{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:21:30Z","timestamp":1780485690324,"version":"3.54.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the National Key R&D Program of China","award":["2019YFC1712302"],"award-info":[{"award-number":["2019YFC1712302"]}]},{"name":"the National Key R&D Program of China","award":["2019YFC1712304"],"award-info":[{"award-number":["2019YFC1712304"]}]},{"name":"Jiangxi Science and Technology Innovation Platform Project","award":["20194AFD45001"],"award-info":[{"award-number":["20194AFD45001"]}]},{"name":"Special Projects of Local Science and Technology Development Guided by the Central Government","award":["20192ZDD02002"],"award-info":[{"award-number":["20192ZDD02002"]}]},{"name":"the University-Enterprise cooperation transverse project","award":["No. 20220046"],"award-info":[{"award-number":["No. 20220046"]}]},{"name":"Jiangxi University of Chinese Medicine Science and Technology Innovation Team Development Program","award":["CXTD22001"],"award-info":[{"award-number":["CXTD22001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>Pulchinenoside B4, a natural saponin monomer from the <jats:italic>Pulsatilla<\/jats:italic> plant, plays an important role as an immunomodulator in the treatment of acute inflammation. Oral ulcer (OU) is a common ulcerative injury disease that occurs in the oral mucosa, including mucosal ulceration and abnormalities of lips and tongue. A close correlation exists between gut microbiota and circulating metabolites in patients with OU. However, the correlation between gut microbiota and serum metabolomics is not clear. Therefore, this study aimed to explore the changes in gut microbiota and metabolites in OU. The 16S ribosomal RNA (<jats:italic>16S rRNA<\/jats:italic>) gene sequencing was used to detect the changes in the composition of gut microbiota in OU rat model. Moreover, the endogenous small metabolites were explored by collecting the non-targeted serum metabolomics data. A total of 34 OU-related biomarkers were identified, mainly related to fatty acid metabolism and inflammatory pathways. The administration of B4 effectively reduced the occurrence of OU and restored the levels of multiple endogenous biomarkers and key gut microbial species to the normal level. This study demonstrated that the gut microbiota and metabolites were altered in the OU rat model, which were significantly restored to the normal level by B4, thereby showing good application prospects in the treatment of OU.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Key points<\/jats:title>\n            <jats:p>\u2022 <jats:italic>The first investigating the correlation between OU and gut microbiota.<\/jats:italic>\n            <\/jats:p>\n            <jats:p>\u2022 <jats:italic>A close correlation between metabolites and gut microbiota in OU disease was successfully identified.<\/jats:italic>\n            <\/jats:p>\n            <jats:p>\u2022 <jats:italic>Pulchinenoside B4 ameliorates oral ulcers in rats by modulating gut microbiota and metabolites.<\/jats:italic>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00253-024-13099-1","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T07:02:14Z","timestamp":1712646134000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pulchinenoside B4 ameliorates oral ulcers in rats by modulating gut microbiota and metabolites"],"prefix":"10.1007","volume":"108","author":[{"given":"Dewei","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhujun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4584-3357","authenticated-orcid":false,"given":"Hui","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,9]]},"reference":[{"key":"13099_CR1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1055\/s-0040-1712776","volume":"30","author":"M Ai-Talqani","year":"2018","unstructured":"Ai-Talqani M, Abdullah B, Hamneedi A (2018) Clinicopathological and immunohistochemical analysis of 21 cases of traumatic ulcerative granuloma with stromal eosinophilia using CD30, CD68 and TGF-\u03b21. J Bagh College Dentistry 30:45\u201353. https:\/\/doi.org\/10.1055\/s-0040-1712776","journal-title":"J Bagh College