{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:58:36Z","timestamp":1788915516169,"version":"build-2803163510"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21776189"],"award-info":[{"award-number":["21776189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s00253-019-10326-y","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T07:21:25Z","timestamp":1577085685000},"page":"1751-1760","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Enhanced \u03b2-glucan and pullulan production by Aureobasidium pullulans with zinc sulfate supplementation"],"prefix":"10.1007","volume":"104","author":[{"given":"D.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7621-8407","authenticated-orcid":false,"given":"G.","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,23]]},"reference":[{"key":"10326_CR1","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"issue":"1","key":"10326_CR2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1756-8722-2-25","volume":"2","author":"G Chan","year":"2009","unstructured":"Chan G, Chan W, Sze D (2009) The effects of \u03b2-glucan on human immune and cancer cells. J Hematol Oncol 2(1):25. https:\/\/doi.org\/10.1186\/1756-8722-2-25","journal-title":"J Hematol Oncol"},{"key":"10326_CR3","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.ijbiomac.2016.11.081","volume":"95","author":"X Chen","year":"2017","unstructured":"Chen X, Wang Q, Liu N, Liu G, Chi Z, Chi Z (2017) A glycosyltransferase gene responsible for pullulan biosynthesis in Aureobasidium melanogenum P16. Int J Biol Macromol 95:539\u2013549. https:\/\/doi.org\/10.1016\/j.ijbiomac.2016.11.081","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"10326_CR4","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00253-011-3477-y","volume":"92","author":"KC Cheng","year":"2011","unstructured":"Cheng KC, Demirci A, Catchmark JM (2011) Pullulan: biosynthesis, production, and applications. Appl Microbiol Biotechnol 92(1):29\u201344. https:\/\/doi.org\/10.1007\/s00253-011-3477-y","journal-title":"Appl Microbiol Biotechnol"},{"issue":"1","key":"10326_CR5","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s13530-016-0257-1","volume":"8","author":"JS Choi","year":"2016","unstructured":"Choi JS, Kim JW, Jung GW, Moon SB, Cho HR, Sung SH, Jung JJ, Kwon YS, Ku SK, Sohn JH (2016) Effect of a \u03b2-glucan from Aureobasidium on TGF-\u03b21-modulated in vitro dermal wound repair. Toxicol Environ Heal Sci 8(1):12\u201318. https:\/\/doi.org\/10.1007\/s13530-016-0257-1","journal-title":"Toxicol Environ Heal Sci"},{"key":"10326_CR6","unstructured":"Donzis BA (1996) Substantially purified beta (1,3) finely ground yeast cell wall glucan composition with dermatological and nutritional uses. US 5576015"},{"key":"10326_CR7","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.tifs.2014.09.002","volume":"41","author":"B Du","year":"2015","unstructured":"Du B, Lin C, Bian Z, Xu B (2015) An insight into anti-inflammatory effects of fungal beta-glucans. Trends Food Sci Technol 41:49\u201359. https:\/\/doi.org\/10.1016\/j.tifs.2014.09.002","journal-title":"Trends Food Sci Technol"},{"key":"10326_CR8","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.carbpol.2007.12.028","volume":"73","author":"XH Duan","year":"2008","unstructured":"Duan XH, Chi ZM, Wang L, Wang XH (2008) Influence of different sugars on pullulan production and activity of \u03b1-phosphoglucose mutase UDPG-pyrophosphorylase and glucosyltransferase involved in pullulan synthesis in Aureobasidium pullulans Y68. Carbohydr Polym 73:587\u2013593. https:\/\/doi.org\/10.1016\/j.carbpol.2007.12.028","journal-title":"Carbohydr Polym"},{"issue":"6","key":"10326_CR9","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.1007\/s00253-015-7148-2","volume":"100","author":"YX Fan","year":"2016","unstructured":"Fan YX, Zhao MJ, Wei LJ, Hu FX, Imanaka T, Bai LQ, Hua Q (2016) Enhancement of UDPG synthetic pathway improves ansamitocin production in Actinosynnem