{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:20:12Z","timestamp":1740108012221,"version":"3.37.3"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"22","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1007\/s00253-022-12222-4","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T08:04:59Z","timestamp":1666339499000},"page":"7661-7670","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A combined inactivated cholera and hepatitis A vaccine-induced potent protective immunity in a mouse model"],"prefix":"10.1007","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-2649","authenticated-orcid":false,"given":"Nourhan H.","family":"AbdelAllah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7347-9564","authenticated-orcid":false,"given":"Ahmed F.","family":"Azmy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2877-9418","authenticated-orcid":false,"given":"Mohamed E.","family":"Rashed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3999-2839","authenticated-orcid":false,"given":"Sameh","family":"AbdelGhani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2244-4406","authenticated-orcid":false,"given":"Yasser","family":"Gaber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"12222_CR1","doi-asserted-by":"publisher","unstructured":"Abbas AM, Rashed ME, El-Gebaly E, AbdelAllah NH, Gaber Y (2022) Comparative evaluation of the humoral immune interaction when BCG and conjugated meningococcal vaccines combined or co-administrated in mice. Comparative Immunology, Microbiology and Infectious Diseases 101778.\u00a0https:\/\/doi.org\/10.1016\/J.CIMID.2022.101778","DOI":"10.1016\/J.CIMID.2022.101778"},{"key":"12222_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/7659684","volume":"2016","author":"NH AbdelAllah","year":"2016","unstructured":"AbdelAllah NH, Abdeltawab NF, Boseila AA, Amin MA (2016) Chitosan and sodium alginate combinations are alternative, efficient, and safe natural adjuvant systems for hepatitis B vaccine in mouse model. Evid-Based Complement Alternat Med 2016:1\u20138. https:\/\/doi.org\/10.1155\/2016\/7659684","journal-title":"Evid-Based Complement Alternat Med"},{"key":"12222_CR3","doi-asserted-by":"publisher","unstructured":"AbdelAllah NH, Gaber Y, AbdelGhani S, Rashed ME, Azmy AF (2021) Chitosan and alginate salt as biomaterials are potential natural adjuvants for killed cholera vaccine. J Biomed Mater Res - Part A 109.\u00a0https:\/\/doi.org\/10.1002\/jbm.a.37240","DOI":"10.1002\/jbm.a.37240"},{"key":"12222_CR4","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.ijbiomac.2020.02.287","volume":"152","author":"NH AbdelAllah","year":"2020","unstructured":"AbdelAllah NH, Gaber Y, Rashed ME, Azmy AF, Abou-Taleb HA, AbdelGhani S (2020) Alginate-coated chitosan nanoparticles act as effective adjuvant for hepatitis A vaccine in mice. Int J Biol Macromol 152:904\u2013912","journal-title":"Int J Biol Macromol"},{"key":"12222_CR5","doi-asserted-by":"publisher","unstructured":"Ali RH, Abdeltawab NF, Hady OA, Amin MA (2017) Synergistic effect of coadministration of Haemophilus influenzae and Neisseria meningitidis vaccines on immune responses to meningitis in mouse model. Preprints. https:\/\/doi.org\/10.20944\/preprints201701.0010.v1","DOI":"10.20944\/preprints201701.0010.v1"},{"key":"12222_CR6","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1016\/j.vaccine.2015.02.011","volume":"33","author":"LV Andreasen","year":"2015","unstructured":"Andreasen LV, Hansen LB, Andersen P, Agger EM, Dietrich J (2015) Aluminium hydroxide potentiates a protective Th1 biased immune response against polio virus that allows for dose sparing in mice and rats. Vaccine 33:1873\u20131879. https:\/\/doi.org\/10.1016\/j.vaccine.2015.02.011","journal-title":"Vaccine"},{"key":"12222_CR7","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1042\/CS20160475","volume":"131","author":"R Babb","year":"2017","unstructured":"Babb R, Chen A, Ogunniyi AD, Hirst TR, Kara EE, McColl SR, Alsharifi M, Paton JC (2017) Enhanced protective responses to a serotype-independent pneumococcal vaccine when combined with an inactivated influenza vaccine. Clin Sci 131:169\u2013180. https:\/\/doi.org\/10.1042\/CS20160475","journal-title":"Clin Sci"},{"key":"12222_CR8","doi-asserted-by":"publisher","unstructured":"Carroll EC, Jin L, Mori A, Mu\u00f1oz-Wolf N, Oleszycka E, Moran HBT, Mansouri S, McEntee CP, Lambe E, Agger EM, Andersen P, Cunningham C, Hertzog P, Fitzgerald KA, Bowie AG, Lavelle EC (2016) The vaccine adjuvant chitosan promotes cellular immunity via DNA sensor cGAS-STING-dependent induction of type I interferons. Immun 