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Therefore, there is an increasing need to develop new environmentally friendly, efficient, and reliable strategies for controlling plant bacterial diseases, and among them, the use of nanoparticles seems promising. The present study aimed to evaluate the feasibility of protecting plants against attacks of gram-negative and gram-positive phytopathogenic bacteria by using electrochemically synthesized silver ultra nanoclusters (ARGIRIUM\u2011SUNCs<jats:sup>\u00ae<\/jats:sup>) with an average size of 1.79\u00a0nm and characterized by rare oxidative states (Ag<jats:sup>2+\/3+<\/jats:sup>). ARGIRIUM\u2011SUNCs strongly inhibited the in vitro growth (effective concentration, EC<jats:sub>50<\/jats:sub>, less than 1\u00a0ppm) and biofilm formation of <jats:italic>Pseudomonas syringae<\/jats:italic> pv. <jats:italic>tomato<\/jats:italic> and of quarantine bacteria <jats:italic>Xanthomonas vesicatoria<\/jats:italic>, <jats:italic>Xylella fastidiosa<\/jats:italic> subsp. <jats:italic>pauca<\/jats:italic>, and <jats:italic>Clavibacter michiganensis<\/jats:italic> subsp. <jats:italic>michiganensis<\/jats:italic>. In addition, treatments with ARGIRIUM\u2011SUNCs also provoked the eradication of biofilm for <jats:italic>P. syringae<\/jats:italic> pv. <jats:italic>tomato<\/jats:italic>, <jats:italic>X. vesicatoria<\/jats:italic>, and <jats:italic>C. michiganensis<\/jats:italic> subsp. <jats:italic>michiganensis.<\/jats:italic> Treatment of tomato plants via root absorption with ARGIRIUM\u2011SUNCs (10\u00a0ppm) is not phytotoxic and protected (80%) the plants against <jats:italic>P. syringae<\/jats:italic> pv. <jats:italic>tomato<\/jats:italic> attacks. ARGIRIUM\u2011SUNCs at low doses induced hormetic effects on <jats:italic>P. syringae<\/jats:italic> pv. <jats:italic>tomato<\/jats:italic>, <jats:italic>X. vesicatoria<\/jats:italic>, and <jats:italic>C. michiganensis<\/jats:italic> subsp. <jats:italic>michiganensis<\/jats:italic> as well as on tomato root growth. The use of ARGIRIUM\u2011SUNCs in protecting plants against phytopathogenic bacteria is a possible alternative control measure.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Key points<\/jats:title>\n                <jats:p><jats:italic>\u2022 ARGIRIUM\u2011SUNC has strong antimicrobial activities against phytopathogenic bacteria;<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 ARGIRIUM\u2011SUNC inhibits biofilm formation at low doses;<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 ARGIRIUM\u2011SUNC protects tomato plants against bacterial speck disease.<\/jats:italic><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00253-023-12596-z","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T10:01:58Z","timestamp":1686218518000},"page":"4519-4531","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Silver nanoclusters with Ag2+\/3+ oxidative states are a new highly effective tool against phytopathogenic bacteria"],"prefix":"10.1007","volume":"107","author":[{"given":"Benedetta","family":"Orfei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1500-7320","authenticated-orcid":false,"given":"Chiaraluce","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Loreti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Tatulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Onofri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Scotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Aceto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Buonaurio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"12596_CR1","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.molliq.2019.04.048","volume":"284","author":"G Angelini","year":"2019","unstructured":"Angelini G, Scotti L, Aceto A, Gasbarri C (2019) Silver nanoparticles as interactive media for the azobenzenes isomerization in aqueous solution: from linear to stretched kinetics. 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