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Antifungal therapy is not very effective, does not prevent recurrencies and usually causes side effects. Therefore, alternative therapies are urgently needed. The goal of this work was to investigate the potential benefits of using mannan oligosaccharides (MOS) extracts together with a <jats:italic>Lactobacillus<\/jats:italic> sp. pool, composed by the most significant species present in the vaginal environment, to prevent infections by <jats:italic>Candida albicans.<\/jats:italic> Microbial growth of isolated strains of the main vaginal lactobacilli and <jats:italic>Candida<\/jats:italic> strains was assessed in the presence of MOS, to screen their impact upon growth. A pool of the lactobacilli was then tested against <jats:italic>C. albicans<\/jats:italic> in competition and prophylaxis studies; bacterial and yeast cell numbers were quantified in specific time points, and the above-mentioned studies were assessed in simulated vaginal fluid (SVF). Finally, adhesion to vaginal epithelial cells (HeLa) was also evaluated, once again resorting to simultaneous exposure (competition) or prophylaxis assays, aiming to measure the effect of MOS presence in pathogen adherence. Results demonstrated that MOS extracts have potential to prevent vaginal candidiasis in synergy with vaginal lactobacilli, with improved results than those obtained when using lactobacilli alone.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Key points<\/jats:title>\n            <jats:p>\n              <jats:list list-type=\"bullet\">\n                <jats:list-item>\n                  <jats:p>\n                    <jats:italic>Potential benefits of MOS extracts with vaginal lactobacilli to prevent C. albicans infections.<\/jats:italic>\n                  <\/jats:p>\n                <\/jats:list-item>\n                <jats:list-item>\n                  <jats:p>\n                    <jats:italic>MOS impacts on growth of vaginal lactobacilli pool and C. albicans in SVF.<\/jats:italic>\n                  <\/jats:p>\n                <\/jats:list-item>\n                <jats:list-item>\n                  <jats:p>\n                    <jats:italic>MOS extracts in synergy with L. crispatus inhibit C. albicans adhesion in HeLa cells.<\/jats:italic>\n                  <\/jats:p>\n                <\/jats:list-item>\n              <\/jats:list>\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical Abstract<\/jats:title>\n          <\/jats:sec>","DOI":"10.1007\/s00253-023-12909-2","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T12:02:07Z","timestamp":1704801727000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Vaginal prevention of Candida albicans: synergistic effect of lactobacilli and mannan oligosaccharides (MOS)"],"prefix":"10.1007","volume":"108","author":[{"given":"Margarida","family":"Faustino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana Odila","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Margarida","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Sofia","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos M. 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