{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:06:10Z","timestamp":1793322370356,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"19","license":[{"start":{"date-parts":[[2018,7,21]],"date-time":"2018-07-21T00:00:00Z","timestamp":1532131200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 162\/490-1 FUGG"],"award-info":[{"award-number":["INST 162\/490-1 FUGG"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007636","name":"Deutsche Bundesstiftung Umwelt","doi-asserted-by":"publisher","award":["31812-01"],"award-info":[{"award-number":["31812-01"]}],"id":[{"id":"10.13039\/100007636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s00253-018-9231-y","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T22:59:23Z","timestamp":1532127563000},"page":"8573-8584","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Biotransformation of ciprofloxacin by Xylaria longipes: structure elucidation and residual antibacterial activity of metabolites"],"prefix":"10.1007","volume":"102","author":[{"given":"Marina","family":"Rusch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Spielmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Zorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5137-5510","authenticated-orcid":false,"given":"Gerd","family":"Hamscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,21]]},"reference":[{"key":"9231_CR1","doi-asserted-by":"publisher","first-page":"5790","DOI":"10.1128\/AEM.03032-05","volume":"72","author":"MD Adjei","year":"2006","unstructured":"Adjei MD, Heinze TM, Deck J, Freeman JP, Williams AJ, Sutherland JB (2006) Transformation of the antibacterial agent norfloxacin by environmental mycobacteria. Appl Environ Microbiol 72:5790\u20135793. https:\/\/doi.org\/10.1128\/AEM.03032-05","journal-title":"Appl Environ Microbiol"},{"key":"9231_CR2","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s002449900501","volume":"37","author":"A Al-Ahmad","year":"1999","unstructured":"Al-Ahmad A, Daschner FD, K\u00fcmmerer K (1999) Biodegradability of cefotiam, ciprofloxacin, meropenem, penicillin G, and sulfamethoxazole and inhibition of waste water bacteria. Arch Environ Contam Toxicol 37:158\u2013163. https:\/\/doi.org\/10.1007\/s002449900501","journal-title":"Arch Environ Contam Toxicol"},{"key":"9231_CR3","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1053\/rvsc.2001.0494","volume":"71","author":"A Anad\u00f3n","year":"2001","unstructured":"Anad\u00f3n A, Mart\u00ednez-Larra\u00f1aga MR, Iturbe J, Mart\u00ednez MA, D\u00edaz MJ, Frejo MT, Mart\u00ednez M (2001) Pharmacokinetics and residues of ciprofloxacin and its metabolites in broiler chickens. Res Vet Sci 71:101\u2013109. https:\/\/doi.org\/10.1053\/rvsc.2001.0494","journal-title":"Res Vet Sci"},{"key":"9231_CR4","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1365\/s10337-004-0277-x","volume":"59","author":"O Ballesteros","year":"2004","unstructured":"Ballesteros O, Sanz-Nebot V, Naval\u00f3n A, V\u00edlchez JL, Barbosa J (2004) Determination of a series of quinolone antibiotic using liquid chromatography-mass-spectrometry. Chromatographia 59:543\u2013550. https:\/\/doi.org\/10.1365\/s10337-004-0277-x","journal-title":"Chromatographia"},{"key":"9231_CR5","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1016\/j.chemosphere.2015.10.137","volume":"144","author":"H B\u00e1rt\u00edkov\u00e1","year":"2016","unstructured":"B\u00e1rt\u00edkov\u00e1 H, Podlipn\u00e1 R, Sk\u00e1lov\u00e1 L (2016) Veterinary drugs in the environment and their toxicity to plants. Chemosphere 144:2290\u20132301. https:\/\/doi.org\/10.1016\/j.chemosphere.2015.10.137","journal-title":"Chemosphere"},{"key":"9231_CR6","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1021\/jf053041t","volume":"54","author":"ABA Boxall","year":"2006","unstructured":"Boxall ABA, Johnson P, Smith EJ, Sinclair CJ, Stutt E, Levy LS (2006) Uptake of veterinary medicines from soil into plants. J Agric Food Chem 54:2288\u20132297. https:\/\/doi.org\/10.1021\/jf053041t","journal-title":"J Agric Food Chem"},{"key":"9231_CR7","unstructured":"BVL (2016) GERMAP 2015 \u2013 Antibiotika-Resistenz und -Verbrauch. https:\/\/www.bvl.bund.de\/SharedDocs\/Downloads\/05_Tierarzneimittel\/germap2015.pdf?