{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:36:59Z","timestamp":1777383419006,"version":"3.51.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"24","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100011710","name":"shaanxi provincial science and technology department","doi-asserted-by":"publisher","award":["2015KTCQ03-05"],"award-info":[{"award-number":["2015KTCQ03-05"]}],"id":[{"id":"10.13039\/501100011710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011710","name":"shaanxi provincial science and technology department","doi-asserted-by":"publisher","award":["2021SF-387"],"award-info":[{"award-number":["2021SF-387"]}],"id":[{"id":"10.13039\/501100011710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s00253-021-11679-z","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T04:20:21Z","timestamp":1638159621000},"page":"9333-9342","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Identification and a phased pH control strategy of diosgenin bio-synthesized by an endogenous Bacillus licheniformis Syt1 derived from Dioscorea zingiberensis C. H. Wright"],"prefix":"10.1007","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0112-3304","authenticated-orcid":false,"given":"Zhongqiu","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lintao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyao","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongsheng","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-7713","authenticated-orcid":false,"given":"Baofu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"11679_CR1","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.biortech.2015.08.010","volume":"196","author":"Y Bai","year":"2015","unstructured":"Bai Y, Zhang L, Jin W, Wei M, Zhou P, Zheng G, Niu L, Nie L, Zhang Y, Wang H, Yu L (2015) In situ high-valued utilization and transformation of sugars from Dioscorea zingiberensis C.H. Wright for clean production of diosgenin. Bioresour Technol 196:642\u2013647. https:\/\/doi.org\/10.1016\/j.biortech.2015.08.010","journal-title":"Bioresour Technol"},{"issue":"44","key":"11679_CR2","doi-asserted-by":"publisher","first-page":"13478","DOI":"10.1073\/pnas.1511482112","volume":"112","author":"AB Banta","year":"2015","unstructured":"Banta AB, Wei JH, Welander PV (2015) A distinct pathway for tetrahymanol synthesis in bacteria. Proc Natl Acad Sci U S A 112(44):13478\u201313483. https:\/\/doi.org\/10.1073\/pnas.1511482112","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"11679_CR3","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1046\/j.1365-2958.2003.03309.x","volume":"47","author":"HB Bode","year":"2003","unstructured":"Bode HB, Zeggel B, Silakowski B, Wenzel SC, Reichenbach H, M\u00fcller R (2003) Steroid biosynthesis in prokaryotes: identification of myxobacterial steroids and cloning of the first bacterial 2,3(S)-oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca. Mol Microbiol 47(2):471\u2013481. https:\/\/doi.org\/10.1046\/j.1365-2958.2003.03309.x","journal-title":"Mol Microbiol"},{"issue":"1","key":"11679_CR4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1021\/jf902369s","volume":"58","author":"M Cavagna","year":"2010","unstructured":"Cavagna M, Dell\u2019Anna R, Monti F, Rossi F, Torriani S (2010) Use of ATR-FTIR microspectroscopy to monitor autolysis of Saccharomyces cerevisiae cells in a base wine. J Agric Food Chem 58(1):39\u201345. https:\/\/doi.org\/10.1021\/jf902369s","journal-title":"J Agric Food Chem"},{"key":"11679_CR5","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.steroids.2018.05.005","volume":"136","author":"Y Chen","year":"2018","unstructured":"Chen Y, Dong Y, Chi Y, He Q, Wu H, Ren Y (2018) Eco-friendly microbial production of diosgenin from saponins in Dioscorea zingiberensis tubers in the presence