{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:22:50Z","timestamp":1793499770117,"version":"4.5.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,4,9]],"date-time":"2011-04-09T00:00:00Z","timestamp":1302307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skeletal Radiol"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1007\/s00256-011-1142-2","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T23:43:13Z","timestamp":1302306193000},"page":"179-186","source":"Crossref","is-referenced-by-count":59,"title":["Different thresholds for detecting osteophytes and joint space narrowing exist between the site investigators and the centralized reader in a multicenter knee osteoarthritis study\u2014data from the Osteoarthritis Initiative"],"prefix":"10.1007","volume":"41","author":[{"given":"Ali","family":"Guermazi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Benichou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Eckstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Kent","family":"Kwoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nevitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daichi","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,4,9]]},"reference":[{"key":"1142_CR1","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S1470-2045(09)70232-3","volume":"10","author":"G Agnelli","year":"2009","unstructured":"Agnelli G, Gussoni G, Bianchini C, Verso M, Mandala M, Cavanna L, et al. Nadroparin for the prevention of thromboembolic events in ambulatory patients with metastatic or locally advanced solid cancer receiving chemotherapy: a randomised, placebo-controlled, double-blind study. Lancet Oncol. 2009;10:943\u20139.","journal-title":"Lancet Oncol"},{"key":"1142_CR2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0197-2456(96)00131-6","volume":"18","author":"SD Walter","year":"1997","unstructured":"Walter SD, Cook DJ, Guyatt GH, King D, Troyan S. Outcome assessment for clinical trials: how many adjudicators do we need? Control Clin Trials. 1997;18:27\u201342.","journal-title":"Control Clin Trials"},{"key":"1142_CR3","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1002\/art.24879","volume":"60","author":"KG Saag","year":"2009","unstructured":"Saag KG, Zanchetta JR, Devogelaer JP, et al. Effects of teriparatide versus alendronate for treating glucocorticoid-induced osteoporosis: thirty-six-month results of a randomized, double-blind, controlled trial. Arthritis Rheum. 2009;60:3346\u201355.","journal-title":"Arthritis Rheum"},{"key":"1142_CR4","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1093\/rheumatology\/kep261","volume":"48","author":"M Soubrier","year":"2009","unstructured":"Soubrier M, Puechal X, Sibilia J, et al. Evaluation of two strategies (initial methotrexate monotherapy vs. its combination with adalimumab) in management of early active rheumatoid arthritis: data from the GUEPARD trial. Rheumatology. 2009;48:1429\u201334.","journal-title":"Rheumatology"},{"key":"1142_CR5","first-page":"S725","volume":"60","author":"CK Kwoh","year":"2009","unstructured":"Kwoh CK, Roemer FW, Hannon MJ, Moore CE, Jakicic JM, Guermazi A, et al. The Joints On Glucosamine (JOG) Study: a randomized, double-blind, placebo-controlled trial to assess the structural benefit of glucosamine in knee osteoarthritis based on 3\u00a0T MRI. Arthritis Rheum. 2009;60:S725\u20136.","journal-title":"Arthritis Rheum"},{"key":"1142_CR6","unstructured":"U.S. Department of Health and Human Services, Food and Drug Administration. Clinical development programs for drugs, devices, and biological products intended for the treatment of osteoarthritis (OA). Draft guidance, July 1999. http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/UCM071577.pdf . Accessed Feb. 18, 2010."},{"key":"1142_CR7","unstructured":"OARSI FDA OA initiative. http:\/\/www.oarsi.org\/index2.cfm?section=OARSI_Initiatives&content=FDA_OA_Initiative . Accessed Feb. 18, 2010."},{"key":"1142_CR8","unstructured":"European Medicines Agency Committee for Medicinal Products for Human Use (CHMP). Guidelines on clinical investigation of medicinal products used in the treatment of osteoarthritis, Jan. 2010 (Doc. Ref. CPMP\/EWP\/784\/97 Rev. 1). http:\/\/www.ema.europa.eu\/pdfs\/human\/ewp\/078497en.pdf . Accessed Feb. 18, 2010."},{"key":"1142_CR9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/CVM-2-4-187","volume":"2","author":"KW Mahaffey","year":"2001","unstructured":"Mahaffey KW, Harrington RA, Akkerhuis M, Kleiman NS, Berdan LG, Crenshaw BS, et al. Disagreements between central clinical events committee and site investigator assessments of myocardial infarction end-points in an international clinical trial: review of the PURSUIT study. Curr Control Trials Cardiovasc. 2001;2:187\u201394.","journal-title":"Curr Control Trials Cardiovasc"},{"key":"1142_CR10","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1067\/mhj.2002.120145","volume":"143","author":"KW Mahaffey","year":"2002","unstructured":"Mahaffey KW, Roe MT, Dyke CK, Newby LK, Kleiman NS, Connolly P, et al. Misreporting of myocardial infarction end points: results of adjudication by a central clinical events committee in the PARAGON-B trial. Am Heart J. 2002;143:242\u20138.","journal-title":"Am Heart J"},{"key":"1142_CR11","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1161\/STROKEAHA.108.539601","volume":"40","author":"T Ninomiya","year":"2009","unstructured":"Ninomiya T, Donnan G, Anderson N, Bladin C, Chambers B, Gordon G, et al. Effects of the end point adjudication process on the results of the perindopril protection against recurrent stroke study (PROGRESS). Stroke. 2009;40:2111\u20135.","journal-title":"Stroke"},{"key":"1142_CR12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1177\/1740774507087972","volume":"5","author":"CB Granger","year":"2008","unstructured":"Granger CB, Vogel V, Cummings SR, Held P, Fiedorek F, Lawrence M, et al. Do we need to adjudicate major clinical events? Clin Trials. 