{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T01:36:45Z","timestamp":1781487405028,"version":"3.54.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T00:00:00Z","timestamp":1484092800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1007\/s00253-017-8098-7","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T09:11:19Z","timestamp":1484125879000},"page":"1351-1357","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A genetic method to enhance the accumulation of S-adenosylmethionine in yeast"],"prefix":"10.1007","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8673-8273","authenticated-orcid":false,"given":"Muneyoshi","family":"Kanai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Mizunuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruyuki","family":"Iefuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,11]]},"reference":[{"key":"8098_CR1","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1271\/bbb.80708","volume":"73","author":"A Ano","year":"2009","unstructured":"Ano A, Suehiro D, Cha-Aim K, Aritomi K, Phonimdaeng P, Nontaso N, Hoshida H, Mizunuma M, Miyakawa T, Akada R (2009) Combinatorial gene overexpression and recessive mutant gene introduction in sake yeast. Biosci Biotechnol Biochem 73:633\u2013640. doi: 10.1271\/bbb.80708","journal-title":"Biosci Biotechnol Biochem"},{"key":"8098_CR2","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1176\/ajp.145.9.1110","volume":"145","author":"KM Bell","year":"1988","unstructured":"Bell KM, Plon L, Bunney WE Jr, Potkin SG (1988) S-adenosylmethionine treatment of depression: a controlled clinical trial. Am J Psychiatry 145:1110\u20131114. doi: 10.1176\/ajp.145.9.1110","journal-title":"Am J Psychiatry"},{"key":"8098_CR3","first-page":"905","volume":"21","author":"JD Bradley","year":"1994","unstructured":"Bradley JD, Flusser D, Katz BP, Schumacher HR Jr, Brandt KD, Chambers MA, Zonay LJ (1994) A randomized, double blind, placebo controlled trial of intravenous loading with S-adenosylmethionine (SAM) followed by oral SAM therapy in patients with knee osteoarthritis. J Rheumatol 21:905\u2013911","journal-title":"J Rheumatol"},{"key":"8098_CR4","doi-asserted-by":"publisher","first-page":"e1004142","DOI":"10.1371\/journal.pgen.1004142","volume":"10","author":"JS Breunig","year":"2014","unstructured":"Breunig JS, Hackett SR, Rabinowitz JD, Kruglyak L (2014) Genetic basis of metabolome variation in yeast. PLoS Genet 10:e1004142. doi: 10.1371\/journal.pgen.1004142","journal-title":"PLoS Genet"},{"key":"8098_CR5","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1007\/s13213-011-0389-0","volume":"62","author":"X Cao","year":"2012","unstructured":"Cao X, Yang M, Xia Y, Dou J, Chen K, Wang H, Xi T, Zhou C (2012) Strain improvement for enhanced production of S-adenosyl-l-methionine in Saccharomyces cerevisiae based on ethionine-resistance and SAM synthetase activity. Ann Microbiol 62:1395\u20131402. doi: 10.1007\/s13213-011-0389-0","journal-title":"Ann Microbiol"},{"key":"8098_CR6","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s11274-016-2010-y","volume":"32","author":"H Chen","year":"2016","unstructured":"Chen H, Wang Z, Wang Z, Dou J, Zhou C (2016) Improving methionine and ATP availability by MET6 and SAM2 co-expression combined with sodium citrate feeding enhanced SAM accumulation in Saccharomyces cerevisiae. World J Microbiol Biotechnol 32:56. doi: 10.1007\/s11274-016-2010-y","journal-title":"World J Microbiol Biotechnol"},{"key":"8098_CR7","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S1096-7192(02)00003-3","volume":"75","author":"SA