{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:34:48Z","timestamp":1783488888006,"version":"3.55.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Skeletal Radiol"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s00256-018-3014-5","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T13:22:47Z","timestamp":1531142567000},"page":"119-127","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Imaging features of phosphaturic mesenchymal tumors"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5391-9537","authenticated-orcid":false,"given":"Stephen M.","family":"Broski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Folpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris E.","family":"Wenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,9]]},"reference":[{"key":"3014_CR1","unstructured":"Kumar R, Folpe AL, Mullan BP. Tumor-induced osteomalacia. Transl Endocrinol Metab 2015;7(3):1871."},{"key":"3014_CR2","first-page":"33","volume":"16","author":"RA McCance","year":"1947","unstructured":"McCance RA. Osteomalacia with Looser's nodes (Milkman's syndrome) due to a raised resistance to vitamin D acquired about the age of 15 years. Q J Med. 1947;16:33\u201346.","journal-title":"Q J Med"},{"key":"3014_CR3","first-page":"554","volume":"14","author":"A Prader","year":"1959","unstructured":"Prader A, Illig R, Uehlinger RE, Stalder G. Rachitis infolge knochentumors (rickets caused by bone tumors). Helv Pediatr Acta. 1959;14:554\u201365.","journal-title":"Helv Pediatr Acta"},{"issue":"1","key":"3014_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00000478-200401000-00001","volume":"28","author":"AL Folpe","year":"2004","unstructured":"Folpe AL, Fanburg-Smith JC, Billings SD, Bisceglia M, Bertoni F, Cho JY, et al. Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature. Am J Surg Pathol. 2004;28(1):1\u201330.","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"3014_CR5","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s002560050581","volume":"29","author":"M Sundaram","year":"2000","unstructured":"Sundaram M, McCarthy EF. Oncogenic osteomalacia. Skelet Radiol. 2000;29(3):117\u201324.","journal-title":"Skelet Radiol"},{"issue":"7746","key":"3014_CR6","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S0140-6736(72)92844-9","volume":"1","author":"DJ Evans","year":"1972","unstructured":"Evans DJ, Azzopardi JG. Distinctive tumours of bone and soft tissue causing acquired vitamin-D-resistant osteomalacia. Lancet. 1972;1(7746):353\u20134.","journal-title":"Lancet"},{"issue":"8","key":"3014_CR7","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1002\/1097-0142(19870415)59:8<1442::AID-CNCR2820590810>3.0.CO;2-Q","volume":"59","author":"N Weidner","year":"1987","unstructured":"Weidner N, Santa Cruz D. Phosphaturic mesenchymal tumors. A polymorphous group causing osteomalacia or rickets. Cancer. 1987;59(8):1442\u201354.","journal-title":"Cancer"},{"key":"3014_CR8","volume-title":"WHO classification of tumours of soft tissue and bone","author":"F CDM","year":"2013","unstructured":"CDM F. WHO classification of tumours of soft tissue and bone. Lyon: IARC Press; 2013."},{"issue":"9","key":"3014_CR9","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1111\/cup.12209","volume":"40","author":"KH Gardner","year":"2013","unstructured":"Gardner KH, Shon W, Folpe AL, Wieland CN, Tebben PJ, Baum CL. Tumor-induced osteomalacia resulting from primary cutaneous phosphaturic mesenchymal tumor: a case and review of the medical literature. J Cutan Pathol. 2013;40(9):780\u20134. quiz 779","journal-title":"J Cutan Pathol"},{"issue":"6","key":"3014_CR10","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.tripleo.2009.07.005","volume":"108","author":"VL Woo","year":"2009","unstructured":"Woo VL, Landesberg R, Imel EA, Singer SR, Folpe AL, Econs MJ, et al. Phosphaturic mesenchymal tumor, mixed connective tissue variant, of the mandible: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(6):925\u201332.