pretiosum. Appl Microbiol Biotechnol 100(6):2651\u20132662. https:\/\/doi.org\/10.1007\/s00253-015-7148-2","journal-title":"Appl Microbiol Biotechnol"},{"key":"10326_CR10","doi-asserted-by":"publisher","first-page":"40539","DOI":"10.1002\/app.40539","volume":"131","author":"S Farris","year":"2014","unstructured":"Farris S, Unalan IU, Introzzi L, Fuentes-Alventosa JM, Cozzolino CA (2014) Pullulan-based films and coatings for food packaging: present applications, emerging opportunities, and future challenges. J Appl Polym Sci 131:40539. https:\/\/doi.org\/10.1002\/app.40539","journal-title":"J Appl Polym Sci"},{"key":"10326_CR11","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1007\/s12257-010-0042-y","volume":"15","author":"W Gao","year":"2010","unstructured":"Gao W, Kim Y, Chung C, Li J, Lee J (2010) Optimization of mineral salts in medium for enhanced production of pullulan by Aureobasidium pullulans HP-2001 using an orthogonal array method. Biotechnol Bioprocess Eng 15:837\u2013845. https:\/\/doi.org\/10.1007\/s12257-010-0042-y","journal-title":"Biotechnol Bioprocess Eng"},{"key":"10326_CR12","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.ijbiomac.2019.07.123","volume":"138","author":"M Hamidi","year":"2019","unstructured":"Hamidi M, Kennedy JF, Khodaiyan F, Mousavi Z, Hosseini SS (2019) Production optimization, characterization and gene expression of pullulan from a new strain of Aureobasidium pullulans. Int J Biol Macromol 138:725\u2013735. https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.07.123","journal-title":"Int J Biol Macromol"},{"key":"10326_CR13","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1021\/ar00019a006","volume":"25","author":"JE Heidlas","year":"1992","unstructured":"Heidlas JE, Williams KW, Whitesides GM (1992) Nucleoside phosphate sugars: syntheses on practical scales for use as reagents in the enzymatic preparation of oligosaccharides and glycoconjugates. Acc Chem Res 25:307\u2013314. https:\/\/doi.org\/10.1021\/ar00019a006","journal-title":"Acc Chem Res"},{"key":"10326_CR14","unstructured":"Huang CY, Cheng YC, Lin YS, Liou GY, Lin SJ, Lai JT (2018) Aureobasidium pullulans, culturing medium and method for producing \u03b2-glucan, a culture of Aureobasidium pullulans and a composition comprising the same. US 9938550 B1"},{"key":"10326_CR15","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jnutbio.2018.06.010","volume":"61","author":"M Jayachandran","year":"2018","unstructured":"Jayachandran M, Chen J, Chung SM, Xu B (2018) A critical review on the impacts of \u03b2-glucans on gut microbiota and human health. J Nutr Biochem 61:101\u2013110. https:\/\/doi.org\/10.1016\/j.jnutbio.2018.06.010","journal-title":"J Nutr Biochem"},{"key":"10326_CR16","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s00253-014-6100-1","volume":"99","author":"X Ju","year":"2015","unstructured":"Ju X, Wang D, Zhang G, Cao D, Wei G (2015) Efficient pullulan production by bioconversion using Aureobasidium pullulans as the whole-cell catalyst. Appl Microbiol Biotechnol 99:211\u2013220. https:\/\/doi.org\/10.1007\/s00253-014-6100-1","journal-title":"Appl Microbiol Biotechnol"},{"key":"10326_CR17","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s10529-009-0127-x","volume":"32","author":"BK Kang","year":"2010","unstructured":"Kang BK, Yang HJ, Choi NS, Ahn KH (2010) Production of pure \u03b2-glucan by Aureobasidium pullulans after pullulan synthetase gene disruption. Biotechnol Lett 32:137\u2013142. https:\/\/doi.org\/10.1007\/s10529-009-0127-x","journal-title":"Biotechnol Lett"},{"issue":"2","key":"10326_CR18","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3109\/1040841X.2013.826176","volume":"41","author":"Y Li","year":"2015","unstructured":"Li Y, Chi Z, Wang GY, Wang ZP, Liu GL, Lee CF, Ma ZC, Chi ZM (2015) Taxonomy of Aureobasidium spp. and biosynthesis and regulation of their extracellular polymers. Crit Rev Microbiol 