{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T18:18:29Z","timestamp":1776017909734,"version":"3.50.1"},"reference-count":113,"publisher":"Springer Science and Business Media LLC","issue":"20","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s00253-021-11546-x","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T09:02:59Z","timestamp":1632214979000},"page":"7785-7799","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Escherichia coli Nissle 1917 secondary metabolism: aryl polyene biosynthesis and phosphopantetheinyl transferase crosstalk"],"prefix":"10.1007","volume":"105","author":[{"given":"Courtney V.","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brianna G.","family":"Jarboe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haley M.","family":"Majer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy T.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7070-663X","authenticated-orcid":false,"given":"Joris","family":"Beld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"issue":"9963","key":"11546_CR1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0140-6736(14)61682-2","volume":"385","author":"I Abubakar","year":"2015","unstructured":"Abubakar I, Tillmann T, Banerjee A (2015) Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 385(9963):117\u2013171","journal-title":"Lancet"},{"issue":"1","key":"11546_CR2","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0040-4020(01)97645-8","volume":"39","author":"H Achenbach","year":"1983","unstructured":"Achenbach H, B\u00f6ttger-Vetter A, Hunkler D, Fautz E, Reichenbach H (1983) Investigations on the biosynthesis of flexirubin\u2014The origin of benzene ring B and its substituents. Tetrahedron 39(1):175\u2013185","journal-title":"Tetrahedron"},{"issue":"01","key":"11546_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4236\/ijoc.2016.61001","volume":"6","author":"N Al Soom","year":"2016","unstructured":"Al Soom N, Thiemann T (2016) Hydrogenation of alkenes with NaBH4, CH3CO2H, Pd\/C in the presence of O-and N-benzyl functions. Int J Org Chem 6(01):1\u201311","journal-title":"Int J Org Chem"},{"issue":"1","key":"11546_CR4","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1186\/1471-2164-12-402","volume":"12","author":"N-F Alikhan","year":"2011","unstructured":"Alikhan N-F, Petty NK, Zakour NLB, Beatson SA (2011) BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons. BMC Genomics 12(1):402","journal-title":"BMC Genomics"},{"issue":"3","key":"11546_CR5","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0928-8244(03)00368-7","volume":"40","author":"A Altenhoefer","year":"2004","unstructured":"Altenhoefer A, Oswald S, Sonnenborn U, Enders C, Schulze J, Hacker J, Oelschlaeger TA (2004) The probiotic Escherichia coli strain Nissle 1917 interferes with invasion of human intestinal epithelial cells by different enteroinvasive bacterial pathogens. FEMS Immunol Med Microbiol 40(3):223\u2013229","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"4","key":"11546_CR6","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1128\/mr.51.4.509-518.1987","volume":"51","author":"A Bagg","year":"1987","unstructured":"Bagg A, Neilands JB (1987) Molecular mechanism of regulation of siderophore-mediated iron assimilation. Microbiol Rev 51(4):509\u2013518","journal-title":"Microbiol Rev"},{"key":"11546_CR7","doi-asserted-by":"crossref","unstructured":"Bai X, Zhu S, Wang X, Zhang W, Liu C, Lu X (2017) Identification of a fabZ gene essential for flexirubin synthesis in Cytophaga hutchinsonii. FEMS Microbiol Lett 364(20)","DOI":"10.1093\/femsle\/fnx197"},{"issue":"6426","key":"11546_CR8","doi-asserted-by":"publisher","first-page":"eaau8959","DOI":"10.1126\/science.aau8959","volume":"363","author":"E Ballinger","year":"2019","unstructured":"Ballinger E, Mosior J, Hartman T, Burns-Huang K, Gold B, Morris R, Goullieux L, Blanc I, Vaubourgeix J, Lagrange S (2019) Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition. Science 363(6426):eaau8959","journal-title":"Science"},{"issue":"11","key":"11546_CR9","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1039\/C5NP00091B","volume":"32","author":"EP Balskus","year":"2015","unstructured":"Balskus EP (2015) Colibactin: understanding an elusive gut bacterial genotoxin. Nat Prod Rep 32(11):1534\u20131540","journal-title":"Nat Prod Rep"},{"issue":"4","key":"11546_CR10","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1002\/bit.10160","volume":"76","author":"JL Barker","year":"2001","unstructured":"Barker JL, Frost JW (2001) Microbial synthesis of p-hydroxybenzoic acid from glucose. Biotechnol Bioeng 76(4):376\u2013390","journal-title":"Biotechnol Bioeng"},{"issue":"1","key":"11546_CR11","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1039\/C3NP70054B","volume":"31","author":"J Beld","year":"2014","unstructured":"Beld J, Sonnenschein EC, Vickery CR, Noel JP, Burkart MD (2014) The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life. Nat Prod Rep 31(1):61\u2013108","journal-title":"Nat Prod Rep"},{"issue":"1","key":"11546_CR12","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1039\/C4MB00443D","volume":"11","author":"J Beld","year":"2015","unstructured":"Beld J, Lee DJ, Burkart MD (2015) Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering. Mol Biosys 11(1):38\u201359","journal-title":"Mol Biosys"},{"issue":"4","key":"11546_CR13","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1039\/C5MB00804B","volume":"12","author":"J Beld","year":"2016","unstructured":"Beld J, Abbriano R, Finzel K, Hildebrand M, Burkart MD (2016) Probing fatty acid metabolism in bacteria, cyanobacteria, green microalgae and diatoms with natural and unnatural fatty