{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T04:50:52Z","timestamp":1775191852853,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"17","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31770106"],"award-info":[{"award-number":["31770106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2021JJ40341"],"award-info":[{"award-number":["2021JJ40341"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s00253-023-12636-8","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T06:01:56Z","timestamp":1688968916000},"page":"5439-5451","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of a Pirin-like protein on strain growth and spinosad biosynthesis in Saccharopolyspora spinosa"],"prefix":"10.1007","volume":"107","author":[{"given":"Li","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zirong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyuan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Rang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengbiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunjun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8443-2916","authenticated-orcid":false,"given":"Liqiu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"issue":"5","key":"12636_CR1","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1021\/acsomega.6b00231","volume":"1","author":"A Barman","year":"2016","unstructured":"Barman A, Hamelberg D (2016) Fe(II)\/Fe(III) redox process can significantly modulate the conformational dynamics and electrostatics of pirin in NF-kappaB regulation. ACS Omega 1(5):837\u2013842. https:\/\/doi.org\/10.1021\/acsomega.6b00231","journal-title":"ACS Omega"},{"issue":"6","key":"12636_CR2","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1139\/gen-2021-0094","volume":"65","author":"SC Brunetti","year":"2022","unstructured":"Brunetti SC, Arseneault MKM, Gulick PJ (2022) Characterization and expression of the pirin gene family in Triticum aestivum. Genome 65(6):349\u2013362. https:\/\/doi.org\/10.1139\/gen-2021-0094","journal-title":"Genome"},{"issue":"12","key":"12636_CR3","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nrmicro3546","volume":"13","author":"MJ Bush","year":"2015","unstructured":"Bush MJ, Tschowri N, Schlimpert S, Flardh K, Buttner MJ (2015) c-di-GMP signalling and the regulation of developmental transitions in Streptomycetes. Nat Rev Microbiol 13(12):749\u2013760. https:\/\/doi.org\/10.1038\/nrmicro3546","journal-title":"Nat Rev Microbiol"},{"key":"12636_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.5772\/18262","volume":"2011","author":"FA Chavez","year":"2011","unstructured":"Chavez FA, Banerjee A, Sljivic B (2011) Modeling the metal binding site in cupin protein. On Biomimetics 2011:3\u201328. https:\/\/doi.org\/10.5772\/18262","journal-title":"On Biomimetics"},{"issue":"22","key":"12636_CR5","doi-asserted-by":"publisher","first-page":"3316","DOI":"10.1038\/sj.onc.1202717","volume":"18","author":"R Dechend","year":"1999","unstructured":"Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A (1999) The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB\/Rel and nuclear co-regulators. Oncogene 18(22):3316\u20133323. https:\/\/doi.org\/10.1038\/sj.onc.1202717","journal-title":"Oncogene"},{"issue":"3","key":"12636_CR6","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.molcel.2019.11.006","volume":"77","author":"KA Gallagher","year":"2020","unstructured":"Gallagher KA, Schumacher MA, Bush MJ, Bibb MJ, Chandra G, Holmes NA, Zeng W, Henderson M, Zhang H, Findlay KC, Brennan RG, Buttner