41(2):228\u2013237. https:\/\/doi.org\/10.3109\/1040841X.2013.826176","journal-title":"Crit Rev Microbiol"},{"issue":"6","key":"10326_CR19","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1007\/s12010-015-1934-2","volume":"178","author":"HF Li","year":"2016","unstructured":"Li HF, Zhang YY, Gao YY, Lan YY, Yin XP, Huang LF (2016) Characterization of UGPase from Aureobasidium pullulans NRRL Y-12974 and application in enhanced pullulan production. Appl Biochem Biotechnol 178(6):1141\u20131153. https:\/\/doi.org\/10.1007\/s12010-015-1934-2","journal-title":"Appl Biochem Biotechnol"},{"key":"10326_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jbiotec.2019.06.005","volume":"302","author":"H Li","year":"2019","unstructured":"Li H, Li J, Jiao X, Li K, Sun Y, Zhou W, Shen Y, Qian J, Chang A, Wang J, Zhu H (2019) Characterization of the biosynthetic pathway of nucleotide sugar precursor UDP-glucose during sphingan WL gum production in Sphingomonas sp. WG. J Biotechnol 302:1\u20139. https:\/\/doi.org\/10.1016\/j.jbiotec.2019.06.005","journal-title":"J Biotechnol"},{"key":"10326_CR21","doi-asserted-by":"publisher","first-page":"4865","DOI":"10.1007\/s00253-014-5554-5","volume":"98","author":"Z Ma","year":"2014","unstructured":"Ma Z, Fu W, Liu G, Wang Z, Chi Z (2014) High-level pullulan production by Aureobasidium pullulans var. melanogenium P16 isolated from mangrove system. Appl Microbiol Biotechnol 98:4865\u20134873. https:\/\/doi.org\/10.1007\/s00253-014-5554-5","journal-title":"Appl Microbiol Biotechnol"},{"key":"10326_CR22","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1021\/bp0503181","volume":"22","author":"Z Mao","year":"2006","unstructured":"Mao Z, Shin HD, Chen RR (2006) Engineering the E. coli UDP-glucose synthesis pathway for oligosaccharide synthesis. Biotechnol Prog 22:369\u2013374. https:\/\/doi.org\/10.1021\/bp0503181","journal-title":"Biotechnol Prog"},{"key":"10326_CR23","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1007\/s12257-013-0516-9","volume":"18","author":"N Moriya","year":"2013","unstructured":"Moriya N, Moriya Y, Nomura H, Kusano K, Asada Y, Uchiyama H, Park EY, Okabe M (2013) Improved \u03b2-glucan yield using an Aureobasidium pullulans M-2 mutant strain in a 200-L pilot scale fermentor targeting industrial mass production. Biotechnol Bioprocess Eng 18:1083\u20131089. https:\/\/doi.org\/10.1007\/s12257-013-0516-9","journal-title":"Biotechnol Bioprocess Eng"},{"key":"10326_CR24","doi-asserted-by":"publisher","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","volume":"30","author":"MW Pfaffl","year":"2002","unstructured":"Pfaffl MW, Horgan GW, Dempfle L (2002) Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30:e36. https:\/\/doi.org\/10.1093\/nar\/30.9.e36","journal-title":"Nucleic Acids Res"},{"key":"10326_CR25","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.carbpol.2013.02.082","volume":"95","author":"VD Prajapati","year":"2013","unstructured":"Prajapati VD, Jani GK, Khanda SM (2013) Pullulan: an exopolysaccharide and its various applications. Carbohydr Polym 95:540\u2013549. https:\/\/doi.org\/10.1016\/j.carbpol.2013.02.082","journal-title":"Carbohydr Polym"},{"key":"10326_CR26","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s12223-017-0561-4","volume":"63","author":"S Prasongsuk","year":"2018","unstructured":"Prasongsuk S, Lotrakul P, Ali I, Bankeeree W, Punnapayak H (2018) The current status of Aureobasidium pullulans in biotechnology. Folia Microbiol 63:129\u2013140. https:\/\/doi.org\/10.1007\/s12223-017-0561-4","journal-title":"Folia Microbiol"},{"key":"10326_CR27","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1007\/BF00191190","volume":"42","author":"M Reeslev","year":"1995","unstructured":"Reeslev M, Jensen B (1995) Influence of Zn2+ and Fe3+ on polysaccharide production and mycelium\/yeast dimorphism of Aureobasidium pullulans in batch cultivations. Appl Microbiol Biotechnol 42:910\u2013915. https:\/\/doi.org\/10.1007\/BF00191190","journal-title":"Appl Microbiol