{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:18:06Z","timestamp":1791123486831,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"15","license":[{"start":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T00:00:00Z","timestamp":1369699200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1007\/s00253-013-4986-7","type":"journal-article","created":{"date-parts":[[2013,5,27]],"date-time":"2013-05-27T13:37:21Z","timestamp":1369661841000},"page":"6693-6703","source":"Crossref","is-referenced-by-count":27,"title":["Reactions upstream of glycerate-1,3-bisphosphate drive Corynebacterium glutamicum d-lactate productivity under oxygen deprivation"],"prefix":"10.1007","volume":"97","author":[{"given":"Yota","family":"Tsuge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shougo","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Suda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Inui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Yukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,28]]},"reference":[{"key":"4986_CR1","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.1021\/bi00068a029","volume":"32","author":"J Babul","year":"1993","unstructured":"Babul J, Clifton D, Kretschmer M, Fraenkel DG (1993) Glucose metabolism in Escherichia coli and the effect of increased amount of aldolase. Biochemistry 32:4685\u20134692","journal-title":"Biochemistry"},{"key":"4986_CR2","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1128\/AEM.02972-10","volume":"77","author":"B Blombach","year":"2011","unstructured":"Blombach B, Riester T, Wieschalka S, Ziert C, Youn JW, Wendisch VF, Eikmanns BJ (2011) Corynebacterium glutamicum tailored for efficient isobutanol production. Appl Environ Microbiol 77:3300\u20133310","journal-title":"Appl Environ Microbiol"},{"key":"4986_CR3","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1021\/bi00134a028","volume":"31","author":"SE Davies","year":"1992","unstructured":"Davies SE, Brindle KM (1992) Effects of overexpression of phosphofructokinase on glycolysis in the yeast Saccharomyces cerevisiae. Biochemistry 31:4729\u20134735","journal-title":"Biochemistry"},{"key":"4986_CR4","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1046\/j.1432-1327.1998.2540096.x","volume":"254","author":"H Dominguez","year":"1998","unstructured":"Dominguez H, Rollin C, Guyonvarch A, Guerquin-Kern JL, Cocaign-Bousquet M, Lindley ND (1998) Carbon-flux distribution in the central metabolic pathways of Corynebacterium glutamicum during growth on fructose. Eur J Biochem 254:96\u2013102","journal-title":"Eur J Biochem"},{"key":"4986_CR5","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/(SICI)1097-0290(20000305)67:5<623::AID-BIT13>3.0.CO;2-W","volume":"67","author":"M Emmerling","year":"2000","unstructured":"Emmerling M, Bailey JE, Sauer U (2000) Altered regulation of pyruvate kinase or co-overexpression of phosphofructokinase increases glycolytic fluxes in resting Escherichia coli. Biotechnol Bioeng 67:623\u2013627","journal-title":"Biotechnol Bioeng"},{"key":"4986_CR6","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/mabi.200700028","volume":"7","author":"K Fukushima","year":"2007","unstructured":"Fukushima K, Chang YH, Kimura Y (2007) Enhanced stereocomplex formation of poly(L-lactic acid) and poly (D-lactic acid) in the presence of stereoblock poly(lactic acid). Macromol Biosci 7:829\u2013835","journal-title":"Macromol Biosci"},{"key":"4986_CR7","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1128\/AEM.07056-11","volume":"78","author":"S Hasegawa","year":"2012","unstructured":"Hasegawa S, Uematsu K, Natsuma Y, Suda M, Hiraga K, Jojima T, Inui M, Yukawa H (2012) Improvement of the redox balance increases L-valine production by Corynebacterium glutamicum under oxygen deprivation conditions. Appl Environ Microbiol 78:865\u2013875","journal-title":"Appl Environ Microbiol"},{"key":"4986_CR8","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/(SICI)1097-0290(19980420)58:2\/3<154::AID-BIT7>3.0.CO;2-K","volume":"58","author":"V Hatzimanikatis","year":"1998","unstructured":"Hatzimanikatis V, Emmerling M, Sauer U, Bailey JE (1998) Application of mathematical tools for metabolic design of microbial ethanol production. Biotechnol Bioeng 58:154\u2013161","journal-title":"Biotechnol Bioeng"},{"key":"4986_CR9","doi-asserted-by":"crossref","unstructured":"Ikada Y, Jamshidi K, Tsuji H, Hyon S (1987) Stereocomplex formation between enantiomeric poly (lactides). Macromolecules 20: 904\u2013906","DOI":"10.1021\/ma00170a034"},{"key":"4986_CR10","doi-asserted-by":"crossref","unstructured":"Ikeda M, Mizuno Y, Awane S, Hayashi M, Mitsuhashi S, Takeno S. (2011) Identification and application of a different glucose uptake system that functions as an alternative to the phosphotransferase system in Corynebacterium glutamicum. Appl Microbiol Biotechnol 90:1443\u20131451","DOI":"10.1007\/s00253-011-3210-x"},{"key":"4986_CR11","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1128\/AEM.69.2.725-733.2003","volume":"69","author":"M Inui","year":"2003","unstructured":"Inui M, Nakata K, Roh JH, Vert\u00e8s AA, Yukawa H (2003) Isolation and molecular characterization of pMG160, a mobilizable cryptic plasmid from Rhodobacter blasticus. Appl Environ Microbiol 69:725\u2013733","journal-title":"Appl Environ Microbiol"},{"key":"4986_CR12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000086705","volume":"8","author":"M Inui","year":"2004","unstructured":"Inui M, Kawaguchi H, Murakami S, Vert\u00e8s AA, Yukawa H (2004a) Metabolic engineering of Corynebacterium glutamicum for fuel ethanol production under oxygen-deprivation conditions. J Mol Microbiol Biotechnol 8:243\u2013254","journal-title":"J Mol Microbiol Biotechnol"},{"key":"4986_CR13","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000079827","volume":"7","author":"M Inui","year":"2004","unstructured":"Inui M, Murakami S, Okino S, Kawaguchi H, Vert\u00e8s AA, Yukawa H (2004b) Metabolic analysis of Corynebacterium glutamicum during lactate and succinate productions under oxygen deprivation conditions. J Mol Microbiol Biotechnol 7:182\u2013196","journal-title":"J Mol Microbiol Biotechnol"},{"key":"4986_CR14","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1099\/mic.0.2006\/005587-0","volume":"153","author":"M Inui","year":"2007","unstructured":"Inui M, Suda M, Okino S, Nonaka H, Puskas LG, Vert\u00e8s AA, Yukawa H (2007) Transcriptional profiling of Corynebacterium glutamicum metabolism during organic acid production under oxygen deprivation conditions. Microbiology 153:2491\u20132504","journal-title":"Microbiology"},{"key":"4986_CR15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00253-010-2493-7","volume":"87","author":"T Jojima","year":"2010","unstructured":"Jojima T, Fujii M, Mori E, Inui M, Yukawa H (2010) Engineering of sugar metabolism of Corynebacterium glutamicum for production of amino acid L-alanine under oxygen deprivation. Appl Microbiol Biotechnol 87:159\u2013165","journal-title":"Appl Microbiol Biotechnol"},{"key":"4986_CR16","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0141-3910(97)00204-8","volume":"59","author":"S Karjomaa","year":"1998","unstructured":"Karjomaa S, Suortti T, Lempiainen R, Selin J, Itavaara M (1998) Microbial degradation of poly-(L-lactic acid) oligomers. Polym Degrad Stab 59:333\u2013336","journal-title":"Polym Degrad Stab"},{"key":"4986_CR17","unstructured":"Kinoshita S (1985) Glutamic acid bacteria. In: Demain AL, Solomon NA (ed) Biology of industrial microorganisms. Cummings, London, pp 115\u2013146"},{"key":"4986_CR18","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.1128\/AEM.68.9.4274-4282.2002","volume":"68","author":"BJ Koebmann","year":"2002","unstructured":"Koebmann BJ, Solem C, Pedersen MB, Nilsson D, Jensen PR (2002a) Expression