{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:49:23Z","timestamp":1792118963955,"version":"4.4.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T00:00:00Z","timestamp":1325030400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1007\/s00253-011-3810-5","type":"journal-article","created":{"date-parts":[[2011,12,27]],"date-time":"2011-12-27T10:05:48Z","timestamp":1324980348000},"page":"1351-1358","source":"Crossref","is-referenced-by-count":51,"title":["Quantification and characterization of \u03b2-lactam resistance genes in 15 sewage treatment plants from East Asia and North America"],"prefix":"10.1007","volume":"95","author":[{"given":"Ying","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Xiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Wei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Wen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-Guang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Guo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert H. P.","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,12,28]]},"reference":[{"key":"3810_CR1","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.watres.2006.11.045","volume":"41","author":"EA Auerbach","year":"2007","unstructured":"Auerbach EA, Seyfried EE, McMahon KD (2007) Tetracycline resistance genes in activated sludge wastewater treatment plants. Water Res 41:1143\u20131151","journal-title":"Water Res"},{"key":"3810_CR2","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1128\/AAC.00378-06","volume":"50","author":"G B\u00f6nemann","year":"2006","unstructured":"B\u00f6nemann G, Stiens M, P\u00fchler A, Schl\u00fcter A (2006) Mobilizable IncQ-related plasmid carrying a new quinolone resistance gene, qnrS2, isolated from the bacterial community of a wastewater treatment plant. Antimicrob Agents Chemother 50:3075\u20133080","journal-title":"Antimicrob Agents Chemother"},{"key":"3810_CR3","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.mib.2006.08.011","volume":"9","author":"R Cant\u00f3n","year":"2006","unstructured":"Cant\u00f3n R, Coque T (2006) The CTX-M \u03b2-lactamase pandemic. Curr Opin Microbiol 9:466\u2013475","journal-title":"Curr Opin Microbiol"},{"issue":"3","key":"3810_CR4","doi-asserted-by":"crossref","first-page":"e17549","DOI":"10.1371\/journal.pone.0017549","volume":"6","author":"M Colomer-Lluch","year":"2011","unstructured":"Colomer-Lluch M, Jofre J, Muniesa M (2011) Antibiotic resistance genes in the bacteriophage DNA fraction of environmental samples. PLoS One 6(3):e17549. doi: 10.1371\/journal.pone.0017549","journal-title":"PLoS One"},{"key":"3810_CR5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1128\/MMBR.00016-10","volume":"74","author":"J Davies","year":"2010","unstructured":"Davies J, Davies D (2010) Origins and evolution of antibiotic resistance. Microbiol Mol Biol Rev 74:417\u2013433","journal-title":"Microbiol Mol Biol Rev"},{"key":"3810_CR6","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1651-2227.2007.00580.x","volume":"97","author":"H Ding","year":"2008","unstructured":"Ding H, Yang YH, Chen Y, Wang Y, Fan SZ, She SZ (2008) Antimicrobial usage in paediatric intensive care units in China. Acta Pediatr 97:100\u2013104","journal-title":"Acta Pediatr"},{"key":"3810_CR7","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1016\/j.scitotenv.2009.02.034","volume":"407","author":"C Faria","year":"2009","unstructured":"Faria C, Vaz-Moreira I, Serapicos E, Nunes OC, Manaia CM (2009) Antibiotic resistance in coagulase negative staphylococci isolated from wastewater and drinking water. Sci Total Environ 407:3876\u20133882","journal-title":"Sci Total Environ"},{"key":"3810_CR8","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1097\/01.inf.0000178064.55193.1c","volume":"24","author":"LA Grohskopf","year":"2005","unstructured":"Grohskopf LA, Huskins WC, Sinkowitz-Cochran RL, Levine GL, Goldmann DA, Jarvis WR (2005) Use of antimicrobial agents in United States neonatal and pediatric intensive care patients. Pediatr Infect Dis J 24:766\u2013773","journal-title":"Pediatr Infect Dis J"},{"key":"3810_CR9","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1093\/jac\/dkp256","volume":"64","author":"PM Hawkey","year":"2009","unstructured":"Hawkey PM, Jones AM (2009) The changing epidemiology of resistance. J Antimicrob Chemother 64:i3\u2013i10","journal-title":"J Antimicrob Chemother"},{"key":"3810_CR10","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1574-6941.2006.00073.x","volume":"56","author":"I Henriques","year":"2006","unstructured":"Henriques I, Moura A, Alves A, Saavedra MJ, Correia A (2006) Analysing diversity among \u03b2-lactamase encoding genes in aquatic environments. FEMS Microbiol Ecol 56:418\u2013429","journal-title":"FEMS Microbiol Ecol"},{"key":"3810_CR11","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1128\/AEM.68.6.2838-2842.2002","volume":"68","author":"A Iversen","year":"2002","unstructured":"Iversen A, Kuhn I, Franklin A, Mollby R (2002) High Prevalence of vancomycin-resistant Enterococci in Swedish sewage. Appl Environ Microbiol 68:2838\u20132842","journal-title":"Appl