{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:17:19Z","timestamp":1790140639867,"version":"4.0.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Korea Innovation Foundation","award":["2021-DD-UP-0369"],"award-info":[{"award-number":["2021-DD-UP-0369"]}]},{"DOI":"10.13039\/501100007053","name":"Korea Institute of Energy Technology Evaluation and Planning","doi-asserted-by":"publisher","award":["20214000000500"],"award-info":[{"award-number":["20214000000500"]}],"id":[{"id":"10.13039\/501100007053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"DOI":"10.1007\/s00253-024-13402-0","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T06:22:49Z","timestamp":1736835769000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Characterization and design of dipeptide media formulation for scalable therapeutic production"],"prefix":"10.1007","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6126-8164","authenticated-orcid":false,"given":"Jinsung","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6140-412X","authenticated-orcid":false,"given":"Seo-Young","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0901-708X","authenticated-orcid":false,"given":"Dong-Yup","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"13402_CR1","doi-asserted-by":"publisher","first-page":"e07276","DOI":"10.1016\/J.HELIYON.2021.E07276","volume":"7","author":"S Achour","year":"2021","unstructured":"Achour S, Hosni Z, Darghouthi S, Syme C (2021) Assisted dipeptide bond formation: glycine as a case study. Heliyon 7:e07276. https:\/\/doi.org\/10.1016\/J.HELIYON.2021.E07276","journal-title":"Heliyon"},{"key":"13402_CR2","doi-asserted-by":"publisher","first-page":"1900565","DOI":"10.1002\/BIOT.201900565","volume":"15","author":"AS Ali","year":"2020","unstructured":"Ali AS, Chen R, Raju R, Kshirsagar R, Gilbert A, Zang L, Karger BL, Ivanov AR (2020) Multi-omics reveals impact of cysteine feed concentration and resulting redox imbalance on cellular energy metabolism and specific productivity in CHO cell bioprocessing. Biotechnol J 15:1900565. https:\/\/doi.org\/10.1002\/BIOT.201900565","journal-title":"Biotechnol J"},{"key":"13402_CR3","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00726-006-0331-0","volume":"31","author":"A Biegel","year":"2006","unstructured":"Biegel A, Kn\u00fctter I, Hartrodt B, Gebauer S, Theis S, Luckner P, Kottra G, Rastetter M, Zebisch K, Thondorf I, Daniel H, Neubert K, Brandsch M (2006) The renal type H+\/peptide symporter PEPT2: structure-affinity relationships. Amino Acids 31:137\u2013156. https:\/\/doi.org\/10.1007\/s00726-006-0331-0","journal-title":"Amino Acids"},{"key":"13402_CR4","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.3390\/cells11121929","volume":"11","author":"M Coulet","year":"2022","unstructured":"Coulet M, Kepp O, Kroemer G, Basmaciogullari S (2022) Metabolic profiling of CHO cells during the production of biotherapeutics. Cells 11:1929. https:\/\/doi.org\/10.3390\/cells11121929","journal-title":"Cells"},{"key":"13402_CR5","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1023\/A:1016476220296\/METRICS","volume":"13","author":"KMY Covitz","year":"1996","unstructured":"Covitz KMY, Amidon GL, Sad\u00e9e W (1996) Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells. Pharm Res 13:1631\u20131634. https:\/\/doi.org\/10.1023\/A:1016476220296\/METRICS","journal-title":"Pharm Res"},{"key":"13402_CR6","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1002\/jctb.7078","volume":"97","author":"W Cui","year":"2022","unstructured":"Cui W, Ou J, Xu J, Anderson N, Borys M, Li Z, Khetan A, Liu S (2022) Impact of preparation pH and temperature on amino acid stability of highly concentrated cell culture feed media. J Chem Technol Biotechnol 97:2078\u20132086. https:\/\/doi.org\/10.1002\/jctb.7078","journal-title":"J Chem Technol Biotechnol"},{"key":"13402_CR7","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s10989-018-9684-y","volume":"25","author":"Z Du","year":"2019","unstructured":"Du Z, Liu J, Zhang D, Ding L, Wang Y, Tan D, Zhang T (2019) Individual and synergistic