{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T08:35:58Z","timestamp":1776069358913,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["115770"],"award-info":[{"award-number":["115770"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Skeletal Radiol"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1007\/s00256-022-04259-3","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T07:10:32Z","timestamp":1672989032000},"page":"1339-1348","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Exploring the differences between radiographic joint space width and MRI cartilage thickness changes using data from the IMI-APPROACH cohort"],"prefix":"10.1007","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1929-6350","authenticated-orcid":false,"given":"Myl\u00e8ne P.","family":"Jansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank W.","family":"Roemer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Karien C. A.","family":"Marijnissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margreet","family":"Kloppenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida K.","family":"Haugen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Berenbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floris P. J. G.","family":"Lafeber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paco M. J.","family":"Welsing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon C.","family":"Mastbergen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Wirth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"4259_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar3488","volume":"13","author":"A Guermazi","year":"2011","unstructured":"Guermazi A, Roemer FW, Burstein D, Hayashi D. Why radiography should no longer be considered a surrogate outcome measure for longitudinal assessment of cartilage in knee osteoarthritis. Arthritis Res Ther. 2011;13:1\u201311.","journal-title":"Arthritis Res Ther"},{"key":"4259_CR2","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1002\/art.22016","volume":"54","author":"DJ Hunter","year":"2006","unstructured":"Hunter DJ, Zhang YQ, Tu X, LaValley M, Niu JB, Amin S, et al. Change in joint space width: hyaline articular cartilage loss or alteration in meniscus? Arthritis Rheum. 2006;54:2488\u201395.","journal-title":"Arthritis Rheum"},{"key":"4259_CR3","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.joca.2012.04.016","volume":"20","author":"MB Kinds","year":"2012","unstructured":"Kinds MB, Vincken KL, Hoppinga TN, Bleys RLAW, Viergever MA, Marijnissen ACA, et al. Influence of variation in semiflexed knee positioning during image acquisition on separate quantitative radiographic parameters of osteoarthritis, measured by Knee Images Digital Analysis. Osteoarthr Cartil. 2012;20:997\u20131003.","journal-title":"Osteoarthr Cartil"},{"key":"4259_CR4","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.2147\/DDDT.S295224","volume":"15","author":"WM Oo","year":"2021","unstructured":"Oo WM, Little C, Duong V, Hunter DJ. The Development of disease-modifying therapies for osteoarthritis (DMOADs): the evidence to date. Drug Des Devel Ther. 2021;15:2921.","journal-title":"Drug Des Devel Ther"},{"key":"4259_CR5","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.joca.2012.12.010","volume":"21","author":"H Gudbergsen","year":"2013","unstructured":"Gudbergsen H, Lohmander LS, Jones G, Christensen R, Bartels EM, Danneskiold-Sams\u00f8e B, et al. Correlations between radiographic assessments and MRI features of knee osteoarthritis - a cross-sectional study. Osteoarthr Cartil. 