acids. Mol Biosys 12(4):1299\u20131312","journal-title":"Mol Biosys"},{"issue":"2","key":"11546_CR14","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/BF01135388","volume":"4","author":"I Berner","year":"1991","unstructured":"Berner I, Greiner M, Metzger J, Jung G, Winkelmann G (1991) Identification of enterobactin and linear dihydroxybenzoylserine compounds by HPLC and ion spray mass spectrometry (LC\/MS and MS\/MS). Biol Met 4(2):113\u2013118","journal-title":"Biol Met"},{"issue":"6","key":"11546_CR15","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1039\/C7MT00126F","volume":"9","author":"AG Bobrov","year":"2017","unstructured":"Bobrov AG, Kirillina O, Fosso MY, Fetherston JD, Miller MC, VanCleave TT, Burlison JA, Arnold WK, Lawrenz MB, Garneau-Tsodikova S (2017) Zinc transporters YbtX and ZnuABC are required for the virulence of Yersinia pestis in bubonic and pneumonic plague in mice. Metallomics 9(6):757\u2013772","journal-title":"Metallomics"},{"issue":"6","key":"11546_CR16","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1021\/acs.orglett.5b00432","volume":"17","author":"CA Brotherton","year":"2015","unstructured":"Brotherton CA, Wilson M, Byrd G, Balskus EP (2015) Isolation of a metabolite from the pks island provides insights into colibactin biosynthesis and activity. Org Lett 17(6):1545\u20131548","journal-title":"Org Lett"},{"issue":"11","key":"11546_CR17","doi-asserted-by":"publisher","first-page":"2879","DOI":"10.1021\/acsinfecdis.0c00606","volume":"6","author":"AS Brown","year":"2020","unstructured":"Brown AS, Sissons JA, Owen JG, Ackerley DF (2020) Directed evolution of the nonribosomal peptide synthetase BpsA to enable recognition by the human phosphopantetheinyl transferases for counter-screening antibiotic candidates. ACS Inf Dis 6(11):2879\u20132886","journal-title":"ACS Inf Dis"},{"issue":"5","key":"11546_CR18","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1002\/pro.2050","volume":"21","author":"DC Cantu","year":"2012","unstructured":"Cantu DC, Forrester MJ, Charov K, Reilly PJ (2012) Acyl carrier protein structural classification and normal mode analysis. Protein Sci 21(5):655\u2013666","journal-title":"Protein Sci"},{"issue":"2","key":"11546_CR19","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.cell.2014.06.034","volume":"158","author":"P Cimermancic","year":"2014","unstructured":"Cimermancic P, Medema MH, Claesen J, Kurita K, Brown LCW, Mavrommatis K, Pati A, Godfrey PA, Koehrsen M, Clardy J (2014) Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cell 158(2):412\u2013421","journal-title":"Cell"},{"issue":"1","key":"11546_CR20","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/1758-2229.12019","volume":"5","author":"O Clermont","year":"2013","unstructured":"Clermont O, Christenson JK, Denamur E, Gordon DM (2013) The Clermont Escherichia coli phylo-typing method revisited: improvement of specificity and detection of new phylo-groups. Environ Microbiol Rep 5(1):58\u201365","journal-title":"Environ Microbiol Rep"},{"issue":"1","key":"11546_CR21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1093\/bioinformatics\/btg371","volume":"20","author":"SR Comeau","year":"2004","unstructured":"Comeau SR, Gatchell DW, Vajda S, Camacho CJ (2004) ClusPro: an automated docking and discrimination method for the prediction of protein complexes. Bioinformatics 20(1):45\u201350","journal-title":"Bioinformatics"},{"issue":"2","key":"11546_CR22","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.femsim.2004.04.001","volume":"42","author":"ML Cross","year":"2004","unstructured":"Cross ML, Ganner A, Teilab D, Fray LM (2004) Patterns of cytokine induction by gram-positive and gram-negative probiotic bacteria. FEMS Immunol Med Microbiol 42(2):173\u2013180","journal-title":"FEMS Immunol Med Microbiol"},{"key":"11546_CR23","doi-asserted-by":"publisher","first-page":"16267","DOI":"10.1038\/nmicrobiol.2016.267","volume":"2","author":"J-U Dahl","year":"2017","unstructured":"Dahl J-U, Gray MJ, Bazopoulou D, Beaufay F, Lempart J, Koenigsknecht MJ, Wang Y, Baker JR, Hasler WL, Young VB (2017) The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation. Nat Microbiol 2:16267","journal-title":"Nat Microbiol"},{"issue":"7","key":"11546_CR24","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1101\/gr.2289704","volume":"14","author":"AC Darling","year":"2004","unstructured":"Darling AC, Mau B, Blattner FR, Perna NT (2004) Mauve: multiple alignment of conserved genomic sequence with rearrangements. Genome Res 14(7):1394\u20131403","journal-title":"Genome Res"},{"issue":"1","key":"11546_CR25","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1111\/j.1365-2958.2006.05222.x","volume":"61","author":"NR De Lay","year":"2006","unstructured":"De Lay NR, Cronan JE (2006) A genome rearrangement has orphaned the Escherichia coli K-12 AcpT phosphopantetheinyl transferase from its cognate Escherichia coli O157:H7 substrates. Mol Microbiol 61(1):232\u2013242","journal-title":"Mol Microbiol"},{"issue":"3","key":"11546_CR26","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1534\/genetics.107.081836","volume":"178","author":"NR De Lay","year":"2008","unstructured":"De Lay NR, Cronan JE (2008) Genetic interaction between the Escherichia coli AcpT phosphopantetheinyl transferase and the YejM inner membrane protein. Genetics 178(3):1327\u20131337","journal-title":"Genetics"},{"key":"11546_CR27","unstructured":"DeLano WL (2002) The PyMOL molecular graphics system.