MJ (2020) c-di-GMP arms an anti-sigma to control progression of multicellular differentiation in Streptomyces. Mol Cell 77(3):586\u2013599. https:\/\/doi.org\/10.1016\/j.molcel.2019.11.006","journal-title":"Mol Cell"},{"issue":"12","key":"12636_CR7","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1021\/acschembio.9b00575","volume":"14","author":"B Guo","year":"2019","unstructured":"Guo B, Zhang Y, Hicks G, Huang X, Li R, Roy N, Jia Z (2019) Structure-dependent modulation of substrate binding and biodegradation activity of pirin proteins toward plant flavonols. ACS Chem Biol 14(12):2629\u20132640. https:\/\/doi.org\/10.1021\/acschembio.9b00575","journal-title":"ACS Chem Biol"},{"issue":"1","key":"12636_CR8","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/prot.22128","volume":"74","author":"D Gurmu","year":"2009","unstructured":"Gurmu D, Lu J, Johnson KA, Nordlund P, Holmgren A, Erlandsen H (2009) The crystal structure of the protein YhaK from Escherichia coli reveals a new subclass of redox sensitive enterobacterial bicupins. Proteins 74(1):18\u201331. https:\/\/doi.org\/10.1002\/prot.22128","journal-title":"Proteins"},{"issue":"1","key":"12636_CR9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12934-020-01299-z","volume":"19","author":"H He","year":"2020","unstructured":"He H, Yuan S, Hu J, Chen J, Rang J, Tang J, Liu Z, Xia Z, Ding X, Hu S, Xia L (2020) Effect of the TetR family transcriptional regulator Sp1418 on the global metabolic network of Saccharopolyspora pogona. Microb Cell Fact 19(1):27. https:\/\/doi.org\/10.1186\/s12934-020-01299-z","journal-title":"Microb Cell Fact"},{"issue":"10","key":"12636_CR10","doi-asserted-by":"publisher","first-page":"2740","DOI":"10.1021\/acssynbio.1c00344","volume":"10","author":"H He","year":"2021","unstructured":"He H, Tang J, Chen J, Hu J, Zhu Z, Liu Y, Shuai L, Cao L, Liu Z, Xia Z, Ding X, Hu S, Zhang Y, Rang J, Xia L (2021) Flaviolin-like gene cluster deletion optimized the butenyl-spinosyn biosynthesis route in Saccharopolyspora pogona. ACS Synth Biol 10(10):2740\u20132752. https:\/\/doi.org\/10.1021\/acssynbio.1c00344","journal-title":"ACS Synth Biol"},{"key":"12636_CR11","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.bbrc.2020.12.066","volume":"536","author":"N Hu","year":"2021","unstructured":"Hu N, Bai L, Dai E, Han L, Kang R, Li H, Tang D (2021) Pirin is a nuclear redox-sensitive modulator of autophagy-dependent ferroptosis. Biochem Biophys Res Commun 536:100\u2013106. https:\/\/doi.org\/10.1016\/j.bbrc.2020.12.066","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"12636_CR12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1159\/000487854","volume":"28","author":"Y Huang","year":"2018","unstructured":"Huang Y, Zhang X, Zhao C, Zhuang X, Zhu L, Guo C, Song Y (2018) Improvement of spinosad production upon utilization of oils and manipulation of beta-oxidation in a high-producing Saccharopolyspora spinosa strain. J Mol Microbiol Biotechnol 28(2):53\u201364. https:\/\/doi.org\/10.1159\/000487854","journal-title":"J Mol Microbiol Biotechnol"},{"issue":"9","key":"12636_CR13","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1007\/s00424-020-02379-0","volume":"472","author":"JM Jeckelmann","year":"2020","unstructured":"Jeckelmann JM, Erni B (2020) Transporters of glucose and other carbohydrates in bacteria. Pflugers Arch 472(9):1129\u20131153. https:\/\/doi.org\/10.1007\/s00424-020-02379-0","journal-title":"Pflugers Arch"},{"issue":"49","key":"12636_CR14","doi-asserted-by":"publisher","first-page":"14660","DOI":"10.1021\/acs.jafc.0c04443","volume":"68","author":"Z