{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:52:40Z","timestamp":1782489160245,"version":"3.54.5"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:00:00Z","timestamp":1541462400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:00:00Z","timestamp":1541462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["18-14-00016"],"award-info":[{"award-number":["18-14-00016"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s00253-018-9476-5","type":"journal-article","created":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T19:57:34Z","timestamp":1541534254000},"page":"437-447","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Prospects for the use of spherical gold nanoparticles in immunization"],"prefix":"10.1007","volume":"103","author":[{"given":"Sergey A.","family":"Staroverov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei A.","family":"Volkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel V.","family":"Mezhenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan Yu.","family":"Domnitsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander S.","family":"Fomin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey V.","family":"Kozlov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lev A.","family":"Dykman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga I.","family":"Guliy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,6]]},"reference":[{"key":"9476_CR1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jconrel.2018.02.004","volume":"275","author":"NRG Assis","year":"2018","unstructured":"Assis NRG, Caires AJ, Figueiredo BC, Morais SB, Mambelli FS, Marinho FV, Ladeira LO, Oliveira SC (2018) The use of gold nanorods as a new vaccine platform against schistosomiasis. J Control Release 275:40\u201352","journal-title":"J Control Release"},{"issue":"1","key":"9476_CR2","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.ijpharm.2012.10.033","volume":"441","author":"G Barhate","year":"2013","unstructured":"Barhate G, Gautam M, Gairola S, Jadhav S, Pokharkar V (2013) Quillajasaponaria extract as mucosal adjuvant with chitosan functionalized gold nanoparticles for mucosal vaccine delivery: stability and immunoefficiency studies. Int J Pharm 441(1):636\u2013642","journal-title":"Int J Pharm"},{"key":"9476_CR3","doi-asserted-by":"crossref","unstructured":"Bernas T., Dobrucki J.W. (2000) The role of plasma membrane in bioreduction of two tetrazolium salts, MTT, and CTC, Arch Biochem Biophys 380: 108\u2013116","DOI":"10.1006\/abbi.2000.1907"},{"key":"9476_CR4","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1016\/j.addr.2008.03.013","volume":"60","author":"R Bhattacharya","year":"2008","unstructured":"Bhattacharya R, Mukherjee P (2008) Biological properties of \u201cnaked\u201d metal nanoparticles. Adv Drug Del Rev 60:1289\u20131306","journal-title":"Adv Drug Del Rev"},{"issue":"19","key":"9476_CR5","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/21\/19\/195101","volume":"21","author":"YS Chen","year":"2010","unstructured":"Chen YS, Hung YC, Lin WH, Huang GS (2010) Assessment of gold nanoparticles as a size-dependent vaccine carrier for enhancing the antibody response against synthetic foot-and-mouth disease virus peptide. Nanotechnology 21(19):195101","journal-title":"Nanotechnology"},{"key":"9476_CR6","first-page":"22","volume":"22","author":"QH Cheng","year":"1992","unstructured":"Cheng QH, Niu XY (1992) Investigation on the porcine epidemic diarrhea prevalent on Qinhai. Vet Sci 22:22\u201323","journal-title":"Vet Sci"},{"key":"9476_CR7","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1099\/0022-1317-67-7-1405","volume":"67","author":"B Delmas","year":"1986","unstructured":"Delmas B, Gelfi J, Laude H (1986) Antigenic structure of transmissible gastroenteritis virus. II. Domains in the peplomer glycoprotein. J Gen Virol 67:1405\u20131418","journal-title":"J Gen Virol"},{"key":"9476_CR8","doi-asserted-by":"publisher","first-page":"2740","DOI":"10.1039\/C1CS15237H","volume":"41","author":"EC Dreaden","year":"2012","unstructured":"Dreaden EC, Alkilany AM, Huang X, Murphy CJ, El-Sayed MA (2012) The golden age: gold nanoparticles for biomedicine. Chem Soc Rev 41:2740\u20132779","journal-title":"Chem Soc Rev"},{"key":"9476_CR9","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1039\/C1CS15166E","volume":"41","author":"LA Dykman","year":"2012","unstructured":"Dykman LA, Khlebtsov