{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:51:12Z","timestamp":1791474672782,"version":"4.3.4"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Takaki Shunsuke Foundation For Science and Technology of Bread"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"DOI":"10.1007\/s00253-025-13470-w","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T16:12:58Z","timestamp":1744128778000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficient genes identification via quantitative trait loci analysis by crossbreeding of sake and laboratory yeast"],"prefix":"10.1007","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8673-8273","authenticated-orcid":false,"given":"Muneyoshi","family":"Kanai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Fukuba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Kochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Teramoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Shimoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2784-2016","authenticated-orcid":false,"given":"Takeshi","family":"Akao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"13470_CR1","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1093\/dnares\/dsr029","volume":"18","author":"T Akao","year":"2011","unstructured":"Akao T, Yashiro I, Hosoyama A, Kitagaki H, Horikawa H, Watanabe D, Akada R, Ando Y, Harashima S, Inoue T, Inoue Y, Kajiwara S, Kitamoto K, Kitamoto N, Kobayashi O, Kuhara S, Masubuchi T, Mizoguchi H, Nakao Y, Nakazato A, Namise M, Oba T, Ogata T, Ohta A, Sato M, Shibasaki S, Takatsume Y, Tanimoto S, Tsuboi H, Nishimura A, Yoda K, Ishikawa T, Iwashita K, Fujita N, Shimoi H (2011) Whole-genome sequencing of sake yeast Saccharomyces cerevisiae Kyokai no. 7. DNA Res 18:423\u2013434. https:\/\/doi.org\/10.1093\/dnares\/dsr029","journal-title":"DNA Res"},{"key":"13470_CR2","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1126\/science.1131969","volume":"314","author":"H Alper","year":"2006","unstructured":"Alper H, Moxley J, Nevoigt E, Fink GR, Stephanopoulos G (2006) Engineering yeast transcription machinery for improved ethanol tolerance and production. Science 314:1565\u20131568. https:\/\/doi.org\/10.1126\/science.1131969","journal-title":"Science"},{"key":"13470_CR3","doi-asserted-by":"publisher","unstructured":"Ambroset C, Petit M, Brion C, Sanchez I, Delobel P, Gu\u00e9rin C, Chiapello H, Nicolas P, Bigey F, Dequin S, Blondin B (2011) Deciphering the molecular basis of wine yeast fermentation traits using a combined genetic and genomic approach. G3 (Bethesda) 1:263\u201381. https:\/\/doi.org\/10.1534\/g3.111.000422","DOI":"10.1534\/g3.111.000422"},{"key":"13470_CR4","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1186\/1471-2164-15-495","volume":"15","author":"C Brice","year":"2014","unstructured":"Brice C, Sanchez I, Bigey F, Legras JL, Blondin B (2014) A genetic approach of wine yeast fermentation capacity in nitrogen-starvation reveals the key role of nitrogen signaling. BMC Genomics 15:495. https:\/\/doi.org\/10.1186\/1471-2164-15-495","journal-title":"BMC Genomics"},{"key":"13470_CR5","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.4238\/2014.March.17.19","volume":"13","author":"WY Chen","year":"2014","unstructured":"Chen WY, Liu ZM, Deng GB, Pan ZF, Liang JJ, Zeng XQ, Tashi NM, Long H, Yu MQ (2014) Genetic relationship between lodging and lodging components in barley (Hordeum vulgare) based on unconditional and conditional quantitative trait locus analyses. Genet Mol Res 13:1909\u20131925. https:\/\/doi.org\/10.4238\/2014.March.17.19","journal-title":"Genet Mol Res"},{"key":"13470_CR6","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/ng1674","volume":"37","author":"AM Deutschbauer","year":"2005","unstructured":"Deutschbauer AM, Davis RW (2005) Quantitative trait loci mapped to single-nucleotide resolution in yeast. Nat Genet 