{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:24:23Z","timestamp":1791973463873,"version":"4.4.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Skeletal Radiol"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s00256-021-03715-w","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T19:42:59Z","timestamp":1612294979000},"page":"1667-1675","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Limitations of dual-energy CT in the detection of monosodium urate deposition in dense liquid tophi and calcified tophi"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2155-470X","authenticated-orcid":false,"given":"Se Jin","family":"Ahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Dalbeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bregina","family":"Pool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena K.","family":"Ranganath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prosper","family":"Benhaim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott S.","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"FitzGerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"issue":"6","key":"3715_CR1","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1002\/art.40807","volume":"71","author":"M Chen-Xu","year":"2019","unstructured":"Chen-Xu M, Yokose C, Rai SK, Pillinger MH, Choi HK. Contemporary prevalence of gout and hyperuricemia in the United States and decadal trends: the national health and nutrition examination survey, 2007-2016. Arthritis Rheumatol. 2019;71(6):991\u20139.","journal-title":"Arthritis Rheumatol."},{"issue":"10","key":"3715_CR2","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1136\/ard.2008.099713","volume":"68","author":"HK Choi","year":"2009","unstructured":"Choi HK, Al-Arfaj AM, Eftekhari A, Munk PL, Shojania K, Reid G, et al. Dual-energy computed tomography in tophaceous gout. Ann Rheum Dis. 2009;68(10):1609\u201312.","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"3715_CR3","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1148\/radiol.11102485","volume":"261","author":"KN Glazebrook","year":"2011","unstructured":"Glazebrook KN, Guimaraes LS, Murthy NS, Black DF, Bongartz T, Manek NJ, et al. Identification of intraarticular and periarticular uric acid crystals with dual-energy CT: initial evaluation. Radiology. 2011;261(2):516\u201324.","journal-title":"Radiology."},{"issue":"9","key":"3715_CR4","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1136\/annrheumdis-2011-200976","volume":"71","author":"HK Choi","year":"2012","unstructured":"Choi HK, Burns LC, Shojania K, Koenig N, Reid G, Abufayyah M, et al. Dual-energy CT in gout: a prospective validation study. Ann Rheum Dis. 2012;71(9):1466\u201371.","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"3715_CR5","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1136\/annrheumdis-2013-205095","volume":"74","author":"T Bongartz","year":"2015","unstructured":"Bongartz T, Glazebrook KN, Kavros SJ, Murthy NS, Merry SP, Franz WB 3rd, et al. Dual-energy CT for the diagnosis of gout: an accuracy and diagnostic yield study. Ann Rheum Dis. 2015;74(6):1072\u20137.","journal-title":"Ann Rheum Dis"},{"issue":"12","key":"3715_CR6","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1093\/rheumatology\/kez180","volume":"58","author":"M Gamala","year":"2019","unstructured":"Gamala M, Jacobs JWG, van Laar JM. The diagnostic performance of dual-energy CT for diagnosing gout: a systematic literature review and meta-analysis. Rheumatology (Oxford). 2019;58(12):2117\u201321.","journal-title":"Rheumatology (Oxford)"},{"issue":"10","key":"3715_CR7","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1136\/annrheumdis-2014-205431","volume":"74","author":"A Ogdie","year":"2015","unstructured":"Ogdie A, Taylor WJ, Weatherall M, et al. Imaging modalities for the classification of gout: systematic literature review and meta-analysis. Ann Rheum Dis. 2015;74(10):1868\u201374.","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"3715_CR8","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1002\/art.40929","volume":"71","author":"N Dalbeth","year":"2019","unstructured":"Dalbeth N, Billington K, Doyle A, Frampton C, Tan P, Aati O, et al. Effects of allopurinol dose escalation on bone erosion and urate volume in gout: a dual-energy computed tomography imaging study within a randomized, controlled trial. Arthritis Rheumatol. 2019;71(10):1739\u201346.","journal-title":"Arthritis Rheumatol"},{"issue":"3","key":"3715_CR9","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1136\/annrheumdis-2017-212046","volume":"77","author":"N Dalbeth","year":"2018","unstructured":"Dalbeth N, Nicolaou S, Baumgartner S, Hu J, Fung M, Choi HK. Presence of monosodium urate crystal deposition by dual-energy CT in patients with gout treated with allopurinol. Ann Rheum Dis. 2018;77(3):364\u201370.","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"3715_CR10","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1002\/art.39254","volume":"67","author":"T Neogi","year":"2015","unstructured":"Neogi T, Jansen TL, Dalbeth N, Fransen J, Schumacher HR, Berendsen D, et al. 2015 gout classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Arthritis Rheumatol. 2015;67(10):2557\u201368.","journal-title":"Arthritis Rheumatol."},{"issue":"1","key":"3715_CR11","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1136\/ard.42.1.75","volume":"42","author":"H Paul","year":"1983","unstructured":"Paul H, Reginato AJ, Schumacher HR. Morphological characteristics of monosodium urate: a transmission electron microscopic study of intact natural and synthetic crystals. Ann Rheum Dis. 1983;42(1):75\u201381.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"3715_CR12","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s12891-019-2519-y","volume":"20","author":"P Towiwat","year":"2019","unstructured":"Towiwat P, Chhana A, Dalbeth N. The anatomical pathology of gout: a systematic literature review. BMC Musculoskelet Disord. 2019;20(1):140\u201354.","journal-title":"BMC Musculoskelet Disord"},{"issue":"3","key":"3715_CR13","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1097\/RHU.0b013e318253aa5e","volume":"18","author":"KN Glazebrook","year":"2012","unstructured":"Glazebrook KN, Kakar S, Ida CM, Laurini JA, Moder KG, Leng S. False-negative dual-energy computed tomography in a patient with acute gout. J Clin Rheumatol. 2012;18(3):138\u201341.","journal-title":"J Clin Rheumatol"},{"issue":"4","key":"3715_CR14","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1097\/RLI.0000000000000099","volume":"50","author":"T Diekhoff","year":"2015","unstructured":"Diekhoff T, Kiefer T, Stroux A, Pilhofer I, Juran R, Mews J, et al. Detection and characterization of crystal suspensions using single-source dual-energy computed tomography: a phantom model of crystal arthropathies. Investig Radiol. 2015;50(4):255\u201360.","journal-title":"Investig Radiol"},{"key":"3715_CR15","first-page":"54","volume":"3","author":"CW Denko","year":"1976","unstructured":"Denko CW, Whitehouse MW. Experimental inflammation induced by naturally occurring microcrystalline calcium salts. J Rheumatol. 1976;3:54\u201362.","journal-title":"J Rheumatol"},{"issue":"2","key":"3715_CR16","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1002\/art.39959","volume":"69","author":"A Ogdie","year":"2017","unstructured":"Ogdie A, Taylor WJ, Neogi T, Fransen J, Jansen TL, Ralph SH, et al. Performance of ultrasound in the diagnosis of gout in a multi-center study: comparison with monosodium urate crystal analysis as the gold standard. Arthritis Rheumatol. 2017;69(2):429\u201338.","journal-title":"Arthritis Rheumatol."},{"issue":"4","key":"3715_CR17","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s10067-014-2505-6","volume":"33","author":"FB Lamers-Karnebeek","year":"2014","unstructured":"Lamers-Karnebeek FB, Van Riel PL, Jansen TL. Additive value for ultrasonographic signal in a screening algorithm for patients presenting with acute mono\u2212\/oligoarthritis in whom gout is suspected. Clin Rheumatol. 2014;33(4):555\u20139.","journal-title":"Clin Rheumatol"},{"issue":"6","key":"3715_CR18","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.2214\/AJR.19.21404","volume":"213","author":"S Strobl","year":"2019","unstructured":"Strobl S, Kremser C, Taljanovic M, Gruber J, Stofferin H, Bellmann-Weiler R, et al. Impact of dual-energy CT postprocessing protocol for the detection of gouty arthritis and quantification of tophi in patients presenting with podagra: comparison with iltrasound. Am J Roentgenol. 