{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:37:21Z","timestamp":1782401841035,"version":"3.54.5"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T00:00:00Z","timestamp":1722038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T00:00:00Z","timestamp":1722038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Xiaoyu Li","award":["DUT23YG214"],"award-info":[{"award-number":["DUT23YG214"]}]},{"name":"Yongping Xu","award":["No.2022JH1\/10900013"],"award-info":[{"award-number":["No.2022JH1\/10900013"]}]},{"name":"Jiajun Yin","award":["No. 243"],"award-info":[{"award-number":["No. 243"]}]},{"name":"Jiajun Yin","award":["2021"],"award-info":[{"award-number":["2021"]}]},{"name":"Jibin Li","award":["2021YF16SN012"],"award-info":[{"award-number":["2021YF16SN012"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>\n              <jats:italic>Acinetobacter baumannii<\/jats:italic>, which is resistant to multiple drugs, is an opportunistic pathogen responsible for severe nosocomial infections. With no antibiotics available, phages have obtained clinical attention. However, since immunocompromised patients are often susceptible to infection, the appropriate timing of administration is particularly important. During this research, we obtained a lytic phage vB_AbaM_P1 that specifically targets <jats:italic>A. baumannii<\/jats:italic>. We then assessed its potential as a prophylactic treatment for lung infections caused by clinical strains. The virus experiences a period of inactivity lasting 30\u00a0min and produces approximately 788 particles during an outbreak. Transmission electron microscopy shows that vB_AbaM_P1 was similar to the <jats:italic>Saclayvirus<\/jats:italic>. Based on the analysis of high-throughput sequencing and bioinformatics, vB_AbaM_P1 consists of 107537 bases with a G\u2009+\u2009C content of 37.68%. It contains a total of 177 open reading frames and 14 tRNAs. No antibiotic genes were detected. In vivo experiments, using a cyclophosphamide-induced neutrophil deficiency model, tested the protective effect of phage on neutrophil-deficient rats by prophylactic application of phage. The use of phages resulted in a decrease in rat mortality caused by <jats:italic>A. baumannii<\/jats:italic> and a reduction in the bacterial burden in the lungs. Histologic examination of lung tissue revealed a decrease in the presence of immune cells. The presence of phage vB_AbaM_P1 had a notable impact on preventing <jats:italic>A. baumannii<\/jats:italic> infection, as evidenced by the decrease in oxidative stress in lung tissue and cytokine levels in serum. Our research offers more robust evidence for the early utilization of bacteriophages to mitigate <jats:italic>A. baumannii<\/jats:italic> infection.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Key points<\/jats:title>\n            <jats:p>\u2022<jats:italic>A novel Saclayvirus phage infecting A. baumannii was isolated from sewage.<\/jats:italic>\n            <\/jats:p>\n            <jats:p>\u2022<jats:italic>The whole genome was determined, analyzed, and compared to other phages.<\/jats:italic>\n            <\/jats:p>\n            <jats:p>\u2022<jats:italic>Assaying the effect of phage in preventing infection in neutrophil-deficient models.<\/jats:italic>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00253-024-13208-0","type":"journal-article","created":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T10:01:57Z","timestamp":1722074517000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A novel Saclayvirus Acinetobacter baumannii phage genomic analysis and effectiveness in preventing pneumonia"],"prefix":"10.1007","volume":"108","author":[{"given":"Shibin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingdong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Murtaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jibin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3946-9223","authenticated-orcid":false,"given":"Yongping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,27]]},"reference":[{"issue":"D1","key":"13208_CR1","doi-asserted-by":"publisher","first-page":"D690","DOI":"10.1093\/nar\/gkac920","volume":"51","author":"BP Alcock","year":"2023","unstructured":"Alcock BP, Huynh W, Chalil R, Smith KW, Raphenya AR, Wlodarski MA, Edalatmand A, Petkau A, Syed SA, Tsang KK, Baker SJC, Dave M, McCarthy MC, Mukiri KM, Nasir JA, Golbon B, Imtiaz H, Jiang X, Kaur K, Kwong M, Liang ZC, Niu KC, Shan P, Yang JYJ, Gray KL, Hoad GR, Jia B, Bhando T, Carfrae LA, Farha MA, French S, Gordzevich R, Rachwalski K, Tu MM, Bordeleau E, Dooley D, Griffiths E, Zubyk HL, Brown ED, Maguire F, Beiko RG, Hsiao WWL, Brinkman FSL, Van Domselaar G, McArthur AG (2023) CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database. Nucleic Acids Res 51(D1):D690\u2013D699. https:\/\/doi.org\/10.1093\/nar\/gkac920","journal-title":"Nucleic Acids