{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T07:32:47Z","timestamp":1770535967442,"version":"3.49.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"18","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s00253-020-10805-7","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T06:02:27Z","timestamp":1596520947000},"page":"7979-7989","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Optimization of medium composition and fermentation conditions for \u03b1-ketoglutaric acid production from biodiesel waste by Yarrowia lipolytica"],"prefix":"10.1007","volume":"104","author":[{"given":"Svetlana V.","family":"Kamzolova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5051-2958","authenticated-orcid":false,"given":"Igor G.","family":"Morgunov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,4]]},"reference":[{"key":"10805_CR1","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/978-94-007-5055-5_19","volume-title":"Reprogramming microbial metabolic pathways. Subcellular biochemistry","author":"A Aurich","year":"2012","unstructured":"Aurich A, Specht R, M\u00fcller RA, Stottmeister U, Yovkova V, Otto C, Holz M, Barth G, Heretsch P, Thomas FA, Sicker D, Giannis A (2012) Microbiologically produced carboxylic acids used as building blocks in organic synthesis. In: Wang X, Chen J, Quinn P (eds) Reprogramming microbial metabolic pathways. Subcellular biochemistry, vol 64. Springer, Dordrecht, pp 391\u2013423"},{"key":"10805_CR2","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/elsc.200900027","volume":"9","author":"W Babel","year":"2009","unstructured":"Babel W (2009) The auxiliary substrate concept: from simple considerations to heuristically valuable knowledge. Eng Life Sci 9:285\u2013290. https:\/\/doi.org\/10.1002\/elsc.200900027","journal-title":"Eng Life Sci"},{"key":"10805_CR3","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1128\/JB.48.4.385-391.1944","volume":"48","author":"P Burkholder","year":"1944","unstructured":"Burkholder P, McVeigh J, Moyer D (1944) Studies on some growth factors of yeasts. J Bacteriol 48:385\u2013391","journal-title":"J Bacteriol"},{"key":"10805_CR4","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.energy.2010.11.040","volume":"36","author":"A Chatzifragkou","year":"2011","unstructured":"Chatzifragkou A, Makri A, Belka A, Bellou S, Mavrou M, Mastoridou M, Mystrioti P, Onjaro G, Aggelis G, Papanikolaou S (2011) Biotechnological conversion of biodiesel derived waste glycerol by yeast and fungal species. Energy 36:1097\u20131108. https:\/\/doi.org\/10.1016\/j.energy.2010.11.040","journal-title":"Energy"},{"key":"10805_CR5","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.indcrop.2018.04.014","volume":"119","author":"K Cybulski","year":"2018","unstructured":"Cybulski K, Tomaszewska-Hetman L, Rakicka M, Laba W, Rymowicz W, Rywinska A (2018) The bioconversion of waste products from rapeseed processing into keto acids by Yarrowia lipolytica. Ind Crop Prod 119:102\u2013110. https:\/\/doi.org\/10.1016\/j.indcrop.2018.04.014","journal-title":"Ind Crop Prod"},{"key":"10805_CR6","unstructured":"Debabov VG (2008) Biofuel. Biotechnology in Russia 1:1\u201319. (in Russian)"},{"key":"10805_CR7","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1002\/ejlt.201300358","volume":"116","author":"EG Dedyukhina","year":"2014","unstructured":"Dedyukhina EG, Chistyakova TI, Mironov AA, Kamzolova SV, Morgunov IG, Vainshtein MB (2014) Arachidonic acid synthesis from biodiesel-derived waste by Mortierella alpina. Eur J Lipid Sci Technol 116:429\u2013437. https:\/\/doi.org\/10.1002\/ejlt.201300358","journal-title":"Eur J Lipid Sci Technol"},{"key":"10805_CR8","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3390\/microorganisms7080229","volume":"7","author":"DTH Do","year":"2019","unstructured":"Do DTH, Theron CW, Fickers P (2019) Organic wastes as feedstocks for non-conventional yeast-based bioprocesses. Microorganisms 7:229. https:\/\/doi.org\/10.3390\/microorganisms7080229","journal-title":"Microorganisms"},{"issue":"6","key":"10805_CR9","first-page":"817","volume":"15","author":"LP