{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:11:48Z","timestamp":1787317908356,"version":"build-2736575974"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Skeletal Radiol"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s00256-025-04908-3","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T08:12:55Z","timestamp":1742717575000},"page":"2329-2338","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Recent evolution in imaging techniques for assessment of synovitis in osteoarthritis"],"prefix":"10.1007","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2067-5780","authenticated-orcid":false,"given":"Daichi","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank W.","family":"Roemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Guermazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,22]]},"reference":[{"issue":"10","key":"4908_CR1","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/j.joca.2023.06.005","volume":"31","author":"A De Roover","year":"2023","unstructured":"De Roover A, Escribano-Nunez A, Monteagudo S, Lories R. Fundamentals of osteoarthritis: inflammatory mediators in osteoarthritis. Osteoarthr Cartil. 2023;31(10):1303\u201311.","journal-title":"Osteoarthr Cartil"},{"key":"4908_CR2","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13075-017-1229-9","volume":"19","author":"A Mathiessen","year":"2017","unstructured":"Mathiessen A, Conaghan PG. Synovitis in osteoarthritis: current understanding with therapeutic implications. Arthritis Res Ther. 2017;19:18.","journal-title":"Arthritis Res Ther"},{"issue":"8","key":"4908_CR3","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.joca.2004.03.003","volume":"12","author":"AB Blom","year":"2004","unstructured":"Blom AB, van Lent PL, Holthuysen AE, van der Kraan PM, Roth J, van Rooijen N, van den Berg WB. Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis. Osteoarthr Cartil. 2004;12(8):627\u201335.","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"4908_CR4","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13075-018-1798-2","volume":"21","author":"A Gomez-Aristizabal","year":"2019","unstructured":"Gomez-Aristizabal A, Gandhi R, Mahomed NN, Marshall KW, Viswanathan S. Synovial fluid monocyte\/macrophage subsets and their correlation to patient-reported outcomes in osteoarthritic patients: a cohort study. Arthritis Res Ther. 2019;21(1):26.","journal-title":"Arthritis Res Ther"},{"key":"4908_CR5","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.semarthrit.2010.12.003","volume":"41","author":"D Hayashi","year":"2011","unstructured":"Hayashi D, Roemer FW, Katur A, Felson DT, Yang SO, Alomran F, Guermazi A. Imaging of synovitis in osteoarthritis: current status and outlook. Semin Arthritis Rheum. 2011;41:116\u201330.","journal-title":"Semin Arthritis Rheum"},{"issue":"4","key":"4908_CR6","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.joca.2021.12.003","volume":"30","author":"P Dainese","year":"2022","unstructured":"Dainese P, Wyngaert KV, De Mits S, Wittoek R, Van Ginckel A, Calders P. Association between knee inflammation and knee pain in patients with knee osteoarthritis: a systematic review. Osteoarthr Cartil. 2022;30(4):516\u201334.","journal-title":"Osteoarthr Cartil"},{"issue":"7","key":"4908_CR7","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.3390\/cells10071826","volume":"10","author":"X Yang","year":"2021","unstructured":"Yang X, Thudium CS, Bay-Jensen AC, Karsdal MA, van Santen J, Arden NK, Perry TA, Kluzek S. Association between markers of synovial inflammation, matrix turnover and symptoms in knee osteoarthritis: a cross-sectional study. Cells. 