Res"},{"key":"13208_CR2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1471-2164-12-402","volume":"12","author":"NF Alikhan","year":"2011","unstructured":"Alikhan NF, Petty NK, Ben Zakour NL, Beatson SA (2011) BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons. BMC Genom 12:10. https:\/\/doi.org\/10.1186\/1471-2164-12-402","journal-title":"BMC Genom"},{"issue":"3","key":"13208_CR3","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.sjbs.2016.02.009","volume":"25","author":"SB Almasaudi","year":"2018","unstructured":"Almasaudi SB (2018) Acinetobacter spp. as nosocomial pathogens: epidemiology and resistance features. Saudi J Biol Sci 25(3):586\u2013596. https:\/\/doi.org\/10.1016\/j.sjbs.2016.02.009","journal-title":"Saudi J Biol Sci"},{"issue":"2","key":"13208_CR4","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s00705-019-04483-8","volume":"165","author":"M Asif","year":"2020","unstructured":"Asif M, Alvi IA, Tabassum R, Rehman SU (2020) TAC1, an unclassified bacteriophage of the family Myoviridae infecting Acinetobacter baumannii with a large burst size and a short latent period. Arch Virol 165(2):419\u2013424. https:\/\/doi.org\/10.1007\/s00705-019-04483-8","journal-title":"Arch Virol"},{"issue":"10","key":"13208_CR5","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1101\/gr.6649807","volume":"17","author":"M Bailly-Bechet","year":"2007","unstructured":"Bailly-Bechet M, Vergassola M, Rocha E (2007) Causes for the intriguing presence of tRNAs in phages. Genome Res 17(10):1486\u20131495. https:\/\/doi.org\/10.1101\/gr.6649807","journal-title":"Genome Res"},{"issue":"3","key":"13208_CR6","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.ijantimicag.2019.06.007","volume":"54","author":"J Barros","year":"2019","unstructured":"Barros J, Melo LDR, Poeta P, Igrejas G, Ferraz MP, Azeredo J, Monteiro FJ (2019) Lytic bacteriophages against multidrug-resistant Staphylococcus aureus, Enterococcus faecalis and Escherichia coli isolates from orthopaedic implant-associated infections. Int J Antimicrob Ag 54(3):329\u2013337. https:\/\/doi.org\/10.1016\/j.ijantimicag.2019.06.007","journal-title":"Int J Antimicrob Ag"},{"key":"13208_CR7","doi-asserted-by":"publisher","first-page":"8365","DOI":"10.1038\/srep08365","volume":"5","author":"T Brettin","year":"2015","unstructured":"Brettin T, Davis JJ, Disz T, Edwards RA, Gerdes S, Olsen GJ, Olson R, Overbeek R, Parrello B, Pusch GD, Shukla M, Thomason JA 3rd, Stevens R, Vonstein V, Wattam AR, Xia F (2015) RASTtk: a modular and extensible implementation of the RAST algorithm for building custom annotation pipelines and annotating batches of genomes. Sci Rep-Uk 5:8365. https:\/\/doi.org\/10.1038\/srep08365","journal-title":"Sci Rep-Uk"},{"issue":"18","key":"13208_CR8","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3390\/ijms21186709","volume":"21","author":"K Bujak","year":"2020","unstructured":"Bujak K, Decewicz P, Kaminski J, Radlinska M (2020) Identification, characterization, and genomic analysis of NovelSerratia temperate phages from a gold mine. Int J Mol Sci 21(18):28. https:\/\/doi.org\/10.3390\/ijms21186709","journal-title":"Int J Mol Sci"},{"issue":"9","key":"13208_CR9","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/nrmicro2632","volume":"9","author":"SR Casjens","year":"2011","unstructured":"Casjens SR (2011) The DNA-packaging nanomotor of tailed bacteriophages. Nat Rev Microbiol 9(9):647\u2013657. https:\/\/doi.org\/10.1038\/nrmicro2632","journal-title":"Nat Rev Microbiol"},{"issue":"16","key":"13208_CR10","doi-asserted-by":"publisher","first-page":"9077","DOI":"10.1093\/nar\/gkab688","volume":"49","author":"P Chan Patricia","year":"2021","unstructured":"Chan Patricia P, Lin Brian Y, Mak Allysia J, Lowe Todd M (2021) tRNAscan-SE 2.0: improved detection and functional classification of transfer RNA genes. Nucleic Acids Res 49(16):9077\u20139096. https:\/\/doi.org\/10.1093\/nar\/gkab688","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"13208_CR11","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1128\/JB.01637-06","volume":"189","author":"A Daniel","year":"2007","unstructured":"Daniel A, Bonnen PE, Fischetti VA (2007) First complete genome sequence of two Staphylococcus epidermidis bacteriophages. J Bacteriol 189(5):2086\u20132100. https:\/\/doi.org\/10.1128\/JB.01637-06","journal-title":"J Bacteriol"},{"issue":"4","key":"13208_CR12","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1006\/jmbi.1993.1545","volume":"233","author":"T Dokland","year":"1993","unstructured":"Dokland T, Murialdo H (1993) Structural transitions during maturation of bacteriophage-lambda capsids. J Mol Biol 233(4):682\u2013694. https:\/\/doi.org\/10.1006\/jmbi.1993.1545","journal-title":"J Mol Biol"},{"issue":"8","key":"13208_CR13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/v10080397","volume":"10","author":"M Dunne","year":"2018","unstructured":"Dunne