{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:11:33Z","timestamp":1785215493097,"version":"3.55.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"14","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005064","name":"Hebei Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["17275505D"],"award-info":[{"award-number":["17275505D"]}],"id":[{"id":"10.13039\/501100005064","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s00253-020-10699-5","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T09:02:26Z","timestamp":1609232546000},"page":"6375-6383","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Rapid detection of antibiotic resistance genes in lactic acid bacteria using PMMA-based microreactor arrays"],"prefix":"10.1007","volume":"104","author":[{"given":"Zengjun","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guotao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6465-7269","authenticated-orcid":false,"given":"Weihao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"10699_CR1","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.foodres.2015.09.016","volume":"78","author":"H Abriouel","year":"2015","unstructured":"Abriouel H, Casado Mu\u00f1oz MC, Lavilla Lerma L, P\u00e9rez Montoro B, Bockelmann W, Pichner R, Kabisch J, Cho G-S, Franz CMAP, G\u00e1lvez A, Benomar N (2015) New insights in antibiotic resistance of Lactobacillus species from fermented foods. Food Res Int 78:465\u2013481. https:\/\/doi.org\/10.1016\/j.foodres.2015.09.016","journal-title":"Food Res Int"},{"issue":"20","key":"10699_CR2","doi-asserted-by":"publisher","first-page":"3866","DOI":"10.1039\/C6LC00984K","volume":"16","author":"CD Ahrberg","year":"2016","unstructured":"Ahrberg CD, Manz A, Chung BG (2016) Polymerase chain reaction in microfluidic devices. Lab Chip 16(20):3866\u20133884. https:\/\/doi.org\/10.1039\/C6LC00984K","journal-title":"Lab Chip"},{"issue":"6","key":"10699_CR3","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.fm.2006.11.001","volume":"24","author":"MS Ammor","year":"2007","unstructured":"Ammor MS, Bel\u00e9n Fl\u00f3rez A, Mayo B (2007) Antibiotic resistance in non-enterococcal lactic acid bacteria and bifidobacteria. Food Microbiol 24(6):559\u2013570. https:\/\/doi.org\/10.1016\/j.fm.2006.11.001","journal-title":"Food Microbiol"},{"issue":"2","key":"10699_CR4","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.ijfoodmicro.2008.09.021","volume":"128","author":"C Devirgiliis","year":"2008","unstructured":"Devirgiliis C, Caravelli A, Coppola D, Barile S, Perozzi G (2008) Antibiotic resistance and microbial composition along the manufacturing process of Mozzarella di Bufala Campana. Int J Food Microbiol 128(2):378\u2013384. https:\/\/doi.org\/10.1016\/j.ijfoodmicro.2008.09.021","journal-title":"Int J Food Microbiol"},{"key":"10699_CR5","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3389\/fmicb.2013.00301","volume":"4","author":"C Devirgiliis","year":"2013","unstructured":"Devirgiliis C, Zinno P, Perozzi G (2013) Update on antibiotic resistance in foodborne Lactobacillus and Lactococcus species. Front Microbiol 4:301\u2013301. https:\/\/doi.org\/10.3389\/fmicb.2013.00301","journal-title":"Front Microbiol"},{"issue":"1","key":"10699_CR6","first-page":"53","volume":"19","author":"Z Erginkaya","year":"2018","unstructured":"Erginkaya Z, Turhan EU, Tatl\u0131 D (2018) Determination of antibiotic resistance of lactic acid bacteria isolated from traditional Turkish fermented dairy products. Iran J Vet Res 19(1):53\u201356","journal-title":"Iran J Vet Res"},{"issue":"18","key":"10699_CR7","doi-asserted-by":"publisher","first-page":"3249","DOI":"10.1039\/C2LC40630F","volume":"12","author":"AM Foudeh","year":"2012","unstructured":"Foudeh AM, Fatanat Didar T, Veres