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This study aimed to explore the antibacterial activity of three bacteriocins (nisin, enterocin Gr17, and plantaricin RX-8) and their ability to attenuate intestinal barrier dysfunction and inflammatory responses induced by <jats:italic>Listeria monocytogenes<\/jats:italic>, respectively. Bacteriocins have shown excellent antibacterial activity against <jats:italic>L. monocytogenes<\/jats:italic> without causing any cytotoxicity. Bacteriocins inhibited the adhesion and invasion of <jats:italic>L. monocytogenes<\/jats:italic> on Caco-2 cells, lactate dehydrogenase (LDH), trans-epithelial electrical resistance (TEER), and cell migration showed that bacteriocin improved the permeability of Caco-2 cells. These results were attributed to the promotion of tight junction proteins (TJP) assembly, specifically zonula occludens-1 (ZO-1), occludin, and claudin-1. Furthermore, bacteriocins could alleviate inflammation by inhibiting the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-\u03baB) pathways and reducing the secretion of interleukin-6 (IL-6), interleukin-1 \u03b2 (IL-1\u03b2) and tumor necrosis factor \u03b1 (TNF-\u03b1). Among three bacteriocins, plantaricin RX-8 showed the best antibacterial activity against <jats:italic>L. monocytogenes<\/jats:italic> and the most pronounced protective effect on the intestinal barrier due to its unique structure. Based on our findings, we hypothesized that bacteriocins may inhibit the adhesion and invasion of <jats:italic>L. monocytogenes<\/jats:italic> by competing adhesion sites. Moreover, they may further enhance intestinal barrier function by inhibiting the expression of <jats:italic>L. monocytogenes<\/jats:italic> virulence factors, increasing the expression of TJP and decreasing the secretion of inflammatory factors. Therefore, bacteriocins will hopefully be an effective alternative to antibiotics, and this study provides valuable insights into food safety concerns.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Key points<\/jats:title>\n            <jats:p>\n              <jats:italic>\u2022 Bacteriocins show excellent antibacterial activity against L. monocytogenes<\/jats:italic>\n            <\/jats:p>\n            <jats:p>\n              <jats:italic>\u2022 Bacteriocins improve intestinal barrier damage and inflammatory response<\/jats:italic>\n            <\/jats:p>\n            <jats:p>\n              <jats:italic>\u2022 Plantaricin RX-8 has the best protective effect on Caco-2 cells damage<\/jats:italic>\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical Abstract<\/jats:title>\n          <\/jats:sec>","DOI":"10.1007\/s00253-024-13228-w","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T09:01:50Z","timestamp":1718787710000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Bacteriocins attenuate Listeria monocytogenes\u2013induced intestinal barrier dysfunction and inflammatory response"],"prefix":"10.1007","volume":"108","author":[{"given":"Zhao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8365-0671","authenticated-orcid":false,"given":"Guorong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"issue":"1","key":"13228_CR1","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/j.1574-6976.2010.00244.x","volume":"35","author":"H Abriouel","year":"2011","unstructured":"Abriouel H, Franz CM, Ben Omar N, Galvez A (2011) Diversity and applications of Bacillus bacteriocins. 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