{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:58:37Z","timestamp":1792673917186,"version":"4.5.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s00253-017-8670-1","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T11:45:15Z","timestamp":1512387915000},"page":"1045-1054","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Molecular design for recombinant adeno-associated virus (rAAV) vector production"],"prefix":"10.1007","volume":"102","author":[{"given":"Juan Jose","family":"Aponte-Ubillus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Barajas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Peltier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Bardliving","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parviz","family":"Shamlou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"issue":"9","key":"8670_CR1","doi-asserted-by":"crossref","first-page":"6816","DOI":"10.1128\/JVI.71.9.6816-6822.1997","volume":"71","author":"JM Allen","year":"1997","unstructured":"Allen JM, Debelak DJ, Reynolds TC, Miller AD (1997) Identification and elimination of replication-competent adeno-associated virus (AAV) that can arise by nonhomologous recombination during AAV vector production. J Virol 71(9):6816\u20136822","journal-title":"J Virol"},{"issue":"1","key":"8670_CR2","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1006\/mthe.1999.0010","volume":"1","author":"JM Allen","year":"2000","unstructured":"Allen JM, Halbert CL, Miller AD (2000) Improved adeno-associated virus vector production with transfection of a single helper adenovirus gene, E4orf6. Mol Ther 1(1):88\u201395. https:\/\/doi.org\/10.1006\/mthe.1999.0010","journal-title":"Mol Ther"},{"key":"8670_CR3","doi-asserted-by":"publisher","unstructured":"Aslanidi G, Lamb K, Zolotukhin S (2009) An inducible system for highly efficient production of recombinant adeno-associated virus (rAAV) vectors in insect Sf9 cells. Proc Natl Acad Sci U S A 106(13):5059\u20135064. https:\/\/doi.org\/10.1073\/pnas.0810614106","DOI":"10.1073\/pnas.0810614106"},{"issue":"6","key":"8670_CR4","doi-asserted-by":"publisher","first-page":"423","DOI":"10.2174\/156652310793797685","volume":"10","author":"E Ayuso","year":"2010","unstructured":"Ayuso E, Mingozzi F, Bosch F (2010) Production, purification and characterization of adeno-associated vectors. Curr Gene Ther 10(6):423\u2013436. https:\/\/doi.org\/10.2174\/156652310793797685","journal-title":"Curr Gene Ther"},{"issue":"1","key":"8670_CR5","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/1475-2859-11-124","volume":"11","author":"A Backovic","year":"2012","unstructured":"Backovic A, Cervelli T, Salvetti A, Zentilin L, Giacca M, Galli A (2012) Capsid protein expression and adeno-associated virus like particles assembly in Saccharomyces cerevisiae. Microb Cell Factories 11(1):124. https:\/\/doi.org\/10.1186\/1475-2859-11-124","journal-title":"Microb Cell Factories"},{"issue":"3","key":"8670_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173010","volume":"12","author":"D Barajas","year":"2017","unstructured":"Barajas D, Aponte-Ubillus JJ, Akeefe H, Cinek T, Peltier J, Gold D (2017) Generation of infectious recombinant Adeno-associated virus in Saccharomyces cerevisiae. PLoS One 12(3):e0173010. https:\/\/doi.org\/10.1371\/journal.pone.0173010","journal-title":"PLoS One"},{"issue":"3","key":"8670_CR7","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/jphp.12353","volume":"67","author":"RM Bill","year":"2015","unstructured":"Bill RM (2015) Recombinant protein subunit vaccine synthesis in microbes: a role for yeast? J Pharm Pharmacol 67(3):319\u2013328. https:\/\/doi.org\/10.1111\/jphp.12353","journal-title":"J Pharm Pharmacol"},{"issue":"10","key":"8670_CR8","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/sj.gt.3302226","volume":"11","author":"MJ Booth","year":"2004","unstructured":"Booth MJ, Mistry A, Li X, Thrasher A, Coffin RS (2004) Transfection-free and scalable recombinant AAV vector production using HSV\/AAV hybrids. Gene Ther 11(10):829\u2013837. https:\/\/doi.org\/10.1038\/sj.gt.3302226","journal-title":"Gene Ther"},{"issue":"2","key":"8670_CR9","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1089\/humc.2013.087","volume":"24","author":"LM Bryant","year":"2013","unstructured":"Bryant LM, Christopher DM, Giles AR, Hinderer C, Rodriguez JL, Smith JB, Traxler EA, Tycko J, Wojno AP, Wilson JM (2013) Lessons learned from the clinical development and market authorization of Glybera. Hum Gene Ther Clin Dev 24(2):55\u201364. https:\/\/doi.org\/10.1089\/humc.2013.087","journal-title":"Hum Gene Ther Clin Dev"},{"issue":"5","key":"8670_CR10","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1089\/hum.2005.16.541","volume":"16","author":"BJ Carter","year":"2005","unstructured":"Carter BJ (2005) Adeno-associated virus vectors in clinical trials. Hum Gene Ther 16(5):541\u2013550. https:\/\/doi.org\/10.1089\/hum.2005.16.541","journal-title":"Hum Gene Ther"},{"issue":"11","key":"8670_CR11","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/gt.2008.61","volume":"15","author":"S Cecchini","year":"2008","unstructured":"Cecchini S, Negrete A, Kotin RM (2008) Toward exascale production of recombinant adeno-associated virus for gene transfer applications. Gene Ther 15(11):823\u2013830. https:\/\/doi.org\/10.1038\/gt.2008.61","journal-title":"Gene Ther"},{"issue":"8","key":"8670_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023474","volume":"6","author":"T Cervelli","year":"2011","unstructured":"Cervelli T, Backovic A, Galli A (2011) Formation of AAV single stranded DNA genome from a circular plasmid in Saccharomyces cerevisiae. PLoS One 6(8):e23474. https:\/\/doi.org\/10.1371\/journal.pone.0023474","journal-title":"PLoS One"},{"issue":"4","key":"8670_CR13","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1002\/1521-2254(200007\/08)2:4<260::AID-JGM111>3.0.CO;2-8","volume":"2","author":"G Chadeuf","year":"2000","unstructured":"Chadeuf G, Favre D, Tessier J, Provost N, Nony P, Kleinschmidt J, Moullier P, Salvetti A (2000) Efficient recombinant adeno-associated virus production by a stable rep-cap HeLa cell line correlates with adenovirus-induced amplification of the integrated rep-cap genome. J Gene Med 2(4):260\u2013268. https:\/\/doi.org\/10.1002\/1521-2254(200007\/08)2:4<260::AID-JGM111>3.0.CO;2-8","journal-title":"J Gene Med"},{"issue":"5","key":"8670_CR14","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1038\/mt.2008.35","volume":"16","author":"H Chen","year":"2008","unstructured":"Chen H (2008) Intron splicing\u2013mediated expression of AAV Rep and Cap genes and production of AAV vectors in insect cells. Mol Ther 16(5):924\u2013930. https:\/\/doi.org\/10.1038\/mt.2008.35","journal-title":"Mol Ther"},{"issue":"1","key":"8670_CR15","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1046\/j.1523-1755.2002.0610s1009.x","volume":"61","author":"KR Clark","year":"2002","unstructured":"Clark KR (2002) Recent advances in recombinant adeno-associated virus vector production. Kidney Int 61(1):S9\u201315. https:\/\/doi.org\/10.1046\/j.1523-1755.2002.0610s1009.x","journal-title":"Kidney Int"},{"issue":"10","key":"8670_CR16","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1089\/hum.1995.6.10-1329","volume":"6","author":"KR Clark","year":"1995","unstructured":"Clark KR, Voulgaropoulou F, Fraley DM, Johnson PR (1995) Cell lines for the production of recombinant adeno-associated virus. Hum Gene Ther 6(10):1329\u20131341. https:\/\/doi.org\/10.1089\/hum.1995.6.10-1329","journal-title":"Hum Gene