Liu","year":"2020","unstructured":"Liu Z, Zhu Z, Tang J, He H, Wan Q, Luo Y, Huang W, Yu Z, Hu Y, Ding X, Xia L (2020) RNA-Seq-based transcriptomic analysis of Saccharopolyspora spinosa revealed the critical function of PEP phosphonomutase in the replenishment pathway. J Agric Food Chem 68(49):14660\u201314669. https:\/\/doi.org\/10.1021\/acs.jafc.0c04443","journal-title":"J Agric Food Chem"},{"issue":"5","key":"12636_CR15","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1007\/s00253-021-11164-7","volume":"105","author":"Y Liu","year":"2021","unstructured":"Liu Y, Wang H, Li S, Zhang Y, Cheng X, Xiang W, Wang X (2021) Engineering of primary metabolic pathways for titer improvement of milbemycins in Streptomyces bingchenggensis. Appl Microbiol Biotechnol 105(5):1875\u20131887. https:\/\/doi.org\/10.1007\/s00253-021-11164-7","journal-title":"Appl Microbiol Biotechnol"},{"issue":"1","key":"12636_CR16","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s12934-021-01630-2","volume":"20","author":"Z Liu","year":"2021","unstructured":"Liu Z, Xiao J, Tang J, Liu Y, Shuai L, Cao L, Xia Z, Ding X, Rang J, Xia L (2021) Effects of acuC on the growth development and spinosad biosynthesis of Saccharopolyspora spinosa. Microb Cell Fact 20(1):141. https:\/\/doi.org\/10.1186\/s12934-021-01630-2","journal-title":"Microb Cell Fact"},{"issue":"12","key":"12636_CR17","doi-asserted-by":"publisher","first-page":"e00508","DOI":"10.1128\/AEM.00508-20","volume":"86","author":"M Lyu","year":"2020","unstructured":"Lyu M, Cheng Y, Han X, Wen Y, Song Y, Li J, Chen Z (2020) AccR, a TetR family transcriptional repressor, coordinates short-chain acyl coenzyme A homeostasis in Streptomyces avermitilis. Appl Environ Microbiol 86(12):e00508-e520. https:\/\/doi.org\/10.1128\/AEM.00508-20","journal-title":"Appl Environ Microbiol"},{"issue":"2","key":"12636_CR18","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3390\/biology10020116","volume":"10","author":"F Perez-Dominguez","year":"2021","unstructured":"Perez-Dominguez F, Carrillo-Beltran D, Blanco R, Munoz JP, Leon-Cruz G, Corvalan AH, Urzua U, Calaf GM, Aguayo F (2021) Role of pirin, an oxidative stress sensor protein, in epithelial carcinogenesis. Biology (basel) 10(2):116. https:\/\/doi.org\/10.3390\/biology10020116","journal-title":"Biology (basel)"},{"issue":"9","key":"12636_CR19","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1007\/s11274-017-2328-0","volume":"33","author":"A Romero-Rodriguez","year":"2017","unstructured":"Romero-Rodriguez A, Rocha D, Ruiz-Villafan B, Guzman-Trampe S, Maldonado-Carmona N, Vazquez-Hernandez M, Zelarayan A, Rodriguez-Sanoja R, Sanchez S (2017) Carbon catabolite regulation in Streptomyces: new insights and lessons learned. World J Microbiol Biotechnol 33(9):162. https:\/\/doi.org\/10.1007\/s11274-017-2328-0","journal-title":"World J Microbiol Biotechnol"},{"issue":"13","key":"12636_CR20","doi-asserted-by":"publisher","first-page":"6061","DOI":"10.1007\/s00253-014-5662-2","volume":"98","author":"B Ruiz-Villafan","year":"2014","unstructured":"Ruiz-Villafan B, Rodriguez-Sanoja R, Aguilar-Osorio G, Gosset G, Sanchez S (2014) Glucose kinases from Streptomyces peucetius var. caesius. Appl Microbiol Biotechnol 98(13):6061\u20136071. https:\/\/doi.org\/10.1007\/s00253-014-5662-2","journal-title":"Appl Microbiol Biotechnol"},{"issue":"1","key":"12636_CR21","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1128\/JB.00710-06","volume":"189","author":"PC