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Collagen density maps were reconstructed from the DECT datasets and used to measure densities in regions of interest (ROIs) placed in the scapholunate (SL) ligament (dorsal, palmar, proximal), lunotriquetral (LT) ligament, and extensor carpi radialis (ECR) tendon, (<jats:italic>n<\/jats:italic>\u2009=\u2009260 measurements). The presence of calcifications on standard CT images in these regions was assessed by a blinded reader. Densities were compared with nonparametric tests, and linear regression analysis was performed to investigate the impact of age, sex, and CT- detected calcium deposition on collagen density.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Collagen density in the SL ligament was significantly higher in CPPD patients than in controls (overall mean: 265.4\u2009\u00b1\u200932.1 HU vs. 196.3\u2009\u00b1\u200933.8 HU;<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In the ECR tendon, collagen densities did not differ significantly (<jats:italic>p<\/jats:italic>\u2009=\u20090.672): 161.3\u2009\u00b1\u200920.1 HU in CPPD vs. 163.6\u2009\u00b1\u200912.0 HU in controls. Regression analysis showed that diagnosis, but not age or calcification, had a significant impact on collagen density.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Collagen density of the SL ligament is significantly higher in CPPD patients than in control patients. Further research is needed to understand these changes in the extracellular matrix of ligaments in CPPD.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00256-020-03580-z","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T11:02:42Z","timestamp":1597489362000},"page":"417-423","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Dual-energy CT collagen density mapping of wrist ligaments reveals tissue remodeling in CPPD patients: first results from a clinical cohort"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9763-2420","authenticated-orcid":false,"given":"Katharina","family":"Ziegeler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia-Theresa","family":"Richter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay Geert A.","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Hamm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Diekhoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,15]]},"reference":[{"key":"3580_CR1","unstructured":"Salaffi F, De Angelis R, Grassi W, Prevalence MP, study IGM. 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The authors\u2019 department has a master research agreement with Canon Medical Systems, but there was no specific funding for the work presented.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}