M, Hupfeld M, Klumpp J, Loessner MJ (2018) Molecular basis of bacterial host interactions by gram-positive targeting bacteriophages. Viruses-Basel 10(8):25. https:\/\/doi.org\/10.3390\/v10080397","journal-title":"Viruses-Basel"},{"key":"13208_CR14","doi-asserted-by":"publisher","unstructured":"Essoh C, Vernadet JP, Vergnaud G, Coulibaly A, Kakou-N'Douba A, N'Guetta AS, Resch G, Pourcel C (2019) Complete genome sequences of five Acinetobacter baumannii phages from Abidjan, Cote d'Ivoire. Microbiol Resour Ann 8(1). https:\/\/doi.org\/10.1128\/MRA.01358-18","DOI":"10.1128\/MRA.01358-18"},{"key":"13208_CR15","doi-asserted-by":"publisher","unstructured":"Evseev PV, Lukianova AA, Shneider MM, Korzhenkov AA, Bugaeva EN, Kabanova AP, Miroshnikov KK, Kulikov EE, Toshchakov SV, Ignatov AN, Miroshnikov KA (2020) Origin and evolution of Studiervirinae bacteriophages infecting Pectobacterium: horizontal transfer assists adaptation to new niches. Microorganisms 8(11). https:\/\/doi.org\/10.3390\/microorganisms8111707","DOI":"10.3390\/microorganisms8111707"},{"key":"13208_CR16","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fmicb.2020.01273","volume":"11","author":"MD Finton","year":"2020","unstructured":"Finton MD, Meisal R, Porcellato D, Brandal LT, Lindstedt BA (2020) Whole genome sequencing and characterization of multidrug-resistant (MDR) bacteria strains isolated from a Norwegian University Campus Pond. Front Microbiol 11:12. https:\/\/doi.org\/10.3389\/fmicb.2020.01273","journal-title":"Front Microbiol"},{"issue":"1","key":"13208_CR17","doi-asserted-by":"publisher","first-page":"8292","DOI":"10.1038\/s41598-017-07910-5","volume":"7","author":"JR Garneau","year":"2017","unstructured":"Garneau JR, Depardieu F, Fortier LC, Bikard D, Monot M (2017) PhageTerm: a tool for fast and accurate determination of phage termini and packaging mechanism using next-generation sequencing data. Sci Rep-Uk 7(1):8292. https:\/\/doi.org\/10.1038\/s41598-017-07910-5","journal-title":"Sci Rep-Uk"},{"issue":"5430","key":"13208_CR18","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/246221a0","volume":"246","author":"MR Geier","year":"1973","unstructured":"Geier MR, Trigg ME, Merril CR (1973) Fate of bacteriophage-lambda in non-immune germfree mice. Nature 246(5430):221\u2013223. https:\/\/doi.org\/10.1038\/246221a0","journal-title":"Nature"},{"issue":"1","key":"13208_CR19","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/mSphere.00310-16","volume":"2","author":"A Giammanco","year":"2017","unstructured":"Giammanco A, Cala C, Fasciana T, Dowzicky MJ (2017) Global Assessment of the activity of tigecycline against multidrug-resistant gram-negative pathogens between 2004 and 2014 as part of the tigecycline evaluation and surveillance trial. mSphere 2(1):10. https:\/\/doi.org\/10.1128\/mSphere.00310-16","journal-title":"mSphere"},{"key":"13208_CR20","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fcimb.2021.681731","volume":"11","author":"YL Gong","year":"2021","unstructured":"Gong YL, Peng Y, Luo XQ, Zhang C, Shi YL, Zhang YX, Deng J, Peng YZ, Luo GX, Li HS (2021) Different infection profiles and antimicrobial resistance patterns between burn ICU and common wards. Front Cell Infect Mi 11:14. https:\/\/doi.org\/10.3389\/fcimb.2021.681731","journal-title":"Front Cell Infect Mi"},{"issue":"2","key":"13208_CR21","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/s0092-8674(00)80976-9","volume":"84","author":"H GoodrichBlair","year":"1996","unstructured":"GoodrichBlair H, Shub DA (1996) Beyond homing: competition between intron endonucleases confers a selective advantage on flanking genetic markers. Cell 84(2):211\u2013221. https:\/\/doi.org\/10.1016\/s0092-8674(00)80976-9","journal-title":"Cell"},{"key":"13208_CR22","doi-asserted-by":"publisher","first-page":"W181","DOI":"10.1093\/nar\/gkn179","volume":"36","author":"JR Grant","year":"2008","unstructured":"Grant JR, Stothard P (2008) The CGView server: a comparative genomics tool for circular genomes. Nucleic Acids Res 36:W181\u2013W184. https:\/\/doi.org\/10.1093\/nar\/gkn179","journal-title":"Nucleic Acids Res"},{"issue":"18","key":"13208_CR23","doi-asserted-by":"publisher","first-page":"3829","DOI":"10.1111\/bph.15526","volume":"178","author":"A Guillon","year":"2021","unstructured":"Guillon A, Pardessus J, L\u2019Hostis G, Fevre C, Barc C, Dalloneau E, Jouan Y, Bodier-Montagutelli E, Perez Y, Thorey C, Mereghetti L, Cabrera M, Riou M, Vecellio L, Le Guellec S, Heuze-Vourc\u2019h N (2021) Inhaled bacteriophage therapy in a porcine model of pneumonia caused by Pseudomonas aeruginosa during mechanical ventilation. Br J Pharmacol 178(18):3829\u20133842. https:\/\/doi.org\/10.1111\/bph.15526","journal-title":"Br J Pharmacol"},{"key":"13208_CR24","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/srep14802","volume":"5","author":"K Hodyra-Stefaniak","year":"2015","unstructured":"Hodyra-Stefaniak