37:1333\u20131340. https:\/\/doi.org\/10.1038\/ng1674","journal-title":"Nat Genet"},{"key":"13470_CR7","doi-asserted-by":"publisher","first-page":"e73325","DOI":"10.1371\/journal.pone.0073325","volume":"8","author":"CT Dickman","year":"2013","unstructured":"Dickman CT, Moehring AJ (2013) A novel approach identifying hybrid sterility QTL on the autosomes of Drosophila simulans and D. mauritiana. PLoS One 8:e73325. https:\/\/doi.org\/10.1371\/journal.pone.0073325","journal-title":"PLoS One"},{"key":"13470_CR8","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/s12864-018-4562-8","volume":"19","author":"M Eder","year":"2018","unstructured":"Eder M, Sanchez I, Brice C, Camarasa C, Legras JL, Dequin S (2018) QTL mapping of volatile compound production in Saccharomyces cerevisiae during alcoholic fermentation. BMC Genomics 19:166. https:\/\/doi.org\/10.1186\/s12864-018-4562-8","journal-title":"BMC Genomics"},{"key":"13470_CR9","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511761676","author":"PD Ellis","year":"2010","unstructured":"Ellis PD (2010) The essential guide to effect sizes: Statistical power, meta-analysis, and the interpretationof research results. University Press, Cambridge, UK. https:\/\/doi.org\/10.1017\/CBO9780511761676","journal-title":"University Press, Cambridge, UK"},{"key":"13470_CR10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S1389-1723(04)70250-9","volume":"98","author":"K Furukawa","year":"2004","unstructured":"Furukawa K, Kitano H, Mizoguchi H, Hara S (2004) Effect of cellular inositol content on ethanol tolerance of Saccharomyces cerevisiae in sake brewing. J Biosci Bioeng 98:107\u2013113. https:\/\/doi.org\/10.1016\/S1389-1723(04)70250-9","journal-title":"J Biosci Bioeng"},{"key":"13470_CR11","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/yea.320110408","volume":"11","author":"RD Geitz","year":"1995","unstructured":"Geitz RD, Scheistl RH, Wellems AR, Woods RA (1995) Studies on the transformation of intact yeast cells by the LiAc\/SS-DNA\/PEG procedure. Yeast 11:355\u2013360. https:\/\/doi.org\/10.1002\/yea.320110408","journal-title":"Yeast"},{"key":"13470_CR12","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1002\/(SICI)1097-0061(199910)15:14<1541::AID-YEA476>3.0.CO;2-K","volume":"15","author":"AL Goldstein","year":"1999","unstructured":"Goldstein AL, McCusker JH (1999) Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae. Yeast 15:1541\u20131553. https:\/\/doi.org\/10.1002\/(SICI)1097-0061(199910)15:14%3c1541::AID-YEA476%3e3.0.CO;2-K","journal-title":"Yeast"},{"key":"13470_CR13","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1016\/j.jbiosc.2017.01.014","volume":"55","author":"E Ichikawa","year":"1991","unstructured":"Ichikawa E, Hosokawa N, Hata Y (1991) Breeding of sake yeast with improved ethyl caproate productivity. Agric Biol Chem 55:2153\u20132154. https:\/\/doi.org\/10.1016\/j.jbiosc.2017.01.014","journal-title":"Agric Biol Chem"},{"key":"13470_CR14","doi-asserted-by":"publisher","first-page":"e989761","DOI":"10.4161\/15592324.2014.989761","volume":"10","author":"H Imai","year":"2015","unstructured":"Imai H, Noda Y, Tamaoki M (2015) Alteration of Arabidopsis SLAC1 promoter and its association with natural variation in drought tolerance. Plant Signal Behav 10:e989761. https:\/\/doi.org\/10.4161\/15592324.2014.989761","journal-title":"Plant Signal Behav"},{"key":"13470_CR15","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jbiosc.2016.07.007","volume":"123","author":"M Kanai","year":"2017","unstructured":"Kanai M, Kawata T, Yoshida Y, Kita Y, Ogawa T, Mizunuma M, Watanabe D, Shimoi H, Mizuno A, Yamada O, Fujii T, Iefuji H (2017) Sake yeast YHR032W\/ERC1 haplotype contributes to high S-adenosylmethionine accumulation in sake yeast strains. J Biosci Bioeng 123:8\u201314. https:\/\/doi.org\/10.1016\/j.jbiosc.2016.07.007","journal-title":"J Biosci