Christopher","year":"2002","unstructured":"Christopher SA, Melnyk S, James SJ, Kruger WD (2002) S-adenosylhomocysteine, but not homocysteine, is toxic to yeast lacking cystathionine beta-synthase. Mol Genet Metab 75:335\u2013343. doi: 10.1016\/S1096-7192(02)00003-3","journal-title":"Mol Genet Metab"},{"key":"8098_CR8","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/j.1538-7836.2005.01141.x","volume":"3","author":"M Den Heijer","year":"2005","unstructured":"Den Heijer M, Lewington S, Clarke R (2005) Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. J Thromb Haemost 3:292\u2013299. doi: 10.1111\/j.1538-7836.2005.01141.x","journal-title":"J Thromb Haemost"},{"key":"8098_CR9","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0165-1781(95)02656-H","volume":"56","author":"M Fava","year":"1995","unstructured":"Fava M, Giannelli A, Rapisarda V, Patralia A, Guaraldi GP (1995) Rapidity of onset of the antidepressant effect of parenteral S-adenosyl-l-methionine. Psychiatry Res 56:295\u2013297. doi: 10.1016\/0165-1781(95)02656-H","journal-title":"Psychiatry Res"},{"key":"8098_CR10","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/ijc.23031","volume":"122","author":"S Guruswamy","year":"2008","unstructured":"Guruswamy S, Swamy MV, Choi CI, Steele VE, Rao CV (2008) S-adenosyl l-methionine inhibits azoxymethane-induced colonic aberrant crypt foci in F344 rats and suppresses human colon cancer Caco-2 cell growth in 3D culture. Int J Cancer 122:25\u201330. doi: 10.1002\/ijc.23031","journal-title":"Int J Cancer"},{"key":"8098_CR11","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.jbiosc.2015.03.010","volume":"120","author":"K Hayakawa","year":"2015","unstructured":"Hayakawa K, Kajihata S, Matsuda F, Shimizu H (2015) 13C-metabolic flux analysis in S-adenosyl-l-methionine production by Saccharomyces cerevisiae. J Biosci Bioeng 120:532\u2013538. doi: 10.1016\/j.jbiosc.2015.03.010","journal-title":"J Biosci Bioeng"},{"key":"8098_CR12","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.jbiotec.2006.05.009","volume":"126","author":"J He","year":"2006","unstructured":"He J, Deng J, Zheng Y, Gu J (2006) A synergistic effect on the production of S-adenosyl-l-methionine in Pichia pastoris by knocking in of S-adenosyl-l-methionine synthase and knocking out of cystathionine-beta synthase. J Biotechnol 126:519\u2013527. doi: 10.1016\/j.jbiotec.2006.05.009","journal-title":"J Biotechnol"},{"key":"8098_CR13","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s13213-010-0039-y","volume":"60","author":"L Huang","year":"2010","unstructured":"Huang L, Wei PL, Zang R, Xu ZN, Cen PL (2010) High-throughput screening of high-yield colonies of Rhizopus oryzae for enhanced production of fumaric acid. Ann Microbiol 60:287\u2013292. doi: 10.1007\/s13213-010-0039-y","journal-title":"Ann Microbiol"},{"key":"8098_CR14","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1046\/j.1432-1033.2003.03418.x","volume":"270","author":"RN Hvorup","year":"2003","unstructured":"Hvorup RN, Winnen B, Chang AB, Jiang Y, Zhou XF, Saier MH Jr (2003) The multidrug\/oligosaccharidyl-lipid\/polysaccharide (MOP) exporter superfamily. Eur J Biochem 270:799\u2013813. doi: 10.1046\/j.1432-1033.2003.03418.x","journal-title":"Eur J Biochem"},{"key":"8098_CR15","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1271\/bbb.64.229","volume":"64","author":"T Inoue","year":"2000","unstructured":"Inoue T, Iefuji H, Fujii T, Soga H, Satoh K (2000) Cloning and characterization of a gene complementing the mutation of an ethanol-sensitive mutant of sake yeast. Biosci Biotechnol Biochem 64:229\u2013236. doi: 10.1271\/bbb.64.229","journal-title":"Biosci