{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T17:41:46Z","timestamp":1785606106421,"version":"3.56.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"13","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31872746"],"award-info":[{"award-number":["31872746"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81773620"],"award-info":[{"award-number":["81773620"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific Research Projects of Shanghai Municipal Commission of Health and Family Planning","award":["201740140"],"award-info":[{"award-number":["201740140"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s00253-020-10638-4","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T01:02:38Z","timestamp":1588294958000},"page":"5889-5898","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Interleukin-22 ameliorated acetaminophen-induced kidney injury by inhibiting mitochondrial dysfunction and inflammatory responses"],"prefix":"10.1007","volume":"104","author":[{"given":"Yilan","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congrong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonglian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongrui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianwen","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,1]]},"reference":[{"key":"10638_CR1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.toxlet.2011.10.023","volume":"208","author":"ST Ahmad","year":"2012","unstructured":"Ahmad ST, Arjumand W, Nafees S, Seth A, Ali N, Rashid S, Sultana S (2012) Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress, apoptosis and inflammation. Toxicol Lett 208:149\u2013161","journal-title":"Toxicol Lett"},{"key":"10638_CR2","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/cc7800","volume":"13","author":"TN Athuraliya","year":"2009","unstructured":"Athuraliya TN, Jones AL (2009) Prolonged N,acetylcysteine therapy in late acetaminophen poisoning associated with acute liver failure-a need to be more cautious? Crit Care 13:144","journal-title":"Crit Care"},{"key":"10638_CR3","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/j.1527-3458.2006.00250.x","volume":"12","author":"A Bertolini","year":"2006","unstructured":"Bertolini A, Ferrari A, Ottani A, Guerzoni S, Tacchi R, Leone S (2006) Paracetamol: new vistas of an old drug. CNS Drug Rev 12:250\u2013275","journal-title":"CNS Drug Rev"},{"key":"10638_CR4","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1080\/20014091111677","volume":"31","author":"JG Bessems","year":"2001","unstructured":"Bessems JG, Vermeulen NP (2001) Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches. Crit Rev Toxicol 31:55\u2013138","journal-title":"Crit Rev Toxicol"},{"key":"10638_CR5","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1007\/s00467-017-3774-5","volume":"33","author":"A Bonavia","year":"2018","unstructured":"Bonavia A, Singbartl K (2018) A review of the role of immune cells in acute kidney injury. Pediatr Nephrol 33:1629\u20131639","journal-title":"Pediatr Nephrol"},{"key":"10638_CR6","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.chom.2015.07.004","volume":"18","author":"M Borghi","year":"2015","unstructured":"Borghi M, De Luca A, Puccetti M, Jaeger M, Mencacci A, Oikonomou V, Pariano M, Garlanda C, Moretti S, Bartoli A, Sobel J, van de Veerdonk FL, Dinarello CA, Netea MG, Romani L (2015) Pathogenic NLRP3 Inflammasome activity during Candida infection is negatively regulated by IL-22 via activation of NLRC4 and IL-1Ra. Cell Host Microbe 18:198\u2013209","journal-title":"Cell Host Microbe"},{"key":"10638_CR7","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1081\/CLT-100105413","volume":"39","author":"K Boutis","year":"2001","unstructured":"Boutis K, Shannon M (2001) Nephrotoxicity after acute severe acetaminophen poisoning in adolescents. J Toxicol Clin Toxicol 39:441\u2013445","journal-title":"J Toxicol Clin Toxicol"},{"key":"10638_CR8","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.7150\/thno.20955","volume":"7","author":"W Chen","year":"2017","unstructured":"Chen W, Zhang X, Fan J, Zai W, Luan J, Li Y, Wang S, Chen Q, Wang Y, Liang Y, Ju D (2017) Tethering interleukin-22 