Dudina","year":"1979","unstructured":"Dudina LP, Eroshin VK (1979) Identification of the limiting component of the medium during microbial continuous cultivation. Prikl Biokhim Mikrobiol 15(6):817\u2013821 (in Russian)","journal-title":"Prikl Biokhim Mikrobiol"},{"key":"10805_CR10","first-page":"533","volume":"57","author":"IT Ermakova","year":"1987","unstructured":"Ermakova IT, Morgunov IG (1987) Pathways of glycerol metabolism in Yarrowia (Candida) lipolytica yeasts. Mikrobiologiya 57:533\u2013537","journal-title":"Mikrobiologiya"},{"key":"10805_CR11","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1007\/BF00257036","volume":"23","author":"IT Ermakova","year":"1986","unstructured":"Ermakova IT, Shishkanova NV, Melnikova OF, Finogenova TV (1986) Properties of Candida lipolytica mutants with the modified glyoxylate cycle and their ability to produce citric and isocitric acid. I. Physiological, biochemical and cytological characteristics of mutants grown on glucose or hexadecane. Appl Microbiol Biotechnol 23:372\u2013377. https:\/\/doi.org\/10.1007\/BF00257036","journal-title":"Appl Microbiol Biotechnol"},{"issue":"6\u20137","key":"10805_CR12","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.femsyr.2004.09.004","volume":"5","author":"P Fickers","year":"2005","unstructured":"Fickers P, Benetti P-H, Wach\u00e9 Y, Marty A, Mauersberger S, Smit MS, Nicaud J-M (2005) Hydrophobic substrate utilisation by the yeast Yarrowia lipolytica, and its potential applications. FEMS Yeast Res 5(6\u20137):527\u2013543. https:\/\/doi.org\/10.1016\/j.femsyr.2004.09.004","journal-title":"FEMS Yeast Res"},{"issue":"4","key":"10805_CR13","doi-asserted-by":"publisher","first-page":"574","DOI":"10.3390\/microorganisms8040574","volume":"8","author":"P Fickers","year":"2020","unstructured":"Fickers P, Cheng H, Sze Ki Lin C (2020) Sugar alcohols and organic acids synthesis in Yarrowia lipolytica: where are we? Microorganisms 8(4):574. https:\/\/doi.org\/10.3390\/microorganisms8040574","journal-title":"Microorganisms"},{"key":"10805_CR14","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1007\/s10438-005-0076-7","volume":"41","author":"TV Finogenova","year":"2005","unstructured":"Finogenova TV, Morgunov IG, Kamzolova SV, Chernyavskaya OG (2005) Organic acid production by the yeast Yarrowia lipolytica: a review of prospects. Appl Biochem Microbiol 41:418\u2013425. https:\/\/doi.org\/10.1007\/s10438-005-0076-7","journal-title":"Appl Biochem Microbiol"},{"issue":"6","key":"10805_CR15","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1111\/1567-1364.12176","volume":"14","author":"M Gatter","year":"2014","unstructured":"Gatter M, F\u00f6rster A, B\u00e4r K, Winter M, Otto C, Petzsch P, Je\u017ekov\u00e1 M, Bahr K, Pfeiffer M, Matth\u00e4us F, Barth G (2014) A newly identified fatty alcohol oxidase gene is mainly responsible for the oxidation of long-chain \u03c9-hydroxy fatty acids in Yarrowia lipolytica. FEMS Yeast Res 14(6):858\u2013872. https:\/\/doi.org\/10.1111\/1567-1364.12176","journal-title":"FEMS Yeast Res"},{"issue":"3","key":"10805_CR16","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3109\/1040841X.2013.770386","volume":"40","author":"M Groenewald","year":"2014","unstructured":"Groenewald M, Boekhout T, Neuv\u00e9glise C, Gaillardin C, van Dijck PV, Wyss M (2014) Yarrowia lipolytica: safety assessment of an oleaginous yeast with a great industrial potential. Crit Rev Microbiol 40(3):187\u2013206. https:\/\/doi.org\/10.3109\/1040841X.2013.770386","journal-title":"Crit Rev Microbiol"},{"key":"10805_CR17","doi-asserted-by":"publisher","first-page":"7003","DOI":"10.1007\/s00253-014-5745-0","volume":"98","author":"H Guo","year":"2014","unstructured":"Guo H, Madzak C, Du G, Zhou J, Chen J (2014) Effects of pyruvate dehydrogenase subunits overexpression on the \u03b1-ketoglutarate production in Yarrowia lipolytica WSH-Z06. Appl Microbiol Biotechnol 98:7003\u20137012. https:\/\/doi.org\/10.1007\/s00253-014-5745-0","journal-title":"Appl Microbiol