K, Miernikiewicz P, Drapala J, Drab M, Jonczyk-Matysiak E, Lecion D, Kazmierczak Z, Beta W, Majewska J, Harhala M, Bubak B, Klopot A, Gorski A, Dabrowska K (2015) Mammalian host-versus-phage immune response determines phage fate in vivo. Sci Rep-Uk 5:13. https:\/\/doi.org\/10.1038\/srep14802","journal-title":"Sci Rep-Uk"},{"issue":"1","key":"13208_CR25","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.jmb.2007.12.064","volume":"377","author":"HF Hou","year":"2008","unstructured":"Hou HF, Liang YH, Li LF, Su XD, Dong YH (2008) Crystal structures of Streptococcus mutans 2\u2019-deoxycytidylate deaminase and its complex with substrate analog and allosteric regulator dCTP x Mg2+. J Mol Biol 377(1):220\u2013231. https:\/\/doi.org\/10.1016\/j.jmb.2007.12.064","journal-title":"J Mol Biol"},{"key":"13208_CR26","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3389\/fphar.2019.00092","volume":"10","author":"YQ Huang","year":"2019","unstructured":"Huang YQ, Zhou Q, Wang WG, Huang Q, Liao J, Li JY, Long L, Ju T, Zhang Q, Wang HQ, Xu HQ, Tu ML (2019) Acinetobacter baumannii ventilator-associated pneumonia: clinical efficacy of combined antimicrobial therapy and in vitro drug sensitivity test results. Front Pharmacol 10:11. https:\/\/doi.org\/10.3389\/fphar.2019.00092","journal-title":"Front Pharmacol"},{"issue":"7","key":"13208_CR27","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/microorganisms8071089","volume":"8","author":"MS Islam","year":"2020","unstructured":"Islam MS, Hu Y, Mizan MFR, Yan T, Nime I, Zhou Y, Li JQ (2020) Characterization of Salmonella phage LPST153 that effectively targets most prevalent Salmonella serovars. Microorganisms 8(7):18. https:\/\/doi.org\/10.3390\/microorganisms8071089","journal-title":"Microorganisms"},{"issue":"14","key":"13208_CR28","doi-asserted-by":"publisher","first-page":"4200","DOI":"10.1128\/AEM.00526-16","volume":"82","author":"J Jeon","year":"2016","unstructured":"Jeon J, Ryu CM, Lee JY, Park JH, Yong D, Lee K (2016) In vivo application of bacteriophage as a potential therapeutic agent to control OXA-66-like carbapenemase-producing Acinetobacter baumannii strains belonging to sequence type 357. Appl Environ Microb 82(14):4200\u20134208. https:\/\/doi.org\/10.1128\/AEM.00526-16","journal-title":"Appl Environ Microb"},{"key":"13208_CR29","doi-asserted-by":"publisher","unstructured":"Jeon J, Yong D (2019) Two novel bacteriophages improve survival in galleria mellonella infection and mouse acute pneumonia models infected with extensively drug-resistant Pseudomonas aeruginosa. Appl Environ Microb 85(9). https:\/\/doi.org\/10.1128\/AEM.02900-18","DOI":"10.1128\/AEM.02900-18"},{"issue":"33","key":"13208_CR30","doi-asserted-by":"publisher","first-page":"20277","DOI":"10.1016\/s0021-9258(17)30501-x","volume":"265","author":"S Kaneda","year":"1990","unstructured":"Kaneda S, Nalbantoglu J, Takeishi K, Shimizu K, Gotoh O, Seno T, Ayusawa D (1990) Structural and functional analysis of the human thymidylate synthase gene. J Biol Chem 265(33):20277\u201320284. https:\/\/doi.org\/10.1016\/s0021-9258(17)30501-x","journal-title":"J Biol Chem"},{"issue":"2","key":"13208_CR31","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/0022-2836(89)90350-1","volume":"205","author":"I Katsura","year":"1989","unstructured":"Katsura I (1989) Structure and inherent properties of the bacteriophage lambda-head shell .6. DNA-packaging-defective mutants in the major capsid protein. J Mol Biol 205(2):397\u2013405. https:\/\/doi.org\/10.1016\/0022-2836(89)90350-1","journal-title":"J Mol Biol"},{"issue":"3","key":"13208_CR32","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/s0022-2836(05)80211-6","volume":"213","author":"I Katsura","year":"1990","unstructured":"Katsura I, Kobayashi H (1990) Structure and inherent properties of the bacteriophage-lambda head shell .7. Molecular design of the form-determining major capsid protein. J Mol Biol 213(3):503\u2013511. https:\/\/doi.org\/10.1016\/s0022-2836(05)80211-6","journal-title":"J Mol Biol"},{"issue":"49","key":"13208_CR33","doi-asserted-by":"publisher","first-page":"48627","DOI":"10.1074\/jbc.M306981200","volume":"278","author":"JA Korhonen","year":"2003","unstructured":"Korhonen JA, Gaspari M, Falkenberg M (2003) TWINKLE Has 5\u2032 -> 3\u2032 DNA helicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein. J Biol Chem 278(49):48627\u201348632. https:\/\/doi.org\/10.1074\/jbc.M306981200","journal-title":"J Biol Chem"},{"issue":"2","key":"13208_CR34","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.chom.2019.01.014","volume":"25","author":"KE Kortright","year":"2019","unstructured":"Kortright KE, Chan BK, Koff JL, Turner PE (2019) Phage therapy: a renewed approach to combat antibiotic-resistant bacteria. Cell Host Microbe 25(2):219\u2013232. https:\/\/doi.org\/10.1016\/j.chom.2019.01.014","journal-title":"Cell Host