2008;5:56\u201360.","journal-title":"Clin Trials"},{"key":"1142_CR13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/1740774509105223","volume":"6","author":"J Pogue","year":"2009","unstructured":"Pogue J, Walter SD, Yusuf S. Evaluating the benefit of event adjudication of cardiovascular outcomes in large simple RCTs. Clin Trials. 2009;6:239\u201351.","journal-title":"Clin Trials"},{"key":"1142_CR14","doi-asserted-by":"crossref","first-page":"S229","DOI":"10.1016\/S1063-4584(09)60451-9","volume":"17","author":"MC Nevitt","year":"2009","unstructured":"Nevitt MC, Felson DT, Maeda JS, Aliabadi PA, McAlindon T, Lynch JA, et al. Central vs. clinic reading of knee radiographs for baseline OA in the Osteoarthritis Initiative Progression Cohort: implications for public data users. Osteoarth Cartil. 2009;17:S229 (Suppl 1).","journal-title":"Osteoarth Cartil"},{"key":"1142_CR15","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","volume":"16","author":"JH Kellgren","year":"1957","unstructured":"Kellgren JH, Lawrence JS. Radiological assessment of osteoarthritis. Ann Rheum Dis. 1957;16:494\u2013502.","journal-title":"Ann Rheum Dis"},{"key":"1142_CR16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2106\/JBJS.H.01385","volume":"91","author":"A Guermazi","year":"2009","unstructured":"Guermazi A, Hunter DJ, Roemer FW. Plain radiography and magnetic resonance imaging diagnostics in osteoarthritis: validated staging and scoring. J Bone Joint Surg Am. 2009;91:54\u201362.","journal-title":"J Bone Joint Surg Am"},{"key":"1142_CR17","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1136\/ard.2007.082107","volume":"68","author":"DJ Hunter","year":"2009","unstructured":"Hunter DJ, Niu J, Zhang Y, Totterman S, Tamez J, Dabrowski C, et al. Change in cartilage morphometry: a sample of the progression cohort of the Osteoarthritis Initiative. Ann Rheum Dis. 2009;68:349\u201356.","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"1142_CR18","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1007\/s00330-004-2312-6","volume":"14","author":"M Kothari","year":"2004","unstructured":"Kothari M, Guermazi A, von Ingersleben G, Miaux Y, Sieffert M, Block JE, et al. Fixed-flexion radiography of the knee provides reproducible joint space width measurements in osteoarthritis. Eur Radiol. 2004;14(9):1568\u201373.","journal-title":"Eur Radiol"},{"key":"1142_CR19","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s00256-002-0603-z","volume":"32","author":"C Peterfy","year":"2003","unstructured":"Peterfy C, Li J, Zaim S, Duryea J, Lynch J, Mizux Y, et al. Comparison of fixed-flexion positioning with fluoroscopic semi-flexed positioning for quantifying radiographic joint-space width in the knee: test-retest reproducibility. Skeletal Radiol. 2003;32:128\u201332.","journal-title":"Skeletal Radiol"},{"key":"1142_CR20","first-page":"3","volume":"3","author":"RD Altman","year":"1995","unstructured":"Altman RD, Hochberg M, Murphy WAJ, Wolfe F, Lequesne M. Atlas of individual radiographic features in osteoarthritis. Osteoarthritis Cartilage. 1995;3:3\u201370.","journal-title":"Osteoarthritis Cartilage"},{"issue":"12","key":"1142_CR21","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1136\/ard.58.12.766","volume":"58","author":"N Bellamy","year":"1999","unstructured":"Bellamy N, Tesar P, Walker D, Klestov A, Muirden K, Kuhnert P, et al. Perceptual variation in grading hand, hip and knee radiographs: observations based on an Australian twin registry study of osteoarthritis. Ann Rheum Dis. 1999;58(12):766\u20139.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"1142_CR22","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1136\/ard.51.1.80","volume":"51","author":"C Cooper","year":"1992","unstructured":"Cooper C, Cushnaghan J, Kirwan JR, Dieppe PA, Rogers J, McAlindon T, et al. Radiographic assessment of the knee joint in osteoarthritis. Ann Rheum Dis. 1992;51(1):80\u20132.","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"1142_CR23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1053\/joca.1998.0152","volume":"7","author":"KP Gunther","year":"1999","unstructured":"Gunther KP, Sun Y. Reliability of radiographic assessment in hip and knee osteoarthritis. Osteoarthritis Cartilage. 1999;7(2):239\u201346.","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"1142_CR24","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s10067-004-0934-3","volume":"23","author":"C Vilalta","year":"2004","unstructured":"Vilalta C, Nunez M, Segur JM, Domingo A, Carbonell JA, Macule F. Knee osteoarthritis: interpretation variability of radiological signs. Clin Rheumatol. 2004;23(6):501\u20134.","journal-title":"Clin Rheumatol"},{"issue":"3","key":"1142_CR25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3109\/03009749709065675","volume":"26","author":"Y Sun","year":"1997","unstructured":"Sun Y, Gunther KP, Brenner H. Reliability of radiographic grading of osteoarthritis of the hip and knee. Scand J Rheumatol. 1997;26(3):155\u201365.","journal-title":"Scand J Rheumatol"}],"container-title":["Skeletal Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00256-011-1142-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00256-011-1142-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00256-011-1142-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T15:47:42Z","timestamp":1558712862000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00256-011-1142-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,9]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["1142"],"URL":"https:\/\/doi.org\/10.1007\/s00256-011-1142-2","relation":{},"ISSN":["0364-2348","1432-2161"],"issn-type":[{"value":"0364-2348","type":"print"},{"value":"1432-2161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,9]]}}}