Ther"},{"key":"8670_CR17","doi-asserted-by":"publisher","first-page":"16002","DOI":"10.1038\/mtm.2016.2","volume":"3","author":"N Cl\u00e9ment","year":"2016","unstructured":"Cl\u00e9ment N, Grieger JC (2016) Manufacturing of recombinant adeno-associated viral vectors for clinical trials. Mol Ther Methods Clin Dev 3:16002. https:\/\/doi.org\/10.1038\/mtm.2016.2","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"8","key":"8670_CR18","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1089\/hum.2009.094","volume":"20","author":"N Cl\u00e9ment","year":"2009","unstructured":"Cl\u00e9ment N, Knop DR, Byrne BJ (2009) Large-scale adeno-associated viral vector production using a herpesvirus-based system enables manufacturing for clinical studies. Hum Gene Ther 20(8):796\u2013806. https:\/\/doi.org\/10.1089\/hum.2009.094","journal-title":"Hum Gene Ther"},{"issue":"2","key":"8670_CR19","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0378-1119(99)00347-9","volume":"238","author":"RF Collaco","year":"1999","unstructured":"Collaco RF, Cao X, Trempe JP (1999) A helper virus-free packaging system for recombinant adeno-associated virus vectors. Gene 238(2):397\u2013405. https:\/\/doi.org\/10.1016\/S0378-1119(99)00347-9","journal-title":"Gene"},{"issue":"11","key":"8670_CR20","doi-asserted-by":"crossref","first-page":"8780","DOI":"10.1128\/JVI.71.11.8780-8789.1997","volume":"71","author":"JE Conway","year":"1997","unstructured":"Conway JE, Zolotukhin S, Muzyczka N, Hayward GS, Byrne BJ (1997) Recombinant adeno-associated virus type 2 replication and packaging is entirely supported by a herpes simplex virus type 1 amplicon expressing Rep and cap. J Virol 71(11):8780\u20138789","journal-title":"J Virol"},{"issue":"6","key":"8670_CR21","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1038\/sj.gt.3300937","volume":"6","author":"JE Conway","year":"1999","unstructured":"Conway JE, Rhys CM, Zolotukhin I, Zolotukhin S, Muzyczka N, Hayward GS, Byrne BJ (1999) High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap. Gene Ther 6(6):986\u2013993. https:\/\/doi.org\/10.1038\/sj.gt.3300937","journal-title":"Gene Ther"},{"issue":"13","key":"8670_CR22","doi-asserted-by":"publisher","first-page":"6609","DOI":"10.1093\/nar\/gkt404","volume":"41","author":"B Dong","year":"2013","unstructured":"Dong B, Moore AR, Dai J, Roberts S, Chu K, Kapranov P, Moss B, Xiao W (2013) A concept of eliminating nonhomologous recombination for scalable and safe AAV vector generation for human gene therapy. Nucleic Acids Res 41(13):6609\u20136617. https:\/\/doi.org\/10.1093\/nar\/gkt404","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"8670_CR23","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1002\/biot.201500176","volume":"11","author":"VV Emmerling","year":"2016","unstructured":"Emmerling VV, Pegel A, Milian EG, Venereo-Sanchez A, Kunz M, Wegele J, Kamen AA, Kochanek S, Hoerer M (2016) Rational plasmid design and bioprocess optimization to enhance recombinant adeno-associated virus (AAV) productivity in mammalian cells. Biotechnol J 11(2):290\u2013297. https:\/\/doi.org\/10.1002\/biot.201500176","journal-title":"Biotechnol J"},{"issue":"2","key":"8670_CR24","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1586\/erv.12.153","volume":"12","author":"F Fernandes","year":"2013","unstructured":"Fernandes F, Teixeira AP, Carinhas N, Carrondo MJ, Alves PM (2013) Insect cells as a production platform of complex virus-like particles. Expert Rev Vaccines 12(2):225\u2013236. https:\/\/doi.org\/10.1586\/erv.12.153","journal-title":"Expert Rev Vaccines"},{"issue":"16","key":"8670_CR25","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1089\/hum.1998.9.16-2353","volume":"9","author":"GP Gao","year":"1998","unstructured":"Gao GP, Qu G, Faust LZ, Engdahl RK, Xiao W, Hughes JV, Zoltick PW, Wilson