Microbe"},{"key":"13208_CR35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ijfoodmicro.2014.01.019","volume":"176","author":"W Kot","year":"2014","unstructured":"Kot W, Hansen LH, Neve H, Hammer K, Jacobsen S, Pedersen PD, Sorensen SJ, Heller KJ, Vogensen FK (2014) Sequence and comparative analysis of Leuconostoc dairy bacteriophages. Int J Food Microbiol 176:29\u201337. https:\/\/doi.org\/10.1016\/j.ijfoodmicro.2014.01.019","journal-title":"Int J Food Microbiol"},{"issue":"7","key":"13208_CR36","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1093\/molbev\/msw054","volume":"33","author":"S Kumar","year":"2016","unstructured":"Kumar S, Stecher G, Tamura K (2016) MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol Biol Evol 33(7):1870\u20134. https:\/\/doi.org\/10.1093\/molbev\/msw054","journal-title":"Mol Biol Evol"},{"issue":"7","key":"13208_CR37","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/md18070370","volume":"18","author":"J Li","year":"2020","unstructured":"Li J, Li Y, Li YY, Yang ZS, Jin HX (2020) Physicochemical properties of collagen from Acaudina molpadioides and its protective effects against H2O2-induced injury in RAW264.7 Cells. Mar Drugs 18(7):13. https:\/\/doi.org\/10.3390\/md18070370","journal-title":"Mar Drugs"},{"key":"13208_CR38","doi-asserted-by":"publisher","first-page":"26455","DOI":"10.1038\/srep26455","volume":"6","author":"X Li","year":"2016","unstructured":"Li X, Koc C, Kuhner P, Stierhof YD, Krismer B, Enright MC, Penades JR, Wolz C, Stehle T, Cambillau C, Peschel A, Xia G (2016) An essential role for the baseplate protein Gp45 in phage adsorption to Staphylococcus aureus. Sci Rep-Uk 6:26455. https:\/\/doi.org\/10.1038\/srep26455","journal-title":"Sci Rep-Uk"},{"issue":"28","key":"13208_CR39","doi-asserted-by":"publisher","first-page":"7429","DOI":"10.1039\/d0sc00293c","volume":"11","author":"YH Li","year":"2020","unstructured":"Li YH, Gong SH, Pan W, Chen YY, Liu B, Li N, Tang B (2020b) A tumor acidity activatable and Ca2+-assisted immuno-nanoagent enhances breast cancer therapy and suppresses cancer recurrence. Chem Sci 11(28):7429\u20137437. https:\/\/doi.org\/10.1039\/d0sc00293c","journal-title":"Chem Sci"},{"issue":"13","key":"13208_CR40","doi-asserted-by":"publisher","first-page":"4369","DOI":"10.1128\/JB.186.13.4369-4375.2004","volume":"186","author":"J Liu","year":"2004","unstructured":"Liu J, Mushegian A (2004) Displacements of prohead protease genes in the late operons of double-stranded-DNA bacteriophages. J Bacteriol 186(13):4369\u20134375. https:\/\/doi.org\/10.1128\/JB.186.13.4369-4375.2004","journal-title":"J Bacteriol"},{"key":"13208_CR41","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fmicb.2020.01947","volume":"11","author":"A Luscher","year":"2020","unstructured":"Luscher A, Simonin J, Falconnet L, Valot B, Hocquet D, Chanson M, Resch G, Kohler T, van Delden C (2020) Combined bacteriophage and antibiotic treatment prevents Pseudomonas aeruginosa infection of wild type and CFTR-epithelial cells. Front Microbiol 11:12. https:\/\/doi.org\/10.3389\/fmicb.2020.01947","journal-title":"Front Microbiol"},{"issue":"11","key":"13208_CR42","doi-asserted-by":"publisher","first-page":"e3001424","DOI":"10.1371\/journal.pbio.3001424","volume":"19","author":"E Maffei","year":"2021","unstructured":"Maffei E, Shaidullina A, Burkolter M, Heyer Y, Estermann F, Druelle V, Sauer P, Willi L, Michaelis S, Hilbi H, Thaler DS, Harms A (2021) Systematic exploration of Escherichia coli phage-host interactions with the BASEL phage collection. PLoS Biol 19(11):e3001424. https:\/\/doi.org\/10.1371\/journal.pbio.3001424","journal-title":"PLoS Biol"},{"issue":"Pt 11","key":"13208_CR43","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1099\/jmm.0.060004-0","volume":"62","author":"S Manepalli","year":"2013","unstructured":"Manepalli S, Gandhi JA, Ekhar VV, Asplund MB, Coelho C, Martinez LR (2013) Characterization of a cyclophosphamide-induced murine model of immunosuppression to study Acinetobacter baumannii pathogenesis. J Med Microbiol 62(Pt 11):1747\u20131754. https:\/\/doi.org\/10.1099\/jmm.0.060004-0","journal-title":"J Med Microbiol"},{"issue":"8","key":"13208_CR44","doi-asserted-by":"publisher","first-page":"e104853","DOI":"10.1371\/journal.pone.0104853","volume":"9","author":"M Merabishvili","year":"2014","unstructured":"Merabishvili M, Vandenheuvel D, Kropinski AM, Mast J, De Vos D, Verbeken G, Noben JP, Lavigne R, Vaneechoutte M, Pirnay JP (2014) Characterization of newly isolated lytic bacteriophages active against Acinetobacter baumannii. PLoS ONE 9(8):e104853. https:\/\/doi.org\/10.1371\/journal.pone.0104853","journal-title":"PLoS ONE"},{"issue":"1","key":"13208_CR45","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.cell.2006.08.038","volume":"127","author":"J Nandakumar","year":"2006","unstructured":"Nandakumar J, Shuman S, Lima CD (2006) RNA ligase structures reveal the basis