Biotechnol"},{"key":"10805_CR18","doi-asserted-by":"publisher","first-page":"8138","DOI":"10.1038\/srep08138","volume":"5","author":"H Guo","year":"2015","unstructured":"Guo H, Liu P, Madzak C, Du G, Zhou J, Chen J (2015) Identification and application of keto acids transporters in Yarrowia Lipolytica. Sci Rep 5:8138. https:\/\/doi.org\/10.1038\/srep08138","journal-title":"Sci Rep"},{"key":"10805_CR19","doi-asserted-by":"publisher","first-page":"9875","DOI":"10.1007\/s00253-016-7913-x","volume":"100","author":"H Guo","year":"2016","unstructured":"Guo H, Su S, Madzak C, Zhou J, Chen H, Chen G (2016) Applying pathway engineering to enhance production of alpha-ketoglutarate in Yarrowia lipolytica. Appl Microbiol Biotechnol 100:9875\u20139884. https:\/\/doi.org\/10.1007\/s00253-016-7913-x","journal-title":"Appl Microbiol Biotechnol"},{"key":"10805_CR20","doi-asserted-by":"publisher","first-page":"5517","DOI":"10.1007\/s00253-013-4772-6","volume":"97","author":"SV Kamzolova","year":"2013","unstructured":"Kamzolova SV, Morgunov IG (2013) \u03b1-Ketoglutaric acid production from rapeseed oil by Yarrowia lipolytica yeast. Appl Microbiol Biotechnol 97:5517\u20135525. https:\/\/doi.org\/10.1007\/s00253-013-4772-6","journal-title":"Appl Microbiol Biotechnol"},{"key":"10805_CR21","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s00253-012-4222-x","volume":"96","author":"SV Kamzolova","year":"2012","unstructured":"Kamzolova SV, Chiglintseva MN, Lunina JN, Morgunov IG (2012) \u03b1-Ketoglutaric acid production by Yarrowia lipolytica and its regulation. Appl Microbiol Biotechnol 96:783\u2013791. https:\/\/doi.org\/10.1007\/s00253-012-4222-x","journal-title":"Appl Microbiol Biotechnol"},{"key":"10805_CR22","first-page":"144","volume-title":"Atomno-absorbcionnyj analiz [Atomic Absorption Analysis]","author":"I Khavezov","year":"1983","unstructured":"Khavezov I, Tsalev D (1983) Atomno-absorbcionnyj analiz [Atomic Absorption Analysis]. In: Khavezov I, Tsalev D (eds) . Khimia, Leningrad, p 144 (in Russian)"},{"key":"10805_CR23","doi-asserted-by":"publisher","first-page":"122155","DOI":"10.1016\/j.biortech.2019.122155","volume":"293","author":"LR Kumar","year":"2019","unstructured":"Kumar LR, Yellapu SK, Tyagi RD, Zhang X (2019) A review on variation in crude glycerol composition, bio-valorization of crude and purified glycerol as carbon source for lipid production. Bioresour Technol 293:122155. https:\/\/doi.org\/10.1016\/j.biortech.2019.122155","journal-title":"Bioresour Technol"},{"key":"10805_CR24","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.biortech.2017.06.074","volume":"243","author":"S Magdouli","year":"2017","unstructured":"Magdouli S, Guedri T, Tarek R, Brar SK, Blais JF (2017) Valorization of raw glycerol and crustacean waste into value added products by Yarrowia lipolytica. Bioresour Technol 243:57\u201368. https:\/\/doi.org\/10.1016\/j.biortech.2017.06.074","journal-title":"Bioresour Technol"},{"issue":"7","key":"10805_CR25","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1016\/j.biortech.2009.11.024","volume":"101","author":"A Makri","year":"2010","unstructured":"Makri A, Fakas S, Aggelis G (2010) Metabolic activities of biotechnological interest in Yarrowia lipolytica grown on glycerol in repeated batch cultures. Bioresour Technol 101(7):2351\u20132358. https:\/\/doi.org\/10.1016\/j.biortech.2009.11.024","journal-title":"Bioresour Technol"},{"issue":"1","key":"10805_CR26","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s13068-016-0593-z","volume":"9","author":"AM Miro\u0144czuk","year":"2016","unstructured":"Miro\u0144czuk AM, Rzechonek DA, Biegalska A, Rakicka M, Dobrowolski A (2016) A novel strain of Yarrowia lipolytica as a platform for value-added product synthesis from glycerol. Biotechnol Biofuels 9(1):180. https:\/\/doi.org\/10.1186\/s13068-016-0593-z","journal-title":"Biotechnol Biofuels"},{"key":"10805_CR27","unstructured":"Morgunov IG (2009) Metabolic organization of oxidative pathways of Yarrowia lipolytica yeast \u2013 producers of organic acids. Dissertation, Russian Academy of