":"J Interferon Cytokine Res"},{"key":"3569_CR46","doi-asserted-by":"crossref","unstructured":"Romanova J, Krenn BM, Wolschek M, Ferko B, Romanovskaja-Romanko E, et al. (2009) Preclinical evaluation of a replication-deficient Intranasal \u0394NS1 H5N1 influenza vaccine. PLoS ONE 4(6):e5984. doi: 10.1371\/journal.pone.0005984","DOI":"10.1371\/journal.pone.0005984"},{"issue":"20","key":"3569_CR47","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1016\/j.vaccine.2009.02.027","volume":"27","author":"J Schulze-Horsel","year":"2009","unstructured":"Schulze-Horsel J, Schulze M, Agalaridis G, Genzel Y, Reichl U (2009) Infection dynamics and virus-induced apoptosis in cell culture-based influenza vaccine production\u2014flow cytometry and mathematical modeling. Vaccine 27(20):2712\u20132722","journal-title":"Vaccine"},{"issue":"20","key":"3569_CR48","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1002\/elps.200800042","volume":"29","author":"J Schwarzer","year":"2008","unstructured":"Schwarzer J, Rapp E, Reichl U (2008) N-glycan analysis by CGE-LIF: profiling influenza A virus hemagglutinin N-glycosylation during vaccine production. Electrophoresis 29(20):4203\u20134214","journal-title":"Electrophoresis"},{"issue":"Pt 7","key":"3569_CR49","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1099\/vir.0.020370-0","volume":"91","author":"C Seitz","year":"2010","unstructured":"Seitz C, Frensing T, H\u00f6per D, Kochs G, Reichl U (2010) High yields of influenza A virus in Madin\u2013Darby canine kidney cells are promoted by an insufficient interferon-induced antiviral state. J Gen Virol 91(Pt 7):1754\u20131763","journal-title":"J Gen Virol"},{"issue":"17","key":"3569_CR50","doi-asserted-by":"crossref","first-page":"7989","DOI":"10.1128\/JVI.74.17.7989-7996.2000","volume":"74","author":"J Talon","year":"2000","unstructured":"Talon J, Horvath CM, Polley R, Basler CF, Muster T, Palese P, Garc\u00eda-Sastre A (2000) Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein. J Virol 74(17):7989\u20137996","journal-title":"J Virol"},{"issue":"1","key":"3569_CR51","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF02123572","volume":"162","author":"K Tobita","year":"1975","unstructured":"Tobita K, Sugiura A, Enomote C, Furuyama M (1975) Plaque assay and primary isolation of influenza A viruses in an established line of canine kidney cells (MDCK) in the presence of trypsin. Med Microbiol Immunol 162(1):9\u201314","journal-title":"Med Microbiol Immunol"},{"issue":"25\u201326","key":"3569_CR52","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1016\/S0264-410X(01)00053-6","volume":"19","author":"JA Tree","year":"2001","unstructured":"Tree JA, Richardson C, Fooks AR, Clegg JC, Looby D (2001) Comparison of large-scale mammalian cell culture systems with egg culture for the production of influenza virus A vaccine strains. Vaccine 19(25\u201326):3444\u20133450","journal-title":"Vaccine"},{"issue":"1\u20132","key":"3569_CR53","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.virusres.2008.04.028","volume":"136","author":"M Ueda","year":"2008","unstructured":"Ueda M, Yamate M, Du A, Daidoji T, Okuno Y, Ikuta K, Nakaya T (2008) Maturation efficiency of viral glycoproteins in the ER impacts the production of influenza A virus. Virus Res 136(1\u20132):91\u201397","journal-title":"Virus Res"},{"issue":"21","key":"3569_CR54","doi-asserted-by":"crossref","first-page":"11323","DOI":"10.1128\/JVI.01034-10","volume":"84","author":"Z Wang","year":"2010","unstructured":"Wang Z, Robb NC, Lenz E, Wolff T, Fodor E, Pleschka S (2010) NS reassortment of an H7-type highly pathogenic avian influenza virus affects its propagation by altering the regulation of viral RNA production and antiviral host response. J Virol 84(21):11323\u201311335","journal-title":"J Virol"},{"issue":"1","key":"3569_CR55","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ab.2008.04.036","volume":"379","author":"E Willems","year":"2008","unstructured":"Willems E, Leyns L, Vandesompele J (2008) Standardization of real-time PCR gene expression data from independent biological replicates. Anal Biochem 379(1):127\u2013129","journal-title":"Anal Biochem"},{"issue":"5","key":"3569_CR56","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/BF01314969","volume":"140","author":"M Yamaoka","year":"1995","unstructured":"Yamaoka M, Homma M, Hotta H (1995) MDCK cell cultures supplemented with high concentrations of trypsin exhibit remarkable susceptibility to influenza C virus. Arch Virol 140(5):937\u2013944","journal-title":"Arch Virol"},{"issue":"7","key":"3569_CR57","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ni1087","volume":"5","author":"M Yoneyama","year":"2004","unstructured":"Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T (2004) The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 5(7):730\u2013737","journal-title":"Nat Immunol"},{"issue":"Pt 11","key":"3569_CR58","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1099\/vir.0.013722-0","volume":"90","author":"DF Young","year":"2009","unstructured":"Young DF, Galiano MC, Lemon K, Chen YH, Andrejeva J, Duprex WP, Rima BK, Randall RE (2009) Mumps virus Enders strain is sensitive to interferon (IFN) despite encoding a functional IFN antagonist. J Gen Virol 90(Pt 11):2731\u20132738","journal-title":"J Gen Virol"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-011-3569-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00253-011-3569-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-011-3569-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T18:48:43Z","timestamp":1592938123000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00253-011-3569-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,14]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["3569"],"URL":"https:\/\/doi.org\/10.1007\/s00253-011-3569-8","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,14]]}}}