for RNA specificity and conformational changes that drive ligation forward. Cell 127(1):71\u201384. https:\/\/doi.org\/10.1016\/j.cell.2006.08.038","journal-title":"Cell"},{"issue":"1","key":"13208_CR46","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12929-020-0617-7","volume":"27","author":"D Nie","year":"2020","unstructured":"Nie D, Hu Y, Chen Z, Li MK, Hou Z, Luo XX, Mao XG, Xue XY (2020) Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection. J Biomed Sci 27(1):8. https:\/\/doi.org\/10.1186\/s12929-020-0617-7","journal-title":"J Biomed Sci"},{"key":"13208_CR47","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.2147\/idr.S169432","volume":"11","author":"TS Niu","year":"2018","unstructured":"Niu TS, Xiao TT, Guo LH, Yu W, Chen YB, Zheng BW, Huang C, Yu X, Xiao YH (2018) Retrospective comparative analysis of risk factors and outcomes in patients with carbapenem-resistant Acinetobacter baumannii bloodstream infections: cefoperazone-sulbactam associated with resistance and tigecycline increased the mortality. Infect Drug Resist 11:2021\u20132030. https:\/\/doi.org\/10.2147\/idr.S169432","journal-title":"Infect Drug Resist"},{"key":"13208_CR48","doi-asserted-by":"publisher","unstructured":"Palser S, Smith S, Nash EF, Agarwal A, Smyth AR (2019) Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis. Cochrane Database Syst Rev 12:CD012300. https:\/\/doi.org\/10.1002\/14651858.CD012300.pub2","DOI":"10.1002\/14651858.CD012300.pub2"},{"issue":"4","key":"13208_CR49","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.celrep.2020.107956","volume":"32","author":"A Pasechnek","year":"2020","unstructured":"Pasechnek A, Rabinovich L, Stadnyuk O, Azulay G, Mioduser J, Argov T, Borovok I, Sigal N, Herskovits AA (2020) Active lysogeny in Listeria monocytogenes is a bacteria-phage adaptive response in the mammalian environment. Cell Rep 32(4):17. https:\/\/doi.org\/10.1016\/j.celrep.2020.107956","journal-title":"Cell Rep"},{"issue":"D1","key":"13208_CR50","doi-asserted-by":"publisher","first-page":"D418","DOI":"10.1093\/nar\/gkac993","volume":"51","author":"T Paysan-Lafosse","year":"2023","unstructured":"Paysan-Lafosse T, Blum M, Chuguransky S, Grego T, Pinto BL, Salazar GA, Bileschi ML, Bork P, Bridge A, Colwell L, Gough J, Haft DH, Letunic I, Marchler-Bauer A, Mi H, Natale DA, Orengo CA, Pandurangan AP, Rivoire C, Sigrist CJA, Sillitoe I, Thanki N, Thomas PD, Tosatto SCE, Wu CH, Bateman A (2023) InterPro in 2022. Nucleic Acids Res 51(D1):D418\u2013D427. https:\/\/doi.org\/10.1093\/nar\/gkac993","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"13208_CR51","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1586\/eri.13.12","volume":"11","author":"JN Pendleton","year":"2013","unstructured":"Pendleton JN, Gorman SP, Gilmore BF (2013) Clinical relevance of the ESKAPE pathogens. Expert Rev Anti-Infe 11(3):297\u2013308. https:\/\/doi.org\/10.1586\/eri.13.12","journal-title":"Expert Rev Anti-Infe"},{"issue":"15","key":"13208_CR52","doi-asserted-by":"publisher","first-page":"7449","DOI":"10.1128\/jvi.00385-15","volume":"89","author":"DP Pires","year":"2015","unstructured":"Pires DP, Boas DV, Sillankorva S, Azeredo J (2015) Phage therapy: a step forward in the Treatment of Pseudomonas aeruginosa Infections. J Virol 89(15):7449\u20137456. https:\/\/doi.org\/10.1128\/jvi.00385-15","journal-title":"J Virol"},{"issue":"9","key":"13208_CR53","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1164\/rccm.201812-2372OC","volume":"200","author":"J Prazak","year":"2019","unstructured":"Prazak J, Iten M, Cameron DR, Save J, Grandgirard D, Resch G, Goepfert C, Leib SL, Takala J, Jakob SM, Que YA, Haenggi M (2019) Bacteriophages improve outcomes in experimental Staphylococcus aureus ventilator-associated pneumonia. Am J Respir Crit Care Med 200(9):1126\u20131133. https:\/\/doi.org\/10.1164\/rccm.201812-2372OC","journal-title":"Am J Respir Crit Care Med"},{"key":"13208_CR54","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.coviro.2018.09.004","volume":"31","author":"PE Prevelige Jr","year":"2018","unstructured":"Prevelige PE Jr, Cortines JR (2018) Phage assembly and the special role of the portal protein. Curr Opin Virol 31:66\u201373. https:\/\/doi.org\/10.1016\/j.coviro.2018.09.004","journal-title":"Curr Opin Virol"},{"issue":"8","key":"13208_CR55","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1086\/533452","volume":"197","author":"LB Rice","year":"2008","unstructured":"Rice LB (2008) Federal funding for the study of antimicrobial resistance in nosocomial pathogens: No ESKAPE. J Infect Dis 197(8):1079\u20131081. https:\/\/doi.org\/10.1086\/533452","journal-title":"J Infect Dis"},{"issue":"21","key":"13208_CR56","doi-asserted-by":"publisher","first-page":"11265","DOI":"10.1128\/JVI.01769-10","volume":"85","author":"SB Santos","year":"2011","unstructured":"Santos SB, Kropinski AM, Ceyssens PJ, Ackermann HW, Villegas