JM (1998) High-titer adeno-associated viral vectors from a Rep\/Cap cell line and hybrid shuttle virus. Hum Gene Ther 9(16):2353\u20132362. https:\/\/doi.org\/10.1089\/hum.1998.9.16-2353","journal-title":"Hum Gene Ther"},{"issue":"5","key":"8670_CR26","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1006\/mthe.2001.0591","volume":"5","author":"G Gao","year":"2002","unstructured":"Gao G, Lu F, Sanmiguel JC, Tran PT, Abbas Z, Lynd KS, Marsh J, Spinner NB, Wilson JM (2002) Rep\/Cap gene amplification and high-yield production of AAV in an A549 cell line expressing Rep\/Cap. Mol Ther 5(5):644\u2013649. https:\/\/doi.org\/10.1006\/mthe.2001.0591","journal-title":"Mol Ther"},{"key":"8670_CR27","unstructured":"Gene Therapy Clinical Trials Worldwide (2017). Wiley online library. http:\/\/www.abedia.com\/wiley\/ . Accessed Sep 2017"},{"issue":"18","key":"8670_CR28","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1089\/hum.1998.9.18-2745","volume":"9","author":"D Grimm","year":"1998","unstructured":"Grimm D, Kern A, Rittner K, Kleinschmidt JA (1998) Novel tools for production and purification of recombinant adeno associated virus vectors. Hum Gene Ther 9(18):2745\u20132760. https:\/\/doi.org\/10.1089\/hum.1998.9.18-2745","journal-title":"Hum Gene Ther"},{"issue":"1","key":"8670_CR29","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/mt.2008.227","volume":"17","author":"B Hauck","year":"2009","unstructured":"Hauck B, Murphy SL, Smith PH, Qu G, Liu X, Zelenaia O, Mingozzi F, Sommer JM, High KA, Wright JF (2009) Undetectable transcription of cap in a clinical AAV vector: implications for preformed capsid in immune responses. Mol Ther 17(1):144\u2013152. https:\/\/doi.org\/10.1038\/mt.2008.227","journal-title":"Mol Ther"},{"issue":"20","key":"8670_CR30","doi-asserted-by":"publisher","first-page":"6466","DOI":"10.1073\/pnas.81.20.6466","volume":"81","author":"PL Hermonat","year":"1984","unstructured":"Hermonat PL, Muzyczka N (1984) Use of adeno-associated virus as a mammalian DNA cloning vector: transduction of neomycin resistance into mammalian tissue culture cells. Proc Natl Acad Sci U S A 81(20):6466\u20136470. https:\/\/doi.org\/10.1073\/pnas.81.20.6466","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"8670_CR31","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jviromet.2013.06.008","volume":"193","author":"X Huang","year":"2013","unstructured":"Huang X, Hartley A-V, Yin Y, Herskowitz JH, Lah JJ, Ressler KJ (2013) AAV2 production with optimized N\/P ratio and PEI-mediated transfection results in low toxicity and high titer for in vitro and in vivo applications. J Virol Methods 193(2):270\u2013277. https:\/\/doi.org\/10.1016\/j.jviromet.2013.06.008","journal-title":"J Virol Methods"},{"issue":"5","key":"8670_CR32","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1016\/S1525-0016(16)40477-6","volume":"7","author":"K Hwang","year":"2003","unstructured":"Hwang K, Mandell T, Kintner H, Zolotukhin S, Snyder RO, Byrne BJ (2003) High titer recombinant adeno-associated virus production using replication deficient herpes simplex viruses type I. Mol Ther 7(5):S14\u2013S15. https:\/\/doi.org\/10.1016\/S1525-0016(16)40477-6","journal-title":"Mol Ther"},{"key":"8670_CR33","doi-asserted-by":"publisher","unstructured":"Kang W, Wang L, Harrell H, Liu J, Thomas DL, Mayfield TL, Scotti MM, Ye GJ, Veres G, Knop DR (2009) An efficient rHSV-based complementation system for the production of multiple rAAV vector serotypes. Gene Ther 16(2):229\u2013239. https:\/\/doi.org\/10.1038\/gt.2008.158","DOI":"10.1038\/gt.2008.158"},{"issue":"2","key":"8670_CR34","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/lam.12695","volume":"64","author":"HJ Kim","year":"2016","unstructured":"Kim HJ, Kim H-J (2016) Yeast as an expression system for