of genes encoding F(1)-ATPase results in uncoupling of glycolysis from biomass production in Lactococcus lactis. Appl Environ Microbiol 68:4274\u20134282","journal-title":"Appl Environ Microbiol"},{"key":"4986_CR19","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1128\/JB.184.14.3909-3916.2002","volume":"184","author":"BJ Koebmann","year":"2002","unstructured":"Koebmann BJ, Westerhoff HV, Snoep JL, Nilsson D, Jensen PR (2002b) The glycolytic flux in Escherichia coli is controlled by the demand for ATP. J Bacteriol 184:3909\u20133916","journal-title":"J Bacteriol"},{"key":"4986_CR20","doi-asserted-by":"crossref","unstructured":"Larsson C, Nilsson A, Blomberg A, Gustafsson L. (1997) Glycolytic flux is conditionally correlated with ATP concentration in Saccharomyces cerevisiae: a chemostat study under carbon- or nitrogen-limiting conditions. J Bacteriol 179:7243\u20137250.","DOI":"10.1128\/jb.179.23.7243-7250.1997"},{"key":"4986_CR21","doi-asserted-by":"crossref","unstructured":"Lindner SN, Seibold GM, Henrich A, Kr\u00e4mer R, Wendisch VF. (2011) Phosphotransferase system-independent glucose utilization in Corynebacterium glutamicum by inositol permeases and glucokinases. Appl Environ Microbiol 77:3571\u20133581","DOI":"10.1128\/AEM.02713-10"},{"key":"4986_CR22","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1128\/AEM.07790-11","volume":"78","author":"B Litsanov","year":"2012","unstructured":"Litsanov B, Brocker M, Bott M (2012) Toward homosuccinate fermentation: metabolic engineering of Corynebacterium glutamicum for anaerobic production of succinate from glucose and formate. Appl Environ Microbiol 78:3325\u20133337","journal-title":"Appl Environ Microbiol"},{"key":"4986_CR23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2323\/jgam.7.145","volume":"7","author":"K Nakayama","year":"1961","unstructured":"Nakayama K, Kitada S, Kinoshita S (1961) Studies on lysine fermentation I. The control mechanism on lysine accumulation by homoserine and threonine. J Gen Appl Microbiol 7:145\u2013154","journal-title":"J Gen Appl Microbiol"},{"key":"4986_CR24","doi-asserted-by":"crossref","first-page":"7858","DOI":"10.1128\/AEM.01692-09","volume":"75","author":"K Okano","year":"2009","unstructured":"Okano K, Yoshida S, Yamada R, Tanaka T, Ogino C, Fukuda H, Kondo A (2009) Improved production of homo-D-lactic acid via xylose fermentation by introduction of xylose assimilation genes and redirection of the phosphoketolase pathway to the pentose phosphate pathway in L-Lactate dehydrogenase gene-deficient Lactobacillus plantarum. Appl Environ Microbiol 75:7858\u20137861","journal-title":"Appl Environ Microbiol"},{"key":"4986_CR25","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00253-005-1900-y","volume":"68","author":"S Okino","year":"2005","unstructured":"Okino S, Inui M, Yukawa H (2005) Production of organic acids by Corynebacterium glutamicum under oxygen deprivation. Appl Microbiol Biotechnol 68:475\u2013480","journal-title":"Appl Microbiol Biotechnol"},{"key":"4986_CR26","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00253-008-1668-y","volume":"81","author":"S Okino","year":"2008","unstructured":"Okino S, Noburyu R, Suda M, Jojima T, Inui M, Yukawa H (2008a) An efficient succinic acid production process in a metabolically engineered Corynebacterium glutamicum strain. Appl Microbiol Biotechnol 81:459\u2013464","journal-title":"Appl Microbiol Biotechnol"},{"key":"4986_CR27","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00253-007-1336-7","volume":"78","author":"S Okino","year":"2008","unstructured":"Okino S, Suda M, Fujikura K, Inui M, Yukawa H (2008b) Production of D-lactic acid by Corynebacterium glutamicum under oxygen deprivation. Appl Microbiol Biotechnol 78:449\u2013454","journal-title":"Appl Microbiol Biotechnol"},{"key":"4986_CR28","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.enzmictec.2011.05.002","volume":"49","author":"M