Biotechnol Biochem"},{"key":"8098_CR16","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1271\/bbb.60377","volume":"70","author":"H Izu","year":"2006","unstructured":"Izu H, Shobayashi M, Manabe Y, Goto K, Iefuji H (2006) S-Adenosylmethionine (SAM)-accumulating sake yeast suppresses acute alcohol-induced liver injury in mice. Biosci Biotechnol Biochem 70:2982\u20132989. doi: 10.1271\/bbb.60377","journal-title":"Biosci Biotechnol Biochem"},{"key":"8098_CR17","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1111\/j.1432-1033.2004.04009.x","volume":"271","author":"J J\u00e4nne","year":"2004","unstructured":"J\u00e4nne J, Alhonen L, Pietil\u00e4 M, Kein\u00e4nen TA (2004) Genetic approaches to the cellular functions of polyamines in mammals. Eur J Biochem 271:877\u2013894. doi: 10.1111\/j.1432-1033.2004.04009.x","journal-title":"Eur J Biochem"},{"key":"8098_CR18","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1007\/s00253-012-4261-3","volume":"97","author":"M Kanai","year":"2013","unstructured":"Kanai M, Masuda M, Takaoka Y, Ikeda H, Masaki K, Fujii T, Iefuji H (2013) Adenosine kinase-deficient mutant of Saccharomyces cerevisiae accumulates S-adenosylmethionine because of an enhanced methionine biosynthesis pathway. Appl Microbiol Biotechnol 97:1183\u20131190. doi: 10.1007\/s00253-012-4261-3","journal-title":"Appl Microbiol Biotechnol"},{"key":"8098_CR19","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jbiosc.2016.07.007","volume":"123","author":"M Kanai","year":"2017","unstructured":"Kanai M, Kawata T, Yoshida Y, Kita Y, Ogawa T, Mizunuma M, Watanabe D, Shimoi H, Mizuno A, Yamada O, Fujii T, Iefuji H (2017) Sake yeast YHR032W\/ERC1 haplotype contributes to high S-adenosylmethionine accumulation in sake yeast strains. J Biosci Bioeng 123:8\u201314. doi: 10.1016\/j.jbiosc.2016.07.007","journal-title":"J Biosci Bioeng"},{"key":"8098_CR20","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s11814-010-0100-3","volume":"27","author":"SW Lee","year":"2010","unstructured":"Lee SW, Park BS, Choi ES, Oh MK (2010) Overexpression of ethionine resistance gene for maximized production of S-adenosylmethionine in Saccharomyces cerevisiae sake kyokai No. 6. Korean J Chem Eng 27:587\u2013589. doi: 10.1007\/s11814-010-0100-3","journal-title":"Korean J Chem Eng"},{"key":"8098_CR21","doi-asserted-by":"crossref","first-page":"1183S","DOI":"10.1093\/ajcn\/76.5.1183S","volume":"76","author":"CS Lieber","year":"2002","unstructured":"Lieber CS (2002) S-adenosyl-l-methionine: its role in the treatment of liver disorders. Am J Clin Nutr 76:1183S\u20131187S","journal-title":"Am J Clin Nutr"},{"key":"8098_CR22","doi-asserted-by":"crossref","first-page":"1177S","DOI":"10.1093\/ajcn\/76.5.1177S","volume":"76","author":"ML Mart\u00ednez-Chantar","year":"2002","unstructured":"Mart\u00ednez-Chantar ML, Garc\u00eda-Trevijano ER, Latasa MU, P\u00e9rez-Mato I, S\u00e1nchez del Pino MM, Corrales FJ, Avila MA, Mato JM (2002) Importance of a deficiency in S-adenosyl-l-methionine synthesis in the pathogenesis of liver injury. Am J Clin Nutr 76:1177S\u20131182S","journal-title":"Am J Clin Nutr"},{"key":"8098_CR23","first-page":"111","volume":"56","author":"KS McCully","year":"1969","unstructured":"McCully KS (1969) Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol 56:111\u2013128","journal-title":"Am J Pathol"},{"key":"8098_CR24","doi-asserted-by":"crossref","first-page":"1158S","DOI":"10.1093\/ajcn\/76.5.1158S","volume":"76","author":"D Mischoulon","year":"2002","unstructured":"Mischoulon D, Fava M (2002) Role of S-adenosyl-l-methionine in the treatment of