Soo","year":"2007","unstructured":"Soo PC, Horng YT, Lai MJ, Wei JR, Hsieh SC, Chang YL, Tsai YH, Lai HC (2007) Pirin regulates pyruvate catabolism by interacting with the pyruvate dehydrogenase E1 subunit and modulating pyruvate dehydrogenase activity. J Bacteriol 189(1):109\u2013118. https:\/\/doi.org\/10.1128\/JB.00710-06","journal-title":"J Bacteriol"},{"issue":"1","key":"12636_CR22","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/s42003-020-0924-2","volume":"3","author":"CF Sun","year":"2020","unstructured":"Sun CF, Xu WF, Zhao QW, Luo S, Chen XA, Li YQ, Mao XM (2020) Crotonylation of key metabolic enzymes regulates carbon catabolite repression in Streptomyces roseosporus. Commun Biol 3(1):192. https:\/\/doi.org\/10.1038\/s42003-020-0924-2","journal-title":"Commun Biol"},{"key":"12636_CR23","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.ymben.2018.06.008","volume":"48","author":"A Tala","year":"2018","unstructured":"Tala A, Damiano F, Gallo G, Pinatel E, Calcagnile M, Testini M, Fico D, Rizzo D, Sutera A, Renzone G, Scaloni A, De Bellis G, Siculella L, De Benedetto GE, Puglia AM, Peano C, Alifano P (2018) Pirin: a novel redox-sensitive modulator of primary and secondary metabolism in Streptomyces. Metab Eng 48:254\u2013268. https:\/\/doi.org\/10.1016\/j.ymben.2018.06.008","journal-title":"Metab Eng"},{"issue":"1","key":"12636_CR24","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/s41587-019-0335-4","volume":"38","author":"W Wang","year":"2020","unstructured":"Wang W, Li S, Li Z, Zhang J, Fan K, Tan G, Ai G, Lam SM, Shui G, Yang Z, Lu H, Jin P, Li Y, Chen X, Xia X, Liu X, Dannelly HK, Yang C, Yang Y, Zhang S, Alterovitz G, Xiang W, Zhang L (2020) Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces. Nat Biotechnol 38(1):76\u201383. https:\/\/doi.org\/10.1038\/s41587-019-0335-4","journal-title":"Nat Biotechnol"},{"issue":"2","key":"12636_CR25","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1111\/1751-7915.13813","volume":"15","author":"Q Wang","year":"2022","unstructured":"Wang Q, Lu X, Yang H, Yan H, Wen Y (2022) Redox-sensitive transcriptional regulator SoxR directly controls antibiotic production, development and thiol-oxidative stress response in Streptomyces avermitilis. Microb Biotechnol 15(2):561\u2013576. https:\/\/doi.org\/10.1111\/1751-7915.13813","journal-title":"Microb Biotechnol"},{"key":"12636_CR26","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.bbrep.2015.08.001","volume":"3","author":"T Widiatningrum","year":"2015","unstructured":"Widiatningrum T, Maeda S, Kataoka K, Sakurai T (2015) A pirin-like protein from Pseudomonas stutzeri and its quercetinase activity. Biochem Biophys Rep 3:144\u2013149. https:\/\/doi.org\/10.1016\/j.bbrep.2015.08.001","journal-title":"Biochem Biophys Rep"},{"issue":"1","key":"12636_CR27","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/mmi.14405","volume":"113","author":"H Yan","year":"2020","unstructured":"Yan H, Lu X, Sun D, Zhuang S, Chen Q, Chen Z, Li J, Wen Y (2020) BldD, a master developmental repressor, activates antibiotic production in two Streptomyces species. Mol Microbiol 113(1):123\u2013142. https:\/\/doi.org\/10.1111\/mmi.14405","journal-title":"Mol Microbiol"},{"issue":"1","key":"12636_CR28","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nmeth.3213","volume":"12","author":"J Yang","year":"2015","unstructured":"Yang J, Yan R, Roy A, Xu D, Poisson J, Zhang Y (2015) The I-TASSER Suite: protein structure and function prediction. Nat Methods 