T, Tabrizian M (2012) Microfluidic designs and techniques using lab-on-a-chip devices for pathogen detection for point-of-care diagnostics. Lab Chip 12(18):3249\u20133266. https:\/\/doi.org\/10.1039\/C2LC40630F","journal-title":"Lab Chip"},{"issue":"12","key":"10699_CR8","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1039\/C2LC21247A","volume":"12","author":"A Gansen","year":"2012","unstructured":"Gansen A, Herrick AM, Dimov IK, Lee LP, Chiu DT (2012) Digital LAMP in a sample self-digitization (SD) chip. Lab Chip 12(12):2247\u20132254. https:\/\/doi.org\/10.1039\/C2LC21247A","journal-title":"Lab Chip"},{"issue":"3","key":"10699_CR9","doi-asserted-by":"publisher","first-page":"167","DOI":"10.2144\/000113072","volume":"46","author":"M Goto","year":"2009","unstructured":"Goto M, Honda E, Ogura A, Nomoto A, Hanaki K-I (2009) Colorimetric detection of loop-mediated isothermal amplification reaction by using hydroxy naphthol blue. BioTechniques 46(3):167\u2013172. https:\/\/doi.org\/10.2144\/000113072","journal-title":"BioTechniques"},{"key":"10699_CR10","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3389\/fmicb.2013.00202","volume":"4","author":"M Gueimonde","year":"2013","unstructured":"Gueimonde M, S\u00e1nchez B, G de Los Reyes-Gavil\u00e1n C, Margolles A (2013) Antibiotic resistance in probiotic bacteria. Front Microbiol 4:202\u2013202. https:\/\/doi.org\/10.3389\/fmicb.2013.00202","journal-title":"Front Microbiol"},{"issue":"3","key":"10699_CR11","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1111\/1750-3841.13645","volume":"82","author":"H Guo","year":"2017","unstructured":"Guo H, Pan L, Li L, Lu J, Kwok L, Menghe B, Zhang H, Zhang W (2017) Characterization of antibiotic resistance genes from Lactobacillus isolated from traditional dairy products. J Food Sci 82(3):724\u2013730. https:\/\/doi.org\/10.1111\/1750-3841.13645","journal-title":"J Food Sci"},{"issue":"7","key":"10699_CR12","doi-asserted-by":"publisher","first-page":"4166","DOI":"10.1007\/s13197-014-1459-7","volume":"52","author":"UK Hanapi","year":"2015","unstructured":"Hanapi UK, Desa MNM, Ismail A, Mustafa S (2015) A higher sensitivity and efficiency of common primer multiplex PCR assay in identification of meat origin using NADH dehydrogenase subunit 4 gene. J Food Sci Technol 52(7):4166\u20134175. https:\/\/doi.org\/10.1007\/s13197-014-1459-7","journal-title":"J Food Sci Technol"},{"key":"10699_CR13","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.envint.2018.02.003","volume":"114","author":"N Hanna","year":"2018","unstructured":"Hanna N, Sun P, Sun Q, Li X, Yang X, Ji X, Zou H, Ottoson J, Nilsson LE, Berglund B, Dyar OJ, Tamhankar AJ, St\u00e5lsby Lundborg C (2018) Presence of antibiotic residues in various environmental compartments of Shandong province in eastern China: its potential for resistance development and ecological and human risk. Environ Int 114:131\u2013142. https:\/\/doi.org\/10.1016\/j.envint.2018.02.003","journal-title":"Environ Int"},{"issue":"3","key":"10699_CR14","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1007\/s00253-015-7184-y","volume":"100","author":"G Jaimee","year":"2016","unstructured":"Jaimee G, Halami PM (2016) Emerging resistance to aminoglycosides in lactic acid bacteria of food origin\u2014an impending menace. Appl Microbiol Biotechnol 100(3):1137\u20131151. https:\/\/doi.org\/10.1007\/s00253-015-7184-y","journal-title":"Appl Microbiol Biotechnol"},{"issue":"3","key":"10699_CR15","doi-asserted-by":"publisher","first-page":"556","DOI":"10.4103\/0377-4929.85092","volume":"54","author":"N Joseph","year":"2011","unstructured":"Joseph N, Sistla S, Dutta T, Badhe A, Rasitha D, Parija S (2011) Reliability of Kirby-Bauer disk diffusion method for detecting meropenem