Environ Microbiol"},{"key":"3810_CR12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/10643380902772589","volume":"41","author":"KL Jury","year":"2011","unstructured":"Jury KL, Khan SJ, Vancov T, Stuetz RM, Ashbolt NJ (2011) Are sewage treatment plants promoting antibiotic resistance? Crit Rev Env Sci Technol 41:243\u2013270","journal-title":"Crit Rev Env Sci Technol"},{"key":"3810_CR13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/jac\/dkg293","volume":"52","author":"K K\u00fcmmerer","year":"2003","unstructured":"K\u00fcmmerer K (2003) Significance of antibiotics in the environment. J Antimicrob Chemother 52:5\u20137","journal-title":"J Antimicrob Chemother"},{"key":"3810_CR14","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1111\/j.1462-2920.2009.01878.x","volume":"11","author":"D Li","year":"2009","unstructured":"Li D, Yang M, Hu J, Zhang J, Liu R, Gu X, Zhang Y, Wang ZY (2009) Antibiotic-resistance profile in environmental bacteria isolated from penicillin production wastewater treatment plant and the receiving river. Environ Microbiol 11:1506\u20131517","journal-title":"Environ Microbiol"},{"key":"3810_CR15","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1128\/CMR.8.4.557","volume":"8","author":"DM Livermore","year":"1995","unstructured":"Livermore DM (1995) beta-lactamases in laboratory and clinical resistance. Clin Microbiol Rev 8:557\u2013584","journal-title":"Clin Microbiol Rev"},{"key":"3810_CR16","first-page":"33","volume":"101","author":"DM Livermore","year":"1996","unstructured":"Livermore DM (1996) Are all beta-lactams created equal? Scand J Infect Dis Suppl 101:33\u201343","journal-title":"Scand J Infect Dis Suppl"},{"key":"3810_CR17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/jac\/41.suppl_4.25","volume":"41","author":"DM Livermore","year":"1998","unstructured":"Livermore DM (1998) beta-Lactamase-mediated resistance and opportunities for its control. J Antimicrob Chemother 41:25\u201341","journal-title":"J Antimicrob Chemother"},{"key":"3810_CR18","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1093\/jac\/dkm340","volume":"60","author":"A Moura","year":"2007","unstructured":"Moura A, Henriques I, Ribeiro R, Correia A (2007) Prevalence and characterization of integrons from bacteria isolated from a slaughterhouse wastewater treatment plant. J Antimicrob Chemother 60:1243\u20131250","journal-title":"J Antimicrob Chemother"},{"key":"3810_CR19","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1007\/s00018-004-4060-9","volume":"61","author":"K Poole","year":"2004","unstructured":"Poole K (2004) Resistance to \u03b2-lactam antibiotics. Cell Mol Life Sci 61:2200\u20132223","journal-title":"Cell Mol Life Sci"},{"key":"3810_CR20","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.marpolbul.2005.06.034","volume":"50","author":"BJ Richardson","year":"2005","unstructured":"Richardson BJ, Lam PKS, Martin M (2005) Emerging chemicals of concern: Pharmaceuticals and personal care products (PPCPs) in Asia, with particular reference to Southern China. Mar Pollut Bull 50:913\u2013920","journal-title":"Mar Pollut Bull"},{"key":"3810_CR21","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1289\/ehp.9770","volume":"115","author":"AR Sapkota","year":"2007","unstructured":"Sapkota AR, Curriero FC, Gibson KE, Schwab KJ (2007) Antibiotic-resistant enterococci and fecal indicators in surface water and groundwater impacted by a concentrated swine feeding operation. Environ Health Perspect 115:1040\u20131045","journal-title":"Environ Health Perspect"},{"key":"3810_CR22","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1128\/AEM.02159-06","volume":"73","author":"A Schl\u00fcter","year":"2007","unstructured":"Schl\u00fcter A, Szczepanowski R, Kurz N, Schneiker S, Krahn I, P\u00fchler A (2007a) Erythromycin resistance-conferring plasmid pRSB105, isolated from a sewage treatment plant, harbors a new macrolide resistance determinant, an integron-containing Tn402-like element, and a large region of unknown function. Appl Environ Microbiol 73:1952\u20131960","journal-title":"Appl Environ Microbiol"},{"key":"3810_CR23","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1574-6976.2007.00074.x","volume":"31","author":"A Schl\u00fcter","year":"2007","unstructured":"Schl\u00fcter A, Szczepanowski R, P\u00fchler A, Top EM (2007b) Genomics of IncP-1 antibiotic resistance plasmids isolated from wastewater treatment plants provides evidence for a widely accessible drug resistance gene pool. FEMS Microbiol Rev 31:449\u2013477","journal-title":"FEMS Microbiol Rev"},{"key":"3810_CR24","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1574-6941.2003.tb01073.x","volume":"43","author":"T Schwartz","year":"2003","unstructured":"Schwartz T, Kohnen W, Jansen B, Obst U (2003) Detection of antibiotic-resistant bacteria and their resistance genes in wastewater, surface water, and drinking water biofilms. FEMS Microbiol Ecol 43:325\u2013335","journal-title":"FEMS Microbiol Ecol"},{"key":"3810_CR25","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1099\/mic.0.27317-0","volume":"150","author":"R Szczepanowski","year":"2004","unstructured":"Szczepanowski