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While the probable mechanism of host invasion and pathogenesis is known in many pathogens, very little information is available on <jats:italic>Leptospira<\/jats:italic> invasion\/pathogenesis. For causing systemic infection <jats:italic>Leptospira<\/jats:italic> must transmigrate across epithelial barriers, which is the most critical and challenging step. Extracellular and membrane-bound proteases play a crucial role in the invasion process. An extensive search for the proteins experimentally proven to be involved in the invasion process through cell junction cleavage in other pathogens has resulted in identifying 26 proteins. The similarity searches on the <jats:italic>Leptospira<\/jats:italic> genome for counterparts of these 26 pathogenesis-related proteins identified at least 12 probable coding sequences. The proteins were either extracellular or membrane-bound with a proteolytic domain to cleave the cell junction proteins. This review will emphasize our current understanding of the pathogenic aspects of host cell junction-pathogenic protein interactions involved in the invasion process. Further, potential candidate proteins with cell junction cleavage properties that may be exploited in the diagnostic\/therapeutic aspects of leptospirosis will also be discussed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Key points<\/jats:title>\n            <jats:p>\n              <jats:italic>\u2022 The review focussed on the cell junction cleavage proteins in bacterial pathogenesis<\/jats:italic>\n            <\/jats:p>\n            <jats:p>\n              <jats:italic>\u2022 Cell junction disruptors from Leptospira genome are identified using bioinformatics<\/jats:italic>\n            <\/jats:p>\n            <jats:p>\n              <jats:italic>\u2022 The review provides insights into the therapeutic\/diagnostic interventions possible<\/jats:italic>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00253-023-12945-y","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T09:02:52Z","timestamp":1704877372000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cleavage of cell junction proteins as a host invasion strategy in leptospirosis"],"prefix":"10.1007","volume":"108","author":[{"given":"Preeti","family":"Kumari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhani","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sresha","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2031-9049","authenticated-orcid":false,"given":"Padikara K.","family":"Satheeshkumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"issue":"1","key":"12945_CR1","doi-asserted-by":"publisher","first-page":"1848212","DOI":"10.1080\/21688370.2020.1848212","volume":"9","author":"MS Adil","year":"2021","unstructured":"Adil MS, Narayanan SP, Somanath PR (2021) Cell-cell junctions: structure and regulation in physiology and pathology. 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