to apolipoprotein A-I ameliorates mice from acetaminophen-induced liver injury. Theranostics 7:4135\u20134148","journal-title":"Theranostics"},{"key":"10638_CR9","first-page":"6717212","volume":"2018","author":"Y Chen","year":"2018","unstructured":"Chen Y, Jin S, Teng X, Hu Z, Zhang Z, Qiu X, Tian D, Wu Y (2018a) Hydrogen sulfide attenuates LPS-induced acute kidney injury by inhibiting inflammation and oxidative stress. Oxidative Med Cell Longev 2018:6717212","journal-title":"Oxidative Med Cell Longev"},{"key":"10638_CR10","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.biomaterials.2018.09.046","volume":"187","author":"W Chen","year":"2018","unstructured":"Chen W, Luan J, Wei G, Zhang X, Fan J, Zai W, Wang S, Wang Y, Liang Y, Nan Y, Yin C, Li Y, Liu ML, Ju D (2018b) In vivo hepatocellular expression of interleukin-22 using penetratin-based hybrid nanoparticles as potential anti-hepatitis therapeutics. Biomaterials 187:66\u201380","journal-title":"Biomaterials"},{"key":"10638_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/taap.1996.8074","volume":"143","author":"SD Cohen","year":"1997","unstructured":"Cohen SD, Pumford NR, Khairallah EA, Boekelheide K, Pohl LR, Amouzadeh HR, Hinson JA (1997) Selective protein covalent binding and target organ toxicity. Toxicol Appl Pharmacol 143:1\u201312","journal-title":"Toxicol Appl Pharmacol"},{"key":"10638_CR12","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.it.2010.06.004","volume":"31","author":"S Eyerich","year":"2010","unstructured":"Eyerich S, Eyerich K, Cavani A, Schmidt-Weber C (2010) IL-17 and IL-22: siblings, not twins. Trends Immunol 31:354\u2013361","journal-title":"Trends Immunol"},{"key":"10638_CR13","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/s41586-019-0899-7","volume":"566","author":"K Gronke","year":"2019","unstructured":"Gronke K, Hern\u00e1ndez PP, Zimmermann J, Klose CSN, Kofoed-Branzk M, Guendel F, Witkowski M, Tizian C, Amann L, Schumacher F, Glatt H, Triantafyllopoulou A, Diefenbach A (2019) Interleukin-22 protects intestinal stem cells against genotoxic stress. Nature 566:249\u2013253","journal-title":"Nature"},{"key":"10638_CR14","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1038\/s41418-018-0070-2","volume":"25","author":"Q Hou","year":"2018","unstructured":"Hou Q, Ye L, Liu H, Huang L, Yang Q, Turner JR, Yu Q (2018) Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22. Cell Death Differ 25:1657\u20131670","journal-title":"Cell Death Differ"},{"key":"10638_CR15","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1159\/000492589","volume":"43","author":"H Hua","year":"2018","unstructured":"Hua H, Ge X, Wu M, Zhu C, Chen L, Yang G, Zhang Y, Huang S, Zhang A, Jia Z (2018) Rotenone protects against acetaminophen-induced kidney injury by attenuating oxidative stress and inflammation. Kidney Blood Press Res 43:1297\u20131309","journal-title":"Kidney Blood Press Res"},{"key":"10638_CR16","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/cmi.2017.49","volume":"15","author":"H Jaeschke","year":"2018","unstructured":"Jaeschke H (2018) Mechanisms of sterile inflammation in acetaminophen hepatotoxicity. Cell Mol Immunol 15:74\u201375","journal-title":"Cell Mol Immunol"},{"key":"10638_CR17","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1177\/0960327110391384","volume":"30","author":"H Kandi\u015f","year":"2011","unstructured":"Kandi\u015f H, Erkan ME, Yildirim U, G\u00fcne\u015f H, Erba\u015f M, Yildirim HA, Gezer S, Kara IH (2011) Comparison of the effects of N-acetyl cysteine and erdosteine in rats with renal injury caused by paracetamol intoxication. Hum Exp Toxicol 30:1350\u20131358","journal-title":"Hum Exp Toxicol"},{"key":"10638_CR18","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1097\/01.mog.0000160043.10804.60","volume":"21","author":"SK Lazerow","year":"2005","unstructured":"Lazerow SK, Abdi MS, Lewis JH (2005) Drug-induced liver disease 2004. Curr Opin Gastroenterol 21:283\u2013292","journal-title":"Curr Opin Gastroenterol"},{"key":"10638_CR19","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.jhep.2014.05.033","volume":"61","author":"Z Lin","year":"2014","unstructured":"Lin Z, Wu