NG (2012) Gold nanoparticles in biomedical applications: recent advances and perspectives. Chem Soc Rev 41:2256\u20132282","journal-title":"Chem Soc Rev"},{"key":"9476_CR10","doi-asserted-by":"crossref","unstructured":"Dykman LA, Staroverov SA, Bogatyrev VA, Shchyogolev SY (2010a) Adjuvant properties of gold nanoparticles. Nanotechnol 5(11\u201312):748\u2013761 (in Russian)","DOI":"10.1134\/S1995078010110029"},{"key":"9476_CR11","unstructured":"Dykman LA, Staroverov SA, Bogatyrev VA, Shchyogolev SYu (2010b) Gold nanoparticles as an antigen carrier and an adjuvant. Nova science publishers, New York p 54"},{"key":"9476_CR12","unstructured":"Dykman LA, Bogatyrev VA, Shchyogolev SYu, Khlebtsov NG (2008) Gold nanoparticles: synthesis, properties, biomedical applications. Nauka, Moscow (in Russian)"},{"key":"9476_CR13","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.antiviral.2011.06.011","volume":"91","author":"AA Fedorova","year":"2011","unstructured":"Fedorova AA, Azzami K, Ryabchikova EI, Spitsyna YE, Silnikov VN, Ritter W, Gross HJ, Tautz J, Vlassov VV, Beier H, Zenkova MA (2011) Inactivation of a non-enveloped RNA virus by artificial ribonucleases: honey bees. Antivir Res 91:267\u2013277","journal-title":"Antivir Res"},{"key":"9476_CR14","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/physci241020a0","volume":"241","author":"G Frens","year":"1973","unstructured":"Frens G (1973) Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions. Nature Phys Sci 241:20\u201322","journal-title":"Nature Phys Sci"},{"issue":"48","key":"9476_CR15","doi-asserted-by":"publisher","first-page":"6777","DOI":"10.1016\/j.vaccine.2012.09.021","volume":"30","author":"AE Gregory","year":"2012","unstructured":"Gregory AE, Williamson ED, Prior JL (2012) Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity. Vaccine 30(48):6777\u20136782","journal-title":"Vaccine"},{"key":"9476_CR16","unstructured":"Herrington CS, McGee J O\u2019D (eds) (1993) Diagnostic Molecular Pathology: A Practical Approach. Oxford University Press, Oxford"},{"issue":"3","key":"9476_CR17","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1128\/iai.37.3.1148-1155.1982","volume":"37","author":"MC Horzinek","year":"1982","unstructured":"Horzinek MC, Lutz H, Pedersen NC (1982) Antigenic relationships among homologous structural polypeptides of porcine, feline, and canine coronaviruses. Infect Immun 37(3):1148\u20131155","journal-title":"Infect Immun"},{"key":"9476_CR18","doi-asserted-by":"crossref","unstructured":"Khlebtsov NG, Dykman LA (2010) Optical properties and biomedical applications of plasmonic nanoparticles. J Quant Spectrosc Radiat Transf 111:1\u201335","DOI":"10.1016\/j.jqsrt.2009.07.012"},{"key":"9476_CR19","unstructured":"Leiter EH (2001) In: Coligan JE, Kruisbeek AM, Marguilies DH, Shevach EM, Strober W (eds) The NOD mouse: a model for insulin dependent diabetes mellitus \/\/Current protocols in immunology. vol 3. John Wiley & Sons, New York, pp 15.9.1\u201315.9.23"},{"key":"9476_CR20","unstructured":"Maniatis T, Fritsch EF, Sambrook J (1982) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, New York"},{"key":"9476_CR21","doi-asserted-by":"publisher","first-page":"706","DOI":"10.4067\/S0717-95022013000200059","volume":"31","author":"AMCRPF Martins","year":"2013","unstructured":"Martins AMCRPF, Bersano JG, Ogata R, Amante G, Nastari BDB, Catroxo MHB (2013) Diagnosis to detect porcine transmissible gastroenteritis virus (TGEV) by optical and transmission electron microscopy techniques. Int J Morphol 31:706\u2013715","journal-title":"Int J Morphol"},{"key":"9476_CR22","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.1039\/c2cs15294k","volume":"41","author":"R Mout","year":"2012","unstructured":"Mout R, Moyano DF, Rana S, Rotello VM (2012) Surface functionalization of nanoparticles for nanomedicine. Chem Soc Rev 41:2539\u20132544","journal-title":"Chem Soc Rev"},{"key":"9476_CR23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2460\/ajvr.1989.50.01.111","volume":"50","author":"RA Moxley","year":"1989","unstructured":"Moxley RA, Olson LD (1989) Clinical evaluation of transmissible gastroenteritis virus vaccines and vaccination procedures for inducing lactogenic immunity in sows. Am J Vet Res 50:111\u2013118","journal-title":"Am J Vet Res"},{"key":"9476_CR24","unstructured":"Patent RU2009124039A (2009)"},{"issue":"1","key":"9476_CR25","doi-asserted-by":"publisher","first-page":"93","DOI":"10.5661\/bger-25-93","volume":"25","author":"D Pissuwan","year":"2008","unstructured":"Pissuwan D, Valenzuela SM, Cortie MB (2008) Prospects for gold nanorodparticles in diagnostic and therapeutic applications. Biotechnol Genet Eng Rev 25(1):93\u2013112","journal-title":"Biotechnol Genet Eng Rev"},{"key":"9476_CR26","first-page":"30","volume":"4","author":"S\u0410 Staroverov","year":"2012","unstructured":"Staroverov S\u0410, Fomin \u0410S, Volkov \u0410\u0410, Koslov SV, Khlebtsov BN, Larionov SV, Vasilenko OA, Megennei PV, Vinnikov NT, Dykman L\u0410 (2012) Usage of phage mini-antibodies as means of detecting ferritin concentration in animal blood. Russian Veterinary Journal Productive animals 4:30\u201333 (in Russian)","journal-title":"Russian Veterinary Journal Productive animals"},{"key":"9476_CR27","unstructured":"Straw BE, D\u2019Allaire S, Mengeling WL, Taylor DJ (eds) (2000) Disease of swine. Iowa State University Press, Ames"},{"key":"9476_CR28","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1128\/jvi.56.3.904-911.1985","volume":"56","author":"LS Sturman","year":"1985","unstructured":"Sturman LS, Riehard CS, Holmes KV (1985) Proteolytic cleavage of the E2 glyco protein of murine coronavirus by trypsin and separation of two different 90K cleavage fragments. J. Gen. Virol. 56:904\u2013911","journal-title":"J. Gen. Virol."},{"issue":"2","key":"9476_CR29","doi-asserted-by":"publisher","first-page":"237","DOI":"10.2217\/nnm.13.58","volume":"9","author":"W Tao","year":"2014","unstructured":"Tao W, Ziemer KS, Gill HS (2014) Gold nanoparticle-M2e conjugate coformulated with CpG induces protective immunity against influenza A virus. Nanomedicine (Lond) 9(2):237\u2013251","journal-title":"Nanomedicine (Lond)"},{"key":"9476_CR30","doi-asserted-by":"publisher","unstructured":"Tao W, Hurst BL, Shakya AK, Uddin MJ, Ingrole RS, Hernandez-Sanabria M, Arya RP, Bimler L, Paust S, Tarbet EB, Gill HS (2017) Consensus M2e peptide conjugated to gold nanoparticles confers protection against H1N1, H3N2 and H5N1 influenza A viruses. Antivir Res 141:62\u201372.\u00a0https:\/\/doi.org\/10.1016\/j.antiviral.2017.01.021","DOI":"10.1016\/j.antiviral.2017.01.021"},{"issue":"4","key":"9476_CR31","first-page":"293","volume":"11","author":"AF Versiani","year":"2016","unstructured":"Versiani AF, Andrade LM, Martins EMN (2016) Gold nanoparticles and their applications in biomedicine. FutureVirol 11(4):293\u2013309","journal-title":"FutureVirol"},{"key":"9476_CR32","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1128\/jvi.65.6.3369-3373.1991","volume":"65","author":"RD Wesley","year":"1991","unstructured":"Wesley RD, Woods RD, Cheung AK (1991) Genetic analysis of porcine respiratory Coronavirus, an attenuated variant of transmissible gastroenteritis virus, J. Virol 65:3369\u20133373","journal-title":"Virol"},{"key":"9476_CR33","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1021\/nl300027p","volume":"12","author":"L Xu","year":"2012","unstructured":"Xu L, Liu Y, Chen Z, Li W, Wang L, Wu X, Ji Y, Zhao Y, Ma L, Shao Y, Chen C (2012) Surface-engineered gold nanorods: promising DNA vaccine adjuvant for HIV-1 treatment. Nano Lett 12:2003\u20132012","journal-title":"Nano Lett"},{"key":"9476_CR34","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.rvsc.2018.06.008","volume":"119","author":"Q Zhang","year":"2018","unstructured":"Zhang Q, Xu Y, Chang R, Tong D, Xu X (2018) Transmissible gastroenteritis virus N protein causes endoplasmic reticulum stress, up-regulates interleukin-8 expression and its subcellular localization in the porcine intestinal epithelial cell. Res Vet Sci 119:109\u2013115. https:\/\/doi.org\/10.1016\/j.rvsc.2018.06.008","journal-title":"Res Vet Sci"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00253-018-9476-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-018-9476-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-018-9476-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T05:12:40Z","timestamp":1744175560000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00253-018-9476-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,6]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["9476"],"URL":"https:\/\/doi.org\/10.1007\/s00253-018-9476-5","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,6]]},"assertion":[{"value":"20 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}