2013;21:535\u201343.","journal-title":"Osteoarthr Cartil"},{"key":"4259_CR6","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1002\/jor.24283","volume":"37","author":"GC Lonza","year":"2019","unstructured":"Lonza GC, Gardner-Morse MG, Vacek PM, Beynnon BD. Radiographic-based measurement of tibiofemoral joint space width and magnetic resonance imaging derived articular cartilage thickness are not related in subjects at risk for post traumatic arthritis of the knee. J Orthop Res. 2019;37:1052\u20138.","journal-title":"J Orthop Res"},{"key":"4259_CR7","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1002\/acr.22888","volume":"68","author":"NA Segal","year":"2016","unstructured":"Segal NA, Frick E, Duryea J, Roemer F, Guermazi A, Nevitt MC, et al. Correlations of medial joint space width on fixed-flexed standing computed tomography and radiographs with cartilage and meniscal morphology on magnetic resonance imaging. Arthritis Care Res. 2016;68:1410\u20136.","journal-title":"Arthritis Care Res"},{"key":"4259_CR8","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.joca.2005.04.009","volume":"13","author":"F Cicuttini","year":"2005","unstructured":"Cicuttini F, Hankin J, Jones G, Wluka A. Comparison of conventional standing knee radiographs and magnetic resonance imaging in assessing progression of tibiofemoral joint osteoarthritis. Osteoarthr Cartil. 2005;13:722\u20137.","journal-title":"Osteoarthr Cartil"},{"key":"4259_CR9","doi-asserted-by":"publisher","first-page":"R21","DOI":"10.1186\/ar1875","volume":"8","author":"JP Raynauld","year":"2005","unstructured":"Raynauld JP, Martel-Pelletier J, Berthiaume MJ, Beaudoin G, Choquette D, Haraoui B, et al. Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: Correlation with clinical symptoms and radiographic changes. Arthritis Res Ther. 2005;8:R21.","journal-title":"Arthritis Res Ther"},{"key":"4259_CR10","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1002\/acr.20148","volume":"62","author":"J Duryea","year":"2010","unstructured":"Duryea J, Neumann G, Niu J, Totterman S, Tamez J, Dabrowski C, et al. Comparison of radiographic joint space width with magnetic resonance imaging cartilage morphometry: Analysis of longitudinal data from the osteoarthritis initiative. Arthritis Care Res (Hoboken). 2010;62:932\u20137.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"4259_CR11","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.joca.2006.06.018","volume":"15","author":"O Bruyere","year":"2007","unstructured":"Bruyere O, Genant H, Kothari M, Zaim S, White D, Peterfy C, et al. Longitudinal study of magnetic resonance imaging and standard X-rays to assess disease progression in osteoarthritis. Osteoarthr Cartil. 2007;15:98\u2013103.","journal-title":"Osteoarthr Cartil"},{"key":"4259_CR12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.joca.2012.10.017","volume":"21","author":"W Wirth","year":"2013","unstructured":"Wirth W, Duryea J, Hellio Le Graverand MP, John MR, Nevitt M, Buck RJ, et al. Direct comparison of fixed flexion, radiography and MRI in knee osteoarthritis: responsiveness data from the Osteoarthritis Initiative. Osteoarthr Cartil. 2013;21:117\u201325.","journal-title":"Osteoarthr Cartil"},{"key":"4259_CR13","doi-asserted-by":"crossref","unstructured":"Jansen MP, Mastbergen SC, Eckstein F, van Heerwaarden RJ, Spruijt S, Lafeber FPJG. Comparison between 2D radiographic weight-bearing joint space width and 3D MRI non-weight-bearing cartilage thickness measures in the knee using non-weight-bearing 2D and 3D CT as an intermediary. Ther Adv Chronic Dis. 2021;12.","DOI":"10.1177\/20406223211037868"},{"key":"4259_CR14","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.joca.2015.03.012","volume":"23","author":"DJ Hunter","year":"2015","unstructured":"Hunter DJ, Altman RD, Cicuttini F, Crema MD, Duryea J, Eckstein F, et al. OARSI Clinical Trials Recommendations: knee imaging in clinical trials inosteoarthritis. Osteoarthr Cartil. 2015;23:698\u2013715.","journal-title":"Osteoarthr Cartil"},{"key":"4259_CR15","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1001\/jama.2019.14735","volume":"322","author":"MC Hochberg","year":"2019","unstructured":"Hochberg MC, Guermazi A, Guehring H, Aydemir A, Wax S, Fleuranceau-Morel P, et al. Effect of intra-articular sprifermin vs placebo on femorotibial joint cartilage thickness in patients with osteoarthritis: The FORWARD Randomized Clinical Trial. JAMA - J Am Med Assoc. 