Sciences, Institute of Biochemistry and Physiology of Microorganisms. (in Russian)"},{"issue":"15","key":"10805_CR28","doi-asserted-by":"publisher","first-page":"6443","DOI":"10.1007\/s00253-015-6558-5","volume":"99","author":"IG Morgunov","year":"2015","unstructured":"Morgunov IG, Kamzolova SV (2015) Physiologo-biochemical characteristics of citrate-producing yeast Yarrowia lipolytica grown on glycerol-containing waste of biodiesel industry. Appl Microbiol Biotechnol 99(15):6443\u20136450. https:\/\/doi.org\/10.1007\/s00253-015-6558-5","journal-title":"Appl Microbiol Biotechnol"},{"key":"10805_CR29","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/S0032-9592(03)00259-0","volume":"39","author":"IG Morgunov","year":"2004","unstructured":"Morgunov IG, Kamzolova SV, Perevoznikova OA, Shishkanova NV, Finogenova TV (2004) Pyruvic acid production by a thiamine auxotroph of Yarrowia lipolytica. Process Biochem 39:1469\u20131474. https:\/\/doi.org\/10.1016\/S0032-9592(03)00259-0","journal-title":"Process Biochem"},{"key":"10805_CR30","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s00253-011-3597-4","volume":"92","author":"C Otto","year":"2011","unstructured":"Otto C, Yovkova V, Barth G (2011) Overproduction and secretion of \u03b1-ketoglutaric acid by microorganisms. Appl Microbiol Biotechnol 92:689\u2013695. https:\/\/doi.org\/10.1007\/s00253-011-3597-4","journal-title":"Appl Microbiol Biotechnol"},{"key":"10805_CR31","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s00253-012-4085-1","volume":"95","author":"C Otto","year":"2012","unstructured":"Otto C, Yovkova V, Aurich A, Mauersberger S, Barth G (2012) Variation of the by-product spectrum during \u03b1-ketoglutaric acid production from raw glycerol by overexpression of fumarase and pyruvate carboxylase genes in Yarrowia lipolytica. Appl Microbiol Biotechnol 95:905\u2013917. https:\/\/doi.org\/10.1007\/s00253-012-4085-1","journal-title":"Appl Microbiol Biotechnol"},{"key":"10805_CR32","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/978-3-642-38583-4_5","volume-title":"Yarrowia lipolytica. Microbiology monographs","author":"C Otto","year":"2013","unstructured":"Otto C, Holz M, Barth G (2013) Production of organic acids by Yarrowia lipolytica. In: Barth G (ed) Yarrowia lipolytica. Microbiology monographs, vol 25. Springer, Berlin, Heidelberg, pp 137\u2013151. https:\/\/doi.org\/10.1007\/978-3-642-38583-4_5"},{"key":"10805_CR33","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1007\/s00284-002-3833-3","volume":"46","author":"S Papanikolaou","year":"2003","unstructured":"Papanikolaou S, Muniglia L, Chevalot I, Aggelis G, Marc I, Papanikolaou S, Muniglia L, Chevalot I, Aggelis G, Marc I (2003) Accumulation of a cocoa-butter-like lipid by Yarrowia lipolytica cultivated on agro-industrial residues. Curr Microbiol 46:124\u2013130. https:\/\/doi.org\/10.1007\/s00284-002-3833-3","journal-title":"Curr Microbiol"},{"key":"10805_CR34","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1002\/elsc.201500191","volume":"17","author":"S Papanikolaou","year":"2017","unstructured":"Papanikolaou S, Rontou M, Belka A, Athenaki M, Gardeli C, Mallouchos A, Kalantzi O, Koutinas AA, Kookos IK, Zeng A-P, Aggelis G (2017) Conversion of biodiesel-derived glycerol into biotechnological products of industrial significance by yeast and fungal strains. Eng Life Sci 17:262\u2013281. https:\/\/doi.org\/10.1002\/elsc.201500191","journal-title":"Eng Life Sci"},{"key":"10805_CR35","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.biombioe.2012.11.021","volume":"48","author":"A Rywi\u0144ska","year":"2013","unstructured":"Rywi\u0144ska A, Juszczyk P, Wojtatowicz M, Robak M, Lazar Z, Tomaszewska L, Rymowicz W (2013) Glycerol as a promising substrate for Yarrowia lipolytica biotechnological applications. Biomass Bioenergy 48:148\u2013166. https:\/\/doi.org\/10.1016\/j.biombioe.2012.11.021","journal-title":"Biomass Bioenergy"},{"issue":"1","key":"10805_CR36","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12934-017-0690-0","volume":"16","author":"W