depression: a review of the evidence. Am J Clin Nutr 76:1158S\u20131161S","journal-title":"Am J Clin Nutr"},{"key":"8098_CR25","doi-asserted-by":"publisher","first-page":"6086","DOI":"10.1073\/pnas.0308314101","volume":"101","author":"M Mizunuma","year":"2004","unstructured":"Mizunuma M, Miyamura K, Hirata D, Yokoyama H, Miyakawa T (2004) Involvement of S-adenosylmethionine in G1 cell-cycle regulation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 101:6086\u20136091. doi: 10.1073\/pnas.0308314101","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8098_CR26","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/jsr.12336","volume":"25","author":"N Monoi","year":"2016","unstructured":"Monoi N, Matsuno A, Nagamori Y, Kimura E, Nakamura Y, Oka K, Sano T, Midorikawa T, Sugafuji T, Murakoshi M, Uchiyama A, Sugiyama K, Nishino H, Urade Y (2016) Japanese sake yeast supplementation improves the quality of sleep: a double-blind randomised controlled clinical trial. J Sleep Res 25:116\u2013123. doi: 10.1111\/jsr.12336","journal-title":"J Sleep Res"},{"key":"8098_CR27","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1046\/j.1471-4159.1996.67031328.x","volume":"67","author":"LD Morrison","year":"1996","unstructured":"Morrison LD, Smith DD, Kish SJ (1996) Brain S-adenosylmethionine levels are severely decreased in Alzheimer\u2019s disease. J Neurochem 67:1328\u20131331. doi: 10.1046\/j.1471-4159.1996.67031328.x","journal-title":"J Neurochem"},{"key":"8098_CR28","doi-asserted-by":"publisher","first-page":"8332","DOI":"10.1038\/ncomms9332","volume":"6","author":"F Obata","year":"2015","unstructured":"Obata F, Miura M (2015) Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan. Nat Commun 6:8332. doi: 10.1038\/ncomms9332","journal-title":"Nat Commun"},{"key":"8098_CR29","doi-asserted-by":"publisher","first-page":"11913","DOI":"10.1073\/pnas.1604047113","volume":"113","author":"T Ogawa","year":"2016","unstructured":"Ogawa T, Tsubakiyama R, Kanai M, Koyama T, Fujii T, Iefuji H, Soga T, Kume K, Miyakawa T, Hirata D, Mizunuma M (2016) Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK. Proc Natl Acad Sci 113:11913\u201311918. doi: 10.1073\/pnas.1604047113","journal-title":"Proc Natl Acad Sci"},{"key":"8098_CR30","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0741-8329(02)00232-X","volume":"27","author":"V Purohit","year":"2002","unstructured":"Purohit V, Russo D (2002) Role of S-adenosyl-l-methionine in the treatment of alcoholic liver disease: introduction and summary of the symposium. Alcohol 27:151\u2013154. doi: 10.1016\/S0741-8329(02)00232-X","journal-title":"Alcohol"},{"key":"8098_CR31","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/jlcr.2590030209","volume":"3","author":"F Schlenk","year":"1967","unstructured":"Schlenk F, Zydek CR (1967) The radiopurity of S-adenosylmethionine and S-adenosylethionine preparations. J Labelled Compounds 3:137\u2013143. doi: 10.1002\/jlcr.2590030209","journal-title":"J Labelled Compounds"},{"key":"8098_CR32","doi-asserted-by":"publisher","first-page":"6158","DOI":"10.1038\/ncomms7158","volume":"6","author":"M Schosserer","year":"2015","unstructured":"Schosserer M, Minois N, Angerer TB, Amring M, Dellago H, Harreither E, Calle-Perez A, Pircher A, Gerstl MP, Pfeifenberger S, Brandl C, Sonntagbauer M, Kriegner A, Linder A, Weinh\u00e4usel A, Mohr T, Steiger M, Mattanovich D, Rinnerthaler M, Karl T, Sharma S, Entian KD, Kos M, Breitenbach M, Wilson IB, Polacek N, Grillari-Voglauer R, Breitenbach-Koller L, Grillari J (2015) Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. Nat Commun 6:6158. doi: 