Biotechnol"},{"key":"10326_CR28","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.carbpol.2017.09.044","volume":"181","author":"A Rieder","year":"2018","unstructured":"Rieder A, Ballance S, B\u00f6cker U, Knutsen S (2018) Quantification of 1,3-\u03b2-D-glucan from yeast added as a functional ingredient to bread. Carbohydr Polym 181:34\u201342. https:\/\/doi.org\/10.1016\/j.carbpol.2017.09.044","journal-title":"Carbohydr Polym"},{"key":"10326_CR29","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1007\/s00284-002-3884-5","volume":"46","author":"R Schimoler-O\u2019Rourke","year":"2003","unstructured":"Schimoler-O\u2019Rourke R, Renault S, Mo W, Selitrennikoff CP (2003) Neurospora crassa FKS protein binds to the (1,3)beta-glucan synthase substrate, UDP-glucose. Curr Microbiol 46:408\u2013412. https:\/\/doi.org\/10.1007\/s00284-002-3884-5","journal-title":"Curr Microbiol"},{"key":"10326_CR30","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.carres.2003.10.034","volume":"339","author":"KI Shingel","year":"2004","unstructured":"Shingel KI (2004) Current knowledge on biosynthesis, biological activity, and chemical modification of the exopolysaccharide, pullulan. Carbohydr Res 339:447\u2013460. https:\/\/doi.org\/10.1016\/j.carres.2003.10.034","journal-title":"Carbohydr Res"},{"key":"10326_CR31","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1099\/00221287-139-5-979","volume":"139","author":"L Simon","year":"1993","unstructured":"Simon L, Caye-Vaugie C, Bouchonneau M (1993) Relation between pullulan production, morphological state and growth conditions in Aureobasidium pullulans. J Gen Microbiol 139:979\u2013985. https:\/\/doi.org\/10.1099\/00221287-139-5-979","journal-title":"J Gen Microbiol"},{"key":"10326_CR32","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.carbpol.2017.04.089","volume":"171","author":"RS Singh","year":"2017","unstructured":"Singh RS, Kaur N, Rana V, Kennedy JF (2017) Pullulan: a novel molecule for biomedical applications. Carbohydr Polym 171:102\u2013121. https:\/\/doi.org\/10.1016\/j.carbpol.2017.04.089","journal-title":"Carbohydr Polym"},{"key":"10326_CR33","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.carbpol.2017.06.022","volume":"173","author":"KR Sugumaran","year":"2017","unstructured":"Sugumaran KR, Ponnusami V (2017) Review on production, downstream processing and characterization of microbial pullulan. Carbohydr Polym 173:573\u2013591. https:\/\/doi.org\/10.1016\/j.carbpol.2017.06.022","journal-title":"Carbohydr Polym"},{"key":"10326_CR34","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1271\/bbb1961.37.1635","volume":"37","author":"R Taguchi","year":"1973","unstructured":"Taguchi R, Sakano Y, Kikuchi Y, Sakuma M, Kobayashi T (1973) Synthesis of pullulan by acetone-dried cells and cell-free enzyme from Pullularia pullulans, and the participation of lipid intermediate. Agric Biol Chem 37:1635\u20131641. https:\/\/doi.org\/10.1271\/bbb1961.37.1635","journal-title":"Agric Biol Chem"},{"key":"10326_CR35","doi-asserted-by":"publisher","first-page":"4467","DOI":"10.1007\/s00253-018-8947-z","volume":"102","author":"H Uchiyama","year":"2018","unstructured":"Uchiyama H, Iwai A, Dohra H, Ohnishi T, Kato T, Park EY (2018) The effects of gene disruption of Kre6-like proteins on the phenotype of \u03b2-glucan-producing Aureobasidium pullulans. Appl Microbiol Biotechnol 102:4467\u20134475. https:\/\/doi.org\/10.1007\/s00253-018-8947-z","journal-title":"Appl Microbiol Biotechnol"},{"key":"10326_CR36","doi-asserted-by":"publisher","first-page":"8069","DOI":"10.1007\/s00253-013-5094-4","volume":"97","author":"D Wang","year":"2013","unstructured":"Wang D, Yu X, Wei G (2013) Pullulan production and physiological characteristics of Aureobasidium pullulans under acid stress. Appl Microbiol Biotechnol 97:8069\u20138077. https:\/\/doi.org\/10.1007\/s00253-013-5094-4","journal-title":"Appl Microbiol