44:597\u2013608. https:\/\/doi.org\/10.1016\/j.immuni.2016.02.004","DOI":"10.1016\/j.immuni.2016.02.004"},{"key":"12222_CR9","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1016\/S0264-410X(99)00354-0","volume":"18","author":"PA Czeschinski","year":"2000","unstructured":"Czeschinski PA, Binding N, Witting U (2000) Hepatitis A and hepatitis B vaccinations: immunogenicity of combined vaccine and of simultaneously or separately applied single vaccines. Vaccine 18:1074\u20131080. https:\/\/doi.org\/10.1016\/S0264-410X(99)00354-0","journal-title":"Vaccine"},{"key":"12222_CR10","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1016\/J.VACCINE.2006.11.001","volume":"25","author":"C Dong","year":"2007","unstructured":"Dong C, Dai X, Meng JH (2007) The first experimental study on a candidate combined vaccine against hepatitis A and hepatitis E. Vaccine 25:1662\u20131668. https:\/\/doi.org\/10.1016\/J.VACCINE.2006.11.001","journal-title":"Vaccine"},{"key":"12222_CR11","unstructured":"EMEA (2005), Committee for Medicinal Products for Human Use (CHMP) 1\u201318. Guideline on adjuvants in vaccines for human use. Reproduction"},{"key":"12222_CR12","doi-asserted-by":"publisher","first-page":"e0123400","DOI":"10.1371\/JOURNAL.PONE.0123400","volume":"10","author":"Y Gao","year":"2015","unstructured":"Gao Y, Su Q, Yi Y, Jia Z, Wang H, Lu X, Qiu F, Bi S (2015) Enhanced mucosal immune responses induced by a combined candidate mucosal vaccine based on hepatitis A virus and hepatitis E virus structural proteins linked to tuftsin. PLoS ONE 10:e0123400. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0123400","journal-title":"PLoS ONE"},{"key":"12222_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13104-016-1891-Z\/TABLES\/2","volume":"9","author":"A Gohar","year":"2016","unstructured":"Gohar A, Abdeltawab NF, Fahmy A, Amin MA (2016) Development of safe, effective and immunogenic vaccine candidate for diarrheagenic Escherichia coli main pathotypes in a mouse model Infectious Diseases. BMC Res Notes 9:1\u201318. https:\/\/doi.org\/10.1186\/S13104-016-1891-Z\/TABLES\/2","journal-title":"BMC Res Notes"},{"key":"12222_CR14","doi-asserted-by":"publisher","first-page":"100172","DOI":"10.1016\/J.PVR.2019.100172","volume":"8","author":"A Gohar","year":"2019","unstructured":"Gohar A, Abdeltawab NF, Shehata N, Amin MA (2019) Preclinical study of safety and immunogenicity of combined rubella and human papillomavirus vaccines: towards enhancing vaccination uptake rates in developing countries. Papillomavirus Res 8:100172. https:\/\/doi.org\/10.1016\/J.PVR.2019.100172","journal-title":"Papillomavirus Res"},{"key":"12222_CR15","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1093\/FEMSPD\/FTAA002","volume":"77","author":"S Gupta","year":"2019","unstructured":"Gupta S, Singh D, Gupta M, Bhatnagar R (2019) A combined subunit vaccine comprising BP26, Omp25 and L7\/L12 against brucellosis. Pathog Dis 77:2.\u00a0https:\/\/doi.org\/10.1093\/FEMSPD\/FTAA002","journal-title":"Pathog Dis"},{"key":"12222_CR16","doi-asserted-by":"publisher","unstructured":"Hirai-Yuki A, Whitmire JK, Joyce M, Tyrrell DL, Lemon SM (2019) Murine models of hepatitis A virus infection. Cold Spring Harbor Perspectives in Medicine 9.\u00a0https:\/\/doi.org\/10.1101\/cshperspect.a031674","DOI":"10.1101\/cshperspect.a031674"},{"key":"12222_CR17","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1086\/513984","volume":"175","author":"H Kollaritsch","year":"1997","unstructured":"Kollaritsch H, Que JU, Kunz C, Wiedermann G, Herzog C, Cryz SJ (1997) Safety and immunogenicity of live oral cholera and typhoid vaccines administered alone or in combination with antimalarial drugs, oral polio vaccine, or yellow fever vaccine. J Infect Dis 175:871\u2013875. https:\/\/doi.org\/10.1086\/513984","journal-title":"J Infect Dis"},{"key":"12222_CR18","unstructured":"Leary SL, Underwood W, Anthony R, Cartner S, Corey D, Grandin T, Greenacre CB, Gwaltney-Bran S, McCrackin MA, Meyer R (2013) AVMA guidelines for the euthanasia of animals: 2013 edition. American Veterinary Medical Association,\u00a0Schaumburg, IL"},{"key":"12222_CR19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.4110\/in.2015.15.2.51","volume":"15","author":"S Lee","year":"2015","unstructured":"Lee S, Nguyen MT (2015) Recent advances of vaccine adjuvants for infectious diseases. Immune Netw 15:51. https:\/\/doi.org\/10.4110\/in.2015.15.2.51","journal-title":"Immune Netw"},{"key":"12222_CR20","doi-asserted-by":"publisher","first-page":"7959","DOI":"10.2147\/IJN.S165876","volume":"13","author":"A Malik","year":"2018","unstructured":"Malik A, Gupta M, Gupta V, Gogoi H, Bhatnagar R (2018) Novel application of trimethyl chitosan as an adjuvant in vaccine delivery. Int J Nanomed 