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"1","key":"3014_CR11","doi-asserted-by":"publisher","first-page":"e6","DOI":"10.1097\/RLU.0000000000000460","volume":"40","author":"K Agrawal","year":"2015","unstructured":"Agrawal K, Bhadada S, Mittal BR, Shukla J, Sood A, Bhattacharya A, et al. Comparison of 18F-FDG and 68Ga DOTATATE PET\/CT in localization of tumor causing oncogenic osteomalacia. Clin Nucl Med. 2015;40(1):e6\u2013e10.","journal-title":"Clin Nucl Med"},{"issue":"2","key":"3014_CR12","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1210\/jc.2012-3642","volume":"98","author":"RJ Clifton-Bligh","year":"2013","unstructured":"Clifton-Bligh RJ, Hofman MS, Duncan E, Sim Ie W, Darnell D, Clarkson A, et al. Improving diagnosis of tumor-induced osteomalacia with Gallium-68 DOTATATE PET\/CT. J Clin Endocrinol Metab. 2013;98(2):687\u201394.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"3014_CR13","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s13139-015-0328-2","volume":"49","author":"CL Ho","year":"2015","unstructured":"Ho CL. Ga68-DOTA peptide PET\/CT to detect occult mesenchymal tumor-inducing osteomalacia: a case series of three patients. Nucl Med Mol Imaging. 2015;49(3):231\u20136.","journal-title":"Nucl Med Mol Imaging"},{"issue":"1","key":"3014_CR14","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/cen.12426","volume":"81","author":"S Jadhav","year":"2014","unstructured":"Jadhav S, Kasaliwal R, Lele V, Rangarajan V, Chandra P, Shah H, et al. Functional imaging in primary tumour-induced osteomalacia: relative performance of FDG PET\/CT vs somatostatin receptor-based functional scans: a series of nine patients. Clin Endocrinol. 2014;81(1):31\u20137.","journal-title":"Clin Endocrinol"},{"issue":"8","key":"3014_CR15","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1097\/RLU.0000000000000854","volume":"40","author":"J Zhang","year":"2015","unstructured":"Zhang J, Zhu Z, Zhong D, Dang Y, Xing H, Du Y, et al. 68Ga DOTATATE PET\/CT is an accurate imaging modality in the detection of culprit tumors causing osteomalacia. Clin Nucl Med. 2015;40(8):642\u20136.","journal-title":"Clin Nucl Med"},{"issue":"11","key":"3014_CR16","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1097\/RLU.0b013e31818866bf","volume":"33","author":"M Duet","year":"2008","unstructured":"Duet M, Kerkeni S, Sfar R, Bazille C, Liote F, Orcel P. Clinical impact of somatostatin receptor scintigraphy in the management of tumor-induced osteomalacia. Clin Nucl Med. 2008;33(11):752\u20136.","journal-title":"Clin Nucl Med"},{"issue":"8","key":"3014_CR17","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1097\/00003072-200208000-00007","volume":"27","author":"CA Garcia","year":"2002","unstructured":"Garcia CA, Spencer RP. Bone and In-111 octreotide imaging in oncogenic osteomalacia: a case report. Clin Nucl Med. 2002;27(8):582\u20133.","journal-title":"Clin Nucl Med"},{"issue":"9308","key":"3014_CR18","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/S0140-6736(02)07846-7","volume":"359","author":"SM Jan de Beur","year":"2002","unstructured":"Jan de Beur SM, Streeten EA, Civelek AC, McCarthy EF, Uribe L, Marx SJ, et al. Localisation of mesenchymal tumours by somatostatin receptor imaging. Lancet. 2002;359(9308):761\u20133.","journal-title":"Lancet"},{"issue":"2","key":"3014_CR19","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1097\/00003072-199902000-00016","volume":"24","author":"BD Nguyen","year":"1999","unstructured":"Nguyen BD, Wang EA. Indium-111 pentetreotide scintigraphy of mesenchymal tumor with oncogenic osteomalacia. Clin Nucl Med. 1999;24(2):130\u20131.","journal-title":"Clin Nucl Med"},{"issue":"4","key":"3014_CR20","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1046\/j.1365-2265.2001.01056.x","volume":"54","author":"Y Rhee","year":"2001","unstructured":"Rhee Y, Lee JD, Shin KH, Lee HC, Huh KB, Lim SK. Oncogenic osteomalacia associated with mesenchymal tumour detected by indium-111 octreotide scintigraphy. Clin Endocrinol. 2001;54(4):551\u20134.","journal-title":"Clin Endocrinol"},{"issue":"6","key":"3014_CR21","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1002\/jbmr.1881","volume":"28","author":"WH Chong","year":"2013","unstructured":"Chong WH, Andreopoulou P, Chen CC, Reynolds J, Guthrie L, Kelly M, et al. Tumor localization and biochemical response to cure in tumor-induced osteomalacia. J Bone Miner Res. 2013;28(6):1386\u201398.","journal-title":"J Bone Miner Res"},{"issue":"1","key":"3014_CR22","doi-asserted-by":"publisher","first-page":"35","DOI":"10.4158\/EP.12.1.35","volume":"12","author":"SF Hodgson","year":"2006","unstructured":"Hodgson SF, Clarke BL, Tebben PJ, Mullan BP, Cooney WP 3rd, Shives TC. Oncogenic osteomalacia: localization of underlying peripheral mesenchymal tumors with use of Tc 99m sestamibi scintigraphy. Endocr Pract. 