Papagianni","year":"2012","unstructured":"Papagianni M, Avramidis N (2012) Lactococcus lactis as a cell factory: a twofold increase in phosphofructokinase activity results in a proportional increase in specific rates of glucose uptake and lactate formation. Enzyme Microb Technol 49:197\u2013202","journal-title":"Enzyme Microb Technol"},{"key":"4986_CR29","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1099\/mic.0.26695-0","volume":"150","author":"A Ramos","year":"2004","unstructured":"Ramos A, Neves AR, Ventura R, Maycock C, Lopez P, Santos H (2004) Effect of pyruvate kinase overproduction on glucose metabolism of Lactococcus lactis. Microbiology 150:1103\u20131111","journal-title":"Microbiology"},{"key":"4986_CR30","doi-asserted-by":"crossref","unstructured":"Rud I, Solem C, Jensen PR, Axelsson L, Naterstad K (2008) Co-factor engineering in lactobacilli: effects of uncoupled ATPase activity on metabolic fluxes in Lactobacillus plantarum and L. sakei. Metab Eng 10(5):207\u2013215","DOI":"10.1016\/j.ymben.2008.06.001"},{"key":"4986_CR31","volume-title":"Molecular cloning: a laboratory manual","author":"J Sambrook","year":"1989","unstructured":"Sambrook J, Fritsh E, Maniatis T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor"},{"key":"4986_CR32","first-page":"2237","volume":"130","author":"R Santamaria","year":"1984","unstructured":"Santamaria R, Gil J, Mesas J, Martin J (1984) Characterization of an endogenous plasmid and development of cloning vectors and a transformation system in Brevibacterium lactofermentum. J Gen Microbiol 130:2237\u20132246","journal-title":"J Gen Microbiol"},{"key":"4986_CR33","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/yea.320050408","volume":"5","author":"I Schaaff","year":"1989","unstructured":"Schaaff I, Heinisch J, Zimmermann FK (1989) Overproduction of glycolytic enzymes in yeast. Yeast 5:285\u2013290","journal-title":"Yeast"},{"key":"4986_CR34","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1007\/s002530100778","volume":"57","author":"H Sekine","year":"2001","unstructured":"Sekine H, Shimada T, Hayashi C, Ishiguro A, Tomita F, Yokota A (2001) H+-ATPase defect in Corynebacterium glutamicum abolishes glutamic acid production with enhancement of glucose consumption rate. Appl Microbiol Biotechnol 57:534\u2013540","journal-title":"Appl Microbiol Biotechnol"},{"key":"4986_CR35","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1128\/JB.185.5.1564-1571.2003","volume":"185","author":"C Solem","year":"2003","unstructured":"Solem C, Koebmann BJ, Jensen PR (2003) Glyceraldehyde-3-phosphate dehydrogenase has no control over glycolytic flux in Lactococcus lactis MG1363. J Bacteriol 185:1564\u20131571","journal-title":"J Bacteriol"},{"key":"4986_CR36","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1099\/13500872-141-9-2329","volume":"141","author":"J Snoep","year":"1995","unstructured":"Snoep J, Yomano L, Westerhoff H, Ingram L (1995) Protein burden in Zymomonas mobilis: negative flux and growth control due to overproduction of glycolytic enzymes. Microbiology 141:2329\u20132337","journal-title":"Microbiology"},{"key":"4986_CR37","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1128\/AEM.71.6.3369-3372.2005","volume":"71","author":"N Suzuki","year":"2005","unstructured":"Suzuki N, Okayama S, Nonaka H, Tsuge Y, Inui M, Yukawa H (2005) Large-scale engineering of the Corynebacterium glutamicum genome. Appl Environ Microbiol 71:3369\u20133372","journal-title":"Appl Environ Microbiol"},{"key":"4986_CR38","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1007\/s00253-010-2701-5","volume":"87","author":"Y Tsuchida","year":"2009","unstructured":"Tsuchida Y, Kimura S, Suzuki N, Inui M, Yukawa H (2009) Characterization of a 24-kb plasmid pCGR2 newly isolated from Corynebacterium glutamicum. Appl Microbiol Biotechnol 87:1855\u20131866","journal-title":"Appl Microbiol