\u00a0http:\/\/pymol.org. Accessed 30 Aug 2021"},{"key":"11546_CR28","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1002\/jlac.1995199510243","volume":"10","author":"H Drechsel","year":"1995","unstructured":"Drechsel H, Stephan H, Lotz R, Haag H, Z\u00e4hner H, Hantke K (1995) Jung G (1995) Structure elucidation of yersiniabactin, a siderophore from highly virulent Yersinia strains. Liebigs Ann 10:1727\u20131733","journal-title":"Liebigs Ann"},{"issue":"7","key":"11546_CR29","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1038\/s41591-020-0908-2","volume":"26","author":"PJ Dziuba\u0144ska-Kusibab","year":"2020","unstructured":"Dziuba\u0144ska-Kusibab PJ, Berger H, Battistini F, Bouwman BA, Iftekhar A, Katainen R, Cajuso T, Crosetto N, Orozco M, Aaltonen LA (2020) Colibactin DNA-damage signature indicates mutational impact in colorectal cancer. Nat Med 26(7):1063\u20131069","journal-title":"Nat Med"},{"issue":"5","key":"11546_CR30","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1093\/nar\/gkh340","volume":"32","author":"RC Edgar","year":"2004","unstructured":"Edgar RC (2004) MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res 32(5):1792\u20131797","journal-title":"Nucleic Acids Res"},{"issue":"13","key":"11546_CR31","doi-asserted-by":"publisher","first-page":"3603","DOI":"10.1016\/S0021-9258(19)34183-3","volume":"243","author":"J Elovson","year":"1968","unstructured":"Elovson J, Vagelos PR (1968) Acyl carrier protein X Acyl carrier protein synthetase. J Biol Chem 243(13):3603\u20133611","journal-title":"J Biol Chem"},{"issue":"4","key":"11546_CR32","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1128\/AEM.03283-14","volume":"81","author":"P Engel","year":"2015","unstructured":"Engel P, Vizcaino MI, Crawford JM (2015) Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthesis pathways. Appl Environ Microbiol 81(4):1502\u20131512","journal-title":"Appl Environ Microbiol"},{"issue":"11","key":"11546_CR33","doi-asserted-by":"publisher","first-page":"6986","DOI":"10.1128\/AAC.00130-16","volume":"60","author":"T Fa\u00efs","year":"2016","unstructured":"Fa\u00efs T, Cougnoux A, Dalmasso G, Laurent F, Delmas J, Bonnet R (2016) Antibiotic activity of Escherichia coli against multiresistant Staphylococcus aureus. Antimicrob Agents Chemother 60(11):6986\u20136988","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"11546_CR34","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0378-1119(85)90293-8","volume":"34","author":"TP Fleming","year":"1985","unstructured":"Fleming TP, Nahiik MS, Neilands J, McIntosh MA (1985) Physical and genetic characterization of cloned enterobactin genomic sequences from Escherichia coli K-12. Gene 34(1):47\u201354","journal-title":"Gene"},{"issue":"2","key":"11546_CR35","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1074\/jbc.275.2.959","volume":"275","author":"RS Flugel","year":"2000","unstructured":"Flugel RS, Hwangbo Y, Lambalot RH, Cronan JE, Walsh CT (2000) Holo-(acyl carrier protein) synthase and phosphopantetheinyl transfer in Escherichia coli. J Biol Chem 275(2):959\u2013968","journal-title":"J Biol Chem"},{"issue":"28","key":"11546_CR36","doi-asserted-by":"publisher","first-page":"8495","DOI":"10.1021\/bi970453p","volume":"36","author":"AM Gehring","year":"1997","unstructured":"Gehring AM, Bradley KA, Walsh CT (1997) Enterobactin biosynthesis in Escherichia coli: isochorismate lyase (EntB) is a bifunctional enzyme that is phosphopantetheinylated by EntD and then acylated by EntE using ATP and 2, 3-dihydroxybenzoate. Biochemistry 36(28):8495\u20138503","journal-title":"Biochemistry"},{"issue":"10","key":"11546_CR37","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S1074-5521(98)90115-6","volume":"5","author":"AM Gehring","year":"1998","unstructured":"Gehring AM, DeMoll E, Fetherston JD, Mori I, Mayhew GF, Blattner FR, Walsh CT, Perry RD (1998) Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis. Chem Biol 5(10):573\u2013586","journal-title":"Chem Biol"},{"issue":"8","key":"11546_CR38","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.bbapap.2015.04.015","volume":"1854","author":"JA Gerlt","year":"2015","unstructured":"Gerlt JA, Bouvier JT, Davidson DB, Imker HJ, Sadkhin B, Slater DR, Whalen KL (2015) Enzyme function initiative-enzyme similarity tool (EFI-EST): a web tool for generating protein sequence similarity networks. Biochim Biophys Acta 1854(8):1019\u20131037","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"11546_CR39","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.bmcl.2003.10.032","volume":"14","author":"AM Gilbert","year":"2004","unstructured":"Gilbert AM, Kirisits M, Toy P, Nunn DS, Failli A, Dushin EG, Novikova E, Petersen PJ, Joseph-McCarthy D, McFadyen I (2004) Anthranilate 4H-oxazol-5-ones: novel small molecule antibacterial acyl carrier protein synthase (AcpS) inhibitors. Bioorg Med Chem Lett 14(1):37\u201341","journal-title":"Bioorg Med Chem Lett"},{"key":"11546_CR40","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Alba JM, Baquero F, Cant\u00f3n R, Gal\u00e1n JC (2018) Reconstruction of Escherichia coli ancient diversification by layered phylogenomics and polymorphism fingerprinting. bioRxiv:486399","DOI":"10.1101\/486399"},{"issue":"4","key":"11546_CR41","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1093\/bioinformatics\/15.4.305","volume":"15","author":"P Gouet","year":"1999","unstructured":"Gouet P, Courcelle E, Stuart DI, M\u221a\u00a9 toz F, (1999) ESPript: analysis of multiple sequence alignments in PostScript. Bioinformatics 15(4):305\u2013308","journal-title":"Bioinformatics"},{"issue":"42","key":"11546_CR42","doi-asserted-by":"publisher","first-page":"16615","DOI":"10.1021\/jacs.8b10776","volume":"141","author":"GL Grammbitter","year":"2019","unstructured":"Grammbitter GL, Schmalhofer M, Karimi K, Shi Y-M, Sch\u00f6ner TA, Tobias NJ, Morgner N, Groll M, Bode