2019;322:1360\u201370.","journal-title":"JAMA - J Am Med Assoc"},{"key":"4259_CR16","doi-asserted-by":"publisher","first-page":"e035101","DOI":"10.1136\/bmjopen-2019-035101","volume":"10","author":"EM van Helvoort","year":"2020","unstructured":"van Helvoort EM, van Spil WE, Jansen MP, Welsing PMJ, Kloppenburg M, Loef M, et al. Cohort profile: the applied public-private research enabling osteoarthritis clinical headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical mark. BMJ Open. 2020;10:e035101.","journal-title":"BMJ Open"},{"key":"4259_CR17","first-page":"1588","volume":"31","author":"JC Buckland-Wright","year":"2004","unstructured":"Buckland-Wright JC, Ward RJ, Peterfy C, Mojcik CF, Leff RL. Reproducibility of the semiflexed (metatarsophalangeal) radiographic knee position and automated measurements of medial tibiofemoral joint space width in a multicenter clinical trial of knee osteoarthritis. J Rheumatol. 2004;31:1588\u201397.","journal-title":"J Rheumatol"},{"key":"4259_CR18","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.joca.2007.06.009","volume":"16","author":"ACA Marijnissen","year":"2008","unstructured":"Marijnissen ACA, Vincken KL, Vos PAJM, Saris DBF, Viergever MA, Bijlsma JWJ, et al. Knee Images Digital Analysis (KIDA): a novel method to quantify individual radiographic features of knee osteoarthritis in detail. Osteoarthr Cartil. 2008;16:234\u201343.","journal-title":"Osteoarthr Cartil"},{"key":"4259_CR19","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1016\/j.joca.2021.07.013","volume":"29","author":"MP Jansen","year":"2021","unstructured":"Jansen MP, Welsing PMJ, Vincken KL, Mastbergen SC. Performance of knee image digital analysis of radiographs of patients with end-stage knee osteoarthritis. Osteoarthr Cartil. 2021;29:1530\u20139.","journal-title":"Osteoarthr Cartil"},{"key":"4259_CR20","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/j.joca.2011.05.004","volume":"19","author":"DJ Hunter","year":"2011","unstructured":"Hunter DJ, Guermazi A, Lo GH, Grainger AJ, Conaghan PG, Boudreau RM, et al. Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score). Osteoarthr Cartil. 2011;19:990\u20131002.","journal-title":"Osteoarthr Cartil"},{"key":"4259_CR21","first-page":"S86","volume":"44","author":"DB Kendrick","year":"2004","unstructured":"Kendrick DB, Strout TD. The minimum clinically significant difference in patient-assigned 11-point numeric pain scale scores for pain. Ann Emerg Med. 2004;44:S86\u20137.","journal-title":"Ann Emerg Med"},{"key":"4259_CR22","doi-asserted-by":"crossref","unstructured":"Wirth W, Maschek S, Lalande A, Blanco FJ, Berenbaum F, Van de Stadt LA, et al. Test-retest precision and longitudinal cartilage thickness loss in the IMI-APPROACH cohort. Osteoarthr Cartil. 2022;","DOI":"10.1016\/j.joca.2022.10.015"},{"key":"4259_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12891-022-05926-1","volume":"23","author":"FW Roemer","year":"2022","unstructured":"Roemer FW, Jansen M, Marijnissen ACA, Guermazi A, Heiss R, Maschek S, et al. Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort. BMC Musculoskelet Disord. 2022;23:1\u201320.","journal-title":"BMC Musculoskelet Disord"},{"key":"4259_CR24","doi-asserted-by":"crossref","unstructured":"Jansen MP, Wirth W, Bacardit J, Van Helvoort EM, Marijnissen ACA, Kloppenburg M, et al. Machine-learning predicted and actual two-year structural progression in the IMI-APPROACH cohort. Quant Imaging Med Surg. 2022.","DOI":"10.1016\/j.ostima.2022.100049"},{"key":"4259_CR25","unstructured":"Evans JD. Straightforward statistics for the behavioral sciences. 1st ed. Pacific Grove: Pacific Grove: Brooks\/Cole Pub. Co.; 1996. 146"},{"key":"4259_CR26","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.mric.2011.02.010","volume":"19","author":"JA Choi","year":"2011","unstructured":"Choi JA, Gold GE. MR imaging of articular cartilage physiology. Magn Reson Imaging Clin N Am. 2011;19:249\u201382.","journal-title":"Magn Reson Imaging Clin N Am"},{"key":"4259_CR27","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1007\/s00330-017-5140-1","volume":"28","author":"M Roth","year":"2018","unstructured":"Roth M, Emmanuel K, Wirth W, Kwoh CK, Hunter DJ, Eckstein F. Sensitivity to change and association of three-dimensional meniscal measures with radiographic joint space width loss in rapid clinical progression of knee osteoarthritis. Eur Radiol. 