of Aspergillus awamori. Steroids 136:40\u201346. https:\/\/doi.org\/10.1016\/j.steroids.2018.05.005","journal-title":"Steroids"},{"issue":"8","key":"11679_CR6","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/S1875-5364(15)30053-4","volume":"13","author":"Y Chen","year":"2015","unstructured":"Chen Y, Tang Y-M, Yu S-L, Han Y-W, Kou J-P, Liu B-L, Yu B-Y (2015) Advances in the pharmacological activities and mechanisms of diosgenin. Chin J Nat Medicines 13(8):578\u2013587. https:\/\/doi.org\/10.1016\/S1875-5364(15)30053-4","journal-title":"Chin J Nat Medicines"},{"issue":"4","key":"11679_CR7","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1080\/13102818.2015.1032352","volume":"29","author":"Y Cheng","year":"2015","unstructured":"Cheng Y, Dong C, Huang C, Zhu Y (2015) Enhanced production of diosgenin from Dioscorea zingiberensis in mixed culture solid state fermentation with Trichoderma reesei and Aspergillus fumigatus. Biotechnol Biotechnol Equip 29(4):773\u2013778. https:\/\/doi.org\/10.1080\/13102818.2015.1032352","journal-title":"Biotechnol Biotechnol Equip"},{"issue":"5","key":"11679_CR8","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1007\/s00425-017-2657-0","volume":"245","author":"J Ciura","year":"2017","unstructured":"Ciura J, Szeliga M, Grzesik M, Tyrka M (2017) Next-generation sequencing of representational difference analysis products for identification of genes involved in diosgenin biosynthesis in fenugreek (Trigonella foenum-graecum). Planta 245(5):977\u2013991. https:\/\/doi.org\/10.1007\/s00425-017-2657-0","journal-title":"Planta"},{"key":"11679_CR9","first-page":"45","volume-title":"Chirality, drug metabolism and action","author":"D Davies","year":"1990","unstructured":"Davies D (1990) Chirality, drug metabolism and action. Academic Press, Salt Lake City, pp 45\u201351"},{"issue":"1","key":"11679_CR10","doi-asserted-by":"publisher","first-page":"22","DOI":"10.21273\/horttech.1.1.22","volume":"1","author":"RF Dawson","year":"1991","unstructured":"Dawson RF (1991) Diosgenin production in North America-a brief history. HortTechnology 1(1):22\u201327. https:\/\/doi.org\/10.21273\/horttech.1.1.22","journal-title":"HortTechnology"},{"issue":"19","key":"11679_CR11","doi-asserted-by":"publisher","first-page":"3697","DOI":"10.1002\/jssc.201701349","volume":"41","author":"J Duan","year":"2018","unstructured":"Duan J, Dong X, Shen Y, Gao B, Zhang Z, Gao T, Wang M (2018) Simultaneous determination of enantiomers of carfentrazone-ethyl and its metabolite in eight matrices using high-performance liquid chromatography with tandem mass spectrometry. J Sep Sci 41(19):3697\u20133705. https:\/\/doi.org\/10.1002\/jssc.201701349","journal-title":"J Sep Sci"},{"key":"11679_CR12","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.chroma.2017.05.011","volume":"1505","author":"D Eibler","year":"2017","unstructured":"Eibler D, Vetter W (2017) Enantioseparation and optical rotation of flavor-relevant 4-alkyl-branched fatty acids. J Chromatogr A 1505:87\u201395. https:\/\/doi.org\/10.1016\/j.chroma.2017.05.011","journal-title":"J Chromatogr A"},{"key":"11679_CR13","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.biortech.2014.03.027","volume":"161","author":"S Feng","year":"2014","unstructured":"Feng S, Yang H, Zhan X, Wang W (2014) Novel integration strategy for enhancing chalcopyrite bioleaching by Acidithiobacillus sp. in a 7-L fermenter. Bioresour Technol 161:371\u2013378. https:\/\/doi.org\/10.1016\/j.biortech.2014.03.027","journal-title":"Bioresour Technol"},{"issue":"6","key":"11679_CR14","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/S0141-0229(03)00029-2","volume":"32","author":"P Fernandes","year":"2003","unstructured":"Fernandes P, Cruz A, Angelova B, Pinheiro HM, Cabral JMS (2003) Microbial conversion