HB (2019a) An uncommon yype II PKS catalyzes biosynthesis of aryl polyene pigments. J Am Chem Soc 141(42):16615\u201316623","journal-title":"J Am Chem Soc"},{"issue":"42","key":"11546_CR43","doi-asserted-by":"publisher","first-page":"16615","DOI":"10.1021\/jacs.8b10776","volume":"141","author":"GLC Grammbitter","year":"2019","unstructured":"Grammbitter GLC, Schmalhofer M, Karimi K, Sch\u00f6ner TA, Tobias NJ, Morgner N, Groll M, Bode HB (2019b) An uncommon type II PKS catalyzes biosynthesis of aryl polyene pigments. J Am Chem Soc 141(42):16615\u201316623","journal-title":"J Am Chem Soc"},{"key":"11546_CR44","doi-asserted-by":"crossref","unstructured":"Grammbitter GL, Shi Y-M, Shi Y-N, Vemulapalli SP, Richter C, Schwalbe H, Alanjary M, Schueffler A, Witt M, Griesinger C (2020) The chemical structure of widespread microbial aryl polyene lipids. bioRxiv","DOI":"10.1101\/2020.12.19.423268"},{"issue":"2","key":"11546_CR45","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s10534-005-4341-2","volume":"19","author":"G Grass","year":"2006","unstructured":"Grass G (2006) Iron transport in Escherichia coli: All has not been said and done. Biometals 19(2):159\u2013172","journal-title":"Biometals"},{"issue":"2","key":"11546_CR46","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/0005-2787(76)90231-8","volume":"454","author":"KT Greenwood","year":"1976","unstructured":"Greenwood KT, Luke RKJ (1976) Studies on the enzymatic-synthesis of enterochelin in Escherichia coli K12. Biochim Biophys Acta 454(2):285\u2013297","journal-title":"Biochim Biophys Acta"},{"issue":"16","key":"11546_CR47","doi-asserted-by":"publisher","first-page":"5432","DOI":"10.1128\/JB.186.16.5432-5441.2004","volume":"186","author":"L Grozdanov","year":"2004","unstructured":"Grozdanov L, Raasch C, Schulze J, Sonnenborn U, Gottschalk G, Hacker J, Dobrindt U (2004) Analysis of the genome structure of the nonpathogenic probiotic Escherichia coli strain Nissle 1917. J Bacteriol 186(16):5432\u20135441","journal-title":"J Bacteriol"},{"issue":"39","key":"11546_CR48","doi-asserted-by":"publisher","first-page":"65386","DOI":"10.18632\/oncotarget.18528","volume":"8","author":"B-X Guo","year":"2017","unstructured":"Guo B-X, Wang Q-Q, Li J-H, Gan Z-S, Zhang X-F, Wang Y-Z, Du H-H (2017) Lipocalin 2 regulates intestine bacterial survival by interplaying with siderophore in a weaned piglet model of Escherichia coli infection. Oncotarget 8(39):65386","journal-title":"Oncotarget"},{"issue":"5","key":"11546_CR49","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1094\/MPMI-11-19-0326-CR","volume":"33","author":"Y-W He","year":"2020","unstructured":"He Y-W, Cao X-Q, Poplawsky AR (2020) Chemical structure, biological roles, biosynthesis and regulation of the yellow xanthomonadin pigments in the phytopathogenic genus Xanthomonas. Mol Plant-Microbe Interact 33(5):705\u2013714","journal-title":"Mol Plant-Microbe Interact"},{"issue":"37","key":"11546_CR50","doi-asserted-by":"publisher","first-page":"5978","DOI":"10.3748\/wjg.v12.i37.5978","volume":"12","author":"U Helwig","year":"2006","unstructured":"Helwig U, Lammers KM, Rizzello F, Brigidi P, Rohleder V, Caramelli E, Gionchetti P, Schrezenmeir J, Foelsch UR, Schreiber S (2006) Lactobacilli, bifidobacteria and E. coli nissle induce pro-and anti-inflammatory cytokines in peripheral blood mononuclear cells. World J Gastroent 12(37):5978","journal-title":"World J Gastroent"},{"issue":"10","key":"11546_CR51","first-page":"1108","volume":"41","author":"S Hockertz","year":"1991","unstructured":"Hockertz S (1991) Immunomodulating effect of killed, apathogenic Escherichia coli, strain Nissle 1917, on the macrophage system. Arznei-Forschun 41(10):1108\u20131112","journal-title":"Arznei-Forschun"},{"issue":"1","key":"11546_CR52","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1186\/1471-2105-8-460","volume":"8","author":"DH Huson","year":"2007","unstructured":"Huson DH, Richter DC, Rausch C, Dezulian T, Franz M, Rupp R (2007) Dendroscope: an interactive viewer for large phylogenetic trees. BMC Bioinformatics 8(1):460","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"11546_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0005-2736(78)90125-6","volume":"510","author":"H Irschik","year":"1978","unstructured":"Irschik H, Reichenbach H (1978) Intracellular location of flexirubins in Flexibacter elegans (Cytophagales). BBA Biomembranes 510(1):1\u201310","journal-title":"BBA Biomembranes"},{"issue":"5","key":"11546_CR54","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/BF01566872","volume":"7","author":"CL Jenkins","year":"1982","unstructured":"Jenkins CL, Starr MP (1982) The brominated aryl-polyene (xanthomonadin) pigments of Xanthomonas juglandis protect against photobiological damage. Curr Microbiol 7(5):323\u2013326","journal-title":"Curr Microbiol"},{"key":"11546_CR55","doi-asserted-by":"crossref","unstructured":"Jenkins C, Starr M Formation of halogenated aryl-polyene (Xanthomonadin) pigments by the type and other yellow-pigmented strains of Xanthomonas maltophilia. In: Annales de l'Institut Pasteur\/Microbiologie, 1985. vol 136. Elsevier, p 257\u2013264","DOI":"10.1016\/S0769-2609(85)80071-5"},{"issue":"4","key":"11546_CR56","doi-asserted-by":"publisher","first-page":"e01504","DOI":"10.1128\/mBio.01504-16","volume":"8","author":"A Johns","year":"2017","unstructured":"Johns A, Scharf DH, Gsaller F, Schmidt H, Heinekamp T, Stra\u00dfburger M, Oliver JD, Birch M, Beckmann N, Dobb KS (2017) A nonredundant phosphopantetheinyl transferase, PptA, Is a novel antifungal target that directs secondary metabolite, siderophore, and lysine biosynthesis in Aspergillus fumigatus and is critical for