Dentistry"},{"key":"13099_CR2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1067\/mlc.2003","volume":"141","author":"I Bank","year":"2003","unstructured":"Bank I, Duvdevani M, Livneh A (2003) Expansion of \u03b3\u03b4 T-cells in Beh\u00e7et\u2019s disease: role of disease activity and microbial flora in oral ulcers. J Lab Clin Med 141:33\u201340. https:\/\/doi.org\/10.1067\/mlc.2003","journal-title":"J Lab Clin Med"},{"key":"13099_CR3","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1093\/jac\/43.2.177","volume":"43","author":"E Bergogne","year":"1999","unstructured":"Bergogne E, Bryskier A (1999) The suppository form of antibiotic administration: pharmacokinetics and clinical application. J Antimicrobial Chemotherapy 43:177\u2013185. https:\/\/doi.org\/10.1093\/jac\/43.2.177","journal-title":"J Antimicrobial Chemotherapy"},{"key":"13099_CR4","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.aca.2013.01.022","volume":"769","author":"J Boccard","year":"2013","unstructured":"Boccard J, Rutledge D (2013) A consensus orthogonal partial least squares discriminant analysis (OPLS-DA) strategy for multiblock omics data fusion. Anal Chimica Acta 769:30\u201339. https:\/\/doi.org\/10.1016\/j.aca.2013.01.022","journal-title":"Anal Chimica Acta"},{"issue":"4","key":"13099_CR5","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/S0213-005X(01)72604-3","volume":"19","author":"FJ Caballero-Granado","year":"2001","unstructured":"Caballero-Granado FJ, Becerril B, Cisneros JM, Pach\u00f3n J (2001) On the pathogenicity of Enterococcus spp. Enferm Infecc Microbiol Clin 19(4):184","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"13099_CR6","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1111\/jop.13020","volume":"49","author":"M Cabras","year":"2020","unstructured":"Cabras M, Carrozzo M, Gambino A, Broccoletti R, Sciascia S, Baldovino S, Arduino PG (2020) Value of colchicine as treatment for recurrent oral ulcers: a systematic review. J Oral Pathol Med 49:731\u2013740. https:\/\/doi.org\/10.1111\/jop.13020","journal-title":"J Oral Pathol Med"},{"key":"13099_CR7","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/s12906-020-03043-x","volume":"20","author":"P Chen","year":"2020","unstructured":"Chen P, Yao H, Yuan Q (2020a) Discovery of the possible mechanisms in kouyanqing granule for treatment of oral ulcers based on network pharmacology. BMC Complement Med Ther 20:258. https:\/\/doi.org\/10.1186\/s12906-020-03043-x","journal-title":"BMC Complement Med Ther"},{"key":"13099_CR8","doi-asserted-by":"publisher","first-page":"127924","DOI":"10.1016\/j.snb.2020.127924","volume":"311","author":"X Chen","year":"2020","unstructured":"Chen X, Yangli Xu, Meng L, Chen Xi, Yuan L-M, Cai Q, Shi W, Huang G (2020b) Non-parametric partial least squares-discriminant analysis model based on sum of ranking difference algorithm for tea grade identification using electronic tongue data. Sensor Actuat B-Chem 311:127924","journal-title":"Sensor Actuat B-Chem"},{"key":"13099_CR9","doi-asserted-by":"publisher","first-page":"142619","DOI":"10.1016\/j.scitotenv.2020.142619","volume":"755","author":"H Cheng","year":"2021","unstructured":"Cheng H, Wu B, Wei M, Wang S, Rong X, Du D, Wang C (2021a) Changes in community structure and metabolic function of soil bacteria depending on the type restoration processing in the degraded alpine grassland ecosystems in Northern Tibet. Sci Total Environ 755:142619. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.142619","journal-title":"Sci Total Environ"},{"issue":"9","key":"13099_CR10","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.jgg.2021.08.003","volume":"48","author":"S Cheng","year":"2021","unstructured":"Cheng S, Hu J, Wu X, Pan JA, Jiao N, Li Y, Huang Y, Lin X, Zou Y, Chen Y, Zhu L, Zhi M, Lan P (2021) Altered gut microbiome in FUT2 loss-of-function mutants in support of personalized medicine for inflammatory bowel diseases. J Genet Genomics 20 48(9):771\u2013780. https:\/\/doi.org\/10.1016\/j.jgg.2021.08.003","journal-title":"J Genet Genomics 20"},{"key":"13099_CR11","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/ecco-jcc\/jjaa143","volume":"15","author":"F Crouwel","year":"2021","unstructured":"Crouwel F, Buiter H, Boer N (2021) Gut microbiota-driven drug metabolism in inflammatory bowel disease. J Crohns Colitis 15:307\u2013315. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjaa143","journal-title":"J Crohns Colitis"},{"key":"13099_CR12","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/nature06245","volume":"449","author":"L Dethlefsen","year":"2007","unstructured":"Dethlefsen L, McFall-Ngai M, Relman DA (2007) An ecological and evolutionary perspective on human-microbe mutualism and disease. Nature 449:811\u2013818. https:\/\/doi.org\/10.1038\/nature06245","journal-title":"Nature"},{"key":"13099_CR13","doi-asserted-by":"publisher","first-page":"52","DOI":"10.5281\/zenodo.503330","volume":"31","author":"IN Ebenebe","year":"2021","unstructured":"Ebenebe IN, Uduma OE, Esimone CO, Anukam KC (2021) Development and evaluation of vaginal suppository containing Lactiplantibacillus pentosus KCA1 for treatment of bacterial vaginosis: can Fourier transform-infrared (FT-IR) spectroscopy be used for identification of Lactiplantibacillus pentosus KCA1? J Med Lab Sci 31:52\u201372. https:\/\/doi.org\/10.5281\/zenodo.503330","journal-title":"J Med Lab Sci"},{"issue":"11","key":"13099_CR14","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.3390\/microorganisms9112222","volume":"9","author":"M Ferchichi","year":"2021","unstructured":"Ferchichi M, Sebei K, Boukerb AM, Karray-Bouraoui N, Chevalier S, Feuilloley MGJ, Connil N, Zommiti M (2021) Enterococcus spp.: is it a bad choice for a good use-a conundrum to solve? Microorganisms 26 9(11):2222","journal-title":"Microorganisms 26"},{"key":"13099_CR15","doi-asserted-by":"publisher","first-page":"118723","DOI":"10.1016\/j.ijpharm.2019.118723","volume":"572","author":"A Foppoli","year":"2019","unstructured":"Foppoli A, Maroni A, Moutaharrik S, Melocchi A, Zema L, Palugan L, Cerea M, Gazzaniga A (2019) In vitro and human pharmacoscintigraphic evaluation of an oral 5-ASA delivery system for colonic release. Int J Pharmaceut 572:118723. https:\/\/doi.org\/10.1016\/j.ijpharm.2019.118723","journal-title":"Int J Pharmaceut"},{"key":"13099_CR16","doi-asserted-by":"publisher","first-page":"12205","DOI":"10.1038\/s41598-020-68976-2","volume":"10","author":"X Jin","year":"2020","unstructured":"Jin X, Wang J, Zhang X, Zhang W, Wang H, Chen C (2020) Gene mapping and functional annotation of GWAS of oral ulcers using FUMA software. Sci Rep 10:12205. https:\/\/doi.org\/10.1038\/s41598-020-68976-2","journal-title":"Sci Rep"},{"key":"13099_CR17","doi-asserted-by":"publisher","first-page":"152934","DOI":"10.1016\/j.phymed.2019.152934","volume":"64","author":"N Kang","year":"2019","unstructured":"Kang N, Shen W, Zhang Y, Su Z, Yang S, Liu Y, Xu Q (2019) Anti-inflammatory and immune-modulatory properties of anemoside B4 isolated from Pulsatillachinensis in vivo. Phytomedicine 64:152934. https:\/\/doi.org\/10.1016\/j.phymed.2019.152934","journal-title":"Phytomedicine"},{"key":"13099_CR18","doi-asserted-by":"publisher","first-page":"605783","DOI":"10.3389\/fmicb.2021.605783","volume":"12","author":"L Lee","year":"2021","unstructured":"Lee L, Wong S, Chin S, Singh V, Mutalib N (2021) Editorial: human microbiome: symbiosis to pathogenesis. Front Microbiol 12:605783. https:\/\/doi.org\/10.3389\/fmicb.2021.605783","journal-title":"Front Microbiol"},{"key":"13099_CR19","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.3389\/fpls.2019.01196","volume":"10","author":"QJ Li","year":"2019","unstructured":"Li QJ, Wang X, Wang JR, Su N, Zhang L, Ma YP, Chang ZY, Zhao L, Potter D (2019) Efficient identification of Pulsatilla (Ranunculaceae) using DNA barcodes and micro-morphological characters. Front Plant Sci 10:1196. https:\/\/doi.org\/10.3389\/fpls.2019.01196","journal-title":"Front Plant Sci"},{"key":"13099_CR20","doi-asserted-by":"publisher","first-page":"105079","DOI":"10.1016\/j.phrs.2020.105079","volume":"160","author":"YH Li","year":"2020","unstructured":"Li YH, Zou M, Han Q, Deng LR, Weinshilboum RM (2020) Therapeutic potential of triterpenoid saponin anemoside B4 from Pulsatillachinensis. Pharmacol Res 160:105079. https:\/\/doi.org\/10.1016\/j.phrs.2020.105079","journal-title":"Pharmacol