of steroid compounds: recent developments. Enzyme Microb Technol 32(6):688\u2013705. https:\/\/doi.org\/10.1016\/S0141-0229(03)00029-2","journal-title":"Enzyme Microb Technol"},{"key":"11679_CR15","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.steroids.2018.11.016","volume":"143","author":"N Gong","year":"2019","unstructured":"Gong N, Wang Y, Zhang B, Yang D, Du G, Lu Y (2019) Screening, preparation and characterization of diosgenin versatile solvates. Steroids 143:18\u201324. https:\/\/doi.org\/10.1016\/j.steroids.2018.11.016","journal-title":"Steroids"},{"issue":"5","key":"11679_CR16","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1021\/ac0260903","volume":"75","author":"G Kos","year":"2003","unstructured":"Kos G, Lohninger H, Krska R (2003) Development of a method for the determination of fusarium fungi on corn using mid-infrared spectroscopy with attenuated total reflection and chemometrics. Anal Chem 75(5):1211\u20131217. https:\/\/doi.org\/10.1021\/ac0260903","journal-title":"Anal Chem"},{"issue":"7","key":"11679_CR17","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1093\/molbev\/msw054","volume":"33","author":"S Kumar","year":"2016","unstructured":"Kumar S, Stecher G, Tamura K (2016) MEGA7: molecular evolutionary genetics analysis Version 7.0 for Bigger Datasets. Mol Biol Evol 33(7):1870\u20131874. https:\/\/doi.org\/10.1093\/molbev\/msw054","journal-title":"Mol Biol Evol"},{"issue":"5","key":"11679_CR18","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.3892\/ijo_00000601","volume":"36","author":"C Lepage","year":"2010","unstructured":"Lepage C, Liagre B, Cookmoreau J, Pinon A, Beneytout JL (2010) Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells. Int J Oncol 36(5):1183\u20131191. https:\/\/doi.org\/10.3892\/ijo_00000601","journal-title":"Int J Oncol"},{"issue":"15","key":"11679_CR19","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.5897\/AJPP11.440","volume":"6","author":"P Li","year":"2012","unstructured":"Li P, Mou Y, Lu S, Sun W, Lou J, Yin C, Zhou L (2012) Quantitative determination of diosgenin in Dioscorea zingiberensis cell cultures by microplate- spectrophotometry and high-performance liquid chromatography. Afr J Pharm Pharmacol 6(15):1186\u20131193. https:\/\/doi.org\/10.5897\/AJPP11.440","journal-title":"Afr J Pharm Pharmacol"},{"issue":"4","key":"11679_CR20","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s00253-009-2098-1","volume":"85","author":"L Liu","year":"2010","unstructured":"Liu L, Dong Y-S, Qi S-S, Wang H, Xiu Z-L (2010) Biotransformation of steriodal saponins in Dioscorea zingiberensis C. H. Wright to diosgenin by Trichoderma harzianum. Appl Microbiol Biotechnol 85(4):933\u2013940. https:\/\/doi.org\/10.1007\/s00253-009-2098-1","journal-title":"Appl Microbiol Biotechnol"},{"issue":"3","key":"11679_CR21","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1023\/a:1010110624198","volume":"56","author":"RO Mac\u00eado","year":"1999","unstructured":"Mac\u00eado RO, Barbosa-Filho JM, da Costa EM, de Souza AG (1999) Thermal behaviour of some terpenoids. J Therm Anal Calorim 56(3):1353\u20131357. https:\/\/doi.org\/10.1023\/a:1010110624198","journal-title":"J Therm Anal Calorim"},{"key":"11679_CR22","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.proche.2015.12.055","volume":"16","author":"Mamay Mamay","year":"2015","unstructured":"Mamay, Wahyuningrum D., Hertadi R (2015) Isolation and characterization of levan from moderate halophilic bacteria Bacillus licheniformis BK AG21. Procedia Chemistry 16:292\u2013298. https:\/\/doi.org\/10.1016\/j.proche.2015.12.055","journal-title":"Procedia Chemistry"},{"key":"11679_CR23","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jclepro.2013.12.074","volume":"76","author":"C Pan","year":"2014","unstructured":"Pan