2019;213(6):1315\u201323.","journal-title":"Am J Roentgenol"},{"issue":"7","key":"3715_CR19","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1007\/s10067-018-3980-y","volume":"37","author":"M Gamala","year":"2018","unstructured":"Gamala M, Linn-Rasker SP, Nix M, Heggelman BGF, van Laar JM, Pasker-de Jong PCM, et al. Gouty arthritis: decision-making following dual-energy CT scan in clinical practice, a retrospective analysis. Clin Rheumatol. 2018;37(7):1879\u201384.","journal-title":"Clin Rheumatol"},{"issue":"1","key":"3715_CR20","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s13075-017-1381-2","volume":"19","author":"T Pascart","year":"2017","unstructured":"Pascart T, Grandjean A, Norberciak L, Ducoulombier V, Motte M, Luraschi H, et al. Ultrasonography and dual-energy computed tomography provide different quantification of urate burden in gout: results from a cross-sectional study. Arthritis Res Ther. 2017;19(1):171\u20139.","journal-title":"Arthritis Res Ther"},{"key":"3715_CR21","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1007\/s00256-018-2948-y","volume":"47","author":"Z Yu","year":"2018","unstructured":"Yu Z, Mao Y, Xu Y, Li T, Wang Y, Gao F, et al. Diagnostic accuracy of dual-energy CT in gout: a systematic review and meta-analysis. Skelet Radiol. 2018;47:1587\u201393.","journal-title":"Skelet Radiol"},{"key":"3715_CR22","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12891-016-0943-9","volume":"17","author":"AN Baer","year":"2016","unstructured":"Baer AN, Kurano T, Thakur UJ, et al. Dual-energy computed tomography has limited sensitivity for non-tophaceous gout: a comparison study with tophaceous gout. BMC Musculoskelet Disord. 2016;17:91\u2013100.","journal-title":"BMC Musculoskelet Disord"},{"issue":"3","key":"3715_CR23","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1007\/s10067-017-3753-z","volume":"37","author":"E Jia","year":"2018","unstructured":"Jia E, Zhu J, Huang W, Chen X, Li J. Dual-energy computed tomography has limited diagnostic sensitivity for short-term gout. Clin Rheumatol. 2018;37(3):773\u20137.","journal-title":"Clin Rheumatol"},{"key":"3715_CR24","doi-asserted-by":"crossref","unstructured":"L\u00f6ckmannV. V-H, P., & Schmid, L. Difficult diagnosis of gout: the benefit of dual-energy computed tomography, initial experience in routine clinical practice. Rheumatology Reports 2013;5(1):22\u201323.","DOI":"10.4081\/rr.2013.e5"},{"issue":"1","key":"3715_CR25","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/s13075-020-02283-z","volume":"22","author":"SN Christiansen","year":"2020","unstructured":"Christiansen SN, M\u00fcller FC, \u00d8stergaard M, et al. Dual-energy CT in gout patients: do all colour-coded lesions actually represent monosodium urate crystals? Arthritis Res Ther. 2020;22(1):212.","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"3715_CR26","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.2214\/AJR.19.22222","volume":"214","author":"EH Park","year":"2020","unstructured":"Park EH, Yoo WH, Song YS, Byon JH, Park J, Choi Y. Not all green is tophi: the importance of optimizing minimum attenuation and using a tin filter to minimize clumpy artifacts on foot and ankle dual-energy CT. Am J Roentgenol. 2020;214(6):1335\u201342.","journal-title":"Am J Roentgenol"}],"container-title":["Skeletal Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00256-021-03715-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00256-021-03715-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00256-021-03715-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T07:08:10Z","timestamp":1623827290000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00256-021-03715-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,2]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["3715"],"URL":"https:\/\/doi.org\/10.1007\/s00256-021-03715-w","relation":{},"ISSN":["0364-2348","1432-2161"],"issn-type":[{"value":"0364-2348","type":"print"},{"value":"1432-2161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,2]]},"assertion":[{"value":"28 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}