{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T12:29:08Z","timestamp":1781440148766,"version":"3.54.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["115770"],"award-info":[{"award-number":["115770"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Skeletal Radiol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>Cartilage surface mapping is a technique that can visualize 3D cartilage thickness variation throughout a joint without a need for arbitrary regional definitions. The objective of this cross-sectional study was to utilize this technique to evaluate the cartilage thickness distribution in knee osteoarthritis patients and to analyze to what extent it depends on demographic, radiographic, and MRI structural pathology strata.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Patients of the IMI-APPROACH cohort were included, with MRIs obtained at 1.5\u00a0T or 3\u00a0T. Tibial and femoral cartilage segmentation and registration with a canonical surface were performed semi-automatically. Kellgren-Lawrence and OARSI grading were performed on knee radiographs; MOAKS scoring was performed on MRI scans. The association of demographics and radiographic and MRI scorings with cartilage thickness distribution was analyzed with general linear models using statistical parametric mapping.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Two hundred eighty-seven patients were included. Male sex and height were positively associated with cartilage thickness particularly in the trochlea and medial femur, respectively, with differences up to 0.5\u00a0mm (male vs female), while radiographic joint space narrowing and bone marrow lesions showed region-specific negative associations (up to 0.14\u20130.5\u00a0mm per grade). Kellgren-Lawrence grade, MOAKS meniscal extrusion, and osteophytes showed patterns of positive and negative associations, with increasing grades showing reduced local tibiofemoral cartilage thickness, but greater thickness in the trochlea (both up to 0.2\u20130.3\u00a0mm per grade).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Decreased height, female sex, and increasing tibiofemoral pathology were associated with thinner tibiofemoral cartilage. Unexpected results such as consistently thicker cartilage in the anterior femur with increasing disease or osteophytosis states provide opportunities for future research.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00256-025-04907-4","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T22:08:42Z","timestamp":1742594922000},"page":"2025-2034","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cartilage thickness distribution and its dependence on demographic, radiographic, and MRI structural pathology in knee osteoarthritis\u2014data from the IMI-APPROACH cohort"],"prefix":"10.1007","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1929-6350","authenticated-orcid":false,"given":"Myl\u00e8ne P.","family":"Jansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom D.","family":"Turmezei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishan","family":"Dattani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri A.","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon C.","family":"Mastbergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margreet","family":"Kloppenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida K.","family":"Haugen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Berenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Wirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Eckstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank W.","family":"Roemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"MacKay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"4907_CR1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.joca.2006.11.006","volume":"15","author":"PM van der Kraan","year":"2007","unstructured":"van der Kraan PM, van den Berg WB. 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All participants have received oral and written information and provided written informed consent. The study was registered under clinicaltrials.gov nr: NCT03883568.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"T.D. Turmezei: director and shareholder of KNEE3D Ltd, consulting fees from GSK plc and CurveBeamAI, royalties from Elsevier, scientific advisory board for Chondrometrics GmbH, editorial board for Osteoarthritis Imaging.M. Kloppenburg: consulting fees from Pfizer, CHDR, Novartis, UCB, GSK, and Peptinov, all paid to the institution. Royalties from Wolters-Kluwer and Springer Verlag, all paid to the institution.F.J. Blanco: funding from Gedeon Richter Plc., Bristol-Myers Squibb International Corporation (BMSIC); Sun Pharma Global FZE; Celgene Corporation; Janssen Cilag International N.V; Janssen Research & Development; Viela Bio, Inc.; Astrazeneca AB; UCB BIOSCIENCES GMBH; UCB BIOPHARMA SPRL; AbbVie Deutschland GmbH & Co.KG; Merck KGaA; Amgen, Inc.; Novartis Farmac\u00e9utica, S.A.; Boehringer Ingelheim Espa\u00f1a, S.A; CSL Behring; LLC; Glaxosmithkline Research & Development Limited, Pfizer Inc; Lilly S.A.; Corbus Pharmaceuticals Inc.; Biohope Scientific Solutions for Human Health S.L.; Centrexion Therapeutics Corp.; Sanofi; TEDEC-MEIJI FARMA S.A.; KiniksaPharmaceuticals, Ltd. Grunenthal.I.K. Haugen: research grant (ADVANCE) from Pfizer (payment to institution) and personal fees from Abbvie, Novartis, Gr\u00fcnenthal, and GSK, outside of the submitted work.F. Berenbaum: consulting fees from Grunenthal, GSK, Eli Lilly, Novartis, Pfizer, Servier, and 4P Pharma; honoraria from Viatris, Pfizer, and Zoetis; travel support from Nordic Pharma; holds patents related to 4Moving Biotech; serves on advisory boards for AstraZeneca, Sun Pharma, and Nordic Bioscience; and holds stock in 4P Pharma and 4Moving Biotech. CMO and co-founder of 4Moving Biotech.W. Wirth: employee and shareholder of Chondrometrics GmbH.F. Eckstein: CEO and shareholder of Chondrometrics GmbH; received personal fees from Formation Bio, Peptinov, 4P Pharma, Novartis, and Kolon TissueGene; and grants from PMU, BMBF, EU, NIH, FNIH, Merck, Galapagos NV, Novartis, Kolon TissueGene, CALIBR, ICM, Bioclinica\/Clario, and the Universities of Erlangen, Sydney, Basel, Western Ontario, Stanford, Imperial College, Aachen and Utrecht.F.W. Roemer: shareholder of Boston Imaging Core Lab (BICL), LLC, and consultant to Gr\u00fcnenthal GmbH. Editor in Chief Osteoarthritis Imaging.J.W. MacKay: employee and shareholder of AstraZeneca.The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}