Sabra","year":"2017","unstructured":"Sabra W, Bommareddy RR, Maheshwari G, Papanikolaou S, Zeng AP (2017) Substrates and oxygen dependent citric acid production by Yarrowia lipolytica: insights through transcriptome and fluxome analyses. Microb Cell Factories 16(1):78. https:\/\/doi.org\/10.1186\/s12934-017-0690-0","journal-title":"Microb Cell Factories"},{"issue":"3","key":"10805_CR37","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1134\/S0003683815030151","volume":"51","author":"VY Sekova","year":"2015","unstructured":"Sekova VY, Isakova EP, Deryabina YI (2015) Biotechnological applications of the extremophilic yeast Yarrowia lipolytica (review). Prikl Biokhim Mikrobiol 51(3):290\u2013304 (in Russian). https:\/\/doi.org\/10.1134\/S0003683815030151","journal-title":"Prikl Biokhim Mikrobiol"},{"key":"10805_CR38","doi-asserted-by":"publisher","unstructured":"Shabbir Hussain M, Wheeldon I, Blenner MA (2017) A strong hybrid fatty acid inducible transcriptional sensor built from Yarrowia lipolytica upstream activating and regulatory sequences. Biotechnol J 12(10). https:\/\/doi.org\/10.1002\/biot.201700248","DOI":"10.1002\/biot.201700248"},{"key":"10805_CR39","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.biortech.2016.08.015","volume":"219","author":"Y Song","year":"2016","unstructured":"Song Y, Li J, Shin HD, Liu L, Du G, Chen J (2016) Biotechnological production of alpha-keto acids: current status and perspectives. Bioresour Technol 219:716\u2013724. https:\/\/doi.org\/10.1016\/j.biortech.2016.08.015","journal-title":"Bioresour Technol"},{"key":"10805_CR40","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s10295-005-0254-x","volume":"32","author":"U Stottmeister","year":"2005","unstructured":"Stottmeister U, Aurich A, Wilde H, Andersch J, Schmidt S, Sicker D (2005) White biotechnology for Green chemistry: fermentative 2-oxocarboxylic acids as novel building blocks for subsequent chemical syntheses. J Ind Microbiol Biotechnol 32:651\u2013664. https:\/\/doi.org\/10.1007\/s10295-005-0254-x","journal-title":"J Ind Microbiol Biotechnol"},{"issue":"12","key":"10805_CR41","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1128\/EC.00172-10","volume":"9","author":"K Strijbis","year":"2010","unstructured":"Strijbis K, Distel B (2010) Intracellular acetyl unit transport in fungal carbon metabolism. Eukaryot Cell 9(12):1809\u20131815. https:\/\/doi.org\/10.1128\/EC.00172-10","journal-title":"Eukaryot Cell"},{"key":"10805_CR42","doi-asserted-by":"publisher","first-page":"261","DOI":"10.13031\/2013.20272","volume":"22","author":"JC Thompson","year":"2006","unstructured":"Thompson JC, He BB (2006) Characterization of crude glycerol from biodiesel production from multiple feedstocks. Appl Eng Agric 22:261\u2013265. https:\/\/doi.org\/10.13031\/2013.20272","journal-title":"Appl Eng Agric"},{"key":"10805_CR43","doi-asserted-by":"publisher","first-page":"3069","DOI":"10.1007\/s12010-014-0745-1","volume":"172","author":"L Tomaszewska","year":"2014","unstructured":"Tomaszewska L, Rymowicz W, Rywinska A (2014) Mineral supplementation increases erythrose reductase activity in erythritol biosynthesis from glycerol by Yarrowia lipolytica. Appl Biochem Biotechnol 172:3069\u20133078. https:\/\/doi.org\/10.1007\/s12010-014-0745-1","journal-title":"Appl Biochem Biotechnol"},{"key":"10805_CR44","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.biortech.2017.05.056","volume":"239","author":"N Vivek","year":"2017","unstructured":"Vivek N, Sindhu R, Madhavan A, Anju AJ, Binod P (2017) Recent advances in the production of value added chemicals and lipids utilizing biodiesel industry generated crude glycerol as a substrate \u2013 metabolic aspects, challenges and possibilities: an overview. Bioresour Technol 239:507\u2013517. https:\/\/doi.org\/10.1016\/j.biortech.2017.05.056","journal-title":"Bioresour Technol"},{"issue":"1","key":"10805_CR45","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/2191-0855-3-58","volume":"3","author":"M Workman","year":"2013","unstructured":"Workman M, Holt P, Thykaer J (2013) Comparing cellular performance of Yarrowia lipolytica during growth on glucose and glycerol in submerged cultivations. AMB Express 3(1):58. https:\/\/doi.org\/10.1186\/2191-0855-3-58","journal-title":"AMB Express"},{"key":"10805_CR46","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1186\/2191-0855-3-58","volume":"96","author":"X Yin","year":"2012","unstructured":"Yin X, Madzak C, Du G, Zhou J, Chen J (2012) Enhanced alpha-ketoglutaric acid production in Yarrowia lipolytica WSH-Z06 by regulation of the pyruvate carboxylation pathway. Appl Microbiol Biotechnol 96:1527\u20131537. https:\/\/doi.org\/10.1186\/2191-0855-3-58","journal-title":"Appl Microbiol Biotechnol"},{"key":"10805_CR47","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1007\/s00253-013-5369-9","volume":"98","author":"V Yovkova","year":"2014","unstructured":"Yovkova V, Otto C, Aurich A, Mauersberger S, Barth G (2014) Engineering the \u03b1-ketoglutarate overproduction from raw glycerol by overexpression of the genes encoding NADP+-dependent isocitrate dehydrogenase and pyruvate carboxylase in Yarrowia lipolytica. Appl Microbiol Biotechnol 98:2003\u20132013. https:\/\/doi.org\/10.1007\/s00253-013-5369-9","journal-title":"Appl Microbiol Biotechnol"},{"key":"10805_CR48","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.biortech.2012.03.021","volume":"114","author":"Z Yu","year":"2012","unstructured":"Yu Z, Du G, Zhou J, Chen J (2012) Enhanced \u03b1-ketoglutaric acid production in Yarrowia lipolytica WSH-Z06 by an improved integrated fed-batch strategy. Bioresour Technol 114:597\u2013602. https:\/\/doi.org\/10.1016\/j.biortech.2012.03.021","journal-title":"Bioresour Technol"},{"key":"10805_CR49","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.biortech.2017.07.063","volume":"243","author":"W Zeng","year":"2017","unstructured":"Zeng W, Zhang H, Xu S, Fang F, Zhou J (2017) Biosynthesis of keto acids by fed-batch culture of Yarrowia lipolytica WSH-Z06. Bioresour Technol 243:1037\u20131043. https:\/\/doi.org\/10.1016\/j.biortech.2017.07.063","journal-title":"Bioresour Technol"},{"key":"10805_CR50","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/j.1472-765X.2010.02889.x","volume":"51","author":"J Zhou","year":"2010","unstructured":"Zhou J, Zhou H, Du G, Liu L, Chen J (2010) Screening of a thiamine-auxotrophic yeast for alpha-ketoglutaric acid overproduction. Lett Appl Microbiol 51:264\u2013271. https:\/\/doi.org\/10.1111\/j.1472-765X.2010.02889.x","journal-title":"Lett Appl Microbiol"},{"key":"10805_CR51","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.jbiotec.2012.05.025","volume":"161","author":"J Zhou","year":"2012","unstructured":"Zhou J, Yin X, Madzak C, Du G, Chen J (2012) Enhanced \u03b1-ketoglutarate production in Yarrowia lipolytica WSH-Z06 by alteration of the acetyl-CoA metabolism. J Biotechnol 161:257\u2013264. https:\/\/doi.org\/10.1016\/j.jbiotec.2012.05.025","journal-title":"J Biotechnol"},{"key":"10805_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.foodchem.2013.11.117","volume":"152","author":"SS Zinjarde","year":"2014","unstructured":"Zinjarde SS (2014) Food-related applications of Yarrowia lipolytica. Food Chem 152:1\u201310. https:\/\/doi.org\/10.1016\/j.foodchem.2013.11.117","journal-title":"Food Chem"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-020-10805-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00253-020-10805-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-020-10805-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T23:17:19Z","timestamp":1628032639000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00253-020-10805-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,4]]},"references-count":52,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10805"],"URL":"https:\/\/doi.org\/10.1007\/s00253-020-10805-7","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,4]]},"assertion":[{"value":"19 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This review does not include any researches with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}