Res"},{"key":"13099_CR21","doi-asserted-by":"publisher","first-page":"606689","DOI":"10.3389\/fphar.2020.606689","volume":"11","author":"J Li","year":"2021","unstructured":"Li J, Cao Y, Lu R, Li H, Pang Y, Fu H, Fang G, Chen Q, Liu B, Wu J, Zhou Y, Zhou J (2021) Integrated fecal microbiome and serum metabolomics analysis reveals abnormal changes in rats with immunoglobulin A nephropathy and the intervention effect of Zhen Wu Tang. Front Pharmacol 11:606689. https:\/\/doi.org\/10.3389\/fphar.2020.606689","journal-title":"Front Pharmacol"},{"key":"13099_CR22","doi-asserted-by":"publisher","unstructured":"Liang TT (2021) Study on the hypoglycemic and lipid-lowering effects and mechanism of probiotic lactic acid bacteria based on multi-omics. Shaanxi University of Science & Technology. https:\/\/doi.org\/10.27290\/d.cnki.gxbqc.2021.000446","DOI":"10.27290\/d.cnki.gxbqc.2021.000446"},{"key":"13099_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ecolind.2011.06.030","volume":"14","author":"J Lzask","year":"2012","unstructured":"Lzask J, Pavoine S (2012) Links between the species abundance distribution and the shape of the corresponding rank abundance curve. Ecol Indic 14:1\u20136. https:\/\/doi.org\/10.1016\/j.ecolind.2011.06.030","journal-title":"Ecol Indic"},{"key":"13099_CR24","doi-asserted-by":"publisher","first-page":"106794","DOI":"10.1016\/j.intimp.2020.106794","volume":"87","author":"H Ma","year":"2020","unstructured":"Ma H, Zhou M, Duan W, Chen L, Wang L, Liu P (2020) Anemoside B4 prevents acute ulcerative colitis through inhibiting of TLR4\/NF-\u03baB\/MAPK signaling pathway. Int Immunopharmacol 87:106794. https:\/\/doi.org\/10.1016\/j.intimp.2020.106794","journal-title":"Int Immunopharmacol"},{"issue":"19","key":"13099_CR25","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.3889\/oamjms.2019.689","volume":"7","author":"S Minhas","year":"2019","unstructured":"Minhas S, Sajjad A, Kashif M, Taj F, Waddani HA, Khurshid Z (2019) Oral ulcers presentation in systemic diseases: an update. Open Access Maced J Med Sci 7(19):3341\u20133347. https:\/\/doi.org\/10.3889\/oamjms.2019.689","journal-title":"Open Access Maced J Med Sci"},{"key":"13099_CR26","doi-asserted-by":"publisher","first-page":"109534","DOI":"10.1016\/j.cbi.2021.109534","volume":"345","author":"L Pei","year":"2021","unstructured":"Pei L, He L (2021) Hepatoprotective effect of anemoside B4 against sepsis-induced acute liver injury through modulating the mTOR\/p70S6K-mediated autophagy. Chem Biol Interact 345:109534. https:\/\/doi.org\/10.1016\/j.cbi.2021.109534","journal-title":"Chem Biol Interact"},{"issue":"2","key":"13099_CR27","first-page":"189","volume":"78","author":"LW Poulter","year":"1989","unstructured":"Poulter LW, Lehner T (1989) Immunohistology of oral lesions from patients with recurrent oral ulcers and Beh\u00e7et\u2019s syndrome. Clin Exp Immunol 78(2):189\u2013195","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"13099_CR28","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ajps.2020.06.003","volume":"16","author":"I Seoane-Via\u00f1o","year":"2021","unstructured":"Seoane-Via\u00f1o I, Ong JJ, Luzardo-\u00c1lvarez A, Gonz\u00e1lez-Barcia M, Basit AW, Otero-Espinar FJ, Goyanes A (2021) 3D printed tacrolimus suppositories for the treatment of ulcerative colitis. Asian J Pharm Sci 16(1):110\u2013119. https:\/\/doi.org\/10.1016\/j.ajps.2020.06.003","journal-title":"Asian J Pharm Sci"},{"issue":"1","key":"13099_CR29","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/0016-5085(84)90606-1","volume":"86","author":"GL Simon","year":"1984","unstructured":"Simon GL, Gorbach SL (1984) Intestinal flora in health and disease. Gastroenterology 86(1):174\u2013193 (PMID: 6357937)","journal-title":"Gastroenterology"},{"issue":"8","key":"13099_CR30","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1136\/ijgc-2020-001547","volume":"30","author":"TT Sims","year":"2020","unstructured":"Sims TT, Biegert GWG, Ramogola-Masire D, Ngoni K, Solley T, Ning MS, El Alam MB, Mezzari M, Petrosino J, Zetola NM, Schmeler KM, Colbert LE, Klopp AH, Grover S (2020) Tumor microbial diversity and