{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:41:06Z","timestamp":1790073666002,"version":"4.0.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,11,28]],"date-time":"2015-11-28T00:00:00Z","timestamp":1448668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1007\/s00253-015-7169-x","type":"journal-article","created":{"date-parts":[[2015,11,28]],"date-time":"2015-11-28T06:24:43Z","timestamp":1448691883000},"page":"797-813","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Different mechanisms of resistance modulate sulfite tolerance in wine yeasts"],"prefix":"10.1007","volume":"100","author":[{"given":"Chiara","family":"Nadai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Treu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Campanaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Giacomini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Corich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,28]]},"reference":[{"key":"7169_CR1","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1021\/jf060851b","volume":"54","author":"A Aranda","year":"2006","unstructured":"Aranda A, Jimenez-Marti E, Orozco H, Matallana E, Del Olmo M (2006) Sulfur and adenine metabolisms are linked, and both modulate sulfite resistance in wine yeast. J Agric Food Chem 54:5839\u20135846","journal-title":"J Agric Food Chem"},{"key":"7169_CR2","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.1128\/jb.179.18.5971-5974.1997","volume":"179","author":"D Avram","year":"1997","unstructured":"Avram D, Bakalinsky AT (1997) SSU1 encodes a plasma membrane protein with a central role in a network of proteins conferring sulfite tolerance in Saccharomyces cerevisiae. J Bacteriol 179:5971\u20135974","journal-title":"J Bacteriol"},{"key":"7169_CR3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.5344\/ajev.1990.41.4.319","volume":"40","author":"L Bely","year":"1990","unstructured":"Bely L, Sablayrolles J, Barre P (1990) Description of alcoholic fermentation kinetics: its variability and significance. Am J Enol Viticult 40:319\u2013324","journal-title":"Am J Enol Viticult"},{"key":"7169_CR4","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1111\/j.1567-1364.2008.00434.x","volume":"8","author":"AR Borneman","year":"2008","unstructured":"Borneman AR, Forgan AH, Pretorius IS, Chambers PJ (2008) Comparative genome analysis of a Saccharomyces cerevisiae wine strain. FEMS Yeast Res 8:1185\u20131195","journal-title":"FEMS Yeast Res"},{"issue":"2","key":"7169_CR5","doi-asserted-by":"crossref","first-page":"e1001287","DOI":"10.1371\/journal.pgen.1001287","volume":"7","author":"AR Borneman","year":"2011","unstructured":"Borneman AR, Desany BA, Riches D, Affourtit JP, Forgan AH, Pretorius IS, Egholm M, Chambers PJ (2011) Whole-genome comparison reveals novel genetic elements that characterize the genome of industrial strains of Saccharomyces cerevisiae. PLoS Genet 7(2):e1001287","journal-title":"PLoS Genet"},{"issue":"7","key":"7169_CR6","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/bioinformatics\/btp087","volume":"25","author":"D Campagna","year":"2009","unstructured":"Campagna D, Albiero A, Bilardi A, Caniato E, Forcato C, Manavski S, Vitulo N, Valle G (2009) PASS: a program to align short sequences. Bioinformatics 25(7):967\u2013968","journal-title":"Bioinformatics"},{"key":"7169_CR7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/BF00326407","volume":"22","author":"E Casalone","year":"1992","unstructured":"Casalone E, Colella CM, Daly S, Gallori E, Moriani L, Polsinelli M (1992) Mechanism of resistance to sulfite in Saccharomyces cerevisiae. Curr Genet 22:435\u2013440","journal-title":"Curr Genet"},{"issue":"3","key":"7169_CR8","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/genetics\/145.3.627","volume":"145","author":"H Cherest","year":"1997","unstructured":"Cherest H, Davidian JC, Thomas D, Benes V, Ansorge W, Surdin-Kerjan Y (1997) Molecular characterization of