F, Lin S, Pan X, Jin L, Lu T, Shi L, Wang Y, Xu A, Li X (2014) Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice. J Hepatol 61:825\u2013831","journal-title":"J Hepatol"},{"key":"10638_CR20","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1172\/JCI59755","volume":"122","author":"MR McGill","year":"2012","unstructured":"McGill MR, Sharpe MR, Williams CD, Taha M, Curry SC, Jaeschke H (2012) The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J Clin Invest 122:1574\u20131583","journal-title":"J Clin Invest"},{"key":"10638_CR21","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1002\/ibd.22929","volume":"18","author":"A Mizoguchi","year":"2012","unstructured":"Mizoguchi A (2012) Healing of intestinal inflammation by IL-22. Inflamm Bowel Dis 18:1777\u20131784","journal-title":"Inflamm Bowel Dis"},{"key":"10638_CR22","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/nrneph.2017.10","volume":"13","author":"SR Mulay","year":"2017","unstructured":"Mulay SR, Anders HJ (2017) Crystal nephropathies: mechanisms of crystal-induced kidney injury. Nat Rev Nephrol 13:226\u2013240","journal-title":"Nat Rev Nephrol"},{"key":"10638_CR23","doi-asserted-by":"publisher","first-page":"E5076","DOI":"10.1073\/pnas.1718902115","volume":"115","author":"VL Ngo","year":"2018","unstructured":"Ngo VL, Abo H, Maxim E, Harusato A, Geem D, Medina-Contreras O, Merlin D, Gewirtz AT, Nusrat A, Denning TL (2018) A cytokine network involving IL-36\u03b3, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage. Proc Natl Acad Sci U S A 115:E5076\u2013E5085","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10638_CR24","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.cyto.2014.09.007","volume":"74","author":"E Nikoopour","year":"2015","unstructured":"Nikoopour E, Bellemore SM, Singh B (2015) IL-22, cell regeneration and autoimmunity. Cytokine 74:35\u201342","journal-title":"Cytokine"},{"key":"10638_CR25","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.etp.2017.01.009","volume":"69","author":"MS Reshi","year":"2017","unstructured":"Reshi MS, Shrivastava S, Jaswal A, Sinha N, Uthra C, Shukla S (2017) Gold nanoparticles ameliorate acetaminophen induced hepato-renal injury in rats. Exp Toxicol Pathol 69:231\u2013240","journal-title":"Exp Toxicol Pathol"},{"key":"10638_CR26","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/hep.23267","volume":"51","author":"C Saito","year":"2010","unstructured":"Saito C, Zwingmann C, Jaeschke H (2010) Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine. Hepatology 51:246\u2013254","journal-title":"Hepatology"},{"key":"10638_CR27","doi-asserted-by":"publisher","first-page":"113643","DOI":"10.1016\/j.bcp.2019.113643","volume":"169","author":"S Shan","year":"2019","unstructured":"Shan S, Shen Z, Zhang C, Kou R, Xie K, Song F (2019) Mitophagy protects against acetaminophen-induced acute liver injury in mice through inhibiting NLRP3 inflammasome activation. Biochem Pharmacol 169:113643","journal-title":"Biochem Pharmacol"},{"key":"10638_CR28","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/sj.gene.6363934","volume":"4","author":"A Tachiiri","year":"2003","unstructured":"Tachiiri A, Imamura R, Wang Y, Fukui M, Umemura M, Suda T (2003) Genomic structure and inducible expression of the IL-22 receptor alpha chain in mice. Genes Immun 4:153\u2013159","journal-title":"Genes Immun"},{"key":"10638_CR29","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1007\/s00431-003-1392-7","volume":"163","author":"T Ulinski","year":"2004","unstructured":"Ulinski T, Guigonis V, Dunan O, Bensman A (2004) Acute renal failure after treatment with non-steroidal anti-inflammatory drugs. Eur J Pediatr 163:148\u2013150","journal-title":"Eur J Pediatr"},{"key":"10638_CR30","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1042\/CS20160400","volume":"130","author":"E Vivoli","year":"2016","unstructured":"Vivoli E, Cappon A, Milani S, Piombanti B, Provenzano A, Novo E, Masi A, Navari N, Narducci R, Mannaioni G, Moneti G, Oliveira CP, Parola M, Marra F (2016) NLRP3 inflammasome as a target of berberine in experimental murine liver injury: interference with P2X7 signalling. Clin Sci 130:1793\u20131806","journal-title":"Clin