pathogenicity. Mbio 8(4):e01504-01516","journal-title":"Mbio"},{"key":"11546_CR57","doi-asserted-by":"crossref","unstructured":"Johnston I, Osborn LJ, McManus EA, Kadam A, Schultz KB, Ahern PA, Brown JM, Claesen J (2021) Identification of essential genes for Escherichia coli aryl polyene biosynthesis and function in biofilm formation. NPJ Biofilms Microbiomes 7:article number 56","DOI":"10.1038\/s41522-021-00226-3"},{"issue":"26","key":"11546_CR58","doi-asserted-by":"publisher","first-page":"6828","DOI":"10.1073\/pnas.1800715115","volume":"115","author":"JH Kim","year":"2018","unstructured":"Kim JH, Komatsu M, Shin-ya K, Omura S, Ikeda H (2018) Distribution and functional analysis of the phosphopantetheinyl transferase superfamily in Actinomycetales microorganisms. Proc Natl Acad Sci USA 115(26):6828\u20136833","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"11546_CR59","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1039\/C4MT00341A","volume":"7","author":"E-I Koh","year":"2015","unstructured":"Koh E-I, Hung CS, Parker KS, Crowley JR, Giblin DE, Henderson JP (2015) Metal selectivity by the virulence-associated yersiniabactin metallophore system. Metallomics 7(6):1011\u20131022","journal-title":"Metallomics"},{"issue":"9","key":"11546_CR60","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1038\/nchembio.2441","volume":"13","author":"E-I Koh","year":"2017","unstructured":"Koh E-I, Robinson AE, Bandara N, Rogers BE, Henderson JP (2017) Copper import in Escherichia coli by the yersiniabactin metallophore system. Nat Chem Biol 13(9):1016\u20131021","journal-title":"Nat Chem Biol"},{"issue":"11","key":"11546_CR61","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1136\/gut.2003.037747","volume":"53","author":"W Kruis","year":"2004","unstructured":"Kruis W, Fri\u010d P, Pokrotnieks J, Luk\u00e1\u0161 M, Fixa B, Ka\u0161\u010d\u00e1k M, Kamm M, Weismueller J, Beglinger C, Stolte M (2004) Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut 53(11):1617\u20131623","journal-title":"Gut"},{"key":"11546_CR62","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/S0076-6879(97)79029-3","volume":"279","author":"RH Lambalot","year":"1997","unstructured":"Lambalot RH, Walsh CT (1997) Holo-[Acyl-Carrier-Protein] synthase of Escherichia coli. Methods Enzymol 279:254\u2013262","journal-title":"Methods Enzymol"},{"issue":"11","key":"11546_CR63","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/S1074-5521(96)90181-7","volume":"3","author":"RH Lambalot","year":"1996","unstructured":"Lambalot RH, Gehring AM, Flugel RS, Zuber P, LaCelle M, Marahiel MA, Reid R, Khosla C, Walsh CT (1996) A new enzyme superfamily - the phosphopantetheinyl transferases. Chem Biol 3(11):923\u2013936","journal-title":"Chem Biol"},{"issue":"2","key":"11546_CR64","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1128\/AEM.70.2.670-674.2004","volume":"70","author":"Y Lee","year":"2004","unstructured":"Lee Y, Ho P, Low C, Arvilommi H, Salminen S (2004) Permanent colonization by Lactobacillus casei is hindered by the low rate of cell division in mouse gut. Appl Environ Microbiol 70(2):670\u2013674","journal-title":"Appl Environ Microbiol"},{"issue":"31","key":"11546_CR65","doi-asserted-by":"publisher","first-page":"11075","DOI":"10.1021\/ja0522027","volume":"127","author":"H Lin","year":"2005","unstructured":"Lin H, Fischbach MA, Liu DR, Walsh CT (2005) In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes. J Am Chem Soc 127(31):11075\u201311084","journal-title":"J Am Chem Soc"},{"issue":"15","key":"11546_CR66","doi-asserted-by":"publisher","first-page":"3752","DOI":"10.1039\/C9OB00275H","volume":"17","author":"KS Madden","year":"2019","unstructured":"Madden KS, Jokhoo HR, Conradi FD, Knowles JP, Mullineaux CW, Whiting A (2019) Using Nature\u2019s polyenes as templates: studies of synthetic xanthomonadin analogues and realising their potential as antioxidants. Org Biomol Chem 17(15):3752\u20133759","journal-title":"Org Biomol Chem"},{"issue":"1","key":"11546_CR67","doi-asserted-by":"publisher","first-page":"e53957","DOI":"10.1371\/journal.pone.0053957","volume":"8","author":"R Maltby","year":"2013","unstructured":"Maltby R, Leatham-Jensen MP, Gibson T, Cohen PS, Conway T (2013) Nutritional basis for colonization resistance by human commensal Escherichia coli strains HS and Nissle 1917 against E. coli O157: H7 in the mouse intestine. PLoS One 8(1):e53957","journal-title":"PLoS One"},{"issue":"7","key":"11546_CR68","doi-asserted-by":"publisher","first-page":"e1003437","DOI":"10.1371\/journal.ppat.1003437","volume":"9","author":"P Martin","year":"2013","unstructured":"Martin P, Marcq I, Magistro G, Penary M, Garcie C, Payros D, Boury M, Olier M, Nougayr\u00e8de J-P, Audebert M (2013) Interplay between siderophores and colibactin genotoxin biosynthetic pathways in Escherichia coli. PLoS Path 9(7):e1003437","journal-title":"PLoS Path"},{"issue":"9","key":"11546_CR69","doi-asserted-by":"publisher","first-page":"e1008029","DOI":"10.1371\/journal.ppat.1008029","volume":"15","author":"C Massip","year":"2019","unstructured":"Massip C, Branchu P, Bossuet-Grief N, Chagneau CV, Gaillard D, Martin P, Boury M, S\u00e9cher T, Dubois D, Nougayr\u00e8de J-P (2019) Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917. PLoS Path 15(9):e1008029","journal-title":"PLoS Path"},{"issue":"3","key":"11546_CR70","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.micinf.2020.01.001","volume":"22","author":"C Massip","year":"2020","unstructured":"Massip C, Chagneau CV, Boury M, Oswald E (2020) The synergistic triad between microcin, colibactin, and salmochelin gene clusters in uropathogenic Escherichia coli. Microb Infect 