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As part of this study, a complex biotechnological and phytochemical assessment was conducted on <jats:italic>S. henryi<\/jats:italic> with a focus on phenolic compounds and antioxidant profiling. The following in vitro cultures were tested: microshoot agar and callus, microshoot agitated, and suspension, along with the microshoot culture in PlantForm bioreactors. Qualitative profiling was performed by ultra-high-performance liquid chromatography with a photodiode array detector coupled with ion-trap mass spectrophotometry with electrospray ionization and then quantitative analysis by high-performance liquid chromatography with a diode array detector using standards. In the extracts, mainly the compounds from procyanidins were identified as well as phenolic acids (neochlorogenic acid, caffeic acid, protocatechuic acid) and catechin. The highest content of phenolic compounds was found for in vitro agar microshoot culture (max. total content 229.87\u00a0mg\/100\u00a0g DW) and agitated culture (max. total content 22.82\u00a0mg\/100\u00a0g DW). The max. TPC measured using the Folin-Ciocalteu assay was equal to 1240.51\u00a0mg GAE\/100\u00a0g DW (agar microshoot culture). The extracts were evaluated for their antioxidant potential by the DPPH, FRAP, and chelate iron ion assays. The highest potential was indicated for agar microshoot culture (90% of inhibition and 59.31\u00a0nM\/L TEAC, respectively). The research conducted on the polyphenol profiling and antioxidant potential of <jats:italic>S. henryi <\/jats:italic>in vitro culture extracts indicates the high therapeutic potential of this species.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Key points<\/jats:title>\n            <jats:p>\n              <jats:italic>\u2022 Different types of S. henryi in vitro cultures were compared for the first time. <\/jats:italic>\n            <\/jats:p>\n            <jats:p>\n              <jats:italic>\u2022 The S. henryi in vitro culture strong antioxidant potential was determined for the first time.<\/jats:italic>\n            <\/jats:p>\n            <jats:p>\n              <jats:italic>\u2022 The polyphenol profiling of different types of S. henryi in vitro cultures was shown.<\/jats:italic>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00253-024-13159-6","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T10:02:01Z","timestamp":1715076121000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Phenolic compound profiling and antioxidant potential of different types of Schisandra henryi in vitro cultures"],"prefix":"10.1007","volume":"108","author":[{"given":"Karolina","family":"Jafernik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Kubica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Sharafan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Kruk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena Anna","family":"Malinowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Granica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6351-4047","authenticated-orcid":false,"given":"Agnieszka","family":"Szopa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,7]]},"reference":[{"key":"13159_CR1","doi-asserted-by":"publisher","first-page":"796","DOI":"10.3390\/PLANTS12040796\/S1","volume":"12","author":"MA Aksenova","year":"2023","unstructured":"Aksenova MA, Nechaeva TL, Zubova MY, Goncharuk EA, Kazantseva VV, Katanskaya VM, Lapshin PV, Zagoskina NV (2023) Influence of different precursors on content of polyphenols in Camellia sinensis in vitro callus culture. 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