2006;12(1):35\u201342.","journal-title":"Endocr Pract"},{"issue":"6","key":"3014_CR23","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1002\/jbmr.316","volume":"26","author":"P Andreopoulou","year":"2011","unstructured":"Andreopoulou P, Dumitrescu CE, Kelly MH, Brillante BA, Cutler Peck CM, Wodajo FM, et al. Selective venous catheterization for the localization of phosphaturic mesenchymal tumors. J Bone Miner Res. 2011;26(6):1295\u2013302.","journal-title":"J Bone Miner Res"},{"issue":"3","key":"3014_CR24","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.bone.2005.01.001","volume":"36","author":"JL Dupond","year":"2005","unstructured":"Dupond JL, Mahammedi H, Prie D, Collin F, Gil H, Blagosklonov O, et al. Oncogenic osteomalacia: diagnostic importance of fibroblast growth factor 23 and F-18 fluorodeoxyglucose PET\/CT scan for the diagnosis and follow-up in one case. Bone. 2005;36(3):375\u20138.","journal-title":"Bone"},{"issue":"9","key":"3014_CR25","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1002\/jbmr.1642","volume":"27","author":"Y Jiang","year":"2012","unstructured":"Jiang Y, Xia WB, Xing XP, Silva BC, Li M, Wang O, et al. Tumor-induced osteomalacia: an important cause of adult-onset hypophosphatemic osteomalacia in China: report of 39 cases and review of the literature. J Bone Miner Res. 2012;27(9):1967\u201375.","journal-title":"J Bone Miner Res"},{"issue":"6","key":"3014_CR26","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s00256-013-1798-x","volume":"43","author":"MC Koplas","year":"2014","unstructured":"Koplas MC, Rubin BP, Sundaram M. Phosphaturic mesenchymal tumor: two contrasting cases. Skelet Radiol. 2014;43(6):841\u20135.","journal-title":"Skelet Radiol"},{"issue":"1","key":"3014_CR27","doi-asserted-by":"publisher","first-page":"47","DOI":"10.2463\/mrms.2011-0006","volume":"12","author":"K Nakanishi","year":"2013","unstructured":"Nakanishi K, Sakai M, Tanaka H, Tsuboi H, Hashimoto J, Hashimoto N, et al. Whole-body MR imaging in detecting phosphaturic mesenchymal tumor (PMT) in tumor-induced hypophosphatemic osteomalacia. Magn Reson Med Sci. 2013;12(1):47\u201352.","journal-title":"Magn Reson Med Sci"},{"issue":"2","key":"3014_CR28","doi-asserted-by":"publisher","first-page":"343","DOI":"10.2214\/ajr.167.2.8686600","volume":"167","author":"NA Avila","year":"1996","unstructured":"Avila NA, Skarulis M, Rubino DM, Doppman JL. Oncogenic osteomalacia: lesion detection by MR skeletal survey. AJR Am J Roentgenol. 1996;167(2):343\u20135.","journal-title":"AJR Am J Roentgenol"},{"issue":"4","key":"3014_CR29","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1530\/eje.0.1450469","volume":"145","author":"AE Nelson","year":"2001","unstructured":"Nelson AE, Mason RS, Robinson BG, Hogan JJ, Martin EA, Ahlstrom H, et al. Diagnosis of a patient with oncogenic osteomalacia using a phosphate uptake bioassay of serum and magnetic resonance imaging. Eur J Endocrinol. 2001;145(4):469\u201376.","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"3014_CR30","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s13139-011-0095-7","volume":"45","author":"HJ Seo","year":"2011","unstructured":"Seo HJ, Choi YJ, Kim HJ, Jeong YH, Cho A, Lee JH, et al. Using (18)F-FDG PET\/CT to detect an occult mesenchymal tumor causing oncogenic osteomalacia. Nucl Med Mol Imaging. 2011;45(3):233\u20137.","journal-title":"Nucl Med Mol Imaging"},{"issue":"12","key":"3014_CR31","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1111\/j.1445-5994.2003.00488.x","volume":"33","author":"AM Dissanayake","year":"2003","unstructured":"Dissanayake AM, Wilson JL, Holdaway IM, Reid IR. Oncogenic osteomalacia: culprit tumour detection whole-body magnetic resonance imaging. Intern Med J. 2003;33(12):615\u20136.","journal-title":"Intern Med J"},{"issue":"9","key":"3014_CR32","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1097\/PAS.0b013e3181aa2311","volume":"33","author":"A Bahrami","year":"2009","unstructured":"Bahrami A, Weiss SW, Montgomery E, Horvai AE, Jin L, Inwards CY, et al. RT-PCR analysis for FGF23 using paraffin sections in the diagnosis of phosphaturic mesenchymal tumors with and without known tumor induced osteomalacia. Am J Surg Pathol. 