12(1):7\u20138. https:\/\/doi.org\/10.1038\/nmeth.3213","journal-title":"Nat Methods"},{"issue":"20","key":"12636_CR29","doi-asserted-by":"publisher","first-page":"8629","DOI":"10.1007\/s00253-015-6883-8","volume":"99","author":"Q Yang","year":"2015","unstructured":"Yang Q, Li YL, Yang HJ, Rang J, Tang SJ, He L, Li L, Ding XZ, Xia LQ (2015) Proteomic insights into metabolic adaptation to deletion of metE in Saccharopolyspora spinosa. Appl Microbiol Biot 99(20):8629\u20138641. https:\/\/doi.org\/10.1007\/s00253-015-6883-8","journal-title":"Appl Microbiol Biot"},{"issue":"31","key":"12636_CR30","doi-asserted-by":"publisher","first-page":"12580","DOI":"10.1002\/anie.201811240","volume":"59","author":"R Zhang","year":"2020","unstructured":"Zhang R (2020) The cupin protein Pac13 is suggested by the data to be a homodimer. Angew Chem Int Ed Engl 59(31):12580\u201312583. https:\/\/doi.org\/10.1002\/anie.201811240","journal-title":"Angew Chem Int Ed Engl"},{"issue":"6","key":"12636_CR31","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1021\/acssynbio.0c00114","volume":"9","author":"F Zhang","year":"2020","unstructured":"Zhang F, Gao D, Lin J, Zhu M, Zhuang Z, Duan Y, Zhu X (2020) Construction of inducible genetic switch for the global regulator WblA to sustain both overproduction of tiancimycins and on-demand sporulation in Streptomyces sp. CB03234. ACS Synth Biol 9(6):1460\u20131467. https:\/\/doi.org\/10.1021\/acssynbio.0c00114","journal-title":"ACS Synth Biol"},{"issue":"1","key":"12636_CR32","doi-asserted-by":"publisher","first-page":"14779","DOI":"10.1038\/s41598-021-94251-z","volume":"11","author":"YP Zhang","year":"2021","unstructured":"Zhang YP, Liu XM, Yin T, Li Q, Zou QL, Huang KX, Guo DS, Zhang XL (2021) Comparative transcriptomic analysis of two Saccharopolyspora spinosa strains reveals the relationships between primary metabolism and spinosad production. Sci Rep-Uk 11(1):14779. https:\/\/doi.org\/10.1038\/s41598-021-94251-z","journal-title":"Sci Rep-Uk"},{"issue":"1","key":"12636_CR33","doi-asserted-by":"publisher","first-page":"7205","DOI":"10.1038\/s41467-021-27523-x","volume":"12","author":"G Zhao","year":"2021","unstructured":"Zhao G, Peng W, Song K, Shi J, Lu X, Wang B, Du YL (2021) Molecular basis of enzymatic nitrogen-nitrogen formation by a family of zinc-binding cupin enzymes. Nat Commun 12(1):7205. https:\/\/doi.org\/10.1038\/s41467-021-27523-x","journal-title":"Nat Commun"},{"issue":"5","key":"12636_CR34","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1021\/acs.jnatprod.0c00125","volume":"83","author":"M Zhu","year":"2020","unstructured":"Zhu M, Wang L, Zhang W, Liu Z, Ali M, Imtiaz M, He J (2020) Diisonitrile-mediated reactive oxygens species accumulation leads to bacterial growth inhibition. J Nat Prod 83(5):1634\u20131640. https:\/\/doi.org\/10.1021\/acs.jnatprod.0c00125","journal-title":"J Nat Prod"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-023-12636-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00253-023-12636-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-023-12636-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T14:03:52Z","timestamp":1690812232000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00253-023-12636-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,10]]},"references-count":34,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["12636"],"URL":"https:\/\/doi.org\/10.1007\/s00253-023-12636-8","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,10]]},"assertion":[{"value":"26 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}