2021;10(7):1826.","journal-title":"Cells"},{"issue":"1","key":"4908_CR8","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3899\/jrheum.210285","volume":"49","author":"HT Philpott","year":"2022","unstructured":"Philpott HT, Birmingham TB, Pinto R, Primeau CA, Arsenault D, Lanting BA, Zhu Y, Appleton CT; WOREO Knee Study Group. Synovitis is associated with constant pain in knee osteoarthritis: a cross sectional study of OMERACT Knee Ultrasound Scores. J Rheumatol. 2022;49(1):89\u201397.","journal-title":"J Rheumatol"},{"issue":"3","key":"4908_CR9","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.joca.2015.09.018","volume":"24","author":"FW Roemer","year":"2016","unstructured":"Roemer FW, Jarraya M, Felson DT, Hayashi D, Crema MD, Loeuille D, Guermazi A. Magnetic resonance imaging of Hoffa\u2019s fat pad and relevance for osteoarthritis research: a narrative review. Osteoarthr Cartil. 2016;24(3):383\u201397.","journal-title":"Osteoarthr Cartil"},{"issue":"6","key":"4908_CR10","doi-asserted-by":"publisher","first-page":"3401","DOI":"10.1007\/s00330-020-06671-6","volume":"30","author":"BA de Vries","year":"2020","unstructured":"de Vries BA, van der Heijden RA, Poot DHJ, et al. Quantitative DCE-MRI demonstrates increased blood perfusion in Hoffa\u2019s fat pad signal abnormalities in knee osteoarthritis, but not in patellofemoral pain. Eur Radiol. 2020;30(6):3401\u20138.","journal-title":"Eur Radiol"},{"key":"4908_CR11","doi-asserted-by":"publisher","unstructured":"Roemer FW, Jansen MP, Maschek S, et al. Fluctuation of bone marrow lesions and inflammatory MRI markers over 2 years and concurrent associations with quantitative cartilage loss. Cartilage. Published online October 26, 2024. https:\/\/doi.org\/10.1177\/19476035241287694.","DOI":"10.1177\/19476035241287694"},{"key":"4908_CR12","doi-asserted-by":"publisher","first-page":"1759720X2311717","DOI":"10.1177\/1759720X231171766","volume":"15","author":"WP Maksymowych","year":"2023","unstructured":"Maksymowych WP, Jaremko JL, Pedersen SJ, et al. Comparative validation of the knee inflammation MRI scoring system and the MRI osteoarthritis knee score for semi-quantitative assessment of bone marrow lesions and synovitis-effusion in osteoarthritis: an international multi-reader exercise. Ther Adv Musculoskelet Dis. 2023;15:1759720X231171766.","journal-title":"Ther Adv Musculoskelet Dis"},{"issue":"1","key":"4908_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12891-020-03338-7","volume":"21","author":"MS Harkey","year":"2020","unstructured":"Harkey MS, Davis JE, Price LL, Ward RJ, MacKay JW, Eaton CB, et al. Composite quantitative knee structure metrics predict the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative. BMC Musculoskelet Disord. 2020;21(1):1\u201310.","journal-title":"BMC Musculoskelet Disord"},{"issue":"5","key":"4908_CR14","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1002\/acr.24512","volume":"74","author":"JB Driban","year":"2022","unstructured":"Driban JB, Price LL, LaValley MP, Lo GH, Zhang M, Harkey MS, et al. Novel framework for measuring whole knee osteoarthritis progression using magnetic resonance imaging. Arthritis Care Res. 2022;74(5):799\u2013808.","journal-title":"Arthritis Care Res"},{"issue":"1","key":"4908_CR15","doi-asserted-by":"publisher","first-page":"100138","DOI":"10.1016\/j.ocarto.2021.100138","volume":"3","author":"SE Smith","year":"2021","unstructured":"Smith SE, Hosseinzadeh S, Maetani T, Shilpa P, Collins JE, Kwoh CK, et al. Association