__blob=publicationFile&v=3 . Accessed 20 Feb 2018"},{"key":"9231_CR8","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/sj.jim.2900409","volume":"19","author":"Y Chen","year":"1997","unstructured":"Chen Y, Rosazza JPN, Reese CP, Chang H-Y, Nowakowski MA, Kiplinger JP (1997) Microbial models of soil metabolism: biotransformations of danofloxacin. J Ind Microbiol Biotechnol 19:378\u2013384. https:\/\/doi.org\/10.1038\/sj.jim.2900409","journal-title":"J Ind Microbiol Biotechnol"},{"key":"9231_CR9","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00003-015-1008-y","volume":"11","author":"F Chowdhury","year":"2016","unstructured":"Chowdhury F, Langenk\u00e4mper G, Grote M (2016) Studies on uptake and distribution of antibiotics in red cabbage. J Verbrauch Lebensm 11:61\u201369. https:\/\/doi.org\/10.1007\/s00003-015-1008-y","journal-title":"J Verbrauch Lebensm"},{"key":"9231_CR10","doi-asserted-by":"publisher","first-page":"14128","DOI":"10.1021\/es403470s","volume":"47","author":"M \u010cvan\u010darov\u00e1","year":"2013","unstructured":"\u010cvan\u010darov\u00e1 M, Moeder M, Filipov\u00e1 A, Reemtsma T, Cajthaml T (2013) Biotransformation of the antibiotic agent flumequine by ligninolytic fungi and residual antibacterial activity of the transformation mixtures. Environ Sci Technol 47:14128\u201314136. https:\/\/doi.org\/10.1021\/es403470s","journal-title":"Environ Sci Technol"},{"key":"9231_CR11","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.chemosphere.2014.12.012","volume":"136","author":"M \u010cvan\u010darov\u00e1","year":"2015","unstructured":"\u010cvan\u010darov\u00e1 M, Moeder M, Filipov\u00e1 A, Cajthaml T (2015) Biotransformation of fluoroquinolone antibiotics by ligninolytic fungi - metabolites, enzymes and residual antibacterial activity. Chemosphere 136:311\u2013320. https:\/\/doi.org\/10.1016\/j.chemosphere.2014.12.012","journal-title":"Chemosphere"},{"key":"9231_CR12","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.chemosphere.2014.02.003","volume":"115","author":"M Dalla Bona","year":"2014","unstructured":"Dalla Bona M, Di Leva V, De Liguoro M (2014) The sensitivity of Daphnia magna and Daphnia curvirostris to 10 veterinary antibacterials and to some of their binary mixtures. Chemosphere 115:67\u201374. https:\/\/doi.org\/10.1016\/j.chemosphere.2014.02.003","journal-title":"Chemosphere"},{"key":"9231_CR13","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1590\/S1984-82502011000100004","volume":"50","author":"VMF Frade","year":"2014","unstructured":"Frade VMF, Dias M, Teixeira ACSC, Palma MSA (2014) Environmental contamination by fluoroquinolones. Braz J Pharm Sci 50:41\u201354. https:\/\/doi.org\/10.1590\/S1984-82502011000100004","journal-title":"Braz J Pharm Sci"},{"key":"9231_CR14","doi-asserted-by":"publisher","first-page":"3632","DOI":"10.1021\/ac0015265","volume":"73","author":"EM Golet","year":"2001","unstructured":"Golet EM, Alder AC, Hartmann A, Ternes TA, Giger W (2001) Trace determination of fluoroquinolone antibacterial agents in urban wastewater by solid-phase extraction and liquid chromatography with fluorescence detection. Anal Chem 73:3632\u20133638. https:\/\/doi.org\/10.1021\/ac0015265","journal-title":"Anal Chem"},{"key":"9231_CR15","doi-asserted-by":"publisher","first-page":"3243","DOI":"10.1021\/es0264448","volume":"37","author":"EM