Biotechnol"},{"key":"4986_CR39","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1007\/s00253-006-0788-5","volume":"74","author":"Y Tsuge","year":"2007","unstructured":"Tsuge Y, Suzuki N, Inui M, Yukawa H (2007) Random segment deletion based on IS31831 and Cre\/loxP excision system in Corynebacterium glutamicum. Appl Microbiol Biotechnol 74:1333\u20131341","journal-title":"Appl Microbiol Biotechnol"},{"key":"4986_CR40","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s10295-009-0589-9","volume":"36","author":"J Utrilla","year":"2009","unstructured":"Utrilla J, Gosset G, Martinez A (2009) ATP limitation in a pyruvate formate lyase mutant of Escherichia coli MG1655 increases glycolytic flux to D-lactate. J Ind Microbiol Biotechnol 36:1057\u20131062","journal-title":"J Ind Microbiol Biotechnol"},{"key":"4986_CR41","doi-asserted-by":"crossref","first-page":"7277","DOI":"10.1128\/AEM.70.12.7277-7287.2004","volume":"70","author":"C Wittmann","year":"2004","unstructured":"Wittmann C, Kiefer P, Zelder O (2004) Metabolic fluxes in Corynebacterium glutamicum during lysine production with sucrose as carbon source. Appl Environ Microbiol 70:7277\u20137287","journal-title":"Appl Environ Microbiol"},{"key":"4986_CR42","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1128\/AEM.07998-11","volume":"78","author":"S Yamamoto","year":"2012","unstructured":"Yamamoto S, Gunji W, Suzuki H, Toda H, Suda M, Jojima T, Inui M, Yukawa H (2012) Overexpression of glycolytic genes enhances Corynebacterium glutamicum glucose metabolism and alanine production under oxygen-deprived conditions. Appl Environ Microbiol 78:4447\u20134457","journal-title":"Appl Environ Microbiol"},{"key":"4986_CR43","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00253-011-3356-6","volume":"92","author":"S Yoshida","year":"2011","unstructured":"Yoshida S, Okano K, Tanaka T, Ogino C, Kondo A (2011) Homo-D-lactic acid production from mixed sugars using xylose-assimilating operon-integrated Lactobacillus plantarum. Appl Microbiol Biotechnol 92:67\u201376","journal-title":"Appl Microbiol Biotechnol"},{"key":"4986_CR44","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1099\/mic.0.2006\/003657-0","volume":"153","author":"H Yukawa","year":"2007","unstructured":"Yukawa H, Omumasaba CA, Nonaka H, Kos P, Okai N, Suzuki N, Suda M, Tsuge Y, Watanabe J, Ikeda Y, Vert\u00e8s AA, Inui M (2007) Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R. Microbiology 153:1042\u20131058","journal-title":"Microbiology"},{"key":"4986_CR45","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1128\/AEM.69.1.399-407.2003","volume":"69","author":"S Zhou","year":"2003","unstructured":"Zhou S, Causey TB, Hasona A, Shanmugam KT, Ingram LO (2003) Production of optically pure D-lactic acid in mineral salts medium by metabolically engineered Escherichia coli W3110. Appl Environ Microbiol 69:399\u2013407","journal-title":"Appl Environ Microbiol"},{"key":"4986_CR46","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ymben.2004.10.004","volume":"7","author":"J Zhu","year":"2005","unstructured":"Zhu J, Shimizu K (2005) Effect of a single-gene knockout on the metabolic regulation in Escherichia coli for D-lactate production under microaerobic condition. Metab Eng 7:104\u2013115","journal-title":"Metab Eng"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-013-4986-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00253-013-4986-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-013-4986-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T11:20:17Z","timestamp":1558696817000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00253-013-4986-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,28]]},"references-count":46,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["4986"],"URL":"https:\/\/doi.org\/10.1007\/s00253-013-4986-7","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,28]]}}}