22(3):144\u2013147","journal-title":"Microb Infect"},{"issue":"5","key":"11546_CR71","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1093\/molbev\/mst025","volume":"30","author":"MH Medema","year":"2013","unstructured":"Medema MH, Takano E, Breitling R (2013) Detecting sequence homology at the gene cluster level with MultiGeneBlast. Mol Biol Evol 30(5):1218\u20131223","journal-title":"Mol Biol Evol"},{"issue":"12","key":"11546_CR72","doi-asserted-by":"publisher","first-page":"e1004016","DOI":"10.1371\/journal.pcbi.1004016","volume":"10","author":"MH Medema","year":"2014","unstructured":"Medema MH, Cimermancic P, Sali A, Takano E, Fischbach MA (2014) A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesis. PLoS Comp Biol 10(12):e1004016","journal-title":"PLoS Comp Biol"},{"issue":"1","key":"11546_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/plas.1996.0001","volume":"35","author":"WW Metcalf","year":"1996","unstructured":"Metcalf WW, Jiang W, Daniels LL, Kim SK, Haldimann A, Wanner BL (1996) Conditionally replicative and conjugative plasmids carrying lacZ alpha for cloning, mutagenesis, and allele replacement in bacteria. Plasmid 35(1):1\u201313","journal-title":"Plasmid"},{"key":"11546_CR74","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/s41589-019-0301-y","volume":"15","author":"JC Milligan","year":"2019","unstructured":"Milligan JC, Lee DJ, Jackson DR, Schaub AJ, Beld J, Barajas JF, Hale JJ, Luo R, Burkart MD, Tsai S-C (2019) Molecular basis for interactions between an acyl carrier protein and a ketosynthase. Nat Chem Biol 15:669\u2013671","journal-title":"Nat Chem Biol"},{"issue":"5","key":"11546_CR75","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1111\/j.1462-2920.2008.01840.x","volume":"11","author":"C Monteiro","year":"2009","unstructured":"Monteiro C, Saxena I, Wang X, Kader A, Bokranz W, Simm R, Nobles D, Chromek M, Brauner A, Brown RM (2009) Characterization of cellulose production in Escherichia coli Nissle 1917 and its biological consequences. Environ Microbiol 11(5):1105\u20131116","journal-title":"Environ Microbiol"},{"issue":"4","key":"11546_CR76","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/nrgastro.2012.14","volume":"9","author":"I Mukhopadhya","year":"2012","unstructured":"Mukhopadhya I, Hansen R, El-Omar EM, Hold GL (2012) IBD\u2013what role do Proteobacteria play? Nat Rev Gastro Hepat 9(4):219\u2013230","journal-title":"Nat Rev Gastro Hepat"},{"issue":"1","key":"11546_CR77","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1006\/jmbi.2000.4042","volume":"302","author":"C Notredame","year":"2000","unstructured":"Notredame C, Higgins DG, Heringa J (2000) T-coffee: a novel method for fast and accurate multiple sequence alignment1. J Mol Biol 302(1):205\u2013217","journal-title":"J Mol Biol"},{"issue":"5788","key":"11546_CR78","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1126\/science.1127059","volume":"313","author":"J-P Nougayr\u00e8de","year":"2006","unstructured":"Nougayr\u00e8de J-P, Homburg S, Taieb F, Boury M, Brzuszkiewicz E, Gottschalk G, Buchrieser C, Hacker J, Dobrindt U, Oswald E (2006) Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Science 313(5788):848\u2013851","journal-title":"Science"},{"issue":"6","key":"11546_CR79","doi-asserted-by":"publisher","first-page":"501","DOI":"10.4161\/gmic.21737","volume":"3","author":"M Olier","year":"2012","unstructured":"Olier M, Marcq I, Salvador-Cartier C, Secher T, Dobrindt U, Boury M, Bacqui\u00e9 V, Penary M, Gaultier E, Nougayr\u00e8de J-P (2012) Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity. Gut Microbes 3(6):501\u2013509","journal-title":"Gut Microbes"},{"key":"11546_CR80","doi-asserted-by":"crossref","unstructured":"Oves-Costales D, Kadi N, Challis GL (2009) The long-overlooked enzymology of a nonribosomal peptide synthetase-independent pathway for virulence-conferring siderophore biosynthesis. Chem Commun (43):6530\u20136541","DOI":"10.1039\/b913092f"},{"issue":"7802","key":"11546_CR81","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/s41586-020-2080-8","volume":"580","author":"C Pleguezuelos-Manzano","year":"2020","unstructured":"Pleguezuelos-Manzano C, Puschhof J, Huber AR, van Hoeck A, Wood HM, Nomburg J, Gurjao C, Manders F, Dalmasso G, Stege PB (2020) Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. Nature 580(7802):269\u2013273","journal-title":"Nature"},{"issue":"3","key":"11546_CR82","doi-asserted-by":"publisher","first-page":"e9490","DOI":"10.1371\/journal.pone.0009490","volume":"5","author":"MN Price","year":"2010","unstructured":"Price MN, Dehal PS, Arkin AP (2010) FastTree 2\u2013approximately maximum-likelihood trees for large alignments. PLoS One 5(3):e9490","journal-title":"PLoS One"},{"issue":"2","key":"11546_CR83","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0014-5793(97)01109-5","volume":"415","author":"L Rajagopal","year":"1997","unstructured":"Rajagopal L, Sundari CS, Balasubramanian D, Sonti RV (1997) The bacterial pigment xanthomonadin offers protection against photodamage. FEBS Lett 415(2):125\u2013128","journal-title":"FEBS Lett"},{"key":"11546_CR84","unstructured":"Rambaut A (2007) FigTree, a graphical viewer of phylogenetic trees. See\u00a0http:\/\/tree.bio.ed.ac.uk\/software\/figtree. Accessed 30 Aug 2021"},{"issue":"3","key":"11546_CR85","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/BF00409934","volume":"126","author":"H Reichenbach","year":"1980","unstructured":"Reichenbach H, Kohl W, B\u00f6ttger-Vetter A, Achenbach H (1980) Flexirubin-type pigments in Flavobacterium. Arch Microbiol 126(3):291\u2013293","journal-title":"Arch