producing virus-like particles: what factors do we need to consider? Lett Appl Microbiol 64(2):111\u2013123. https:\/\/doi.org\/10.1111\/lam.12695","journal-title":"Lett Appl Microbiol"},{"key":"8670_CR35","doi-asserted-by":"publisher","first-page":"S227","DOI":"10.1016\/S1525-0016(16)37166-0","volume":"19","author":"DR Knop","year":"2011","unstructured":"Knop DR, Thomas DL, Butts C (2011) SFM rHSV-based production of rAAV vectors in suspension BHK cells. Mol Ther 19:S227. https:\/\/doi.org\/10.1016\/S1525-0016(16)37166-0","journal-title":"Mol Ther"},{"issue":"R1","key":"8670_CR36","doi-asserted-by":"publisher","first-page":"R2","DOI":"10.1093\/hmg\/ddr141","volume":"20","author":"RM Kotin","year":"2011","unstructured":"Kotin RM (2011) Large-scale recombinant adeno-associated virus production. Hu Mol Genet 20(R1):R2\u2013R6. https:\/\/doi.org\/10.1093\/hmg\/ddr141","journal-title":"Hu Mol Genet"},{"issue":"7","key":"8670_CR37","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nrg3742","volume":"15","author":"MA Kotterman","year":"2014","unstructured":"Kotterman MA, Schaffer DV (2014) Engineering adeno-associated viruses for clinical gene therapy. Nat Rev Genet 15(7):445\u2013451. https:\/\/doi.org\/10.1038\/nrg3742","journal-title":"Nat Rev Genet"},{"issue":"1","key":"8670_CR38","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.virol.2005.02.008","volume":"335","author":"C Li","year":"2005","unstructured":"Li C, Samulski RJ (2005) Serotype-specific replicating AAV helper constructs increase recombinant AAV type 2 vector production. Virology 335(1):10\u201321. https:\/\/doi.org\/10.1016\/j.virol.2005.02.008","journal-title":"Virology"},{"key":"8670_CR39","doi-asserted-by":"publisher","unstructured":"Ling C, Wang Y, Lu Y, Wang L, Jayandharan GR, Aslanidi GV, Li B, Cheng B, Ma W, Lentz T, Ling C, Xiao X, Samulski RJ, Muzyczka N, Srivastava A (2015) The adeno-associated virus genome packaging puzzle. J Mol Genet Med 09(03). https:\/\/doi.org\/10.4172\/1747-0862.1000175","DOI":"10.4172\/1747-0862.1000175"},{"issue":"R1","key":"8670_CR40","doi-asserted-by":"publisher","first-page":"R42","DOI":"10.1093\/hmg\/ddv451","volume":"25","author":"JCM Loo van der","year":"2016","unstructured":"van der Loo JCM, Wright JF (2016) Progress and challenges in viral vector manufacturing. Hum Mol Genet 25(R1):R42\u2013R52. https:\/\/doi.org\/10.1093\/hmg\/ddv451","journal-title":"Hum Mol Genet"},{"issue":"7","key":"8670_CR41","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1038\/sj.gt.3300680","volume":"5","author":"T Matsushita","year":"1998","unstructured":"Matsushita T, Elliger S, Elliger C, Podsakoff G, Villarreal L, Kurtzman GJ, Iwaki Y, Colosi P (1998) Adeno-associated virus vectors can be efficiently produced without helper virus. Gene Ther 5(7):938\u2013945. https:\/\/doi.org\/10.1038\/sj.gt.3300680","journal-title":"Gene Ther"},{"issue":"S1","key":"8670_CR42","doi-asserted-by":"publisher","first-page":"S51","DOI":"10.1038\/sj.gt.3302615","volume":"12","author":"O-W Merten","year":"2005","unstructured":"Merten O-W, G\u00e9ny-Fiamma C, Douar AM (2005) Current issues in adeno-associated viral vector production. Gene Ther 12(S1):S51\u2013S61. https:\/\/doi.org\/10.1038\/sj.gt.3302615","journal-title":"Gene Ther"},{"issue":"3","key":"8670_CR43","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1089\/hum.2013.184","volume":"25","author":"M Mietzsch","year":"2014","unstructured":"Mietzsch M, Grasse S, Zurawski C, Weger S, Bennett A, Agbandje-McKenna M, Muzyczka N, Zolotukhin S, Heilbronn R (2014) OneBac: platform for scalable and high-titer production of adeno-associated virus serotype 1-12 vectors for gene therapy. Hum Gene Ther 25(3):212\u2013222. https:\/\/doi.org\/10.1089\/hum.2013.184","journal-title":"Hum Gene