R (2004) Antibiotic multiresistance plasmid pRSB101 isolated from a wastewater treatment plant is related to plasmids residing in phytopathogenic bacteria and carries eight different resistance determinants including a multidrug transport system. Microbiology 150:3613\u20133630","journal-title":"Microbiology"},{"key":"3810_CR26","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1099\/mic.0.028233-0","volume":"155","author":"R Szczepanowski","year":"2009","unstructured":"Szczepanowski R, Linke B, Krahn I, Gartemann KH, Gutzkow T, Eichler W, P\u00fchler A, Schl\u00fcter A (2009) Detection of 140 clinically relevant antibiotic-resistance genes in the plasmid metagenome of wastewater treatment plant bacteria showing reduced susceptibility to selected antibiotics. Microbiology 155:2306\u20132319","journal-title":"Microbiology"},{"key":"3810_CR27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0168-6496(03)00164-8","volume":"45","author":"T Tennstedt","year":"2003","unstructured":"Tennstedt T, Szczepanowski R, Braun S, P\u00fchler A, Schl\u00fcter A (2003) Occurrence of integron-associated resistance gene cassettes located on antibiotic resistance plasmids isolated from a wastewater treatment plant. FEMS Microbiol Ecol 45:239\u2013252","journal-title":"FEMS Microbiol Ecol"},{"key":"3810_CR28","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3201\/eid0908.030089","volume":"9","author":"F Vandenesch","year":"2003","unstructured":"Vandenesch F, Naimi T, Enright MC, Lina G, Nimmo GR, Heffernan H, Liassine N, Bes M, Greenland T, Reverdy ME, Etienne J (2003) Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence. Emerg Infect Dis 9:978\u2013984","journal-title":"Emerg Infect Dis"},{"key":"3810_CR29","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.mimet.2003.10.014","volume":"56","author":"H Volkmann","year":"2004","unstructured":"Volkmann H (2004) Detection of clinically relevant antibiotic-resistance genes in municipal wastewater using real-time PCR (TaqMan). J Microbiol Methods 56:277\u2013286","journal-title":"J Microbiol Methods"},{"key":"3810_CR30","doi-asserted-by":"crossref","first-page":"5714","DOI":"10.1128\/AEM.00382-09","volume":"75","author":"C Xi","year":"2009","unstructured":"Xi C, Zhang Y, Marrs CF, Ye W, Simon C, Foxman B, Nriagu J (2009) Prevalence of antibiotic resistance in drinking water treatment and distribution systems. Appl Environ Microbiol 75:5714\u20135718","journal-title":"Appl Environ Microbiol"},{"key":"3810_CR31","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.1128\/AAC.00774-09","volume":"53","author":"D Yong","year":"2009","unstructured":"Yong D, Toleman MA, Giske CG, Cho HS, Sundman K, Lee K, Walsh TR (2009) Characterization of a new metallo- -lactamase gene, bla NDM-1 , and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae Sequence Type 14 from India. Antimicrob Agents Chemother 53:5046\u20135054","journal-title":"Antimicrob Agents Chemother"},{"key":"3810_CR32","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ijantimicag.2006.08.005","volume":"28","author":"GG Zhanel","year":"2006","unstructured":"Zhanel GG, Wang X, Nichol K, Nikulin A, Wierzbowski AK, Mulvey M, Hoban DJ (2006) Molecular characterisation of Canadian paediatric multidrug-resistant Streptococcus pneumoniae from 1998\u20132004. Int J Antimicro Ag 28:465\u2013471","journal-title":"Int J Antimicro Ag"},{"key":"3810_CR33","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1021\/es103672x","volume":"45","author":"XX Zhang","year":"2011","unstructured":"Zhang XX, Zhang T (2011) Occurrence, abundance, and diversity of tetracycline resistance genes in 15 sewage treatment plants across China and other global locations. Environ Sci Technol 45:2598\u20132604","journal-title":"Environ Sci Technol"},{"key":"3810_CR34","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1021\/es803309m","volume":"43","author":"T Zhang","year":"2009","unstructured":"Zhang T, Zhang M, Zhang XX, Fang HHP (2009a) Tetracycline resistance genes and tetracycline resistant lactose-fermenting Enterobacteriaceae in activated sludge of sewage treatment plants. Environ Sci Technol 43:3455\u20133460","journal-title":"Environ Sci Technol"},{"key":"3810_CR35","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00253-008-1829-z","volume":"82","author":"XX Zhang","year":"2009","unstructured":"Zhang XX, Zhang T, Fang HHP (2009b) Antibiotic resistance genes in water environment. Appl Microbiol Biotechnol 82:397\u2013414","journal-title":"Appl Microbiol Biotechnol"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-011-3810-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00253-011-3810-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-011-3810-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T13:18:40Z","timestamp":1561123120000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00253-011-3810-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,28]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["3810"],"URL":"https:\/\/doi.org\/10.1007\/s00253-011-3810-5","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,28]]}}}