Microbiol"},{"issue":"1","key":"11546_CR86","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1039\/C7RA11198C","volume":"8","author":"A Rohilla","year":"2018","unstructured":"Rohilla A, Khare G, Tyagi AK (2018) A combination of docking and cheminformatics approaches for the identification of inhibitors against 4\u2032 phosphopantetheinyl transferase of Mycobacterium tuberculosis. RSC Adv 8(1):328\u2013341","journal-title":"RSC Adv"},{"issue":"5","key":"11546_CR87","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1128\/IAI.02943-14","volume":"83","author":"SA Schinner","year":"2015","unstructured":"Schinner SA, Mokszycki ME, Adediran J, Leatham-Jensen M, Conway T, Cohen PS (2015) Escherichia coli EDL933 requires gluconeogenic nutrients to successfully colonize the intestines of streptomycin-treated mice precolonized with E. coli Nissle 1917. Infect Immun 83(5):1983\u20131991","journal-title":"Infect Immun"},{"key":"11546_CR88","doi-asserted-by":"crossref","unstructured":"Sch\u00f6ner TA, Fuchs SW, Reinhold-Hurek B, Bode HB (2014a) Identification and biosynthesis of a novel xanthomonadin-dialkylresorcinol-hybrid from Azoarcus sp. BH72. PLoS One 9(3):e90922","DOI":"10.1371\/journal.pone.0090922"},{"issue":"3","key":"11546_CR89","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1111\/1751-7915.12110","volume":"7","author":"TA Sch\u00f6ner","year":"2014","unstructured":"Sch\u00f6ner TA, Fuchs SW, Sch\u00f6nau C, Bode HB (2014b) Initiation of the flexirubin biosynthesis in Chitinophaga pinensis. Microb Biotech 7(3):232\u2013241","journal-title":"Microb Biotech"},{"issue":"20","key":"11546_CR90","doi-asserted-by":"publisher","first-page":"8323","DOI":"10.1007\/s00253-015-6905-6","volume":"99","author":"TA Sch\u00f6ner","year":"2015","unstructured":"Sch\u00f6ner TA, Kresovic D, Bode HB (2015) Biosynthesis and function of bacterial dialkylresorcinol compounds. Appl Microbiol Biotechnol 99(20):8323\u20138328","journal-title":"Appl Microbiol Biotechnol"},{"issue":"3","key":"11546_CR91","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/cbic.201500474","volume":"17","author":"TA Sch\u00f6ner","year":"2016","unstructured":"Sch\u00f6ner TA, Gassel S, Osawa A, Tobias NJ, Okuno Y, Sakakibara Y, Shindo K, Sandmann G, Bode HB (2016) Aryl polyenes, a highly abundant class of bacterial natural products, are functionally related to antioxidative carotenoids. ChemBioChem 17(3):247\u2013253","journal-title":"ChemBioChem"},{"issue":"2","key":"11546_CR92","first-page":"372","volume":"11","author":"M Schultz","year":"2004","unstructured":"Schultz M, Strauch UG, Linde H-J, Watzl S, Obermeier F, G\u00f6ttl C, Dunger N, Grunwald N, Sch\u00f6lmerich J, Rath HC (2004) Preventive effects of Escherichia coli strain Nissle 1917 on acute and chronic intestinal inflammation in two different murine models of colitis. Clin Diagn Lab Immunol 11(2):372\u2013378","journal-title":"Clin Diagn Lab Immunol"},{"issue":"13","key":"11546_CR93","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1093\/nar\/gkg520","volume":"31","author":"T Schwede","year":"2003","unstructured":"Schwede T, Kopp J, Guex N, Peitsch MC (2003) SWISS-MODEL: an automated protein homology-modeling server. Nucleic Acids Res 31(13):3381\u20133385","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"11546_CR94","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13(11):2498\u20132504","journal-title":"Genome Res"},{"key":"11546_CR95","doi-asserted-by":"crossref","unstructured":"Singh V, San Yeoh B, Xiao X, Kumar M, Bachman M, Borregaard N, Joe B, Vijay-Kumar M (2015) Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates E. coli survival in the inflamed gut. Nat Comm 6:article number 7113","DOI":"10.1038\/ncomms8113"},{"issue":"1","key":"11546_CR96","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0378-1119(95)00793-8","volume":"169","author":"K Skorupski","year":"1996","unstructured":"Skorupski K, Taylor RK (1996) Positive selection vectors for allelic exchange. Gene 169(1):47\u201352","journal-title":"Gene"},{"issue":"1","key":"11546_CR97","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/nbt0190-39","volume":"8","author":"DJ Smith","year":"1990","unstructured":"Smith DJ, Burnham MK, Edwards J, Earl AJ, Turner G (1990) Cloning and heterologous expression of the penicillin biosynthetic gene cluster from Penicillium chrysogenum. Nat Biotechnol 8(1):39","journal-title":"Nat Biotechnol"},{"issue":"3\u20134","key":"11546_CR98","first-page":"122","volume":"21","author":"U Sonnenborn","year":"2009","unstructured":"Sonnenborn U, Schulze J (2009) The non-pathogenic Escherichia coli strain Nissle 1917\u2013features of a versatile probiotic. Microb Ecol Health Dis 21(3\u20134):122\u2013158","journal-title":"Microb Ecol Health Dis"},{"key":"11546_CR99","doi-asserted-by":"crossref","unstructured":"Sophie T, Pauline F, Laetitia L, Gaillard D, Martin P, Matteo S, Oswald E (2020) The genotoxin colibactin shapes gut microbiota in mice. mSphere 5(4)","DOI":"10.1128\/mSphere.00589-20"},{"issue":"1\u20132","key":"11546_CR100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00428572","volume":"113","author":"MP Starr","year":"1977","unstructured":"Starr MP, Jenkins CL, Bussey LB, Andrewes AG (1977) Chemotaxonomic significance of the xanthomonadins, novel brominated aryl-polyene pigments produced by bacteria of the genus Xanthomonas. Arch Microbiol 113(1\u20132):1\u20139","journal-title":"Arch Microbiol"},{"issue":"8","key":"11546_CR101","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1039\/b109741p","volume":"1","author":"C Thirsk","year":"2002","unstructured":"Thirsk C, Whiting A (2002) Polyene natural products. J Chem Soc Perkin Trans 1(8):999\u20131023","journal-title":"J Chem Soc Perkin