resistance among non-fermenting gram-negative bacilli. Indian J Pathol Microbiol 54(3):556\u2013560. https:\/\/doi.org\/10.4103\/0377-4929.85092","journal-title":"Indian J Pathol Microbiol"},{"issue":"10","key":"10699_CR16","doi-asserted-by":"publisher","first-page":"4707","DOI":"10.1128\/AAC.00112-11","volume":"55","author":"AE Markelz","year":"2011","unstructured":"Markelz AE, Mende K, Murray CK, Yu X, Zera WC, Hospenthal DR, Beckius ML, Calvano T, Akers KS (2011) Carbapenem susceptibility testing errors using three automated systems, disk diffusion, Etest, and broth microdilution and carbapenem resistance genes in isolates of Acinetobacter baumannii-calcoaceticus complex. Antimicrob Agents Chemother 55(10):4707\u20134711. https:\/\/doi.org\/10.1128\/AAC.00112-11","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"10699_CR17","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.ijfoodmicro.2005.03.008","volume":"105","author":"S Mathur","year":"2005","unstructured":"Mathur S, Singh R (2005) Antibiotic resistance in food lactic acid bacteria\u2014a review. Int J Food Microbiol 105(3):281\u2013295. https:\/\/doi.org\/10.1016\/j.ijfoodmicro.2005.03.008","journal-title":"Int J Food Microbiol"},{"issue":"3","key":"10699_CR18","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1093\/jac\/dkw511","volume":"72","author":"RA Moran","year":"2016","unstructured":"Moran RA, Anantham S, Holt KE, Hall RM (2016) Prediction of antibiotic resistance from antibiotic resistance genes detected in antibiotic-resistant commensal Escherichia coli using PCR or WGS. J Antimicrob Chemother 72(3):700\u2013704. https:\/\/doi.org\/10.1093\/jac\/dkw511","journal-title":"J Antimicrob Chemother"},{"issue":"9","key":"10699_CR19","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.1021\/ac071903e","volume":"79","author":"R Mukhopadhyay","year":"2007","unstructured":"Mukhopadhyay R (2007) When PDMS isn\u2019t the best. Anal Chem 79(9):3248\u20133253. https:\/\/doi.org\/10.1021\/ac071903e","journal-title":"Anal Chem"},{"key":"10699_CR20","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/s41429-019-0218-4","volume":"72","author":"M Noda","year":"2019","unstructured":"Noda M, Danshiitsoodol N, Inoue Y, Okamoto T, Sultana N, Sugiyama M (2019) Antibiotic susceptibility of plant-derived lactic acid bacteria conferring health benefits to human. J Antibiot 72:834\u2013842. https:\/\/doi.org\/10.1038\/s41429-019-0218-4","journal-title":"J Antibiot"},{"issue":"1","key":"10699_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12275-015-4656-9","volume":"53","author":"T Notomi","year":"2015","unstructured":"Notomi T, Mori Y, Tomita N, Kanda H (2015) Loop-mediated isothermal amplification (LAMP): principle, features, and future prospects. J Microbiol 53(1):1\u20135. https:\/\/doi.org\/10.1007\/s12275-015-4656-9","journal-title":"J Microbiol"},{"issue":"12","key":"10699_CR22","doi-asserted-by":"publisher","first-page":"E63","DOI":"10.1093\/nar\/28.12.e63","volume":"28","author":"T Notomi","year":"2000","unstructured":"Notomi T, Okayama H, Masubuchi H, Yonekawa T, Watanabe K, Amino N, Hase T (2000) Loop-mediated isothermal amplification of DNA. Nucleic Acids Res 28(12):E63\u2013E63","journal-title":"Nucleic Acids Res"},{"key":"10699_CR23","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.bios.2015.08.052","volume":"75","author":"J Oh Seung","year":"2016","unstructured":"Oh Seung J, Park Byung H, Jung Jae H, Choi G, Lee DC, Kim DH, Seo Tae S (2016) Centrifugal loop-mediated isothermal amplification microdevice for rapid, multiplex and colorimetric foodborne pathogen detection. Biosens Bioelectron 75:293\u2013300. https:\/\/doi.org\/10.1016\/j.bios.2015.08.052","journal-title":"Biosens