Bioeng"},{"key":"13470_CR16","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1080\/09168451.2020.1717924","volume":"84","author":"M Kanai","year":"2020","unstructured":"Kanai M, Kawata T, Morimoto T, Mizunuma M, Watanabe D, Akao T, Fujii T, Iefuji H (2020) The sake yeast YHR032W\/ERC1 allele contributes to the regulation of the tetrahydrofolate content in the folate synthetic pathway in sake yeast strains. Biosci Biotechnol Biochem 84:1073\u20131076. https:\/\/doi.org\/10.1080\/09168451.2020.1717924","journal-title":"Biosci Biotechnol Biochem"},{"key":"13470_CR17","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1002\/yea.1634","volume":"25","author":"T Katou","year":"2008","unstructured":"Katou T, Kitagaki H, Akao T, Shimoi H (2008) Brewing characteristics of haploid strains isolated from sake yeast Kyokai No. 7. Yeast 25:799\u2013807. https:\/\/doi.org\/10.1002\/yea.1634","journal-title":"Yeast"},{"key":"13470_CR18","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.jbiosc.2008.12.014","volume":"107","author":"T Katou","year":"2009","unstructured":"Katou T, Namise M, Kitagaki H, Akao T, Shimoi H (2009) QTL mapping of sake brewing characteristics of yeast. J Biosci Bioeng 107:383\u2013393. https:\/\/doi.org\/10.1016\/j.jbiosc.2008.12.014","journal-title":"J Biosci Bioeng"},{"key":"13470_CR19","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1146\/annurev-food-030212-182545","volume":"4","author":"H Kitagaki","year":"2013","unstructured":"Kitagaki H, Kitamoto K (2013) Breeding research on sake yeasts in Japan: history, recent technological advances, and future perspectives. Annu Rev Food Sci Technol 4:215\u2013235. https:\/\/doi.org\/10.1146\/annurev-food-030212-182545","journal-title":"Annu Rev Food Sci Technol"},{"key":"13470_CR20","doi-asserted-by":"publisher","unstructured":"Kodama K (1993) Sake-brewing yeast. The yeasts -2nd edition- 4:129\u2013168. https:\/\/doi.org\/10.1016\/B978-0-08-092543-1.50014-X","DOI":"10.1016\/B978-0-08-092543-1.50014-X"},{"key":"13470_CR21","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1186\/s12870-022-03842-z","volume":"22","author":"K Koyama","year":"2022","unstructured":"Koyama K, Kono A, Ban Y, Bahena-Garrido SM, Ohama T, Iwashita K, Fukuda H, Goto-Yamamoto N (2022) Genetic architecture of berry aroma compounds in a QTL (quantitative trait loci) mapping population of interspecific hybrid grapes (Vitis labruscana \u00d7 Vitis vinifera). BMC Plant Biol 22:458. https:\/\/doi.org\/10.1186\/s12870-022-03842-z","journal-title":"BMC Plant Biol"},{"key":"13470_CR22","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Durbin R (2009) Fast and accurate short read alignment with Burrows-Wheeler Transform. Bioinformatics 25:1754\u20131760. https:\/\/doi.org\/10.1093\/bioinformatics\/btp324","journal-title":"Bioinformatics"},{"key":"13470_CR23","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R, 1000 Genome Project Data Processing Subgroup (2009) The Sequence alignment\/map (SAM) format and SAMtools. Bioinformatics 25:2078\u20139. https:\/\/doi.org\/10.1093\/bioinformatics\/btp352","journal-title":"Bioinformatics"},{"key":"13470_CR24","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1126\/science.7624781","volume":"269","author":"T Maeda","year":"1995","unstructured":"Maeda T, Takekawa M, Saito H (1995) Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. Science 269:554\u2013558. https:\/\/doi.org\/10.1126\/science.7624781","journal-title":"Science"},{"key":"13470_CR25","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1083\/jcb.201102092","volume":"193","author":"K Mao","year":"2011","unstructured":"Mao K, Wang K, Zhao M, Xu T, Klionsky DJ (2011) Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae. J Cell Biol 193:755\u2013767. https:\/\/doi.org\/10.1083\/jcb.201102092","journal-title":"J Cell Biol"},{"key":"13470_CR26","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1534\/g3.116.037283","volume":"7","author":"M