{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:02:23Z","timestamp":1791028943972,"version":"4.1.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T00:00:00Z","timestamp":1313539200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skeletal Radiol"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1007\/s00256-011-1180-9","type":"journal-article","created":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T10:10:24Z","timestamp":1313575824000},"page":"1137-1140","source":"Crossref","is-referenced-by-count":16,"title":["The osteoclast\u2014what\u2019s new?"],"prefix":"10.1007","volume":"40","author":[{"given":"Nicolas A.","family":"Athanasou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,8,17]]},"reference":[{"key":"1180_CR1","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.2106\/00004623-199607000-00016","volume":"78","author":"NA Athanasou","year":"1996","unstructured":"Athanasou NA. Cellular biology of bone-resorbing cells. J Bone Joint Surg Am. 1996;78:1096\u2013112.","journal-title":"J Bone Joint Surg Am"},{"key":"1180_CR2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","volume":"93","author":"DL Lacey","year":"1998","unstructured":"Lacey DL, Timms E. Tan HL, Kelley MJ, Dunstan CR, Burgess T et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 1998;93:165\u201376.","journal-title":"Cell"},{"key":"1180_CR3","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1359\/jbmr.2000.15.1.2","volume":"15","author":"LC Hofbauer","year":"2000","unstructured":"Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Boyle WJ, Riggs BL. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res. 2000;15:2\u201312.","journal-title":"J Bone Miner Res"},{"key":"1180_CR4","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature01658","volume":"423","author":"WJ Boyle","year":"2003","unstructured":"Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature. 2003;423:337\u201342.","journal-title":"Nature"},{"key":"1180_CR5","doi-asserted-by":"publisher","first-page":"427","DOI":"10.2353\/ajpath.2007.060834","volume":"170","author":"SL Teitelbaum","year":"2007","unstructured":"Teitelbaum SL. Osteoclasts: what do they do and how do they do it? Am J Pathol. 2007;170:427\u201335.","journal-title":"Am J Pathol"},{"key":"1180_CR6","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.bone.2006.09.023","volume":"40","author":"M Asagiri","year":"2007","unstructured":"Asagiri M, Takayanagi H. The molecular understanding of osteoclast differentiation. Bone. 2007;40:251\u201364.","journal-title":"Bone"},{"key":"1180_CR7","first-page":"337","volume":"24","author":"HJ Knowles","year":"2009","unstructured":"Knowles HJ, Athanasou NA. Canonical and non-canonical pathways of osteoclast formation. Histol Histopathol. 2009;24:337\u201346.","journal-title":"Histol Histopathol"},{"key":"1180_CR8","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1172\/JCI11176","volume":"106","author":"J Lam","year":"2000","unstructured":"Lam J, Takeshita S, Barker JE, Kenagawa O, Ross FP, Teitelbaum SL, et al. TNF\u03b1 induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest. 2000;106:1481\u201388.","journal-title":"J Clin Invest"},{"key":"1180_CR9","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1182\/blood-2004-03-0850","volume":"104","author":"E Merck","year":"2004","unstructured":"Merck E, Gaillard C, Gorman DM, Montero-Julian F, Durand I, Zurawhis M, et al. OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells. Blood. 2004;104:1386\u201395.","journal-title":"Blood"},{"key":"1180_CR10","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/nature02444","volume":"428","author":"T Koga","year":"2004","unstructured":"Koga T, Inui M, Inoue K, Kim S, Suematsu A, Kobayashi E, et al. Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature. 2004;428:758\u201363.","journal-title":"Nature"},{"key":"1180_CR11","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s11154-006-9009-x","volume":"7","author":"A Bruzzaniti","year":"2006","unstructured":"Bruzzaniti A, Baron R. Molecular regulation of osteoclast activity. Rev Endocr Metab Disord. 2006;7:123\u201339.","journal-title":"Rev Endocr Metab Disord."},{"key":"1180_CR12","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1002\/jemt.10375","volume":"61","author":"MH Helfrich","year":"2003","unstructured":"Helfrich MH. Osteoclast diseases. Microsc Res Tech. 2003;61:514\u201332.","journal-title":"Microsc Res Tech."},{"key":"1180_CR13","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1172\/JCI24281","volume":"115","author":"GD Roodman","year":"2005","unstructured":"Roodman GD, Windle JJ. Paget disease of bone. J Clin Invest. 2005;115:200\u20138.","journal-title":"J Clin Invest"},{"key":"1180_CR14","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/nrrheum.2010.137","volume":"6","author":"FR Singer","year":"2010","unstructured":"Singer FR, Leach RJ. Do all Paget disease risk genes incriminate the osteoclast? Nat Rev Rheumatol. 2010;6:502\u20133.","journal-title":"Nat Rev Rheumatol"},{"key":"1180_CR15","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1172\/JCI28550","volume":"116","author":"MN Weitzmann","year":"2006","unstructured":"Weitzmann MN, Pacifici R. Estrogen deficiency and bone loss: an inflammatory tale. J Clin Invest. 2006;116:1186\u201394.","journal-title":"J Clin Invest"},{"key":"1180_CR16","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.rdc.2010.03.003","volume":"36","author":"S Karmakar","year":"2010","unstructured":"Karmakar S, Kay J, Gravallese MEM. Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention. Rheum Dis Clin North Am. 2010;36:385\u2013404.","journal-title":"Rheum Dis Clin North Am"},{"key":"1180_CR17","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.bone.2010.08.004","volume":"48","author":"P Juarez","year":"2011","unstructured":"Juarez P, Guise TA. TGF-beta in cancer and bone: implications for treatment of bone metastases. Bone. 2011;48:23\u20139.","journal-title":"Bone"},{"key":"1180_CR18","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S1470-2045(10)70010-3","volume":"11","author":"D Thomas","year":"2010","unstructured":"Thomas D, Henshaw R, Skubitz K, Chawla S, Staddon A, Blay JY, et al. Denosumab in patients with giant cell tumour of bone: an open-label phase 2 study. Lancet Oncol. 2010;11:275\u201380.","journal-title":"Lancet Oncol"}],"container-title":["Skeletal Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00256-011-1180-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00256-011-1180-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00256-011-1180-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00256-011-1180-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T22:23:48Z","timestamp":1565389428000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00256-011-1180-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,17]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["1180"],"URL":"https:\/\/doi.org\/10.1007\/s00256-011-1180-9","relation":{},"ISSN":["0364-2348","1432-2161"],"issn-type":[{"value":"0364-2348","type":"print"},{"value":"1432-2161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,17]]}}}