Bioelectron"},{"issue":"8","key":"10699_CR24","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1016\/j.foodcont.2011.02.006","volume":"22","author":"L Pan","year":"2011","unstructured":"Pan L, Hu X, Wang X (2011) Assessment of antibiotic resistance of lactic acid bacteria in Chinese fermented foods. Food Control 22(8):1316\u20131321. https:\/\/doi.org\/10.1016\/j.foodcont.2011.02.006","journal-title":"Food Control"},{"issue":"51","key":"10699_CR25","doi-asserted-by":"publisher","first-page":"11312","DOI":"10.1021\/acs.jafc.7b03655","volume":"65","author":"B Pang","year":"2017","unstructured":"Pang B, Ding X, Wang G, Zhao C, Xu Y, Fu K, Sun J, Song X, Wu W, Liu Y, Song Q, Hu J, Li J, Mu Y (2017) Rapid and quantitative detection of Vibrio parahemolyticus by the mixed-dye-based loop-mediated isothermal amplification assay on a self-priming compartmentalization microfluidic chip. J Agric Food Chem 65(51):11312\u201311319. https:\/\/doi.org\/10.1021\/acs.jafc.7b03655","journal-title":"J Agric Food Chem"},{"issue":"1","key":"10699_CR26","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1039\/C7LC00993C","volume":"18","author":"Y Qiao","year":"2018","unstructured":"Qiao Y, Zhao X, Zhu J, Tu R, Dong L, Wang L, Dong Z, Wang Q, Du W (2018) Fluorescence-activated droplet sorting of lipolytic microorganisms using a compact optical system. Lab Chip 18(1):190\u2013196. https:\/\/doi.org\/10.1039\/C7LC00993C","journal-title":"Lab Chip"},{"issue":"20","key":"10699_CR27","doi-asserted-by":"publisher","first-page":"8162","DOI":"10.1073\/pnas.1100356108","volume":"108","author":"K Ren","year":"2011","unstructured":"Ren K, Dai W, Zhou J, Su J, Wu H (2011) Whole-Teflon microfluidic chips. Proc Natl Acad Sci U S A 108(20):8162\u20138166. https:\/\/doi.org\/10.1073\/pnas.1100356108","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10699_CR28","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00216-002-1683-2","volume":"375","author":"R Schoske","year":"2003","unstructured":"Schoske R, Vallone PM, Ruitberg CM, Butler JM (2003) Multiplex PCR design strategy used for the simultaneous amplification of 10 Y chromosome short tandem repeat (STR) loci. Anal Bioanal Chem 375(3):333\u2013343. https:\/\/doi.org\/10.1007\/s00216-002-1683-2","journal-title":"Anal Bioanal Chem"},{"issue":"16","key":"10699_CR29","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1039\/C8LC00424B","volume":"18","author":"TND Trinh","year":"2018","unstructured":"Trinh TND, Lee NY (2018) A rapid and eco-friendly isothermal amplification microdevice for multiplex detection of foodborne pathogens. Lab Chip 18(16):2369\u20132377. https:\/\/doi.org\/10.1039\/C8LC00424B","journal-title":"Lab Chip"},{"issue":"9","key":"10699_CR30","doi-asserted-by":"publisher","first-page":"4775","DOI":"10.3168\/jds.2011-5271","volume":"95","author":"N Zhou","year":"2012","unstructured":"Zhou N, Zhang JX, Fan MT, Wang J, Guo G, Wei XY (2012) Antibiotic resistance of lactic acid bacteria isolated from Chinese yogurts. J Dairy Sci 95(9):4775\u20134783. https:\/\/doi.org\/10.3168\/jds.2011-5271","journal-title":"J Dairy Sci"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-020-10699-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00253-020-10699-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-020-10699-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:02:42Z","timestamp":1622592162000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00253-020-10699-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,2]]},"references-count":30,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10699"],"URL":"https:\/\/doi.org\/10.1007\/s00253-020-10699-5","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,2]]},"assertion":[{"value":"17 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}