Mart\u00ed-Raga","year":"2017","unstructured":"Mart\u00ed-Raga M, Peltier E, Mas A, Beltran G, Marullo P (2017) Genetic causes of phenotypic adaptation to the second fermentation of sparkling wines in Saccharomyces cerevisiae. G3 (Bethesda) 7:399\u2013412. https:\/\/doi.org\/10.1534\/g3.116.037283","journal-title":"G3 (Bethesda)"},{"key":"13470_CR27","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1101\/gr.107524.110","volume":"20","author":"A McKenna","year":"2010","unstructured":"McKenna A, Hanna M, Banks E, Sivachenko A, Cibulskis K, Kernytsky A, Garimella K, Altshuler D, Gabriel S, Daly M, DePristo MA (2010) The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res 20:1297\u20131303. https:\/\/doi.org\/10.1101\/gr.107524.110","journal-title":"Genome Res"},{"key":"13470_CR28","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1002\/yea.320050503","volume":"5","author":"RK Mortimer","year":"1989","unstructured":"Mortimer RK, Schild D, Contopoulou CR, Kans JA (1989) Genetic map of Saccharomyces cerevisiae, edition 10. Yeast 5:321\u2013403. https:\/\/doi.org\/10.1002\/yea.320050503","journal-title":"Yeast"},{"key":"13470_CR29","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1128\/MCB.01817-07","volume":"28","author":"Y Murakami","year":"2008","unstructured":"Murakami Y, Tatebayashi K, Saito H (2008) Two adjacent docking sites in the yeast Hog1 mitogen-activated protein (MAP) kinase differentially interact with the Pbs2 MAP kinase kinase and the Ptp2 protein tyrosine phosphatase. Mol Cell Biol 28:2481\u20132494. https:\/\/doi.org\/10.1128\/MCB.01817-07","journal-title":"Mol Cell Biol"},{"key":"13470_CR30","doi-asserted-by":"crossref","unstructured":"Nanba K, Obata T, Kayashima S (1978) The setting of the small sake brewing. J Soc Brew Jpn 73:295\u2013300 (in Japanese). https:\/\/www.jstage.jst.go.jp\/article\/jbrewsocjapan1915\/73\/4\/73_4_295\/_article\/-char\/ja\/","DOI":"10.6013\/jbrewsocjapan1915.73.295"},{"key":"13470_CR31","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.jbiosc.2015.11.012","volume":"121","author":"H Negoro","year":"2016","unstructured":"Negoro H, Kotaka A, Matsumura K, Tsutsumi H, Hata Y (2016) Enhancement of malate-production and increase in sensitivity to dimethyl succinate by mutation of the VID24 gene in Saccharomyces cerevisiae. J Biosci Bioeng 121:665\u2013671. https:\/\/doi.org\/10.1016\/j.jbiosc.2015.11.012","journal-title":"J Biosci Bioeng"},{"key":"13470_CR32","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s10681-015-1531-z","volume":"125","author":"H Negoro","year":"2018","unstructured":"Negoro H, Sakamoto M, Kotaka A, Matsumura K, Hata Y (2018) Mutation in the peroxin-coding gene PEX22 contributing to high malate production in Saccharomyces cerevisiae. J Biosci Bioeng 125:211\u2013217. https:\/\/doi.org\/10.1007\/s10681-015-1531-z","journal-title":"J Biosci Bioeng"},{"key":"13470_CR33","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1128\/MCB.01017-15","volume":"36","author":"A Nishimura","year":"2016","unstructured":"Nishimura A, Yamamoto K, Oyama M, Kozuka-Hata H, Saito H, Tatebayashi K (2016) Scaffold protein Ahk1, which associates with Hkr1, Sho1, Ste11, and Pbs2, inhibits cross talk signaling from the Hkr1 osmosensor to the Kss1 mitogen-activated protein kinase. Mol Cell Biol 36:1109\u20131123. https:\/\/doi.org\/10.1128\/MCB.01017-15","journal-title":"Mol Cell Biol"},{"key":"13470_CR34","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s12934-015-0245-1","volume":"14","author":"J Noble","year":"2015","unstructured":"Noble J, Sanchez I, Blondin B (2015) Identification of new Saccharomyces cerevisiae variants of the MET2 and SKP2 genes controlling the sulfur assimilation pathway and the production of undesirable sulfur compounds during alcoholic fermentation. Microb Cell Fact 14:68. https:\/\/doi.org\/10.1186\/s12934-015-0245-1","journal-title":"Microb