of quantitative measures of effusion-synovitis and Hoffa-synovitis with radiographic and pain progression: data from the FNIH OA biomarkers consortium. Osteoarthr Cartil Open. 2021;3(1):100138.","journal-title":"Osteoarthr Cartil Open"},{"issue":"8","key":"4908_CR16","doi-asserted-by":"publisher","first-page":"5746","DOI":"10.1007\/s00330-021-07698-z","volume":"31","author":"JW MacKay","year":"2021","unstructured":"MacKay JW, Nezhad FS, Rifai T, Kaggie JD, Naish JH, Roberts C, et al. Dynamic contrast-enhanced MRI of synovitis in knee osteoarthritis: repeatability, discrimination and sensitivity to change in a prospective experimental study. Eur Radiol. 2021;31(8):5746\u201358.","journal-title":"Eur Radiol"},{"issue":"3","key":"4908_CR17","first-page":"e200078","volume":"3","author":"AD Desai","year":"2021","unstructured":"Desai AD, Caliva F, Iriondo C, Mortazi A, Jambawalikar S, Bagci U, et al. The international workshop on osteoarthritis imaging knee MRI segmentation challenge: a multi-institute evaluation and analysis framework on a standardized dataset. Radiology: Artificial Intelligence. 2021;3(3):e200078.","journal-title":"Radiology: Artificial Intelligence"},{"issue":"1","key":"4908_CR18","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s13075-021-02436-8","volume":"23","author":"BA de Vries","year":"2021","unstructured":"de Vries BA, Breda SJ, Sveinsson B, McWalter EJ, Meuffels DE, Krestin GP, Hargreaves BA, Gold GE, Oei EHG. Detection of knee synovitis using non-contrast-enhanced qDESS compared with contrast-enhanced MRI. Arthritis Res Ther. 2021;23(1):55.","journal-title":"Arthritis Res Ther"},{"issue":"12","key":"4908_CR19","doi-asserted-by":"publisher","first-page":"9369","DOI":"10.1007\/s00330-021-08025-2","volume":"31","author":"J Thoenen","year":"2021","unstructured":"Thoenen J, Stevens KJ, Turmezei TD, Chaudhari A, Watkins LE, McWalter EJ, Hargreaves BA, Gold GE, MacKay JW, Kogan F. Non-contrast MRI of synovitis in the knee using quantitative DESS. Eur Radiol. 2021;31(12):9369\u201379.","journal-title":"Eur Radiol"},{"issue":"3","key":"4908_CR20","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1148\/radiol.2016160155","volume":"283","author":"HJ Yoo","year":"2017","unstructured":"Yoo HJ, Hong SH, Oh HY, Choi JY, Chae HD, Ahn JM, Kang HS. Diagnostic accuracy of a fluid-attenuated inversion-recovery sequence with fat suppression for assessment of peripatellar synovitis: preliminary results and comparison with contrast-enhanced MR imaging. Radiology. 2017;283(3):769\u201378.","journal-title":"Radiology"},{"issue":"8","key":"4908_CR21","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1097\/RLI.0000000000001065","volume":"59","author":"GC Feuerriegel","year":"2024","unstructured":"Feuerriegel GC, Goller SS, von Deuster C, Sutter R. Inflammatory knee synovitis: evaluation of an accelerated FLAIR sequence compared with standard contrast-enhanced imaging. Invest Radiol. 2024;59(8):599\u2013604.","journal-title":"Invest Radiol"},{"issue":"1","key":"4908_CR22","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s12891-020-3122-y","volume":"21","author":"C Treutlein","year":"2020","unstructured":"Treutlein C, Bauerle T, Nagel AM, Guermazi A, Kleyer A, Simon D, Schett G, Hepp T, Uder M, Roemer FW. Comprehensive assessment of knee joint synovitis at 7T MRI using contrast-enhanced and non-enhanced sequences. BMC Musculoskelet Disord. 