Trans"},{"issue":"4","key":"11546_CR102","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.chembiol.2014.02.014","volume":"21","author":"P Tufar","year":"2014","unstructured":"Tufar P, Rahighi S, Kraas FI, Kirchner DK, L\u00f6hr F, Henrich E, K\u00f6pke J, Dikic I, G\u00fcntert P, Marahiel MA (2014) Crystal structure of a PCP\/Sfp complex reveals the structural basis for carrier protein posttranslational modification. Chem Biol 21(4):552\u2013562","journal-title":"Chem Biol"},{"issue":"7164","key":"11546_CR103","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/nature06244","volume":"449","author":"PJ Turnbaugh","year":"2007","unstructured":"Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI (2007) The human microbiome project. Nature 449(7164):804","journal-title":"Nature"},{"issue":"8","key":"11546_CR104","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.ijmm.2006.06.003","volume":"296","author":"M Valdebenito","year":"2006","unstructured":"Valdebenito M, Crumbliss AL, Winkelmann G, Hantke K (2006) Environmental factors influence the production of enterobactin, salmochelin, aerobactin, and yersiniabactin in Escherichia coli strain Nissle 1917. Int J Med Microbiol 296(8):513\u2013520","journal-title":"Int J Med Microbiol"},{"issue":"1","key":"11546_CR105","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1128\/AAC.00744-09","volume":"54","author":"G Vassiliadis","year":"2010","unstructured":"Vassiliadis G, Destoumieux-Garz\u00f3n D, Lombard C, Rebuffat S, Peduzzi J (2010) Isolation and characterization of two members of the siderophore-microcin family, microcins M and H47. Antimicrob Agents Chemother 54(1):288\u2013297","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"11546_CR106","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nchem.2221","volume":"7","author":"MI Vizcaino","year":"2015","unstructured":"Vizcaino MI, Crawford JM (2015) The colibactin warhead crosslinks DNA. Nat Chem 7(5):411\u2013417","journal-title":"Nat Chem"},{"issue":"26","key":"11546_CR107","doi-asserted-by":"publisher","first-page":"9244","DOI":"10.1021\/ja503450q","volume":"136","author":"MI Vizcaino","year":"2014","unstructured":"Vizcaino MI, Engel P, Trautman E, Crawford JM (2014) Comparative metabolomics and structural characterizations illuminate colibactin pathway-dependent small molecules. J Am Chem Soc 136(26):9244\u20139247","journal-title":"J Am Chem Soc"},{"key":"11546_CR108","doi-asserted-by":"publisher","first-page":"24255","DOI":"10.1038\/srep24255","volume":"6","author":"Y-Y Wang","year":"2016","unstructured":"Wang Y-Y, Zhang X-S, Luo H-D, Ren N-N, Jiang X-H, Jiang H, Li Y-Q (2016) Characterization of discrete phosphopantetheinyl transferases in Streptomyces tsukubaensis L19 unveils a complicate phosphopantetheinylation network. Sci Rep 6:24255","journal-title":"Sci Rep"},{"issue":"W1","key":"11546_CR109","doi-asserted-by":"publisher","first-page":"W237","DOI":"10.1093\/nar\/gkv437","volume":"43","author":"T Weber","year":"2015","unstructured":"Weber T, Blin K, Duddela S, Krug D, Kim HU, Bruccoleri R, Lee SY, Fischbach MA, M\u00fcller R, Wohlleben W (2015) antiSMASH 30\u2014a comprehensive resource for the genome mining of biosynthetic gene clusters. Nucleic Acids Res 43(W1):W237\u2013W243","journal-title":"Nucleic Acids Res"},{"issue":"6428","key":"11546_CR110","doi-asserted-by":"publisher","first-page":"eaar7785","DOI":"10.1126\/science.aar7785","volume":"363","author":"MR Wilson","year":"2019","unstructured":"Wilson MR, Jiang Y, Villalta PW, Stornetta A, Boudreau PD, Carr\u00e1 A, Brennan CA, Chun E, Ngo L, Samson LD (2019) The human gut bacterial genotoxin colibactin alkylates DNA. Science 363(6428):eaar7785","journal-title":"Science"},{"issue":"6457","key":"11546_CR111","doi-asserted-by":"publisher","first-page":"eaax2685","DOI":"10.1126\/science.aax2685","volume":"365","author":"M Xue","year":"2019","unstructured":"Xue M, Kim CS, Healy AR, Wernke KM, Wang Z, Frischling MC, Shine EE, Wang W, Herzon SB, Crawford JM (2019) Structure elucidation of colibactin and its DNA cross-links. Science 365(6457):eaax2685","journal-title":"Science"},{"issue":"1","key":"11546_CR112","doi-asserted-by":"publisher","first-page":"11888","DOI":"10.1038\/s41598-017-12244-3","volume":"7","author":"G Yang","year":"2017","unstructured":"Yang G, Zhang Y, Lee NK, Cozad MA, Kearney SE, Luesch H, Ding Y (2017) Cyanobacterial Sfp-type phosphopantetheinyl transferases functionalize carrier proteins of diverse biosynthetic pathways. Sci Rep 7(1):11888","journal-title":"Sci Rep"},{"issue":"1","key":"11546_CR113","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/mmi.12084","volume":"87","author":"L Zhou","year":"2013","unstructured":"Zhou L, Wang JY, Wang J, Poplawsky A, Lin S, Zhu B, Chang C, Zhou T, Zhang LH, He YW (2013) The diffusible factor synthase XanB2 is a bifunctional chorismatase that links the shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways. Mol Microbiol 87(1):80\u201393","journal-title":"Mol Microbiol"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-021-11546-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00253-021-11546-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-021-11546-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T16:16:15Z","timestamp":1633882575000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00253-021-11546-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,21]]},"references-count":113,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["11546"],"URL":"https:\/\/doi.org\/10.1007\/s00253-021-11546-x","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,21]]},"assertion":[{"value":"3 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}