Cell Fact"},{"key":"13470_CR35","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1128\/AEM.06341-11","volume":"78","author":"C Noguchi","year":"2012","unstructured":"Noguchi C, Watanabe D, Zhou Y, Akao T, Shimoi H (2012) Association of constitutive hyperphosphorylation of Hsf1p with a defective ethanol stress response in Saccharomyces cerevisiae sake yeast strains. Appl Environ Microbiol 78:385\u2013392. https:\/\/doi.org\/10.1128\/AEM.06341-11","journal-title":"Appl Environ Microbiol"},{"key":"13470_CR36","doi-asserted-by":"publisher","first-page":"jkac316","DOI":"10.1093\/g3journal\/jkac316","volume":"13","author":"T Ochiai","year":"2023","unstructured":"Ochiai T, Sakaguchi M, Kawakami SI, Ishikawa A (2023) Identification of candidate genes responsible for innate fear behavior in the chicken. G3 (Bethesda) 13:jkac316. https:\/\/doi.org\/10.1093\/g3journal\/jkac316","journal-title":"G3 (Bethesda)"},{"key":"13470_CR37","doi-asserted-by":"publisher","first-page":"11913","DOI":"10.1073\/pnas.1604047113","volume":"113","author":"T Ogawa","year":"2016","unstructured":"Ogawa T, Tsubakiyama R, Kanai M, Koyama T, Fujii T, Iefuji H, Soga T, Kume K, Miyakawa T, Hirata D, Mizunuma M (2016) Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK. Proc Natl Acad Sci USA 113:11913\u201311918. https:\/\/doi.org\/10.1073\/pnas.1604047113","journal-title":"Proc Natl Acad Sci USA"},{"key":"13470_CR38","doi-asserted-by":"publisher","first-page":"114296","DOI":"10.1016\/j.celrep.2024.114296","volume":"43","author":"TY Oliveira","year":"2024","unstructured":"Oliveira TY, Merkenschlager J, Eisenreich T, Bortolatto J, Yao KH, Gatti DM, Churchill GA, Nussenzweig MC, Breton G (2024) Quantitative trait loci mapping provides insights into the genetic regulation of dendritic cell numbers in mouse tissues. Cell Rep 43:114296. https:\/\/doi.org\/10.1016\/j.celrep.2024.114296","journal-title":"Cell Rep"},{"key":"13470_CR39","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1126\/science.276.5319.1702","volume":"276","author":"F Posas","year":"1997","unstructured":"Posas F, Saito H (1997) Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK. Science 276:1702\u20131705. https:\/\/doi.org\/10.1126\/science.276.5319.1702","journal-title":"Science"},{"key":"13470_CR40","doi-asserted-by":"publisher","first-page":"e49640","DOI":"10.1371\/journal.pone.0049640","volume":"7","author":"F Salinas","year":"2012","unstructured":"Salinas F, Cubillos FA, Soto D, Garcia V, Bergstr\u00f6m A, Warringer J, Ganga MA, Louis EJ, Liti G, Martinez C (2012) The genetic basis of natural variation in oenological traits in Saccharomyces cerevisiae. PLoS ONE 7:e49640. https:\/\/doi.org\/10.1371\/journal.pone.0049640","journal-title":"PLoS ONE"},{"key":"13470_CR41","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12863-024-01199-w","volume":"25","author":"S Sasazaki","year":"2024","unstructured":"Sasazaki S, Kondo H, Moriishi Y, Kawaguchi F, Oyama K, Mannen H (2024) Comprehensive genotyping analysis of single nucleotide polymorphisms responsible for beef marbling in Japanese Black cattle. BMC Genom Data 25:17. https:\/\/doi.org\/10.1186\/s12863-024-01199-w","journal-title":"BMC Genom Data"},{"key":"13470_CR42","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s10681-015-1531-z","volume":"207","author":"T Satoh","year":"2016","unstructured":"Satoh T, Tezuka K, Kawamoto T, Matsumoto S, Satoh-Nagasawa N, Ueda K, Sakurai K, Watanabe A, Takahashi H, Akagi H (2016) Identification of QTLs controlling low-temperature germination of the East European rice (Oryza sativa L.) variety Maratteli. Euphytica 207:245\u2013254. https:\/\/doi.org\/10.1007\/s10681-015-1531-z","journal-title":"Euphytica"},{"key":"13470_CR43","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1128\/AEM.68.4.2018-2025.2002","volume":"68","author":"H Shimoi","year":"2002","unstructured":"Shimoi H, Sakamoto