Golet","year":"2003","unstructured":"Golet EM, Xifra I, Siegrist H, Alder AC, Giger W (2003) Environmental exposure assessment of fluoroquinolone antibacterial agents from sewage to soil. Environ Sci Technol 37:3243\u20133249. https:\/\/doi.org\/10.1021\/es0264448","journal-title":"Environ Sci Technol"},{"key":"9231_CR16","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.vetmic.2007.03.017","volume":"124","author":"M Grobbel","year":"2007","unstructured":"Grobbel M, L\u00fcbke-Becker A, Wieler LH, Froyman R, Friederichs S, Filios S (2007) Comparative quantification of the in vitro activity of veterinary fluoroquinolones. Vet Microbiol 124:73\u201381. https:\/\/doi.org\/10.1016\/j.vetmic.2007.03.017","journal-title":"Vet Microbiol"},{"key":"9231_CR17","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s00003-009-0316-5","volume":"4","author":"M Grote","year":"2009","unstructured":"Grote M, Meri\u00e7 DH, Langenk\u00e4mper G, Hayen H, Betsche T, Freitag M (2009) Untersuchungen zum Transfer pharmakologisch wirksamer Substanzen aus der Nutztierhaltung in Poree und Wei\u00dfkohl. J Verbrauch Lebensm 4:287\u2013304. https:\/\/doi.org\/10.1007\/s00003-009-0316-5","journal-title":"J Verbrauch Lebensm"},{"key":"9231_CR18","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1002\/mrc.1260320313","volume":"32","author":"U Holzgrabe","year":"1994","unstructured":"Holzgrabe U, Branch SK (1994) 1H, 19F and 13C NMR spectral data of fifteen gyrase inhibitors and some metabolites. Magn Reson Chem 32:192\u2013196. https:\/\/doi.org\/10.1002\/mrc.1260320313","journal-title":"Magn Reson Chem"},{"key":"9231_CR19","doi-asserted-by":"publisher","first-page":"6","DOI":"10.2165\/00003495-199958002-00002","volume":"58","author":"DC Hooper","year":"1999","unstructured":"Hooper DC (1999) Mode of action of fluoroquinolones. Drugs 58:6\u201310. https:\/\/doi.org\/10.2165\/00003495-199958002-00002","journal-title":"Drugs"},{"key":"9231_CR20","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1046\/j.1365-3164.1999.00179.x","volume":"10","author":"PJ Ihrke","year":"1999","unstructured":"Ihrke PJ, Papich MG, DeManuelle TC (1999) The use of fluoroquinolones in veterinary dermatology. Vet Dermatol 10:193\u2013204. https:\/\/doi.org\/10.1046\/j.1365-3164.1999.00179.x","journal-title":"Vet Dermatol"},{"key":"9231_CR21","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.etap.2014.09.011","volume":"38","author":"F Janusch","year":"2014","unstructured":"Janusch F, Scherz G, Mohring SAI, Hamscher G (2014) Determination of fluoroquinolones in chicken feces\u2014a new liquid-liquid extraction method combined with LC-MS\/MS. Environ Toxicol Pharmacol 38:792\u2013799. https:\/\/doi.org\/10.1016\/j.etap.2014.09.011","journal-title":"Environ Toxicol Pharmacol"},{"key":"9231_CR22","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s00253-005-0177-5","volume":"71","author":"W Karl","year":"2006","unstructured":"Karl W, Schneider J, Wetzstein H-G (2006) Outlines of an \u201cexploding\u201d network of metabolites generated from the fluoroquinolone enrofloxacin by the brown rot fungus Gloeophyllum striatum. Appl Microbiol Biotechnol 71:101\u2013113. https:\/\/doi.org\/10.1007\/s00253-005-0177-5","journal-title":"Appl Microbiol Biotechnol"},{"key":"9231_CR23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1139\/v66-008","volume":"44","author":"RE Klinck","year":"1966","unstructured":"Klinck RE, Stothers JB (1966) Nuclear magnetic resonance studies IX. The chemical shift of the formyl proton in aliphatic aldehydes. Can J Chem 44:45\u201351. https:\/\/doi.org\/10.1139\/v66-008","journal-title":"Can J