2018;28:1844\u201353.","journal-title":"Eur Radiol"},{"key":"4259_CR28","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.ejrad.2016.12.009","volume":"87","author":"M Roth","year":"2017","unstructured":"Roth M, Wirth W, Emmanuel K, Culvenor AG, Eckstein F. The contribution of 3D quantitative meniscal and cartilage measures to variation in normal radiographic joint space width\u2014Data from the Osteoarthritis Initiative healthy reference cohort. Eur J Radiol. 2017;87:90\u20138.","journal-title":"Eur J Radiol"},{"key":"4259_CR29","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1016\/j.joca.2013.09.006","volume":"21","author":"M Marsh","year":"2013","unstructured":"Marsh M, Souza RB, Wyman BT, Hellio Le Graverand MP, Subburaj K, Link TM, et al. Differences between X-ray and MRI-determined knee cartilage thickness in weight-bearing and non-weight-bearing conditions. Osteoarthr Cartil. 2013;21:1876\u201385.","journal-title":"Osteoarthr Cartil"},{"key":"4259_CR30","doi-asserted-by":"publisher","first-page":"343","DOI":"10.2214\/ajr.183.2.1830343","volume":"183","author":"GE Gold","year":"2004","unstructured":"Gold GE, Han E, Stainsby J, Wright G, Brittain J, Beaulieu C. Musculoskeletal MRI at 3.0 T: relaxation times and image contrast. Am J Roentgenol. 2004;183:343\u201351.","journal-title":"Am J Roentgenol"}],"container-title":["Skeletal Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00256-022-04259-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00256-022-04259-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00256-022-04259-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T10:09:08Z","timestamp":1684231748000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00256-022-04259-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,6]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["4259"],"URL":"https:\/\/doi.org\/10.1007\/s00256-022-04259-3","relation":{},"ISSN":["0364-2348","1432-2161"],"issn-type":[{"value":"0364-2348","type":"print"},{"value":"1432-2161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,6]]},"assertion":[{"value":"19 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"FWR: shareholder of Boston Imaging Core Lab (BICL), LLC and consultant to Calibr and Gr\u00fcnenthal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"MK: consulting fees from Abbvie, Pfizer, Kiniksa, Flexion, Galapagos, Jansen, CHDR, Novartis, UCB, all paid to institution.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"FJB: funding from Gedeon Richter Plc., Bristol-Myers Squibb International Corporation (BMSIC), Sun Pharma Global FZE, Celgene Corporation, Janssen Cilag International N.V, Janssen Research & Development, Viela Bio, Inc., Astrazeneca AB, UCB BIOSCIENCES GMBH, UCB BIOPHARMA SPRL, AbbVie Deutschland GmbH & Co.KG, Merck KGaA, Amgen, Inc., Novartis Farmac\u00e9utica, S.A., Boehringer Ingelheim Espa\u00f1a, S.A, CSL Behring, LLC, Glaxosmithkline Research & Development Limited, Pfizer Inc, Lilly S.A., Corbus Pharmaceuticals Inc., Biohope Scientific Solutions for Human Health S.L., Centrexion Therapeutics Corp., Sanofi, MEIJI FARMA S.A., Kiniksa Pharmaceuticals, Ltd. Grunenthal, Asofarma Mexico, Gebro Pharma, Roche, Galapagos, Regeneron.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"IKH: research grant (ADVANCE) from Pfizer (payment to institution) and consulting fees from Novartis and GSK, outside of the submitted work.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"FB: Institutional grants from TRB Chemedica and Pfizer. Consulting fees from AstraZeneca, Boehringer Ingelheim, Bone Therapeutics, Cellprothera, Galapagos, Gilead, Grunenthal, GSK, Eli Lilly, MerckSerono, Nordic Bioscience, Novartis, Pfizer, Sanofi, Servier, Peptinov, 4P Pharma. Honoraria for lectures from Pfizer, Eli Lilly, Viatris, Ach\u00e9 Laboratories. SShareholder of 4Moving Biotech, 4P Pharma and Peptinov.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"WW: Employee and shareholder of Chondrometrics GmbH and consulting fees from Galapagos NV.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The other authors have nothing to disclose.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}}]}}