2020;21(1):116.","journal-title":"BMC Musculoskelet Disord"},{"issue":"11","key":"4908_CR23","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.3390\/diagnostics13111960","volume":"13","author":"JH Kang","year":"2023","unstructured":"Kang JH, Moon SG, Jung HG, Kwon EY. Fluid-attenuated inversion recovery sequence with fat suppression for assessment of ankle synovitis without contrast enhancement: comparison with contrast-enhanced MRI. Diagnostics (Basel). 2023;13(11):1960.","journal-title":"Diagnostics (Basel)"},{"issue":"2","key":"4908_CR24","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1002\/jmri.28870","volume":"59","author":"JG Raya","year":"2024","unstructured":"Raya JG, Duarte A, Wang N, Mazzoli V, Jaramillo D, Blamire AM, Dietrich O. Applications of diffusion-weighted MRI to the musculoskeletal system. J Magn Reson Imaging. 2024;59(2):376\u201396.","journal-title":"J Magn Reson Imaging"},{"issue":"1","key":"4908_CR25","doi-asserted-by":"publisher","first-page":"e4614","DOI":"10.1002\/nbm.4614","volume":"35","author":"HJC Sandford","year":"2021","unstructured":"Sandford HJC, MacKay JW, Watkins LE, Gold GE, Kogan F, Mazzoli V. Gadolinium-free assessment of synovitis using diffusion tensor imaging. NMR Biomed. 2021;35(1):e4614.","journal-title":"NMR Biomed"},{"issue":"2","key":"4908_CR26","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1148\/radiol.2020191685","volume":"295","author":"AM Barendregt","year":"2020","unstructured":"Barendregt AM, Mazzoli V, van Gulik EC, Schonenberg-Meinema D, Nassar-Sheikh Rashid A, Nusman CM, Dolman KM, van den Berg JM, Kuijpers TW, Nederveen AJ, Maas M, Hemke R. Juvenile idiopathic arthritis: diffusion-weighted MRI in the assessment of arthritis in the knee. Radiology. 2020;295(2):373\u201380.","journal-title":"Radiology"},{"issue":"5","key":"4908_CR27","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1136\/ard.2010.139618","volume":"70","author":"A Guermazi","year":"2011","unstructured":"Guermazi A, Roemer FW, Hayashi D, Crema MD, Niu J, Zhang Y, et al. Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring sytem in people with, or at high risk of, knee osteoarthritis: the MOST study. Ann Rheum Dis. 2011;70(5):805\u201311.","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"4908_CR28","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3899\/jrheum.130541","volume":"41","author":"A Guermazi","year":"2014","unstructured":"Guermazi A, Hayashi D, Roemer FW, Zhu Y, Niu J, Crema MD, et al. Synovitis in knee osteoarthritis assessed by contrast-enhanced magnetic resonance imaging (MRI) is associated with radiographic tibiofemoral osteoarthritis and MRI-detected widespread cartilage damage: the MOST study. J Rheumatol. 2014;41(3):501\u20138.","journal-title":"J Rheumatol"},{"issue":"12","key":"4908_CR29","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1007\/s00270-024-03752-7","volume":"47","author":"MW Little","year":"2024","unstructured":"Little MW, O\u2019Grady A, Briggs J, Gibson M, Speirs A, Al-Rekabi A, Yoong P, Ariyanayagam T, Davies N, Tayton E, Tavares S, MacGill S, McLaren C, Harrison R. Genicular artery embolism in patients with osteoarthritis of the knee (GENESIS) using permanent microspheres: long-term results. Cardiovasc Intervent Radiol. 2024;47(12):1750\u201362.","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"1","key":"4908_CR30","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s13063-021-05942-x","volume":"23","author":"TA van Zadelhoff","year":"2022","unstructured":"van Zadelhoff TA, Moelker A, Bierma-Zeinstra SMA, Bos PK, Krestin GP, Oei EHG. Genicular artery embolization as a novel treatment for mild to moderate knee osteoarthritis: protocol design of a randomized sham-controlled clinical trial. Trials. 