antioxidant effects of dipeptides in in vitro antioxidant evaluation systems. Int J Pept Res Ther 25:391\u2013399. https:\/\/doi.org\/10.1007\/s10989-018-9684-y","journal-title":"Int J Pept Res Ther"},{"key":"13402_CR8","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1093\/jn\/123.5.909","volume":"123","author":"KS Emmerson","year":"1993","unstructured":"Emmerson KS, Phang JM (1993) Hydrolysis of proline dipeptides completely fulfills the proline requirement in a proline-auxotrophic Chinese hamster ovary cell line. J Nutr 123:909\u2013914. https:\/\/doi.org\/10.1093\/jn\/123.5.909","journal-title":"J Nutr"},{"key":"13402_CR9","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1093\/jn\/131.9.2562s","volume":"131","author":"P F\u00fcrst","year":"2001","unstructured":"F\u00fcrst P (2001) New developments in glutamine delivery. J Nutr 131:2562\u20132568. https:\/\/doi.org\/10.1093\/jn\/131.9.2562s","journal-title":"J Nutr"},{"key":"13402_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/S00253-024-13147-W\/FIGURES\/8","volume":"108","author":"N Gangwar","year":"2024","unstructured":"Gangwar N, Balraj K, Rathore AS (2024) Explainable AI for CHO cell culture media optimization and prediction of critical quality attribute. Appl Microbiol Biotechnol 108:1\u201316. https:\/\/doi.org\/10.1007\/S00253-024-13147-W\/FIGURES\/8","journal-title":"Appl Microbiol Biotechnol"},{"key":"13402_CR11","doi-asserted-by":"publisher","first-page":"2908","DOI":"10.1002\/bit.26794","volume":"115","author":"D Geoghegan","year":"2018","unstructured":"Geoghegan D, Arnall C, Hatton D, Noble-Longster J, Sellick C, Senussi T, James DC (2018) Control of amino acid transport into Chinese hamster ovary cells. Biotechnol Bioeng 115:2908\u20132929. https:\/\/doi.org\/10.1002\/bit.26794","journal-title":"Biotechnol Bioeng"},{"key":"13402_CR12","doi-asserted-by":"publisher","first-page":"e2946","DOI":"10.1002\/BTPR.2946","volume":"36","author":"N Ghaffari","year":"2020","unstructured":"Ghaffari N, Jardon MA, Krahn N, Butler M, Kennard M, Turner RFB, Gopaluni B, Piret JM (2020) Effects of cysteine, asparagine, or glutamine limitations in Chinese hamster ovary cell batch and fed-batch cultures. Biotechnol Prog 36:e2946. https:\/\/doi.org\/10.1002\/BTPR.2946","journal-title":"Biotechnol Prog"},{"key":"13402_CR13","doi-asserted-by":"publisher","first-page":"3672","DOI":"10.1021\/acs.jproteome.7b00382","volume":"16","author":"KM Heffner","year":"2017","unstructured":"Heffner KM, Hizal DB, Yerganian GS, Kumar A, Can \u00d6, O\u2019meally R, Cole R, Chaerkady R, Wu H, Bowen MA, Betenbaugh MJ (2017) Lessons from the hamster: Cricetulus griseus tissue and CHO cell line proteome comparison. J Proteome Res 16:3672\u20133687. https:\/\/doi.org\/10.1021\/acs.jproteome.7b00382","journal-title":"J Proteome Res"},{"key":"13402_CR14","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s10616-012-9468-8","volume":"65","author":"Y Imamoto","year":"2012","unstructured":"Imamoto Y, Tanaka H, Takahashi K, Konno Y, Suzawa T (2012) Advantages of AlaGln as an additive to cell culture medium: use with anti-CD20 chimeric antibody-producing POTELLIGENT\u2122 CHO cell lines. Cytotechnology 65:135\u2013143. https:\/\/doi.org\/10.1007\/s10616-012-9468-8","journal-title":"Cytotechnology"},{"key":"13402_CR15","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1002\/bit.24507","volume":"109","author":"S Kang","year":"2012","unstructured":"Kang S, Mullen J, Miranda LP, Deshpande R (2012) Utilization of tyrosine- and histidine-containing dipeptides to enhance productivity and culture viability. Biotechnol Bioeng 109:2286\u20132294. https:\/\/doi.org\/10.1002\/bit.24507","journal-title":"Biotechnol Bioeng"},{"key":"13402_CR16","doi-asserted-by":"publisher","first-page":"108480","DOI":"10.1016\/j.biotechadv.2024.108480","volume":"78","author":"H Kavoni","year":"2025","unstructured":"Kavoni H, Savizi ISP, Lewis NE, Shojaosadati SA (2025) Recent advances in culture medium design for enhanced production of monoclonal antibodies in CHO cells: a comparative study of machine learning and