Chem"},{"key":"9231_CR24","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1007\/s11095-013-1250-x","volume":"31","author":"B Marquez","year":"2014","unstructured":"Marquez B, Pourcelle V, Vallet CM, Mingeot-Leclercq M-P, Tulkens PM, Marchand-Bruynaert J, Van Bambeke F (2014) Pharmacological characterization of 7-(4-(piperazin-1-yl)) ciprofloxacin derivatives: antibacterial activity, cellular accumulation, susceptibility to efflux transporters, and intracellular activity. Pharm Res 31:1290\u20131301. https:\/\/doi.org\/10.1007\/s11095-013-1250-x","journal-title":"Pharm Res"},{"key":"9231_CR25","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.envpol.2006.11.035","volume":"148","author":"E Mart\u00ednez-Carballo","year":"2007","unstructured":"Mart\u00ednez-Carballo E, Gonz\u00e1lez-Barreiro C, Scharf S, Gans O (2007) Environmental monitoring study of selected veterinary antibiotics in animal manure and soils in Austria. Environ Pollut 148:570\u2013579. https:\/\/doi.org\/10.1016\/j.envpol.2006.11.035","journal-title":"Environ Pollut"},{"key":"9231_CR26","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.watres.2009.12.032","volume":"44","author":"K McClellan","year":"2010","unstructured":"McClellan K, Halden RU (2010) Pharmaceuticals and personal care products in archived U.S. biosolids from the 2001 EPA national sewage sludge survey. Water Res 44:658\u2013668. https:\/\/doi.org\/10.1016\/j.watres.2009.12.032","journal-title":"Water Res"},{"key":"9231_CR27","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1016\/S0045-6535(03)00272-8","volume":"52","author":"L Migliore","year":"2003","unstructured":"Migliore L, Cozzolino S, Fiori M (2003) Phytotoxicity to and uptake of enrofloxacin in crop plants. Chemosphere 52:1233\u20131244. https:\/\/doi.org\/10.1016\/S0045-6535(03)00272-8","journal-title":"Chemosphere"},{"key":"9231_CR28","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.3389\/fmicb.2017.01792","volume":"8","author":"DR Olic\u00f3n-Hern\u00e1ndez","year":"2017","unstructured":"Olic\u00f3n-Hern\u00e1ndez DR, Gonz\u00e1lez-L\u00f3pez J, Aranda E (2017) Overview of the biochemical potential of filamentous fungi to degrade pharmaceutical compounds. Front Microbiol 8:1792. https:\/\/doi.org\/10.3389\/fmicb.2017.01792","journal-title":"Front Microbiol"},{"key":"9231_CR29","first-page":"983","volume-title":"Veterinary pharmacology and therapeutics","author":"MG Papich","year":"2009","unstructured":"Papich MG, Riviere JE (2009) Fluoroquinolone antimicrobial drugs. In: Riviere JE, Papich MG (eds) Veterinary pharmacology and therapeutics, 9th edn. Wiley-Blackwell, Iowa, pp 983\u20131012","edition":"9"},{"key":"9231_CR30","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/j.1574-6968.1999.tb13723.x","volume":"177","author":"IA Parshikov","year":"1999","unstructured":"Parshikov IA, Freeman JP, Lay JO, Beger RD, Williams AJ, Sutherland JB (1999) Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin by the fungus Mucor ramannianus. FEMS Microbiol Lett 177:131\u2013135. https:\/\/doi.org\/10.1111\/j.1574-6968.1999.tb13723.x","journal-title":"FEMS Microbiol Lett"},{"key":"9231_CR31","doi-asserted-by":"publisher","first-page":"2664","DOI":"10.1128\/AEM.66.6.2664-2667.2000","volume":"66","author":"IA Parshikov","year":"2000","unstructured":"Parshikov IA, Freeman JP, Lay JO, Beger RD, Williams AJ, Sutherland JB (2000) Microbiological transformation of enrofloxacin by the fungus Mucor ramannianus. Appl Environ Microbiol 66:2664\u20132667. https:\/\/doi.org\/10.1128\/AEM.66.6.2664-2667.2000","journal-title":"Appl Environ Microbiol"},{"key":"9231_CR32","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1038\/sj\/jim\/7000077","volume":"26","author":"IA Parshikov","year":"2001","unstructured":"Parshikov IA, Freeman JP, Lay JO, Moody JD, Williams