Biotechnol"},{"key":"10326_CR37","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1002\/jctb.4600","volume":"91","author":"D Wang","year":"2016","unstructured":"Wang D, Bian J, Wei G, Jiang M, Dong M (2016a) Simultaneously enhanced production and molecular weight of pullulan using a two-stage agitation speed control strategy. J Chem Technol Biotechnol 91:467\u2013475. https:\/\/doi.org\/10.1002\/jctb.4600","journal-title":"J Chem Technol Biotechnol"},{"key":"10326_CR38","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.carbpol.2016.05.035","volume":"150","author":"D Wang","year":"2016","unstructured":"Wang D, Ju X, Zhang G, Wang D, Wei G (2016b) Copper sulfate improves pullulan production by bioconversion using whole cells of Aureobasidium pullulans as the catalyst. Carbohydr Polym 150:209\u2013215. https:\/\/doi.org\/10.1016\/j.carbpol.2016.05.035","journal-title":"Carbohydr Polym"},{"key":"10326_CR39","doi-asserted-by":"publisher","first-page":"8921","DOI":"10.1007\/s00253-018-9292-y","volume":"102","author":"D Wang","year":"2018","unstructured":"Wang D, Ni T, Ju X, Wei G (2018) Sodium chloride improves pullulan production by Aureobasidium pullulans but reduces the molecular weight of pullulan. Appl Microbiol Biotechnol 102:8921\u20138930. https:\/\/doi.org\/10.1007\/s00253-018-9292-y","journal-title":"Appl Microbiol Biotechnol"},{"key":"10326_CR40","first-page":"115","volume":"71","author":"TP West","year":"1992","unstructured":"West TP, Reed-Hamer B (1992) Influence of vitamins and mineral salts upon pullulan synthesis of Aureobasidium pullulans. Microbios 71:115\u2013123","journal-title":"Microbios"},{"key":"10326_CR41","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/j.carbpol.2012.04.038","volume":"89","author":"X Yu","year":"2012","unstructured":"Yu X, Wang Y, Wei G, Dong Y (2012) Media optimization for elevated molecular weight and mass production of pigment-free pullulan. Carbohydr Polym 89:928\u2013934. https:\/\/doi.org\/10.1016\/j.carbpol.2012.04.038","journal-title":"Carbohydr Polym"},{"key":"10326_CR42","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1023\/a:1000212003810","volume":"72","author":"NA Yurlova","year":"1997","unstructured":"Yurlova NA, de Hoog GH (1997) A new variety of Aureobasidium pullulans characterized by exopolysaccharide structure, nutritional physiology and molecular features. Antonie Van Leeuwenhoek 72:141\u2013147. https:\/\/doi.org\/10.1023\/a:1000212003810","journal-title":"Antonie Van Leeuwenhoek"},{"issue":"6","key":"10326_CR43","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ymben.2011.10.001","volume":"13","author":"X Zhou","year":"2011","unstructured":"Zhou X, Wu H, Li Z, Zhou X, Bai L, Deng Z (2011) Over-expression of UDP-glucose pyrophosphorylase increases validamycin A but decreases validoxylamine a production in Streptomyces hygroscopicus var. jinggangensis 5008. Metab Eng 13(6):68\u2013776. https:\/\/doi.org\/10.1016\/j.ymben.2011.10.001","journal-title":"Metab Eng"},{"key":"10326_CR44","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.foodhyd.2015.07.003","volume":"52","author":"F Zhu","year":"2016","unstructured":"Zhu F, Du B, Xu B (2016) A critical review on production and industrial applications of beta-glucans. Food Hydrocoll 52:275\u2013288. https:\/\/doi.org\/10.1016\/j.foodhyd.2015.07.003","journal-title":"Food Hydrocoll"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-019-10326-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00253-019-10326-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-019-10326-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:11:45Z","timestamp":1608595905000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00253-019-10326-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,23]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10326"],"URL":"https:\/\/doi.org\/10.1007\/s00253-019-10326-y","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,23]]},"assertion":[{"value":"5 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}