systems biology approaches. Biotechnol Adv 78:108480. https:\/\/doi.org\/10.1016\/j.biotechadv.2024.108480","journal-title":"Biotechnol Adv"},{"key":"13402_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/biot.202200029","volume":"17","author":"D Komuczki","year":"2022","unstructured":"Komuczki D, Stadermann A, Bentele M, Unsoeld A, Grillari J, Mueller MM, Paul A, Fischer S (2022) High cysteine concentrations in cell culture media lead to oxidative stress and reduced bioprocess performance of recombinant CHO cells. Biotechnol J 17:1\u201313. https:\/\/doi.org\/10.1002\/biot.202200029","journal-title":"Biotechnol J"},{"key":"13402_CR18","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1002\/jctb.5861","volume":"94","author":"F Krattenmacher","year":"2019","unstructured":"Krattenmacher F, Heermann T, Calvet A, Krawczyk B, Noll T (2019) Effect of manufacturing temperature and storage duration on stability of chemically defined media measured with LC-MS\/MS. J Chem Technol Biotechnol 94:1144\u20131155. https:\/\/doi.org\/10.1002\/jctb.5861","journal-title":"J Chem Technol Biotechnol"},{"key":"13402_CR19","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ymben.2024.07.008","volume":"85","author":"P Ladiwala","year":"2024","unstructured":"Ladiwala P, Cai X, Naik HM, Aliyu L, Schilling M, Antoniewicz MR, Betenbaugh MJ (2024) Ala-Cys-Cys-Ala dipeptide dimer alleviates problematic cysteine and cystine levels in media formulations and enhances CHO cell growth and metabolism. Metab Eng 85:105\u2013115. https:\/\/doi.org\/10.1016\/j.ymben.2024.07.008","journal-title":"Metab Eng"},{"key":"13402_CR20","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.brainres.2005.06.014","volume":"1052","author":"FV Mena","year":"2005","unstructured":"Mena FV, Baab PJ, Zielke CL, Huang Y, Zielke HR (2005) Formation of extracellular glutamate from glutamine: exclusion of pyroglutamate as an intermediate. Brain Res 1052:88\u201396. https:\/\/doi.org\/10.1016\/j.brainres.2005.06.014","journal-title":"Brain Res"},{"key":"13402_CR21","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/J.COPBIO.2013.08.020","volume":"26","author":"S Mitsuhashi","year":"2014","unstructured":"Mitsuhashi S (2014) Current topics in the biotechnological production of essential amino acids, functional amino acids, and dipeptides. Curr Opin Biotechnol 26:38\u201344. https:\/\/doi.org\/10.1016\/J.COPBIO.2013.08.020","journal-title":"Curr Opin Biotechnol"},{"key":"13402_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/J.YMBEN.2024.03.002","author":"HM Naik","year":"2024","unstructured":"Naik HM, Cai X, Ladiwala P, Reddy JV, Betenbaugh MJ, Antoniewicz MR (2024) Elucidating uptake and metabolic fate of dipeptides in CHO cell cultures using 13C labeling experiments and kinetic modeling. Metab Eng. https:\/\/doi.org\/10.1016\/J.YMBEN.2024.03.002","journal-title":"Metab Eng"},{"key":"13402_CR23","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1152\/ajprenal.1993.264.2.f306","volume":"264","author":"KA Nath","year":"1993","unstructured":"Nath KA, Salahudeen AK (1993) Autoxidation of cysteine generates hydrogen peroxide: cytotoxicity and attenuation by pyruvate. Am J Physiol - Ren Fluid Electrolyte Physiol 264:306\u2013314. https:\/\/doi.org\/10.1152\/ajprenal.1993.264.2.f306","journal-title":"Am J Physiol - Ren Fluid Electrolyte Physiol"},{"key":"13402_CR24","doi-asserted-by":"publisher","first-page":"26658","DOI":"10.1039\/D2RA04044A","volume":"12","author":"H Nishino","year":"2022","unstructured":"Nishino H, Kitamura M, Okada S, Miyake R, Okumura M, Muraoka T (2022) Cysteine-based protein folding modulators for trapping intermediates and misfolded forms. RSC Adv 12:26658\u201326664. https:\/\/doi.org\/10.1039\/D2RA04044A","journal-title":"RSC Adv"},{"key":"13402_CR25","doi-asserted-by":"publisher","first-page":"9998","DOI":"10.1093\/NAR\/GKZ730","volume":"47","author":"C Ntountoumi","year":"2019","unstructured":"Ntountoumi C, Vlastaridis P, Mossialos D, Stathopoulos C, Iliopoulos I, Promponas V, Oliver SG, Amoutzias GD (2019) Low complexity regions in the