two high affinity sulfate transporters in Saccharomyces cerevisiae. Genetics 145(3):627\u2013635","journal-title":"Genetics"},{"key":"7169_CR9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1201\/9781482294644","volume-title":"Wine microbiology: science and technology","author":"C Delfini","year":"2001","unstructured":"Delfini C, Formica JV (2001) Isolation selection and purification of wine yeasts. In: Wine microbiology: science and technology. Dekker, New York, US, pp. 193\u2013218"},{"key":"7169_CR10","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1365-2672.2005.02818.x","volume":"100","author":"B Divol","year":"2006","unstructured":"Divol B, Miot-Sertier C, Lonvaud-Funel A (2006) Genetic characterization of strains of Saccharomyces cerevisiae responsible for \u2018refermentation\u2019 in Botrytis-affected wines. J Appl Microbiol 100:516\u2013526","journal-title":"J Appl Microbiol"},{"key":"7169_CR11","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00253-012-4186-x","volume":"95","author":"B Divol","year":"2012","unstructured":"Divol B, du Toit M, Duckitt E (2012) Surviving in the presence of sulphur dioxide: strategies developed by wine yeasts. Appl Microbiol Biotechnol 95:601\u2013613","journal-title":"Appl Microbiol Biotechnol"},{"key":"7169_CR12","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-33349-6","volume-title":"Wine microbiology. Practical applications and procedures","author":"KC Fugelsang","year":"2007","unstructured":"Fugelsang KC, Edwards CG (2007) Wine microbiology. Practical applications and procedures. Springer, New York, USA"},{"issue":"Pt12","key":"7169_CR13","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1099\/mic.0.041673-0","volume":"156","author":"V Galeote","year":"2010","unstructured":"Galeote V, Novo M, Salema-Oom M, Brion C, Val\u00e9rio E, Gon\u00e7alves P, Dequin S (2010) FSY1, a horizontally transferred gene in the Saccharomyces cerevisiae EC1118 wine yeast strain, encodes a high-affinity fructose\/H+ symporter. Microbiology 156(Pt12):3754\u20133761. doi: 10.1099\/mic.0.041673-0","journal-title":"Microbiology"},{"issue":"5287","key":"7169_CR14","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1126\/science.274.5287.546","volume":"274","author":"A Goffeau","year":"1996","unstructured":"Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG (1996) Life with 6000 genes. Science 274(5287):546\u2013567","journal-title":"Science"},{"key":"7169_CR15","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0922-338X(98)80146-3","volume":"86","author":"N Goto-Yamamoto","year":"1998","unstructured":"Goto-Yamamoto N, Kitano K, Shiki K, Yoshida Y, Suzuki T, Iwata T, Yamane Y, Hara S (1998) SSU1-R, a sulfite resistance gene of wine yeast, is an allele of SSU1 with a different upstream sequence. J Ferment Bioeng 86:427\u2013433","journal-title":"J Ferment Bioeng"},{"key":"7169_CR16","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1021\/jf021015e","volume":"51","author":"M Herrero","year":"2003","unstructured":"Herrero M, Garcia LA, Diaz M (2003) The effect of SO2 on the production of ethanol, acetaldehyde, organic acids and flavor volatiles during industrial cider fermentation. J Agric Food Chem 51:3455\u20133459","journal-title":"J Agric Food Chem"},{"key":"7169_CR17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF00413023","volume":"145","author":"H Hinze","year":"1986","unstructured":"Hinze H, Holzer H (1986) Analysis of the energy metabolism after incubation of Saccharomyces cerevisiae with sulfite or nitrite. Arch Microbiol 145:27\u201331","journal-title":"Arch Microbiol"},{"key":"7169_CR18","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0966-842X(99)01509-7","volume":"7","author":"SM Jazwinski","year":"1999","unstructured":"Jazwinski SM (1999) Molecular mechanisms of yeast longevity. Trends Microbiol 7:247\u2013252","journal-title":"Trends