{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:44:19Z","timestamp":1771465459329,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T00:00:00Z","timestamp":1446163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council (BE)","doi-asserted-by":"publisher","award":["614739-A_HERO"],"award-info":[{"award-number":["614739-A_HERO"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1007\/s00253-015-7081-4","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T00:36:25Z","timestamp":1446165385000},"page":"837-846","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A novel isothermal microcalorimetry tool to assess drug effects on Ancylostoma ceylanicum and Necator americanus"],"prefix":"10.1007","volume":"100","author":[{"given":"Dayana","family":"Flores","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordana","family":"Panic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Braissant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,10,30]]},"reference":[{"key":"7081_CR1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/978-1-61779-108-6_20","volume":"740","author":"O Braissant","year":"2011","unstructured":"Braissant O, Daniels AUD (2011) Closed ampoule isothermal microcalorimetry for continuous real-time detection and evaluation of cultured mammalian cell activity and responses. Methods Mol Biol 740:191\u2013208. doi: 10.1007\/978-1-61779-108-6","journal-title":"Methods Mol Biol"},{"key":"7081_CR2","doi-asserted-by":"crossref","first-page":"9369","DOI":"10.3390\/s101009369","volume":"10","author":"O Braissant","year":"2010","unstructured":"Braissant O, Wirz D, G\u00f6pfert B, Daniels AUU (2010) Biomedical use of isothermal microcalorimeters. Sensors 10:9369\u20139383. doi: 10.3390\/s101009369","journal-title":"Sensors"},{"key":"7081_CR3","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/biot.201400494","volume":"10","author":"O Braissant","year":"2015","unstructured":"Braissant O, Keiser J, Meister I, Bachmann A, Wirz D, G\u00f6pfert B, Bonkat G, Wads\u00f6 I (2015) Isothermal microcalorimetry accurately detects bacteria, tumorous microtissues, and parasitic worms in a label-free well-plate assay. Biotechnol J 10:460\u20138. doi: 10.1002\/biot.201400494","journal-title":"Biotechnol J"},{"key":"7081_CR4","unstructured":"Flecknell P (2002) Replacement, reduction and refinement. ALTEX 19:73\u20138"},{"key":"7081_CR5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.addr.2011.11.001","volume":"64","author":"S Gaisford","year":"2012","unstructured":"Gaisford S (2012) Isothermal microcalorimetry for quantifying amorphous content in processed pharmaceuticals. Adv Drug Deliv Rev 64:431\u2013439. doi: 10.1016\/j.addr.2011.11.001","journal-title":"Adv Drug Deliv Rev"},{"key":"7081_CR6","volume-title":"An introduction to wavelets and other filtering methods in finance and economics","author":"R Gen\u00e7ay","year":"2002","unstructured":"Gen\u00e7ay R, Sel\u00e7uk F, Brandon W (2002) An introduction to wavelets and other filtering methods in finance and economics, 1st edn. Academic Press, London","edition":"1"},{"key":"7081_CR7","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/0020-7519(91)90144-V","volume":"21","author":"JH Gill","year":"1991","unstructured":"Gill JH, Redwin JM, Van Wyk JA, Lacey E (1991) Detection of resistance to ivermectin in Haemonchus contortus. Int J Parasitol 21:771\u2013776. doi: 10.1016\/0020-7519(91)90144-V","journal-title":"Int J Parasitol"},{"key":"7081_CR8","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s10973-011-2117-1","volume":"110","author":"C Jes\u00fas","year":"2011","unstructured":"Jes\u00fas C, Socorro F, Rodr\u00edguez de Rivera M (2011) New approach to Tian\u2019s equation applied to heat conduction and liquid injection calorimeters. J Therm Anal Calorim 110:1523\u20131532. doi: 10.1007\/s10973-011-2117-1","journal-title":"J Therm Anal Calorim"},{"key":"7081_CR9","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1001\/jama.299.16.1937","volume":"299","author":"J Keiser","year":"2008","unstructured":"Keiser J, Utzinger J (2008) Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA 299:1937\u20131948. doi: 10.1001\/jama.299.16.1937","journal-title":"JAMA"},{"key":"7081_CR10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0065-308X(10)73008-6","volume":"73","author":"J Keiser","year":"2010","unstructured":"Keiser J, Utzinger J (2010) The