proteins of prokaryotes perform important functional roles and are highly conserved. Nucleic Acids Res 47:9998\u201310009. https:\/\/doi.org\/10.1093\/NAR\/GKZ730","journal-title":"Nucleic Acids Res"},{"key":"13402_CR26","doi-asserted-by":"publisher","first-page":"162","DOI":"10.3177\/jnsv.68.162","volume":"68","author":"H Ozawa","year":"2022","unstructured":"Ozawa H, Miyazawa T, Burdeos GC, Miyazawa T (2022) Biological functions of antioxidant dipeptides. J Nutr Sci Vitaminol (Tokyo) 68:162\u2013171. https:\/\/doi.org\/10.3177\/jnsv.68.162","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"13402_CR27","doi-asserted-by":"publisher","first-page":"e202400072","DOI":"10.1002\/BIOT.202400072","volume":"19","author":"KT Pang","year":"2024","unstructured":"Pang KT, Hong YF, Shozui F, Furomitsu S, Myint M, Ho YS, Silberberg YR, Walsh I, Lakshmanan M (2024) Genome-scale modeling of CHO cells unravel the critical role of asparagine in cell culture feed media. Biotechnol J 19:e202400072. https:\/\/doi.org\/10.1002\/BIOT.202400072","journal-title":"Biotechnol J"},{"key":"13402_CR28","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/S0006-2952(02)01173-5","volume":"64","author":"A Paolicchi","year":"2002","unstructured":"Paolicchi A, Dominici S, Pieri L, Maellaro E, Pompella A (2002) Glutathione catabolism as a signaling mechanism. Biochem Pharmacol 64:1027\u20131035. https:\/\/doi.org\/10.1016\/S0006-2952(02)01173-5","journal-title":"Biochem Pharmacol"},{"key":"13402_CR29","doi-asserted-by":"publisher","first-page":"100702","DOI":"10.1016\/j.coche.2021.100702","volume":"33","author":"S-Y Park","year":"2021","unstructured":"Park S-Y, Park C-H, Choi D-H, Hong JK, Lee D-Y (2021) Bioprocess digital twins of mammalian cell culture for advanced biomanufacturing. Curr Opin Chem Eng 33:100702. https:\/\/doi.org\/10.1016\/j.coche.2021.100702","journal-title":"Curr Opin Chem Eng"},{"key":"13402_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00253-023-12997-0","volume":"108","author":"S-Y Park","year":"2024","unstructured":"Park S-Y, Song J, Choi D-H, Park U, Cho H, Hong BH, Silberberg YR, Lee D-Y (2024a) Exploring metabolic effects of dipeptide feed media on CHO cell cultures by in silico model-guided flux analysis. Appl Microbiol Biotechnol 108:1\u201316. https:\/\/doi.org\/10.1007\/s00253-023-12997-0","journal-title":"Appl Microbiol Biotechnol"},{"key":"13402_CR31","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/j.tibtech.2024.03.001","volume":"42","author":"SY Park","year":"2024","unstructured":"Park SY, Choi DH, Song J, Lakshmanan M, Richelle A, Yoon S, Kontoravdi C, Lewis NE, Lee DY (2024b) Driving towards digital biomanufacturing by CHO genome-scale models. Trends Biotechnol 42:1192\u20131203. https:\/\/doi.org\/10.1016\/j.tibtech.2024.03.001","journal-title":"Trends Biotechnol"},{"key":"13402_CR32","doi-asserted-by":"publisher","unstructured":"Procopio-Melino R, Kotch FW, Prashad AS, Gomes JM, Wang W, Arve B, Dawdy A, Chen L, Sperry J, Hosselet C, He T, Kriz R, Lin L, Marquette K, Tchistiakova L, Somers W, Rouse JC, Zhong X (2022) Cysteine metabolic engineering and selective disulfide reduction produce superior antibody-drug-conjugates. Sci Rep 12 https:\/\/doi.org\/10.1038\/s41598-022-11344-z","DOI":"10.1038\/s41598-022-11344-z"},{"key":"13402_CR33","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s13568-016-0221-0","volume":"6","author":"A S\u00e1nchez-Kopper","year":"2016","unstructured":"S\u00e1nchez-Kopper A, Becker M, Pfizenmaier J, Kessler C, Karau A, Takors R (2016) Tracking dipeptides at work-uptake and intracellular fate in CHO culture. AMB Express 6:48. https:\/\/doi.org\/10.1186\/s13568-016-0221-0","journal-title":"AMB Express"},{"key":"13402_CR34","doi-asserted-by":"publisher","first-page":"6483","DOI":"10.1007\/S00253-019-09921-W\/FIGURES\/7","volume":"103","author":"H Tang","year":"2019","unstructured":"Tang H, Zhang X, Zhang W, Fan L, Wang H, Tan WS, Zhao L (2019) Insight into the roles of tyrosine on rCHO cell performance in fed-batch cultures. Appl Microbiol Biotechnol 