Microbiol"},{"key":"7169_CR19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1046\/j.1365-2621.2000.00341.x","volume":"35","author":"S-Q Liu","year":"2000","unstructured":"Liu S-Q, Pilone GJ (2000) An overview of formation and roles of acetaldehyde in winemaking with emphasis on microbiological implications. Int J Food Sci Technol 35:49\u201361","journal-title":"Int J Food Sci Technol"},{"key":"7169_CR20","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s11274-005-9110-4","volume":"22","author":"CA Lopes","year":"2006","unstructured":"Lopes CA, Rodriguez ME, Querol A, Bramardi S, Caballero AC (2006) Relationship between molecular and enological features of Patagonian wine yeasts: relevance in selection protocols. World J Microbiol Biotechnol 22:827\u2013833","journal-title":"World J Microbiol Biotechnol"},{"key":"7169_CR21","doi-asserted-by":"crossref","unstructured":"Marks VD, Ho Sui SJ, Erasmus D, van der Merwe GK, Brumm J, Wasserman WW, Bryan J, van Vuuren HJ (2008) Dynamics of the yeast transcriptome during wine fermentation reveals a novel fermentation stress response. FEMS Yeast Res 8:35\u201352","DOI":"10.1111\/j.1567-1364.2007.00338.x"},{"key":"7169_CR22","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/mutage\/geh058","volume":"19","author":"ZQ Meng","year":"2004","unstructured":"Meng ZQ, Qin GH, Zhang B, Bai JL (2004) DNA damaging effects of sulfur dioxide derivatives in cells from various organs of mice. Mutagenesis 19:465\u2013468","journal-title":"Mutagenesis"},{"issue":"7","key":"7169_CR23","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nmeth.1226","volume":"5","author":"A Mortazavi","year":"2008","unstructured":"Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B (2008) Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 5(7):621\u2013628","journal-title":"Nat Methods"},{"key":"7169_CR24","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1099\/mic.0.036723-0","volume":"156","author":"T Nardi","year":"2010","unstructured":"Nardi T, Corich V, Giacomini A, Blondin B (2010) A sulphite inducible form of the sulphite efflux gene SSU1 in a Saccharomyces cerevisiae wine yeast. Microbiology 156:1686\u20131696","journal-title":"Microbiology"},{"key":"7169_CR25","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1289\/ehp.8564209","volume":"64","author":"P Neta","year":"1985","unstructured":"Neta P, Huie RE (1985) Free-radical chemistry of sulfite. Environ Health Perspect 64:209\u2013217","journal-title":"Environ Health Perspect"},{"issue":"38","key":"7169_CR26","doi-asserted-by":"crossref","first-page":"16333","DOI":"10.1073\/pnas.0904673106","volume":"106","author":"M Novo","year":"2009","unstructured":"Novo M, Bigey F, Beyne E, Galeote V, Gavory F, Mallet S, Cambon B, Legras J, Wincker P, Casaregola S, Dequin S (2009) Eukaryote-to-eukaryote gene transfer events revealed by the genome sequence of the wine yeast Saccharomyces cerevisiae EC1118. Proc Natl Acad Sci U S A 106(38):16333\u201316338","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7169_CR27","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/1097-0061(200007)16:10<881::AID-YEA576>3.0.CO;2-3","volume":"16","author":"H Park","year":"2000","unstructured":"Park H, Bakalinsky AT (2000) SSU1 mediates sulphite efflux in Saccharomyces cerevisiae. Yeast 16:881\u2013888","journal-title":"Yeast"},{"key":"7169_CR28","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s12275-008-0053-y","volume":"46","author":"H Park","year":"2008","unstructured":"Park H, Hwang YS (2008) Genome-wide transcriptional responses to sulfite in Saccharomyces cerevisiae. J Microbiol 46:542\u2013548","journal-title":"J Microbiol"},{"key":"7169_CR29","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1101\/gr.436602","volume":"12","author":"JE Perez-Ortin","year":"2002","unstructured":"Perez-Ortin JE, Querol A, Puig S, Barrio E (2002) Molecular characterization of a chromosomal rearrangement involved in the adaptive evolution of yeast strains. Genome Res 