Ther"},{"issue":"10","key":"8670_CR44","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1089\/hum.2015.050","volume":"26","author":"M Mietzsch","year":"2015","unstructured":"Mietzsch M, Casteleyn V, Weger S, Zolotukhin S, Heilbronn R (2015) OneBac 2.0: Sf9 cell lines for production of AAV5 vectors with enhanced infectivity and minimal encapsidation of foreign DNA. Hum Gene Ther 26(10):688\u2013697. https:\/\/doi.org\/10.1089\/hum.2015.050","journal-title":"Hum Gene Ther"},{"issue":"4","key":"8670_CR45","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/bfgp\/eln034","volume":"7","author":"A Negrete","year":"2008","unstructured":"Negrete A, Kotin RM (2008) Strategies for manufacturing recombinant adeno-associated virus vectors for gene therapy applications exploiting baculovirus technology. Brief Funct Genomic Proteomic 7(4):303\u2013311. https:\/\/doi.org\/10.1093\/bfgp\/eln034","journal-title":"Brief Funct Genomic Proteomic"},{"issue":"4","key":"8670_CR46","doi-asserted-by":"publisher","first-page":"207","DOI":"10.4161\/bioe.22856","volume":"4","author":"J Nielsen","year":"2013","unstructured":"Nielsen J (2013) Production of biopharmaceutical proteins by yeast. Bioengineered 4(4):207\u2013211. https:\/\/doi.org\/10.4161\/bioe.22856","journal-title":"Bioengineered"},{"issue":"1","key":"8670_CR47","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1099\/vir.0.067108-0","volume":"96","author":"MM Oers van","year":"2015","unstructured":"van Oers MM, Pijlman GP, Vlak JM (2015) Thirty years of baculovirus-insect cell protein expression: from dark horse to mainstream technology. J Gen Virol 96(1):6\u201323. https:\/\/doi.org\/10.1099\/vir.0.067108-0","journal-title":"J Gen Virol"},{"issue":"24","key":"8670_CR48","doi-asserted-by":"publisher","first-page":"13015","DOI":"10.1128\/JVI.76.24.13015-13027.2002","volume":"76","author":"C Qiao","year":"2002","unstructured":"Qiao C, Wang B, Zhu X, Li J, Xiao X (2002) A novel gene expression control system and its use in stable, high-titer 293 cell-based adeno-associated virus packaging cell lines. J Virol 76(24):13015\u201313027. https:\/\/doi.org\/10.1128\/JVI.76.24.13015-13027.2002","journal-title":"J Virol"},{"key":"8670_CR49","doi-asserted-by":"publisher","unstructured":"Reid CA, Boye SL, Hauswirth WW, Lipinski DM (2017) miRNA-mediated post-transcriptional silencing of transgenes leads to increased adeno-associated viral vector yield and targeting specificity. Gene Ther. doi: https:\/\/doi.org\/10.1038\/gt.2017.50","DOI":"10.1038\/gt.2017.50"},{"issue":"3","key":"8670_CR50","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201600193","volume":"12","author":"M-A Robert","year":"2017","unstructured":"Robert M-A, Chahal PS, Audy A, Kamen A, Gilbert R, Gaillet B (2017) Manufacturing of recombinant adeno-associated viruses using mammalian expression platforms. Biotechnol J 12(3):1600193. https:\/\/doi.org\/10.1002\/biot.201600193","journal-title":"Biotechnol J"},{"key":"8670_CR51","first-page":"131","volume-title":"The development of gene therapy","author":"RJ Samulski","year":"1999","unstructured":"Samulski RJ, Muzyczka N (1999) Adeno-associated viral vectors. In: Friedmann T (ed) The development of gene therapy. Cold Spring Harbor, New York, pp 131\u2013172"},{"issue":"1","key":"8670_CR52","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1146\/annurev-virology-031413-085355","volume":"1","author":"RJ Samulski","year":"2014","unstructured":"Samulski RJ, Muzyczka N (2014) AAV-mediated gene therapy for research and therapeutic purposes. Annu Rev Virol 1(1):427\u2013451. https:\/\/doi.org\/10.1146\/annurev-virology-031413-085355","journal-title":"Annu Rev Virol"},{"issue":"11","key":"8670_CR53","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1089\/hum.2014.041","volume":"25","author":"S