13:7959. https:\/\/doi.org\/10.2147\/IJN.S165876","journal-title":"Int J Nanomed"},{"key":"12222_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/J.BIOMATERIALS.2018.08.054","volume":"184","author":"HBT Moran","year":"2018","unstructured":"Moran HBT, Turley JL, Andersson M, Lavelle EC (2018) Immunomodulatory properties of chitosan polymers. Biomaterials 184:1\u20139. https:\/\/doi.org\/10.1016\/J.BIOMATERIALS.2018.08.054","journal-title":"Biomaterials"},{"key":"12222_CR22","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/0167-5699(96)80606-2","volume":"17","author":"TR Mosmann","year":"1996","unstructured":"Mosmann TR, Sad S (1996) The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 17:138\u2013146. https:\/\/doi.org\/10.1016\/0167-5699(96)80606-2","journal-title":"Immunol Today"},{"key":"12222_CR23","doi-asserted-by":"publisher","first-page":"319","DOI":"10.2310\/7060.2005.12604","volume":"12","author":"D Overbosch","year":"2005","unstructured":"Overbosch D, Peyron F, Picot N, Varichon JP, Dumas R, Chambonneau L, Weber F (2005) Combined typhoid fever and hepatitis A vaccine: comparison of immunogenicity and safety to concomitant monovalent vaccine over 3 years. J Travel Med 12:319\u2013326. https:\/\/doi.org\/10.2310\/7060.2005.12604","journal-title":"J Travel Med"},{"key":"12222_CR24","doi-asserted-by":"publisher","first-page":"4812","DOI":"10.1016\/j.vaccine.2013.07.081","volume":"31","author":"R Scherlie\u00df","year":"2013","unstructured":"Scherlie\u00df R, Buske S, Young K, Weber B, Rades T, Hook S (2013) In vivo evaluation of chitosan as an adjuvant in subcutaneous vaccine formulations. Vaccine 31:4812\u20134819. https:\/\/doi.org\/10.1016\/j.vaccine.2013.07.081","journal-title":"Vaccine"},{"key":"12222_CR25","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1080\/21691401.2019.1576709","volume":"47","author":"P Shende","year":"2019","unstructured":"Shende P, Waghchaure M (2019) Combined vaccines for prophylaxis of infectious conditions. Artif Cells Nanomed Biotechnol 47:696\u2013705. https:\/\/doi.org\/10.1080\/21691401.2019.1576709","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"12222_CR26","doi-asserted-by":"publisher","first-page":"63","DOI":"10.4103\/0974-777X.77298","volume":"3","author":"DAG Skibinski","year":"2011","unstructured":"Skibinski DAG, Baudner BC, Singh M, O\u2019hagan DT (2011) Combination vaccines. J Global Infect Dis 3:63. https:\/\/doi.org\/10.4103\/0974-777X.77298","journal-title":"J Global Infect Dis"},{"key":"12222_CR27","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/334255a0","volume":"334","author":"TL Stevens","year":"1988","unstructured":"Stevens TL, Bossie A, Sanders VM, Fernandez-Botran R, Coffman RL, Mosmann TR, Vitetta ES (1988) Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 334:255\u2013258. https:\/\/doi.org\/10.1038\/334255a0","journal-title":"Nature"},{"key":"12222_CR28","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1080\/14760584.2020.1843434","volume":"19","author":"S Tafreshi","year":"2020","unstructured":"Tafreshi S, yed H (2020) Efficacy, safety, and formulation issues of the combined vaccines. Expert Rev Vaccines 19:949\u2013958. https:\/\/doi.org\/10.1080\/14760584.2020.1843434","journal-title":"Expert Rev Vaccines"},{"key":"12222_CR29","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/J.1708-8305.1998.TB00483.X","volume":"5","author":"C van Hoecke","year":"1998","unstructured":"van Hoecke C, Lebacq E, Beran J, Prymula R, Collard F (1998) Concomitant vaccination against hepatitis A and typhoid fever. J Travel Med 5:116\u2013120. https:\/\/doi.org\/10.1111\/J.1708-8305.1998.TB00483.X","journal-title":"J Travel Med"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-022-12222-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00253-022-12222-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-022-12222-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T03:11:35Z","timestamp":1668568295000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00253-022-12222-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,21]]},"references-count":29,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["12222"],"URL":"https:\/\/doi.org\/10.1007\/s00253-022-12222-4","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"type":"print","value":"0175-7598"},{"type":"electronic","value":"1432-0614"}],"subject":[],"published":{"date-parts":[[2022,10,21]]},"assertion":[{"value":"2 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration"}},{"value":"This study was conducted under the Scientific Research Ethical Committee\u2019s approval (permit number: 019\u201388), Beni-Suef University, Egypt.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}