12:1533\u20131539","journal-title":"Genome Res"},{"key":"7169_CR30","first-page":"2823","volume":"134","author":"BJ Pilkington","year":"1988","unstructured":"Pilkington BJ, Rose AH (1988) Reaction of Saccharomyces cerevisiae and Zygosaccharomyces bailii to sulfite. J Gen Microbiol 134:2823\u20132830","journal-title":"J Gen Microbiol"},{"key":"7169_CR31","volume-title":"Handbook of enology. Vol. 1. The microbiology of wine and vinifications","author":"P Ribereau-Gayon","year":"2006","unstructured":"Ribereau-Gayon P, Dubourdieu D, Doneche B, Lonvaud A (2006) Handbook of enology. Vol. 1. The microbiology of wine and vinifications, 2nd edn. John Wiley and Sons, New York, NY","edition":"2nd"},{"key":"7169_CR32","first-page":"373","volume-title":"Wine microbiology and biotechnology","author":"P Romano","year":"1993","unstructured":"Romano P, Suzzi G (1993) Sulphur dioxide and wine microorganisms. In: Fleet GH (ed) Wine microbiology and biotechnology. Harwood Academic Publishers, Chur, pp. 373\u2013393"},{"key":"7169_CR33","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1002\/yea.1046","volume":"20","author":"T Rossignol","year":"2003","unstructured":"Rossignol T, Dulau L, Julien A, Blondin B (2003) Genome-wide monitoring of wine yeast gene expression during alcoholic fermentation. Yeast 20:1369\u20131385","journal-title":"Yeast"},{"key":"7169_CR34","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0076-6879(06)11009-5","volume":"411","author":"AI Saeed","year":"2006","unstructured":"Saeed AI, Bhagabati NK, Braisted JC, Liang W, Sharov V, Howe EA, Li J, Thiagarajan M, White JA, Quackenbush J (2006) TM4 microarray software suite. Methods Enzymol 411:134\u2013193","journal-title":"Methods Enzymol"},{"issue":"10","key":"7169_CR35","doi-asserted-by":"crossref","first-page":"e77600","DOI":"10.1371\/journal.pone.0077600","volume":"8","author":"M Salma","year":"2013","unstructured":"Salma M, Rousseaux S, Sequeira-Le Grand A, Divol B, Alexandre H (2013) Characterization of the viable but nonculturable (VBNC) state in Saccharomyces cerevisiae. PLoS One 8(10):e77600. doi: 10.1371\/journal.pone.0077600","journal-title":"PLoS One"},{"key":"7169_CR36","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1186\/1471-2164-15-1045","volume":"15","author":"A Sardu","year":"2014","unstructured":"Sardu A, Treu L, Campanaro S (2014) Transcriptome structure variability in Saccharomyces cerevisiae strains determined with a newly developed assembly software. BMC Genomics 15:1045","journal-title":"BMC Genomics"},{"key":"7169_CR37","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF00403203","volume":"125","author":"K-L Schimz","year":"1980","unstructured":"Schimz K-L (1980) The effect of sulfite on the yeast Saccharomyces cerevisiae. Arch Microbiol 125:89\u201395","journal-title":"Arch Microbiol"},{"key":"7169_CR38","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF00425059","volume":"121","author":"K-L Schimz","year":"1979","unstructured":"Schimz K-L, Holzer H (1979) Rapid decrease of ATP content in intact cells of Saccharomyces cerevisiae after incubation with low concentrations of sulfite. Arch Microbiol 121:225\u2013229","journal-title":"Arch Microbiol"},{"key":"7169_CR39","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1755-0238.2005.tb00285.x","volume":"11","author":"JH Swiegers","year":"2005","unstructured":"Swiegers JH, Bartowsky EJ, Henschke PA, Pretorius IS (2005) Yeast and bacterial modulation of wine aroma and flavour. Australian J Grape Wine Res 11:139\u2013173","journal-title":"Australian J Grape Wine Res"},{"key":"7169_CR40","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1128\/.61.4.503-532.1997","volume":"61","author":"D Thomas","year":"1997","unstructured":"Thomas D, Surdin-Kerjan Y (1997) Metabolism of sulfur amino acids in Saccharomyces cerevisiae. Microbiol Mol Biol Rev 61:503\u2013532","journal-title":"Microbiol Mol Biol