Satkunanathan","year":"2014","unstructured":"Satkunanathan S, Wheeler J, Thorpe R, Zhao Y (2014) Establishment of a novel cell line for the enhanced production of recombinant adeno-associated virus vectors for gene therapy. Hum Gene Ther 25(11):929\u2013941. https:\/\/doi.org\/10.1089\/hum.2014.041","journal-title":"Hum Gene Ther"},{"issue":"20","key":"8670_CR54","doi-asserted-by":"publisher","first-page":"9441","DOI":"10.1128\/JVI.74.20.9441-9450.2000","volume":"74","author":"M Schmidt","year":"2000","unstructured":"Schmidt M, Afione S, Kotin RM (2000) Adeno-associated virus type 2 Rep78 induces apoptosis through Caspase activation independently of p53. J Virol 74(20):9441\u20139450. https:\/\/doi.org\/10.1128\/JVI.74.20.9441-9450.2000","journal-title":"J Virol"},{"issue":"11","key":"8670_CR55","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1038\/mt.2009.128","volume":"17","author":"RH Smith","year":"2009","unstructured":"Smith RH, Levy JR, Kotin RM (2009) A simplified baculovirus-AAV expression vector system coupled with one-step affinity purification yields high-titer rAAV stocks from insect cells. Mol Ther 17(11):1888\u20131896. https:\/\/doi.org\/10.1038\/mt.2009.128","journal-title":"Mol Ther"},{"key":"8670_CR56","unstructured":"Snyder RO (2011) Production of recombinant AAV virions. US patent 7,927,585 B2"},{"key":"8670_CR57","unstructured":"Thakur SS (2002) Production of recombinant adeno-associated viral vectors in yeast. Dissertation. University of Florida. http:\/\/ufdc.ufl.edu\/UFE0044702\/00001"},{"issue":"8","key":"8670_CR58","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1089\/hum.2009.004","volume":"20","author":"DL Thomas","year":"2009","unstructured":"Thomas DL, Wang L, Niamke J, Liu J, Kang W, Scotti MM, Ye G-J, Veres G, Knop DR (2009) Scalable recombinant adeno-associated virus production using recombinant herpes simplex virus type 1 coinfection of suspension-adapted mammalian cells. Hum Gene Ther 20(8):861\u2013870. https:\/\/doi.org\/10.1089\/hum.2009.004","journal-title":"Hum Gene Ther"},{"issue":"10","key":"8670_CR59","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1128\/MCB.4.10.2072","volume":"4","author":"JD Tratschin","year":"1984","unstructured":"Tratschin JD, West MH, Sandbank T, Carter BJ (1984) A human parvovirus, adeno-associated virus, as a eucaryotic vector: transient expression and encapsidation of the procaryotic gene for chloramphenicol acetyltransferase. Mol Cell Biol 4(10):2072\u20132081. https:\/\/doi.org\/10.1128\/MCB.4.10.2072","journal-title":"Mol Cell Biol"},{"issue":"11","key":"8670_CR60","doi-asserted-by":"publisher","first-page":"3251","DOI":"10.1128\/MCB.5.11.3251","volume":"5","author":"JD Tratschin","year":"1985","unstructured":"Tratschin JD, Miller IL, Smith MG, Carter BJ (1985) Adeno-associated virus vector for high-frequency integration, expression, and rescue of genes in mammalian cells. Mol Cell Biol 5(11):3251\u20133260. https:\/\/doi.org\/10.1128\/MCB.5.11.3251","journal-title":"Mol Cell Biol"},{"issue":"16","key":"8670_CR61","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1089\/10430340260355347","volume":"13","author":"M Urabe","year":"2002","unstructured":"Urabe M, Ding C, Kotin RM (2002) Insect cells as a factory to produce adeno-associated virus type 2 vectors. Hum Gene Ther 13(16):1935\u20131943. https:\/\/doi.org\/10.1089\/10430340260355347","journal-title":"Hum Gene Ther"},{"issue":"4","key":"8670_CR62","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1128\/JVI.80.4.1874-1885.2006","volume":"80","author":"M Urabe","year":"2006","unstructured":"Urabe M, Nakakura T, Xin K-Q, Obara Y, Mizukami H, Kume A, Kotin RM, Ozawa K (2006) Scalable generation of high-titer recombinant adeno-associated virus type 5 in insect cells. J Virol 