C, Zhao Y, Liu G, Dou G, Ru Z, Zhu K (2014) Development and demonstration of a cleaner process to produce diosgenin from Dioscorea zingiberensis based on physical separation. J Clean Prod 76:161\u2013166. https:\/\/doi.org\/10.1016\/j.jclepro.2013.12.074","journal-title":"J Clean Prod"},{"issue":"2","key":"11679_CR24","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1078\/072320203322346047","volume":"26","author":"VJ Pidiyar","year":"2003","unstructured":"Pidiyar VJ, Jangid K, Dayananda KM, Kaznowski A, Gonzalez JM, Patole MS, Shouche YS (2003) Phylogenetic affiliation of Aeromonas culicicola MTCC 3249T based on gyrB gene sequence and PCR-amplicon sequence analysis of cytolytic enterotoxin gene. Syst Appl Microbiol 26(2):197\u2013202. https:\/\/doi.org\/10.1078\/072320203322346047","journal-title":"Syst Appl Microbiol"},{"issue":"6","key":"11679_CR25","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.coph.2012.07.002","volume":"12","author":"NA Riobo","year":"2012","unstructured":"Riobo NA (2012) Cholesterol and its derivatives in Sonic Hedgehog signaling and cancer. Curr Opin Pharmacol 12(6):736\u2013741. https:\/\/doi.org\/10.1016\/j.coph.2012.07.002","journal-title":"Curr Opin Pharmacol"},{"issue":"1470","key":"11679_CR26","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1098\/rstb.2006.1837","volume":"361","author":"RE Summons","year":"2006","unstructured":"Summons RE, Bradley AS, Jahnke LL, Waldbauer JR (2006) Steroids, triterpenoids and molecular oxygen. Philos Trans R Soc Lond B Biol Sci 361(1470):951\u2013968. https:\/\/doi.org\/10.1098\/rstb.2006.1837","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"11679_CR27","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.abb.2017.05.017","volume":"632","author":"CJ Thibodeaux","year":"2017","unstructured":"Thibodeaux CJ, Liu H-w (2017) The type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IDI-2): a model for acid\/base chemistry in flavoenzyme catalysis. Arch Biochem Biophys 632:47\u201358. https:\/\/doi.org\/10.1016\/j.abb.2017.05.017","journal-title":"Arch Biochem Biophys"},{"key":"11679_CR28","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.jclepro.2014.05.041","volume":"79","author":"P Wang","year":"2014","unstructured":"Wang P, Ma C, Chen S, Zhu S, Lou Z, Wang H (2014) Conversion of steroid saponins into diosgenin by catalytic hydrolysis using acid-functionalized ionic liquid under microwave irradiation. J Clean Prod 79:265\u2013270. https:\/\/doi.org\/10.1016\/j.jclepro.2014.05.041","journal-title":"J Clean Prod"},{"issue":"990","key":"11679_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2016.00990","volume":"7","author":"JH Wei","year":"2016","unstructured":"Wei JH, Yin X, Welander PV (2016) Sterol synthesis in diverse bacteria. Front Microbiol 7(990):1\u201319. https:\/\/doi.org\/10.3389\/fmicb.2016.00990","journal-title":"Front Microbiol"},{"key":"11679_CR30","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.biortech.2013.07.090","volume":"146","author":"M Wei","year":"2013","unstructured":"Wei M, Bai Y, Ao M, Jin W, Yu P, Zhu M, Yu L (2013) Novel method utilizing microbial treatment for cleaner production of diosgenin from Dioscorea zingiberensis C.H. Wright (DZW). Bioresour Technol 146:549\u2013555. https:\/\/doi.org\/10.1016\/j.biortech.2013.07.090","journal-title":"Bioresour Technol"},{"key":"11679_CR31","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.wasman.2016.09.033","volume":"60","author":"Y Wu","year":"2017","unstructured":"Wu Y, Wang C, Zheng M, Zuo J, Wu J, Wang K, Yang B (2017) Effect of pH on ethanol-type acidogenic fermentation of fruit and vegetable waste. Waste Manage (oxford) 60:158\u2013163. https:\/\/doi.org\/10.1016\/j.wasman.2016.09.033","journal-title":"Waste Manage (oxford)"},{"key":"11679_CR32","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jclepro.2016.05.030","volume":"131","author":"H Yang","year":"2016","unstructured":"Yang H, Yin H, Shen Y, Xia G, Zhang B, Wu X, Cai B, Tam JP (2016) A more ecological and efficient approach for producing diosgenin from Dioscorea zingiberensis tubers via pressurized biphase acid hydrolysis. J Clean Prod 131:10\u201319. https:\/\/doi.org\/10.1016\/j.jclepro.2016.05.030","journal-title":"J Clean Prod"},{"key":"11679_CR33","doi-asserted-by":"publisher","unstructured":"Yue L, Chuan S, Yuanyuan W, Han D, Li K, Jinyuan M, Kaijun W (2021) Effect of pH dynamic control on ethanol-lactic type fermentation (ELTF) performance of glucose. Environ Technol 1\u201313. https:\/\/doi.org\/10.1080\/09593330.2021.1942560","DOI":"10.1080\/09593330.2021.1942560"},{"issue":"4","key":"11679_CR34","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cep.2012.01.005","volume":"54","author":"L Zhang","year":"2012","unstructured":"Zhang L, Zuo B, Wu P, Wang Y, Gao W (2012) Ultrasound effects on the acetylation of dioscorea starch isolated from Dioscorea zingiberensis C.H. Wright. Chem Eng Process 54(4):29\u201336. https:\/\/doi.org\/10.1016\/j.cep.2012.01.005","journal-title":"Chem Eng Process"},{"issue":"1","key":"11679_CR35","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.bej.2009.07.006","volume":"47","author":"Y Zhang","year":"2009","unstructured":"Zhang Y, Tang L, An X, Fu E, Ma C (2009) Modification of cellulase and its application to extraction of diosgenin from Dioscorea zingiberensis C.H. Wright. Biochem Eng J 47(1):80\u201386. https:\/\/doi.org\/10.1016\/j.bej.2009.07.006","journal-title":"Biochem Eng J"},{"issue":"11","key":"11679_CR36","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1002\/ceat.200700234","volume":"30","author":"YQ Zhang","year":"2007","unstructured":"Zhang YQ, Liang JH, Fu EH, Li BX (2007) Effect of modified enzymatic catalysis on the extraction of diosgenin from Dioscorea zingiberensis C H Wright. Chem Eng Technol 30(11):1488\u20131494. https:\/\/doi.org\/10.1002\/ceat.200700234","journal-title":"Chem Eng Technol"},{"issue":"5","key":"11679_CR37","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1007\/s00253-009-2200-8","volume":"85","author":"Y-L Zhu","year":"2010","unstructured":"Zhu Y-L, Huang W, Ni J-R, Liu W, Li H (2010) Production of diosgenin from Dioscorea zingiberensis tubers through enzymatic saccharification and microbial transformation. Appl Microbiol Biotechnol 85(5):1409\u20131416. https:\/\/doi.org\/10.1007\/s00253-009-2200-8","journal-title":"Appl Microbiol Biotechnol"},{"key":"11679_CR38","doi-asserted-by":"publisher","first-page":"112075","DOI":"10.1016\/j.indcrop.2019.112075","volume":"145","author":"F Zolfaghari","year":"2020","unstructured":"Zolfaghari F, Rashidi-Monfared S, Moieni A, Abedini D, Ebrahimi A (2020) Improving diosgenin production and its biosynthesis in Trigonella foenum-graecum L. hairy root cultures. Industrial Crops and Products 145:112075. https:\/\/doi.org\/10.1016\/j.indcrop.2019.112075","journal-title":"Industrial Crops and Products"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-021-11679-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00253-021-11679-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-021-11679-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T10:17:15Z","timestamp":1638785835000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00253-021-11679-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,29]]},"references-count":38,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["11679"],"URL":"https:\/\/doi.org\/10.1007\/s00253-021-11679-z","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,29]]},"assertion":[{"value":"8 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}