2009;33(9):1348\u201354.","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"3014_CR33","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s00256-009-0758-y","volume":"39","author":"AM Flanagan","year":"2010","unstructured":"Flanagan AM, Delaney D, O'Donnell P. Benefits of molecular pathology in the diagnosis of musculoskeletal disease: part II of a two-part review: bone tumors and metabolic disorders. Skelet Radiol. 2010;39(3):213\u201324.","journal-title":"Skelet Radiol"},{"issue":"3","key":"3014_CR34","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1007\/s12020-016-1092-5","volume":"54","author":"MM Slot-Steenks","year":"2016","unstructured":"Slot-Steenks MM, Hamdy NA, van de Sande MA, Vriens D, Cleven AH, Appelman-Dijkstra NM. Identifying the culprit lesion in tumor induced hypophosphatemia, the solution of a clinical enigma. Endocrine. 2016;54(3):642\u20137.","journal-title":"Endocrine"},{"issue":"10","key":"3014_CR35","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1097\/PAS.0000000000000890","volume":"41","author":"A Agaimy","year":"2017","unstructured":"Agaimy A, Michal M, Chiosea S, Petersson F, Hadravsky L, Kristiansen G, et al. Phosphaturic mesenchymal tumors: clinicopathologic, immunohistochemical and molecular analysis of 22 cases expanding their morphologic and immunophenotypic spectrum. Am J Surg Pathol. 2017;41(10):1371\u201380.","journal-title":"Am J Surg Pathol"},{"issue":"12","key":"3014_CR36","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1016\/j.humpath.2013.07.016","volume":"44","author":"M Houang","year":"2013","unstructured":"Houang M, Clarkson A, Sioson L, Elston MS, Clifton-Bligh RJ, Dray M, et al. Phosphaturic mesenchymal tumors show positive staining for somatostatin receptor 2A (SSTR2A). Hum Pathol. 2013;44(12):2711\u20138.","journal-title":"Hum Pathol"},{"key":"3014_CR37","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.bone.2014.04.016","volume":"64","author":"S Breer","year":"2014","unstructured":"Breer S, Brunkhorst T, Beil FT, Peldschus K, Heiland M, Klutmann S, et al. 68Ga DOTA-TATE PET\/CT allows tumor localization in patients with tumor-induced osteomalacia but negative 111In-octreotide SPECT\/CT. Bone. 2014;64:222\u20137.","journal-title":"Bone"},{"issue":"2","key":"3014_CR38","doi-asserted-by":"publisher","first-page":"177","DOI":"10.4158\/EP10151.OR","volume":"17","author":"VS Jagtap","year":"2011","unstructured":"Jagtap VS, Sarathi V, Lila AR, Malhotra G, Sankhe SS, Bandgar T, et al. Tumor-induced osteomalacia: a single center experience. Endocr Pract. 2011;17(2):177\u201384.","journal-title":"Endocr Pract"},{"key":"3014_CR39","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.humpath.2018.02.022","volume":"80","author":"Kimberley N. Sent-Doux","year":"2018","unstructured":"Sent-Doux KN, Mackinnon C, Lee JC, Folpe AL, Habeeb O. Phosphaturic mesenchymal tumor without osteomalacia: additional confirmation of the \u201cnon-phosphaturic\u201d variant, with emphasis on the roles of FGF23 chromogenic in situ hybridization and FN1-FGFR1 fluorescence in situ hybridization. Hum Pathol. 2018. \n                    https:\/\/doi.org\/10.1016\/j.humpath.2018.02.022\n                    \n                  .","journal-title":"Human Pathology"}],"container-title":["Skeletal Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00256-018-3014-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00256-018-3014-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00256-018-3014-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T19:06:52Z","timestamp":1562612812000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00256-018-3014-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,9]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["3014"],"URL":"https:\/\/doi.org\/10.1007\/s00256-018-3014-5","relation":{},"ISSN":["0364-2348","1432-2161"],"issn-type":[{"value":"0364-2348","type":"print"},{"value":"1432-2161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,9]]},"assertion":[{"value":"3 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The need for informed consent was waived by the Institutional Review Board.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}