A, Lavigne R, Krylov VN, Carvalho CM, Ferreira EC, Azeredo J (2011) Genomic and proteomic characterization of the broad-host-range Salmonella phage PVP-SE1: creation of a new phage genus. J Virol 85(21):11265\u201311273. https:\/\/doi.org\/10.1128\/JVI.01769-10","journal-title":"J Virol"},{"issue":"1","key":"13208_CR57","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1534\/genetics.108.090100","volume":"180","author":"Y Shao","year":"2008","unstructured":"Shao Y, Wang IN (2008) Bacteriophage adsorption rate and optimal lysis time. Genetics 180(1):471\u2013482. https:\/\/doi.org\/10.1534\/genetics.108.090100","journal-title":"Genetics"},{"issue":"1","key":"13208_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1086\/668770","volume":"34","author":"DM Sievert","year":"2013","unstructured":"Sievert DM, Ricks P, Edwards JR, Schneider A, Patel J, Srinivasan A, Kallen A, Limbago B, Fridkin S, Natl Healthcare Safety N, Participating NF (2013) Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the national healthcare safety network at the centers for disease control and prevention, 2009\u20132010. Infect Cont Hosp Ep 34(1):1\u201314. https:\/\/doi.org\/10.1086\/668770","journal-title":"Infect Cont Hosp Ep"},{"issue":"7","key":"13208_CR59","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1093\/bioinformatics\/btr039","volume":"27","author":"MJ Sullivan","year":"2011","unstructured":"Sullivan MJ, Petty NK, Beatson SA (2011) Easyfig: a genome comparison visualizer. Bioinformatics 27(7):1009\u20131010. https:\/\/doi.org\/10.1093\/bioinformatics\/btr039","journal-title":"Bioinformatics"},{"key":"13208_CR60","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12864-017-3886-0","volume":"18","author":"K Tang","year":"2017","unstructured":"Tang K, Lin D, Zheng Q, Liu KS, Yang YJ, Han Y, Jiao NZ (2017) Genomic, proteomic and bioinformatic analysis of two temperate phages in Roseobacter clade bacteria isolated from the deep-sea water. BMC Genomics 18:11. https:\/\/doi.org\/10.1186\/s12864-017-3886-0","journal-title":"BMC Genomics"},{"key":"13208_CR61","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/1471-2164-7-150","volume":"7","author":"V Tcherepanov","year":"2006","unstructured":"Tcherepanov V, Ehlers A, Upton C (2006) Genome annotation transfer utility (GATU): rapid annotation of viral genomes using a closely related reference genome. BMC Genomics 7:150. https:\/\/doi.org\/10.1186\/1471-2164-7-150","journal-title":"BMC Genomics"},{"issue":"4844","key":"13208_CR62","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1126\/science.2830673","volume":"239","author":"JJ Trimble","year":"1988","unstructured":"Trimble JJ, Murthy SCS, Bakker A, Grassmann R, Desrosiers RC (1988) A gene for dihydrofolate-reductase in a herpesvirus. Science 239(4844):1145\u20131147. https:\/\/doi.org\/10.1126\/science.2830673","journal-title":"Science"},{"issue":"4","key":"13208_CR63","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/antibiotics9040205","volume":"9","author":"R Vazquez-Lopez","year":"2020","unstructured":"Vazquez-Lopez R, Solano-Galvez SG, Vignon-Whaley JJJ, Vaamonde JAA, Alonzo LAP, Resendiz AR, Alvarez MM, Lopez ENV, Franyuti-Kelly G, Alvarez-Hernandez DA, Guzman VM, Banuelos JEJ, Felix JM, Barrios JAG, Fortes TB (2020) Acinetobacter baumannii resistance: a real challenge for clinicians. Antibiotics-Basel 9(4):22. https:\/\/doi.org\/10.3390\/antibiotics9040205","journal-title":"Antibiotics-Basel"},{"issue":"5","key":"13208_CR64","doi-asserted-by":"publisher","first-page":"631","DOI":"10.2217\/fmb.16.11","volume":"11","author":"Y Wang","year":"2016","unstructured":"Wang Y, Mi ZQ, Niu WK, An XP, Yuan X, Liu HY, Li PY, Liu YN, Feng YZ, Huang Y, Zhang XL, Zhang ZY, Fan H, Peng F, Tong Y, Bai CQ (2016) Intranasal treatment with bacteriophage rescues mice from Acinetobacter baumannii-mediated pneumonia. Future Microbiol 11(5):631\u2013641. https:\/\/doi.org\/10.2217\/fmb.16.11","journal-title":"Future Microbiol"},{"key":"13208_CR65","doi-asserted-by":"publisher","first-page":"674068","DOI":"10.3389\/fmicb.2021.674068","volume":"12","author":"Z Wang","year":"2021","unstructured":"Wang Z, Cai R, Wang G, Guo Z, Liu X, Guan Y, Ji Y, Zhang H, Xi H, Zhao R, Bi L, Liu S, Yang L, Feng X, Sun C, Lei L, Han W, Gu J (2021) Combination therapy of phage vB_KpnM_P-KP2 and gentamicin combats acute pneumonia caused by K47 serotype Klebsiella pneumoniae. Front Microbiol 12:674068. https:\/\/doi.org\/10.3389\/fmicb.2021.674068","journal-title":"Front Microbiol"},{"key":"13208_CR66","unstructured":"WHO (2014) Antimicrobial Resistance: Global Report on Surveillance.