drugs we have and the drugs we need against major helminth infections. Adv Parasitol 73:197\u2013230. doi: 10.1016\/S0065-308X(10)73008-6","journal-title":"Adv Parasitol"},{"key":"7081_CR11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.exppara.2012.11.020","volume":"133","author":"J Keiser","year":"2013","unstructured":"Keiser J, Manneck T, Kirchhofer C, Braissant O (2013) Isothermal microcalorimetry to study the activity of triclabendazole and its metabolites on juvenile and adult Fasciola hepatica. Exp Parasitol 133:265\u2013268. doi: 10.1016\/j.exppara.2012.11.020","journal-title":"Exp Parasitol"},{"key":"7081_CR12","doi-asserted-by":"crossref","first-page":"608","DOI":"10.4269\/ajtmh.2004.71.608","volume":"71","author":"AC Kotze","year":"2004","unstructured":"Kotze AC, Clifford S, O\u2019Grady J, Behnke JM, McCarthy JS (2004) An in vitro larval motility assay to determine anthelmintic sensitivity for human hookworm and Strongyloides species. Am J Trop Med Hyg 71:608\u2013616","journal-title":"Am J Trop Med Hyg"},{"key":"7081_CR13","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1128\/JCM.02382-10","volume":"49","author":"T Manneck","year":"2011","unstructured":"Manneck T, Braissant O, Haggenm\u00fcller Y, Keiser J (2011) Isothermal microcalorimetry to study drugs against Schistosoma mansoni. J Clin Microbiol 49:1217\u20131225. doi: 10.1128\/JCM.02382-10","journal-title":"J Clin Microbiol"},{"key":"7081_CR14","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0140-6736(12)61689-4","volume":"380","author":"CC Murray","year":"2012","unstructured":"Murray CC, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Bas\u00e1\u00f1ez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernab\u00e9 E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, F\u00e8vre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FG, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gonzalez-Medina D, Gosselin R, Grainger R, Grant B, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Haro JM, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo JP, King CH, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Laden F, Lalloo R, Laslett LL, Lathlean T, Leasher JL, Lee YY, Leigh J, Levinson D, Lim SS, Limb E, Lin JK, Lipnick M, Lipshultz SE, Liu W, Loane M, Ohno SL, Lyons R, Mabweijano J, MacIntyre MF, Malekzadeh R, Mallinger L, Manivannan S, Marcenes W, March L, Margolis DJ, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGill N, McGrath J, Medina-Mora ME, Meltzer M, Mensah GA, Merriman TR, Meyer AC, Miglioli V, Miller M, Miller TR, Mitchell PB, Mock C, Mocumbi AO, Moffitt TE, Mokdad AA, Monasta L, Montico M, Moradi-Lakeh M, Moran A, Morawska L, Mori R, Murdoch ME, Mwaniki MK, Naidoo K, Nair MN, Naldi L, Narayan KM, Nelson PK, Nelson RG, Nevitt MC, Newton CR, Nolte S, Norman P, Norman R, O\u2019Donnell M, O\u2019Hanlon S, Olives C, Omer SB, Ortblad K, Osborne R, Ozgediz D, Page A, Pahari B, Pandian JD, Rivero AP, Patten SB, Pearce N, Padilla RP, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Phillips MR, Pierce K, Pion S, Polanczyk GV, Polinder S, Pope CA 3rd, Popova S, Porrini E, Pourmalek F, Prince M, Pullan RL, Ramaiah KD, Ranganathan D, Razavi H, Regan M, Rehm JT, Rein DB, Remuzzi G, Richardson K, Rivara FP, Roberts T, Robinson C, De Le\u00f2n FR, Ronfani L, Room R, Rosenfeld LC, Rushton L, Sacco RL, Saha S, Sampson U, Sanchez-Riera L, Sanman E, Schwebel DC, Scott JG, Segui-Gomez M, Shahraz S, Shepard DS, Shin H, Shivakoti R, Singh D, Singh GM, Singh JA, Singleton J, Sleet DA, Sliwa K, Smith E, Smith JL, Stapelberg NJ, Steer A, Steiner T, Stolk WA, Stovner LJ, Sudfeld C, Syed S, Tamburlini G, Tavakkoli M, Taylor HR, Taylor JA, Taylor WJ, Thomas B, Thomson WM, Thurston GD, Tleyjeh IM, Tonelli M, Towbin JA, Truelsen T, Tsilimbaris MK, Ubeda C, Undurraga EA, van der Werf MJ, van Os J, Vavilala MS, Venketasubramanian N, Wang M, Wang W, Watt K, Weatherall DJ, Weinstock MA, Weintraub R, Weisskopf MG, Weissman MM, White RA, Whiteford H, Wiebe N, Wiersma ST, Wilkinson JD, Williams HC, Williams SR, Witt E, Wolfe F, Woolf AD, Wulf S, Yeh PH, Zaidi AK, Zheng ZJ, Zonies D, Lopez AD, AlMazroa MA, Memish ZA (2012) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990\u20132010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380:2197\u20132223. doi: 