compositional differences among women in Botswana with high-grade cervical dysplasia and cervical cancer. Int J Gynecol Cancer 30(8):1151\u20131156. https:\/\/doi.org\/10.1136\/ijgc-2020-001547","journal-title":"Int J Gynecol Cancer"},{"key":"13099_CR31","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.3389\/fphar.2018.01235","volume":"9","author":"B Sun","year":"2018","unstructured":"Sun B, Yuan J, Wang S, Lin J, Zhang W, Shao J, Wang R, Shi B, Hu H (2018) Qingchang suppository ameliorates colonic vascular permeability in dextran-sulfate-sodium-induced colitis. Front Pharmacol 31 9:1235","journal-title":"Front Pharmacol 31"},{"issue":"3","key":"13099_CR32","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1055\/s-0040-1712776","volume":"14","author":"MDC Surboyo","year":"2020","unstructured":"Surboyo MDC, Mahdani FY, Ernawati DS, Sarasati A, Rezkita F (2020) The macrophage responses during diabetic oral ulcer healing by liquid coconut shell smoke: an immunohistochemical analysis. Eur J Dent 14(3):410\u2013414. https:\/\/doi.org\/10.1055\/s-0040-1712776","journal-title":"Eur J Dent"},{"key":"13099_CR33","doi-asserted-by":"publisher","unstructured":"Toche P P, Salinas L J, Guzm\u00e1n M MA, Afani S A, Jadue A N (2007). Ulceras orales recurrentes: Caracter\u00edsticas cl\u00ednicas y diagn\u00f3stico diferencial [Recurrent oral ulcer: clinical characteristic and differential diagnosis]. Rev Chilena Infectol 24(3):215\u20139. Spanish. https:\/\/doi.org\/10.4067\/s0716-10182007000300007","DOI":"10.4067\/s0716-10182007000300007"},{"key":"13099_CR34","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.mpmed.2021.04.003","volume":"49","author":"S Yogarajah","year":"2021","unstructured":"Yogarajah S, Setterfield J (2021) Mouth ulcers and diseases of the oral cavity. Medicine 49:407\u2013413. https:\/\/doi.org\/10.1016\/j.mpmed.2021.04.003","journal-title":"Medicine"},{"key":"13099_CR35","doi-asserted-by":"publisher","first-page":"153538","DOI":"10.1016\/j.phymed.2021.153538","volume":"85","author":"ZW Yu","year":"2021","unstructured":"Yu ZW, Xie Y, Huang ZC, Yang K, Wang ZG, Hu HL (2021) Study of the therapeutic effect of raw and processed Vladimiriae Radix on ulcerative colitis based on intestinal flora, metabolomics and tissue distribution analysis. Phytomedicine 85:153538. https:\/\/doi.org\/10.1016\/j.phymed.2021.153538","journal-title":"Phytomedicine"},{"issue":"1","key":"13099_CR36","first-page":"603","volume":"14","author":"L Zeng","year":"2022","unstructured":"Zeng L, Li X, Bai G, Liu Y, Lu Q (2022) Rectal administration of Panaxnotoginseng and Colla corii asini suppositories in ulcerative colitis: clinical effect and influence on immune function. Am J Transl Res 15 14(1):603\u2013611","journal-title":"Am J Transl Res 15"},{"key":"13099_CR37","doi-asserted-by":"publisher","first-page":"122728","DOI":"10.1016\/j.jchromb.2021.122728","volume":"1174","author":"ZM Zhang","year":"2021","unstructured":"Zhang ZM, Yang L, Wan Y, Liu C, Jiang S, Shang EX, Duan JA (2021) Integrated gut microbiota and fecal metabolomics reveal the renoprotective effect of Rehmanniae Radix preparate and Corni Fructus on adenine-induced CKD rats. J Chromatogr B Analyt Technol Biomed Life Sci 1174:122728. https:\/\/doi.org\/10.1016\/j.jchromb.2021.122728","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-024-13099-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00253-024-13099-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-024-13099-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T20:44:02Z","timestamp":1748378642000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00253-024-13099-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,9]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["13099"],"URL":"https:\/\/doi.org\/10.1007\/s00253-024-13099-1","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,9]]},"assertion":[{"value":"28 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the procedures were reviewed and approved by the Animal Ethics Committee of Jiangxi University of Traditional Chinese Medicine before and during the experiment.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"292"}}