2022;23(1):24.","journal-title":"Trials"},{"issue":"7","key":"4908_CR31","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/nrrheum.2012.80","volume":"8","author":"PI Mapp","year":"2012","unstructured":"Mapp PI, Walsh DA. Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis. Nat Rev Rheumatol. 2012;8(7):390\u20138.","journal-title":"Nat Rev Rheumatol"},{"issue":"9","key":"4908_CR32","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1016\/j.jvir.2024.06.003","volume":"35","author":"A Dablan","year":"2024","unstructured":"Dablan A, Erdim \u00c7, G\u00fczelbey T, Cing\u00f6z M, Arslan MF, Mutlu \u0130N, K\u0131l\u0131\u00e7kesmez \u00d6. Effectiveness of genicular artery embolization for reducing synovitis as assessed by contrast-enhanced MR imaging in knee osteoarthritis: a pilot study. J Vasc Interv Radiol. 2024;35(9):1313-1322.e6.","journal-title":"J Vasc Interv Radiol"},{"issue":"16","key":"4908_CR33","doi-asserted-by":"publisher","first-page":"4930","DOI":"10.3390\/jcm13164930","volume":"13","author":"V D\u2019Agostino","year":"2024","unstructured":"D\u2019Agostino V, Sorriento A, Cafarelli A, Donati D, Papalexis N, Russo A, et al. Ultrasound imaging in knee osteoarthritis: current role, recent advancements, and future perspectives. J Clin Med. 2024;13(16):4930.","journal-title":"J Clin Med"},{"issue":"2","key":"4908_CR34","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1002\/mp.16640","volume":"51","author":"C du Toit","year":"2024","unstructured":"du Toit C, Dima R, Papernick S, Jonnalagadda M, Tessier D, Fenster A, Lalone E. Three-dimensional ultrasound to investigate synovitis in first carpometacarpal osteoarthritis: a feasibility study. Med Phys. 2024;51(2):1092\u2013104.","journal-title":"Med Phys"},{"issue":"11","key":"4908_CR35","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1002\/acr.25407","volume":"76","author":"P Molyneux","year":"2024","unstructured":"Molyneux P, Bowen C, Ellis R, Rome K, Fitzgerald K, Clark P, et al. Development of an ultrasound imaging atlas for grading osteoarthritis in the first metatarsophalangeal joint. Arthritis Care Res (Hoboken). 2024;76(11):1501\u201310.","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"1","key":"4908_CR36","doi-asserted-by":"publisher","first-page":"100176","DOI":"10.1016\/j.ostima.2024.100176","volume":"4","author":"C Du Toit","year":"2024","unstructured":"Du Toit C, Hutter M, Gyacskov I, Tessier D, Dima R, Fenster A, Lalone E. Deep learning for synovial volume segmentation of the first carpometacarpal joint in osteoarthritis patients. Osteoarthr Imaging. 2024;4(1):100176.","journal-title":"Osteoarthr Imaging"},{"issue":"2","key":"4908_CR37","doi-asserted-by":"publisher","first-page":"100356","DOI":"10.1016\/j.ocarto.2023.100356","volume":"5","author":"R Dima","year":"2023","unstructured":"Dima R, Birmingham TB, Philpott HT, Bryant D, Fenster A, Appleton CT. Cross-sectional reliability and concurrent validity of a quantitative 2-dimensional ultrasound image analysis of effusion and synovial hypertrophy in knee osteoarthritis. Osteoarthr Cartil Open. 2023;5(2):100356.","journal-title":"Osteoarthr Cartil Open"},{"key":"4908_CR38","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3899\/jrheum.191291","volume":"48","author":"WM Oo","year":"2020","unstructured":"Oo WM, Linklater JM, Bennell KL, Pryke D, Yu S, Fu K, et al. Are OMERACT knee osteoarthritis ultrasound scores associated with pain severity, other symptoms, and radiographic and magnetic resonance imaging findings? J Rheumatol. 