AJ, Beger RD, Sutherland JB (2001a) Metabolism of the veterinary fluoroquinolone sarafloxacin by the fungus Mucor ramannianus. J Ind Microbiol Biotechnol 26:140\u2013144. https:\/\/doi.org\/10.1038\/sj\/jim\/7000077","journal-title":"J Ind Microbiol Biotechnol"},{"key":"9231_CR33","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s002530100672","volume":"56","author":"IA Parshikov","year":"2001","unstructured":"Parshikov IA, Heinze TM, Moody JD, Freeman JP, Williams AJ, Sutherland JB (2001b) The fungus Pestalotiopsis guepini as a model for biotransformation of ciprofloxacin and norfloxacin. Appl Microbiol Biotechnol 56:474\u2013477. https:\/\/doi.org\/10.1007\/s002530100672","journal-title":"Appl Microbiol Biotechnol"},{"key":"9231_CR34","doi-asserted-by":"publisher","first-page":"10987","DOI":"10.1016\/j.biortech.2011.08.055","volume":"102","author":"A Prieto","year":"2011","unstructured":"Prieto A, M\u00f6der M, Rodil R, Adrian L, Marco-Urrea E (2011) Degradation of the antibiotics norfloxacin and ciprofloxacin by a white-rot fungus and identification of degradation products. Bioresour Technol 102:10987\u201310995. https:\/\/doi.org\/10.1016\/j.biortech.2011.08.055","journal-title":"Bioresour Technol"},{"key":"9231_CR35","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/nm1347","volume":"12","author":"A Robicsek","year":"2006","unstructured":"Robicsek A, Strahilevitz J, Jacoby GA, Macielag M, Abbanat D, Park CH, Bush K, Hooper DC (2006) Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nat Med 12:83\u201388. https:\/\/doi.org\/10.1038\/nm1347","journal-title":"Nat Med"},{"key":"9231_CR36","doi-asserted-by":"publisher","first-page":"6897","DOI":"10.1021\/acs.jafc.5b02343","volume":"63","author":"M Rusch","year":"2015","unstructured":"Rusch M, Kauschat A, Spielmeyer A, R\u00f6mpp A, Hausmann H, Zorn H, Hamscher G (2015) Biotransformation of the antibiotic danofloxacin by Xylaria longipes leads to an efficient reduction of its antibacterial activity. J Agric Food Chem 63:6897\u20136904. https:\/\/doi.org\/10.1021\/acs.jafc.5b02343","journal-title":"J Agric Food Chem"},{"key":"9231_CR37","doi-asserted-by":"publisher","first-page":"3118","DOI":"10.1021\/acs.jafc.7b01246","volume":"65","author":"M Rusch","year":"2017","unstructured":"Rusch M, Spielmeyer A, Mei\u00dfner J, Kietzmann M, Zorn H, Hamscher G (2017) Efficient reduction of antibacterial activity and cytotoxicity of fluoroquinolones by fungal-mediated N-oxidation. J Agric Food Chem 65:3118\u20133126. https:\/\/doi.org\/10.1021\/acs.jafc.7b01246","journal-title":"J Agric Food Chem"},{"key":"9231_CR38","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1111\/jvp.12130","volume":"37","author":"M Slana","year":"2014","unstructured":"Slana M, Pahor V, Cvitkovi\u010d Mari\u010di\u010d L, Sollner-Dolenc M (2014) Excretion pattern of enrofloxacin after oral treatment of chicken broilers. J Vet Pharmacol Ther 37:611\u2013614. https:\/\/doi.org\/10.1111\/jvp.12130","journal-title":"J Vet Pharmacol Ther"},{"key":"9231_CR39","doi-asserted-by":"publisher","first-page":"S1119","DOI":"10.1093\/clinids\/11.Supplement_5.S1119","volume":"11","author":"F S\u00f6rgel","year":"1989","unstructured":"S\u00f6rgel F (1989) Metabolism of gyrase inhibitors. Rev Infect Dis 11:S1119\u2013S1129. https:\/\/doi.org\/10.1093\/clinids\/11.Supplement_5.S1119","journal-title":"Rev Infect Dis"},{"key":"9231_CR40","doi-asserted-by":"publisher","first-page":"4143","DOI":"10.1021\/ac970425c","volume":"69","author":"DA Vollmer","year":"1997","unstructured":"Vollmer DA, Mansoori B, Locke SJ (1997) Study of 4-quinolone antibiotics in biological samples by short-column liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Anal Chem 