K, Okuda M, Atthi R, Iwashita K, Ito K (2002) The AWA1 gene is required for the foam-forming phenotype and cell surface hydrophobicity of sake yeast. Appl Environ Microbiol 68:2018\u20132025. https:\/\/doi.org\/10.1128\/AEM.68.4.2018-2025.2002","journal-title":"Appl Environ Microbiol"},{"key":"13470_CR44","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.jbiosc.2018.07.027","volume":"127","author":"H Shimoi","year":"2019","unstructured":"Shimoi H, Hanazumi Y, Kawamura N, Yamada M, Shimizu S, Suzuki T, Watanabe D, Akao T (2019) Meiotic chromosomal recombination defect in sake yeasts. J Biosci Bioeng 127:190\u2013196. https:\/\/doi.org\/10.1016\/j.jbiosc.2018.07.027","journal-title":"J Biosci Bioeng"},{"key":"13470_CR45","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/416326a","volume":"416","author":"LM Steinmetz","year":"2002","unstructured":"Steinmetz LM, Sinha H, Richards DR, Spiegelman JI, Oefner PJ, McCusker JH, Davis RW (2002) Dissecting the architecture of a quantitative trait locus in yeast. Nature 416:326\u2013330. https:\/\/doi.org\/10.1038\/416326a","journal-title":"Nature"},{"key":"13470_CR46","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jbiosc.2016.07.002","volume":"123","author":"T Takahashi","year":"2017","unstructured":"Takahashi T, Ohara Y, Sawatari M, Sueno K (2017) Isolation and characterization of sake yeast mutants with enhanced isoamyl acetate productivity. J Biosci Bioeng 123:71\u201377. https:\/\/doi.org\/10.1016\/j.jbiosc.2016.07.002","journal-title":"J Biosci Bioeng"},{"key":"13470_CR47","doi-asserted-by":"publisher","first-page":"3624","DOI":"10.1093\/emboj\/cdg353","volume":"22","author":"K Tatebayashi","year":"2003","unstructured":"Tatebayashi K, Takekawa M, Saito H (2003) A docking site determining specificity of Pbs2 MAPKK for Ssk2\/Ssk22 MAPKKKs in the yeast HOG pathway. EMBO J 22:3624\u20133634. https:\/\/doi.org\/10.1093\/emboj\/cdg353","journal-title":"EMBO J"},{"key":"13470_CR48","doi-asserted-by":"publisher","first-page":"104569","DOI":"10.1016\/j.jbc.2023.104569","volume":"299","author":"K Tatebayashi","year":"2023","unstructured":"Tatebayashi K, Saito H (2023) Two activating phosphorylation sites of Pbs2 MAP2K in the yeast HOG pathway are differentially dephosphorylated by four PP2C phosphatases Ptc1-Ptc4. J Biol Chem 299:104569. https:\/\/doi.org\/10.1016\/j.jbc.2023.104569","journal-title":"J Biol Chem"},{"key":"13470_CR49","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jbiosc.2023.12.001","volume":"137","author":"K Tomonaga","year":"2024","unstructured":"Tomonaga K, Tanaka J, Kiyoshi K, Akao T, Watanabe K, Kadokura T, Nakayama S (2024) Physiological role of the EHL gene in sake yeast and its effects on quality of sake. J Biosci Bioeng 137:195\u2013203. https:\/\/doi.org\/10.1016\/j.jbiosc.2023.12.001","journal-title":"J Biosci Bioeng"},{"key":"13470_CR50","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1093\/bbb\/zbae044","volume":"88","author":"Y Ushiyama","year":"2024","unstructured":"Ushiyama Y, Nishida I, Tomiyama S, Tanaka H, Kume K, Hirata D (2024) Search for protein kinase(s) related to cell growth or viability maintenance in the presence of ethanol in budding and fission yeasts. Biosci Biotechnol Biochem 88:804\u2013815. https:\/\/doi.org\/10.1093\/bbb\/zbae044","journal-title":"Biosci Biotechnol Biochem"},{"key":"13470_CR51","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1002\/yea.320101310","volume":"10","author":"A Wach","year":"1994","unstructured":"Wach A, Brachat A, P\u00f6hlmann R, Philippsen P (1994) New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10:1793\u20131808. https:\/\/doi.org\/10.1002\/yea.320101310","journal-title":"Yeast"},{"key":"13470_CR52","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.jbiosc.2011.08.010","volume":"112","author":"D Watanabe","year":"2011","unstructured":"Watanabe D, Nogami S, Ohya Y, Kanno