10.1016\/S0140-6736(12)61689-4","journal-title":"Lancet"},{"key":"7081_CR15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1756-3305-7-37","volume":"7","author":"RL Pullan","year":"2014","unstructured":"Pullan RL, Smith JL, Jasrasaria R, Brooker SJ (2014) Global numbers of infection and disease burden of soil transmitted helminth infections in 2010. Parasitol Vectors 7:37. doi: 10.1186\/1756-3305-7-37","journal-title":"Parasitol Vectors"},{"key":"7081_CR16","unstructured":"R Core Team (2011) R: A Language and environment for statistical computing"},{"key":"7081_CR17","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/0020-7519(95)00036-2","volume":"25","author":"JC Richards","year":"1995","unstructured":"Richards JC, Behnke JM, Duce IR (1995) In vitro studies on the relative sensitivity to ivermectin of Necator americanus and Ancylostoma ceylanicum. Int J Parasitol 25:1185\u20131191. doi: 10.1016\/0020-7519(95)00036-2","journal-title":"Int J Parasitol"},{"key":"7081_CR18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.mimet.2011.08.009","volume":"87","author":"A Silbereisen","year":"2011","unstructured":"Silbereisen A, Tritten L, Keiser J (2011) Exploration of novel in vitro assays to study drugs against Trichuris spp. J Microbiol Methods 87:169\u2013175. doi: 10.1016\/j.mimet.2011.08.009","journal-title":"J Microbiol Methods"},{"key":"7081_CR19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000885","volume":"4","author":"MJ Smout","year":"2010","unstructured":"Smout MJ, Kotze AC, Mccarthy JS, Loukas A (2010) A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility. PLoS Negl Trop Dis 4, e885. doi: 10.1371\/journal.pntd.0000885","journal-title":"PLoS Negl Trop Dis"},{"key":"7081_CR20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4269\/ajtmh.12-0547","volume":"90","author":"RS Treger","year":"2014","unstructured":"Treger RS, Otchere J, Keil MF, Quagraine JE, Rai G, Mott BT, Humphries DL, Wilson M, Cappello M, Vermeire JJ (2014) In vitro screening of compounds against laboratory and field isolates of human hookworm reveals quantitative differences in anthelmintic susceptibility. Am J Trop Med Hyg 90:71\u201374. doi: 10.4269\/ajtmh.12-0547","journal-title":"Am J Trop Med Hyg"},{"key":"7081_CR21","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1017\/S0031182011001934","volume":"139","author":"L Tritten","year":"2012","unstructured":"Tritten L, Braissant O, Keiser J (2012) Comparison of novel and existing tools for studying drug sensitivity against the hookworm Ancylostoma ceylanicum in vitro. Parasitology 139:348\u2013357. doi: 10.1017\/S0031182011001934","journal-title":"Parasitology"},{"key":"7081_CR22","first-page":"263","volume":"5","author":"J Utzinger","year":"2004","unstructured":"Utzinger J, Keiser J (2004) Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and control. Expert Opin Drug Discov 5:263\u2013285. doi: 10.1517\/14656566.5.2.263","journal-title":"Expert Opin Drug Discov"},{"key":"7081_CR23","doi-asserted-by":"crossref","unstructured":"Wimmersberger D, Tritten L, Keiser J (2013) Development of an in vitro drug sensitivity assay for Trichuris muris first-stage larvae","DOI":"10.1186\/1756-3305-6-42"},{"issue":"Suppl","key":"7081_CR24","first-page":"S85","volume":"131","author":"AJ Wolstenholme","year":"2005","unstructured":"Wolstenholme AJ, Rogers AT (2005) Glutamate-gated chloride channels and the mode of action of the avermectin\/milbemycin anthelmintics. Parasitology 131(Suppl):S85\u2013S95. doi: 10.1017\/S0031182005008218","journal-title":"Parasitology"},{"key":"7081_CR25","first-page":"232","volume":"62","author":"DC Zaharia","year":"2013","unstructured":"Zaharia DC, Popa MG, Steriade AT, Muntean AA, Balint O, Micu\u0163 R, Popa VT, Popa MI, Bogdan MA (2013) Microcalorimetry\u2014a new method for bacterial characterisation. Pneumol 62:232\u2013235","journal-title":"Pneumol"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-015-7081-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00253-015-7081-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-015-7081-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T23:47:44Z","timestamp":1567295264000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00253-015-7081-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,30]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["7081"],"URL":"https:\/\/doi.org\/10.1007\/s00253-015-7081-4","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,30]]}}}