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The animal experiments were designed in accordance with the \u201cGuidelines for Experimental Animal Welfare and Ethical Treatment\u201d of the Ministry of Science and Technology of the People\u2019s Republic of China. Animal usage for the study was approved by the Committee on the Ethical Use of Animals of Xiamen University. The experiments were performed based on the Laboratory Animal Center guidelines for the use of laboratory animals at Xiamen University. All efforts were made to ensure that animal suffering was minimized.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}