103:6483\u20136494. https:\/\/doi.org\/10.1007\/S00253-019-09921-W\/FIGURES\/7","journal-title":"Appl Microbiol Biotechnol"},{"key":"13402_CR35","doi-asserted-by":"publisher","first-page":"6181","DOI":"10.1021\/acs.jafc.5b01026","volume":"63","author":"TS Tseng","year":"2015","unstructured":"Tseng TS, Tsai KC, Chen WC, Wang YT, Lee YC, Lu CK, Don MJ, Chang CY, Lee CH, Lin HH, Hsu HJ, Hsiao NW (2015) Discovery of potent cysteine-containing dipeptide inhibitors against tyrosinase: a comprehensive investigation of 20 \u00d7 20 dipeptides in inhibiting dopachrome formation. J Agric Food Chem 63:6181\u20136188. https:\/\/doi.org\/10.1021\/acs.jafc.5b01026","journal-title":"J Agric Food Chem"},{"key":"13402_CR36","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1002\/elsc.202000017","volume":"20","author":"N Verhagen","year":"2020","unstructured":"Verhagen N, Wijaya AW, Teleki A, Fadhlullah M, Uns\u00f6ld A, Schilling M, Heinrich C, Takors R (2020) Comparison of l-tyrosine containing dipeptides reveals maximum ATP availability for l-prolyl-l-tyrosine in CHO cells. Eng Life Sci 20:384\u2013394. https:\/\/doi.org\/10.1002\/elsc.202000017","journal-title":"Eng Life Sci"},{"key":"13402_CR37","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1016\/j.procbio.2011.03.014","volume":"46","author":"Z Xing","year":"2011","unstructured":"Xing Z, Kenty B, Koyrakh I, Borys M, Pan SH, Li ZJ (2011) Optimizing amino acid composition of CHO cell culture media for a fusion protein production. Process Biochem 46:1423\u20131429. https:\/\/doi.org\/10.1016\/j.procbio.2011.03.014","journal-title":"Process Biochem"},{"key":"13402_CR38","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/S00253-008-1590-3\/TABLES\/4","volume":"81","author":"M Yagasaki","year":"2008","unstructured":"Yagasaki M, Hashimoto SI (2008) Synthesis and application of dipeptides; current status and perspectives. Appl Microbiol Biotechnol 81:13\u201322. https:\/\/doi.org\/10.1007\/S00253-008-1590-3\/TABLES\/4","journal-title":"Appl Microbiol Biotechnol"},{"key":"13402_CR39","doi-asserted-by":"publisher","first-page":"6953","DOI":"10.1007\/S00253-020-10744-3\/FIGURES\/7","volume":"104","author":"W Zhang","year":"2020","unstructured":"Zhang W, Liu X, Tang H, Zhang X, Zhou Y, Fan L, Wang H, Tan WS, Zhao L (2020) Investigation into the impact of tyrosine on the product formation and quality attributes of mAbs in rCHO cell cultures. Appl Microbiol Biotechnol 104:6953\u20136966. https:\/\/doi.org\/10.1007\/S00253-020-10744-3\/FIGURES\/7","journal-title":"Appl Microbiol Biotechnol"},{"key":"13402_CR40","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.theriogenology.2015.08.014","volume":"85","author":"MH Zhao","year":"2016","unstructured":"Zhao MH, Kim NH, Cui XS (2016) GlutaMAX prolongs the shelf life of the culture medium for porcine parthenotes. Theriogenology 85:368\u2013375. https:\/\/doi.org\/10.1016\/j.theriogenology.2015.08.014","journal-title":"Theriogenology"},{"key":"13402_CR41","doi-asserted-by":"publisher","first-page":"1195294","DOI":"10.3389\/FBIOE.2023.1195294\/BIBTEX","volume":"11","author":"T Zhou","year":"2023","unstructured":"Zhou T, Reji R, Kairon RS, Chiam KH (2023) A review of algorithmic approaches for cell culture media optimization. Front Bioeng Biotechnol 11:1195294. https:\/\/doi.org\/10.3389\/FBIOE.2023.1195294\/BIBTEX","journal-title":"Front Bioeng Biotechnol"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-024-13402-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00253-024-13402-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-024-13402-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:33:38Z","timestamp":1770294818000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00253-024-13402-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,14]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["13402"],"URL":"https:\/\/doi.org\/10.1007\/s00253-024-13402-0","relation":{},"ISSN":["1432-0614"],"issn-type":[{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,14]]},"assertion":[{"value":"3 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7"}}