10.1038\/ncomms7158","journal-title":"Nat Commun"},{"key":"8098_CR33","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1007\/BF00171953","volume":"42","author":"N Shiomi","year":"1995","unstructured":"Shiomi N, Fukuda H, Murata K, Kimura A (1995) Improvement of S-adenosylmethionine production by integration of the ethionine-resistance gene into chromosomes of the yeast Saccharomyces cerevisiae. Appl Microbiol Biotechnol 42:730\u2013733. doi: 10.1007\/BF00171953","journal-title":"Appl Microbiol Biotechnol"},{"key":"8098_CR34","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1271\/bbb1961.48.2293","volume":"48","author":"S Shiozaki","year":"1984","unstructured":"Shiozaki S, Shimizu S, Yamada H (1984) Unusual intracellular accumulation of S-adenosyl-l-methionine by microorganisms. Agric Biol Chem 48:2293\u20132300. doi: 10.1271\/bbb1961.48.2293","journal-title":"Agric Biol Chem"},{"key":"8098_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-244X-4-38","volume":"4","author":"RA Shippy","year":"2004","unstructured":"Shippy RA, Mendez D, Jones K, Cergnul I, Karpiak SE (2004) S-adenosylmethionine (SAM-e) for the treatment of depression in people living with HIV\/AIDS. BMC Psychiatry 4:1\u20136. doi: 10.1186\/1471-244X-4-38","journal-title":"BMC Psychiatry"},{"key":"8098_CR36","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1007\/s00253-005-0009-7","volume":"69","author":"M Shobayashi","year":"2006","unstructured":"Shobayashi M, Mukai N, Iwashita K, Hiraga Y, Iefuji H (2006) A new method for isolation of S-adenosylmethionine (SAM)-accumulating yeast. Appl Microbiol Biotechnol 69:704\u2013710. doi: 10.1007\/s00253-005-0009-7","journal-title":"Appl Microbiol Biotechnol"},{"key":"8098_CR37","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0960-8524(01)00221-8","volume":"83","author":"M Sridhar","year":"2002","unstructured":"Sridhar M, KiranSree N, Venkateswa RL (2002) Effect of UV radiation on thermotolerance, ethanol tolerance and osmotolerance of Saccharomyces cerevisiae VS1 and VS3 strains. Bioresour Technol 83:199\u2013202. doi: 10.1016\/S0960-8524(01)00221-8","journal-title":"Bioresour Technol"},{"key":"8098_CR38","doi-asserted-by":"publisher","first-page":"5132","DOI":"10.1128\/MCB.8.12.5132","volume":"8","author":"D Thomas","year":"1988","unstructured":"Thomas D, Rothstein R, Rosenberg N, Surdin-Kerjan Y (1988) SAM2 encodes the second methionine S-adenosyl transferase in Saccharomyces cerevisiae. Mol Cell Biol 8:5132\u20135139. doi: 10.1128\/MCB.8.12.5132","journal-title":"Mol Cell Biol"},{"key":"8098_CR39","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1007\/s12010-015-1943-1","volume":"178","author":"W Zhao","year":"2016","unstructured":"Zhao W, Shi F, Hang B, Huang L, Cai J, Xu Z (2016) The improvement of SAM accumulation by integrating the endogenous methionine adenosyltransferase gene SAM2 in genome of the industrial Saccharomyces cerevisiae strain. Appl Biochem Biotechnol 178:1263\u20131272. doi: 10.1007\/s12010-015-1943-1","journal-title":"Appl Biochem Biotechnol"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-017-8098-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00253-017-8098-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-017-8098-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T07:41:31Z","timestamp":1568706091000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00253-017-8098-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,11]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["8098"],"URL":"https:\/\/doi.org\/10.1007\/s00253-017-8098-7","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,11]]}}}