Y, Zhou Y, Akao T, Shimoi H (2011) Ethanol fermentation driven by elevated expression of the G1 cyclin gene CLN3 in sake yeast. J Biosci Bioeng 112:577\u2013582. https:\/\/doi.org\/10.1016\/j.jbiosc.2011.08.010","journal-title":"J Biosci Bioeng"},{"key":"13470_CR53","doi-asserted-by":"publisher","first-page":"4008","DOI":"10.1128\/AEM.00165-12","volume":"78","author":"D Watanabe","year":"2012","unstructured":"Watanabe D, Araki Y, Zhou Y, Maeya N, Akao T, Shimoi H (2012) A loss-of-function mutation in the PAS kinase Rim15p is related to defective quiescence entry and high fermentation rates of Saccharomyces cerevisiae sake yeast strains. Appl Environ Microbiol 78:4008\u20134016. https:\/\/doi.org\/10.1128\/AEM.00165-12","journal-title":"Appl Environ Microbiol"},{"key":"13470_CR54","doi-asserted-by":"publisher","first-page":"e02083","DOI":"10.1128\/AEM.02083-18","volume":"85","author":"D Watanabe","year":"2018","unstructured":"Watanabe D, Kajihara T, Sugimoto Y, Takagi K, Mizuno M, Zhou Y, Chen J, Takeda K, Tatebe H, Shiozaki K, Nakazawa N, Izawa S, Akao T, Shimoi H, Maeda T, Takagi H (2018) Nutrient signaling via the TORC1-Greatwall-PP2AB55\u03b4 pathway is responsible for the high initial rates of alcoholic fermentation in sake yeast strains of Saccharomyces cerevisiae. Appl Environ Microbiol 85:e02083-e2118. https:\/\/doi.org\/10.1128\/AEM.02083-18","journal-title":"Appl Environ Microbiol"},{"key":"13470_CR55","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41538-023-00215-0","volume":"7","author":"D Watanabe","year":"2023","unstructured":"Watanabe D, Kawashima M, Yoshioka N, Sugimoto Y, Takagi H (2023) Rational design of alcoholic fermentation targeting extracellular carbon. NPJ Sci Food 7:37. https:\/\/doi.org\/10.1038\/s41538-023-00215-0","journal-title":"NPJ Sci Food"},{"key":"13470_CR56","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/s12934-023-02221-z","volume":"22","author":"F Yatabe","year":"2023","unstructured":"Yatabe F, Seike T, Okahashi N, Ishii J, Matsuda F (2023) Improvement of ethanol and 2,3-butanediol production in Saccharomyces cerevisiae by ATP wasting. Microb Cell Fact 22:204. https:\/\/doi.org\/10.1186\/s12934-023-02221-z","journal-title":"Microb Cell Fact"},{"key":"13470_CR57","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s13068-020-01822-9","volume":"13","author":"A Zahoor","year":"2020","unstructured":"Zahoor A, Messerschmidt K, Boecker S, Klamt S (2020) ATPase-based implementation of enforced ATP wasting in Saccharomyces cerevisiae for improved ethanol production. Biotechnol Biofuels 13:185. https:\/\/doi.org\/10.1186\/s13068-020-01822-9","journal-title":"Biotechnol Biofuels"},{"key":"13470_CR58","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jbiotec.2009.05.001","volume":"144","author":"XQ Zhao","year":"2009","unstructured":"Zhao XQ, Bai FW (2009) Mechanisms of yeast stress tolerance and its manipulation for efficient fuel ethanol production. J Biotechnol 144:23\u201330. https:\/\/doi.org\/10.1016\/j.jbiotec.2009.05.001","journal-title":"J Biotechnol"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-025-13470-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00253-025-13470-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-025-13470-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:30:21Z","timestamp":1770294621000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00253-025-13470-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,8]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["13470"],"URL":"https:\/\/doi.org\/10.1007\/s00253-025-13470-w","relation":{},"ISSN":["1432-0614"],"issn-type":[{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,8]]},"assertion":[{"value":"15 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that they have no conflicts of interest related to this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}}],"article-number":"84"}}