69:4143\u20134155. https:\/\/doi.org\/10.1021\/ac970425c","journal-title":"Anal Chem"},{"key":"9231_CR41","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1128\/AEM.63.11.4272-4281.1997","volume":"63","author":"H-G Wetzstein","year":"1997","unstructured":"Wetzstein H-G, Schmeer N, Karl W (1997) Degradation of the fluoroquinolone enrofloxacin by the brown rot fungus Gloeophyllum striatum: identification of metabolites. Appl Environ Microbiol 63:4272\u20134281","journal-title":"Appl Environ Microbiol"},{"key":"9231_CR42","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1128\/AEM.65.4.1556-1563.1999","volume":"65","author":"H-G Wetzstein","year":"1999","unstructured":"Wetzstein H-G, Stadler M, Tichy H-V, Dalhoff A, Karl W (1999) Degradation of ciprofloxacin by basidiomycetes and identification of metabolites generated by the brown rot fungus Gloeophyllum striatum. Appl Environ Microbiol 65:1556\u20131563","journal-title":"Appl Environ Microbiol"},{"key":"9231_CR43","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2191-0855-2-3","volume":"2","author":"H-G Wetzstein","year":"2012","unstructured":"Wetzstein H-G, Schneider J, Karl W (2012) Metabolite proving fungal cleavage of the aromatic core part of a fluoroquinolone antibiotic. AMB Express 2:3. https:\/\/doi.org\/10.1186\/2191-0855-2-3","journal-title":"AMB Express"},{"key":"9231_CR44","unstructured":"WHO (2017) Critically important antimicrobials for human medicine, 5th revision. http:\/\/www.who.int\/foodsafety\/publications\/antimicrobials-fifth\/en\/ . Accessed 20 Feb 2018"},{"key":"9231_CR45","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.chemosphere.2006.10.016","volume":"67","author":"AJ Williams","year":"2007","unstructured":"Williams AJ, Deck J, Freeman JP, Chiarelli MP, Adjei MD, Heinze TM, Sutherland JB (2007) Biotransformation of flumequine by the fungus Cunninghamella elegans. Chemosphere 67:240\u2013243. https:\/\/doi.org\/10.1016\/j.chemosphere.2006.10.016","journal-title":"Chemosphere"},{"key":"9231_CR46","first-page":"131","volume":"37","author":"HJ Zeiler","year":"1987","unstructured":"Zeiler HJ, Petersen U, Gau W, Ploschke HJ (1987) Antibacterial activity of the metabolites of ciprofloxacin and its significance in the bioassay. Arzneimittelforsch 37:131\u2013134","journal-title":"Arzneimittelforsch"},{"key":"9231_CR47","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/j.scitotenv.2009.11.014","volume":"408","author":"L Zhao","year":"2010","unstructured":"Zhao L, Dong YH, Wang H (2010) Residues of veterinary antibiotics in manures from feedlot livestock in eight provinces of China. Sci Total Environ 408:1069\u20131075. https:\/\/doi.org\/10.1016\/j.scitotenv.2009.11.014","journal-title":"Sci Total Environ"},{"key":"9231_CR48","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1002\/mrc.1468","volume":"42","author":"A Zi\u0119ba","year":"2004","unstructured":"Zi\u0119ba A, Ma\u015blankiewicz A, Sitkowski J (2004) 1H, 13C and 15N NMR spectra of ciprofloxacin. Magn Reson Chem 42:903\u2013904. https:\/\/doi.org\/10.1002\/mrc.1468","journal-title":"Magn Reson Chem"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00253-018-9231-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-018-9231-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-018-9231-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T11:16:33Z","timestamp":1604661393000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00253-018-9231-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,21]]},"references-count":48,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["9231"],"URL":"https:\/\/doi.org\/10.1007\/s00253-018-9231-y","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,21]]},"assertion":[{"value":"9 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}