Rev"},{"key":"7169_CR41","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1111\/1462-2920.12327","volume":"16","author":"L Treu","year":"2014","unstructured":"Treu L, Toniolo C, Nadai C, Sardu A, Giacomini A, Corich V, Campanaro S (2014a) A) the impact of genomic variability on gene expression in environmental Saccharomyces cerevisiae strains. Env Microbiol 16:1378\u20131397. doi: 10.1111\/1462-2920.12327","journal-title":"Env Microbiol"},{"issue":"9","key":"7169_CR42","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1007\/s00253-014-5679-6","volume":"98","author":"L Treu","year":"2014","unstructured":"Treu L, Campanaro S, Nadai C, Toniolo C, Nardi T, Giacomini A, Valle G, Blondin B, Corich V (2014b) b) oxidative stress response and nitrogen utilization are strongly variable in Saccharomyces cerevisiae wine strains with different fermentation performances. Appl Microbiol Biotechnol 98(9):4119\u20134135. doi: 10.1007\/s00253-014-5679-6","journal-title":"Appl Microbiol Biotechnol"},{"issue":"11","key":"7169_CR43","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1128\/jb.177.11.3104-3110.1995","volume":"177","author":"JM Vaart van der","year":"1995","unstructured":"van der Vaart JM, Caro LH, Chapman JW, Klis FM, Verrips CT (1995) Identification of three mannoproteins in the cell wall of Saccharomyces cerevisiae. J Bacteriol 177(11):3104\u20133110","journal-title":"J Bacteriol"},{"issue":"1","key":"7169_CR44","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrg2484","volume":"10","author":"Z Wang","year":"2009","unstructured":"Wang Z, Gerstein M, Snyder M (2009) RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet 10(1):57\u201363","journal-title":"Nat Rev Genet"},{"key":"7169_CR45","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/BF00351667","volume":"25","author":"X Xu","year":"1994","unstructured":"Xu X, Wightman JD, Geller BL, Avram D, Bakalinsky AT (1994) Isolation and characterization of sulfite mutants of Saccharomyces cerevisiae. Curr Genet 25:488\u2013496","journal-title":"Curr Genet"},{"issue":"4","key":"7169_CR46","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/gb-2003-4-4-r28","volume":"4","author":"BR Zeeberg","year":"2003","unstructured":"Zeeberg BR, Feng W, Wang G, Wang MD, Fojo AT, Sunshine M, Narasimhan S, Kane DW, Reinhold WC, Lababidi S, Bussey KJ, Riss J, Barrett JC, Weinstein JN (2003) GoMiner: a resource for biological interpretation of genomic and proteomic data. Genome Biol 4(4):R28","journal-title":"Genome Biol"},{"issue":"1","key":"7169_CR47","doi-asserted-by":"crossref","first-page":"e78644","DOI":"10.1371\/journal.pone.0078644","volume":"9","author":"S Zhao","year":"2014","unstructured":"Zhao S, Fung-Leung WP, Bittner A, Ngo K, Liu X (2014) Comparison of RNA-seq and microarray in transcriptome profiling of activated T cells. PLoS ONE 9(1):e78644. doi: 10.1371\/journal.pone.0078644 eCollection 2014","journal-title":"PLoS ONE"},{"issue":"1","key":"7169_CR48","doi-asserted-by":"crossref","first-page":"e86298","DOI":"10.1371\/journal.pone.0086298","volume":"9","author":"A Zimmer","year":"2014","unstructured":"Zimmer A, Durand C, Loira N, Durrens P, Sherman DJ, Marullo P (2014) QTL dissection of lag phase in wine fermentation reveals a new translocation responsible for Saccharomyces cerevisiae adaptation to sulfite. PLoS ONE 9(1):e86298. doi: 10.1371\/journal.pone.0086298 eCollection 2014","journal-title":"PLoS ONE"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-015-7169-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00253-015-7169-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-015-7169-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:27:25Z","timestamp":1692145645000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00253-015-7169-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,28]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["7169"],"URL":"https:\/\/doi.org\/10.1007\/s00253-015-7169-x","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,28]]}}}