\u00a0Australas Med J\u00a07:237"},{"issue":"7643","key":"13208_CR67","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/nature.2017.21550","volume":"543","author":"C Willyard","year":"2017","unstructured":"Willyard C (2017) Drug-resistant bacteria ranked. Nature 543(7643):15\u201315. https:\/\/doi.org\/10.1038\/nature.2017.21550","journal-title":"Nature"},{"issue":"1","key":"13208_CR68","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1128\/cmr.00058-16","volume":"30","author":"D Wong","year":"2017","unstructured":"Wong D, Nielsen TB, Bonomo RA, Pantapalangkoor P, Luna B, Spellberg B (2017) Clinical and pathophysiological overview of Acinetobacter infections: a century of challenges. Clin Microbiol Rev 30(1):409\u2013447. https:\/\/doi.org\/10.1128\/cmr.00058-16","journal-title":"Clin Microbiol Rev"},{"key":"13208_CR69","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.3389\/fmicb.2018.03027","volume":"9","author":"C Yang","year":"2018","unstructured":"Yang C, Wang H, Ma H, Bao R, Liu H, Yang L, Liang B, Jia L, Xie J, Xiang Y, Dong N, Qiu S, Song H (2018) Characterization and genomic analysis of SFPH2, a novel T7 virus infecting Shigella. Front Microbiol 9:3027. https:\/\/doi.org\/10.3389\/fmicb.2018.03027","journal-title":"Front Microbiol"},{"issue":"8","key":"13208_CR70","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1016\/j.bpj.2017.02.041","volume":"112","author":"TC Yang","year":"2017","unstructured":"Yang TC, Ortiz D, Yang Q, De Angelis RW, Sanyal SJ, Catalano CE (2017) Physical and functional characterization of a viral genome maturation complex. Biophys J 112(8):1551\u20131560. https:\/\/doi.org\/10.1016\/j.bpj.2017.02.041","journal-title":"Biophys J"},{"key":"13208_CR71","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1155\/2021\/5453047","volume":"2021","author":"H Ye","year":"2021","unstructured":"Ye H, Luo J, Hu DM, Yang ST, Zhang AL, Qiu YX, Ma XN, Wang J, Hou J, Bai J (2021) Total flavonoids of Crocus sativus petals release tert-butyl hydroperoxide-induced oxidative stress in BRL-3A cells. Oxid Med Cell Longev 2021:15. https:\/\/doi.org\/10.1155\/2021\/5453047","journal-title":"Oxid Med Cell Longev"},{"key":"13208_CR72","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/ncomms14187","volume":"8","author":"MM Yen","year":"2017","unstructured":"Yen MM, Cairns LS, Camilli A (2017) A cocktail of three virulent bacteriophages prevents Vibrio cholerae infection in animal models. Nat Commun 8:7. https:\/\/doi.org\/10.1038\/ncomms14187","journal-title":"Nat Commun"},{"issue":"6","key":"13208_CR73","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.mib.2013.08.008","volume":"16","author":"R Young","year":"2013","unstructured":"Young R (2013) Phage lysis: do we have the hole story yet? Curr Opin Microbiol 16(6):790\u2013797. https:\/\/doi.org\/10.1016\/j.mib.2013.08.008","journal-title":"Curr Opin Microbiol"},{"issue":"2","key":"13208_CR74","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/1751-7915.13594","volume":"14","author":"Y Yuan","year":"2021","unstructured":"Yuan Y, Li X, Wang L, Li G, Cong C, Li R, Cui H, Murtaza B, Xu Y (2021) The endolysin of the Acinetobacter baumannii phage vB_AbaP_D2 shows broad antibacterial activity. Microb Biotechnol 14(2):403\u2013418. https:\/\/doi.org\/10.1111\/1751-7915.13594","journal-title":"Microb Biotechnol"},{"key":"13208_CR75","doi-asserted-by":"publisher","first-page":"197734","DOI":"10.1016\/j.virusres.2019.197734","volume":"272","author":"Y Yuan","year":"2019","unstructured":"Yuan Y, Wang L, Li X, Tan D, Cong C, Xu Y (2019) Efficacy of a phage cocktail in controlling phage resistance development in multidrug resistant Acinetobacter baumannii. Virus Res 272:197734. https:\/\/doi.org\/10.1016\/j.virusres.2019.197734","journal-title":"Virus Res"},{"key":"13208_CR76","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3389\/fmicb.2019.00184","volume":"10","author":"KY Zhang","year":"2019","unstructured":"Zhang KY, Gao YZ, Du MZ, Liu S, Dong C, Guo FB (2019) Vgas: a viral genome annotation system. Front Microbiol 10:184. https:\/\/doi.org\/10.3389\/fmicb.2019.00184","journal-title":"Front Microbiol"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-024-13208-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00253-024-13208-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-024-13208-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T20:43:13Z","timestamp":1748378593000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00253-024-13208-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,27]]},"references-count":76,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["13208"],"URL":"https:\/\/doi.org\/10.1007\/s00253-024-13208-0","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,27]]},"assertion":[{"value":"25 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study followed the ARRIVE guidelines ().\u00a0All animal experiments were approved by the Biomedical Ethics Committee of the Dalian University of Technology (Dalian, China; Approval No. DUTSBE220624_02).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The author declares no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"428"}}