Sci"},{"key":"10638_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.292","volume":"8","author":"S Wang","year":"2017","unstructured":"Wang S, Li Y, Fan J, Zhang X, Luan J, Bian Q, Ding T, Wang Y, Wang Z, Song P, Cui D, Mei X, Ju D (2017) Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation. Cell Death Dis 8:e2937","journal-title":"Cell Death Dis"},{"key":"10638_CR32","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.3389\/fimmu.2019.02277","volume":"10","author":"S Wang","year":"2019","unstructured":"Wang S, Fan J, Mei X, Luan J, Li Y, Zhang X, Chen W, Wang Y, Meng G, Ju D (2019) Interleukin-22 attenuated renal tubular injury in aristolochic acid nephropathy via suppressing activation of NLRP3 inflammasome. Front Immunol 10:2277","journal-title":"Front Immunol"},{"key":"10638_CR33","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.cytogfr.2006.09.001","volume":"17","author":"K Wolk","year":"2006","unstructured":"Wolk K, Sabat R (2006) Interleukin-22: a novel T-cell and NK cell derived cytokine that regulates the biology of tissue cells. Cytokine Factor Rev 17:367\u2013380","journal-title":"Cytokine Factor Rev"},{"key":"10638_CR34","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.immuni.2004.07.007","volume":"21","author":"K Wolk","year":"2004","unstructured":"Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R (2004) IL-22 increases the innate immunity of tissues. Immunity 21:241\u2013254","journal-title":"Immunity"},{"issue":"Suppl 1","key":"10638_CR35","first-page":"170","volume":"3","author":"BL Woolbright","year":"2017","unstructured":"Woolbright BL, Jaeschke H (2017) The impact of sterile inflammation in acute liver injury. J Clin Transl Res 3(Suppl 1):170\u2013188","journal-title":"J Clin Transl Res"},{"key":"10638_CR36","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1681\/ASN.2013060611","volume":"25","author":"MJ Xu","year":"2014","unstructured":"Xu MJ, Feng D, Wang H, Guan Y, Yan X, Gao B (2014) IL-22 ameliorates renal ischemia-reperfusion injury by targeting proximal tubule epithelium. J Am Soc Nephrol 25:967\u2013977","journal-title":"J Am Soc Nephrol"},{"key":"10638_CR37","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.redox.2018.04.019","volume":"17","author":"M Yan","year":"2018","unstructured":"Yan M, Huo Y, Yin S, Hu H (2018) Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions. Redox Biol 17:274\u2013283","journal-title":"Redox Biol"},{"key":"10638_CR38","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1007\/s00253-017-8686-6","volume":"102","author":"W Zai","year":"2018","unstructured":"Zai W, Chen W, Luan J, Fan J, Zhang X, Wu Z, Ding T, Ju D, Liu H (2018) Dihydroquercetin ameliorated acetaminophen-induced hepatic cytotoxicity via activating JAK2\/STAT3 pathway and autophagy. Appl Microbiol Biotechnol 102:1443\u20131453","journal-title":"Appl Microbiol Biotechnol"},{"key":"10638_CR39","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/cmi.2017.22","volume":"15","author":"C Zhang","year":"2018","unstructured":"Zhang C, Feng J, Du J, Zhuo Z, Yang S, Zhang W, Wang W, Zhang S, Iwakura Y, Meng G, Fu YX, Hou B, Tang H (2018) Macrophage-derived IL-1\u03b1 promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity. Cell Mol Immunol 15:973\u2013982","journal-title":"Cell Mol Immunol"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-020-10638-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00253-020-10638-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-020-10638-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T12:27:59Z","timestamp":1620044879000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00253-020-10638-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,1]]},"references-count":39,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10638"],"URL":"https:\/\/doi.org\/10.1007\/s00253-020-10638-4","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,1]]},"assertion":[{"value":"11 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed. All animal experiments were conducted with the approval of the Ethics Committee of Fudan University School of Pharmacy.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}