80(4):1874\u20131885. https:\/\/doi.org\/10.1128\/JVI.80.4.1874-1885.2006","journal-title":"J Virol"},{"key":"8670_CR63","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/978-1-61779-370-7_16","volume":"807","author":"L Wang","year":"2011","unstructured":"Wang L, Blouin V, Brument N, Bello-Roufai M, Francois A (2011) Production and purification of recombinant adeno-associated vectors. Methods Mol Biol 807:361\u2013404. https:\/\/doi.org\/10.1007\/978-1-61779-370-7_16","journal-title":"Methods Mol Biol"},{"issue":"5","key":"8670_CR64","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1128\/JVI.65.5.2476-2483.1991","volume":"65","author":"FW Weindler","year":"1991","unstructured":"Weindler FW, Heilbronn R (1991) A subset of herpes simplex virus replication genes provides helper functions for productive adeno-associated virus replication. J Virol 65(5):2476\u20132483","journal-title":"J Virol"},{"key":"8670_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-61779-370-7_1","volume":"807","author":"MD Weitzman","year":"2011","unstructured":"Weitzman MD, Linden RM (2011) Adeno-associated virus biology. Methods Mol Biol 807:1\u201323. https:\/\/doi.org\/10.1007\/978-1-61779-370-7_1","journal-title":"Methods Mol Biol"},{"issue":"7","key":"8670_CR66","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1089\/hum.2009.064","volume":"20","author":"JF Wright","year":"2009","unstructured":"Wright JF (2009) Transient transfection methods for clinical adeno-associated viral vector production. Hum Gene Ther 20(7):698\u2013706. https:\/\/doi.org\/10.1089\/hum.2009.064","journal-title":"Hum Gene Ther"},{"issue":"1","key":"8670_CR67","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3390\/biomedicines2010080","volume":"2","author":"JF Wright","year":"2014","unstructured":"Wright JF (2014) Product-related impurities in clinical-grade recombinant AAV vectors: characterization and risk assessment. Biomedicine 2(1):80\u201397. https:\/\/doi.org\/10.3390\/biomedicines2010080","journal-title":"Biomedicine"},{"issue":"3","key":"8670_CR68","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1128\/JVI.72.3.2224-2232.1998","volume":"72","author":"X Xiao","year":"1998","unstructured":"Xiao X, Li J, Samulski RJ (1998) Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. J Virol 72(3):2224\u20132232","journal-title":"J Virol"},{"issue":"7","key":"8670_CR69","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.1128\/JVI.76.7.3359-3364.2002","volume":"76","author":"K-N Zhao","year":"2002","unstructured":"Zhao K-N, Frazer IH (2002a) Replication of bovine papillomavirus type 1 (BPV-1) DNA in Saccharomyces cerevisiae following infection with BPV-1 virions. J Virol 76(7):3359\u20133364. https:\/\/doi.org\/10.1128\/JVI.76.7.3359-3364.2002","journal-title":"J Virol"},{"issue":"23","key":"8670_CR70","doi-asserted-by":"publisher","first-page":"12265","DOI":"10.1128\/JVI.76.23.12265-12273.2002","volume":"76","author":"K-N Zhao","year":"2002","unstructured":"Zhao K-N, Frazer IH (2002b) Saccharomyces cerevisiae is permissive for replication of bovine papillomavirus type 1. J Virol 76(23):12265\u201312273. https:\/\/doi.org\/10.1128\/JVI.76.23.12265-12273.2002","journal-title":"J Virol"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00253-017-8670-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-017-8670-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-017-8670-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T17:28:33Z","timestamp":1603474113000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00253-017-8670-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,4]]},"references-count":70,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["8670"],"URL":"https:\/\/doi.org\/10.1007\/s00253-017-8670-1","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,4]]}}}