2020;48:270\u20138.","journal-title":"J Rheumatol"},{"issue":"11","key":"4908_CR39","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1016\/j.joca.2024.06.015","volume":"32","author":"HT Philpott","year":"2024","unstructured":"Philpott HT, Birmingham TB, Carter MM, et al. Association between synovial tissue damage and pain in late-stage knee osteoarthritis: a cross-sectional study. Osteoarthr Cartil. 2024;32(11):1503\u201312.","journal-title":"Osteoarthr Cartil"},{"issue":"9","key":"4908_CR40","doi-asserted-by":"publisher","first-page":"6376","DOI":"10.1007\/s00330-022-08744-0","volume":"32","author":"ST Ulas","year":"2022","unstructured":"Ulas ST, Ziegeler K, Richter ST, Ohrndorf S, Biesen R, Proft F, Poddubnyy D, Diekhoff T. Contrast-enhanced CT techniques and MRI perform equally well in arthritis imaging of the hand: a prospective diagnostic accuracy study. Eur Radiol. 2022;32(9):6376\u201383.","journal-title":"Eur Radiol"},{"issue":"4","key":"4908_CR41","doi-asserted-by":"publisher","first-page":"555","DOI":"10.3348\/kjr.2017.18.4.555","volume":"18","author":"HW Goo","year":"2017","unstructured":"Goo HW, Goo JM. Dual-energy CT: new horizon in medical imaging. Korean J Radiol. 2017;18(4):555\u201369.","journal-title":"Korean J Radiol"},{"issue":"1","key":"4908_CR42","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s00256-020-03526-5","volume":"50","author":"ST Ulas","year":"2021","unstructured":"Ulas ST, Hermann KG, Makowski MR, Biesen R, Proft F, Schilling R, Diekhoff T. Perfusion in hand arthritis on dynamic contrast-enhanced computed tomography: a randomized prospective study using MRI as a standard of reference. Skeletal Radiol. 2021;50(1):59\u201368.","journal-title":"Skeletal Radiol"},{"issue":"6","key":"4908_CR43","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1055\/s-0043-1775741","volume":"27","author":"JM Mostert","year":"2023","unstructured":"Mostert JM, Dur NBJ, Li X, Ellermann JM, Hemke R, Hales L, Mazzoli V, Kogan F, Griffith JF, Oei EHG, van der Heijden RA. Advanced magnetic resonance imaging and molecular imaging of the painful knee. Semin Musculoskelet Radiol. 2023;27(6):618\u201331.","journal-title":"Semin Musculoskelet Radiol"},{"issue":"6","key":"4908_CR44","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.joca.2006.12.010","volume":"15","author":"H Nakamura","year":"2007","unstructured":"Nakamura H, Masuko K, Yudoh K, Kato T, Nishioka K, Sugihara T, Beppu M. Positron emission tomography with 18F-FDG in osteoarthritic knee. Osteoarthr Cartil. 2007;15(6):673\u201381.","journal-title":"Osteoarthr Cartil"},{"issue":"6","key":"4908_CR45","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1002\/jmri.25529","volume":"45","author":"F Kogan","year":"2017","unstructured":"Kogan F, Fan AP, McWalter EJ, Oei EHG, Quon A, Gold GE. PET\/MRI of metabolic activity in osteoarthritis: a feasibility study. J Magn Reson Imaging. 2017;45(6):1736\u201345.","journal-title":"J Magn Reson Imaging"},{"key":"4908_CR46","doi-asserted-by":"crossref","unstructured":"Nguyen BJ, Burt A, Baldassarre RL, Smitaman E, Morshedi M, Kao S, Chang EY, Obrzut S. The prognostic and diagnostic value of 18F-FDG PET\/CT for assessment of symptomatic osteoarthritis. Nucl Med Commun. 2018;39(7):699\u2013706. Erratum in: Nucl Med Commun. 2018;39(10):960.","DOI":"10.1097\/MNM.0000000000000858"},{"issue":"12","key":"4908_CR47","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1097\/MNM.0000000000000376","volume":"36","author":"MA Parsons","year":"2015","unstructured":"Parsons MA, Moghbel M, Saboury B, Torigian DA, Werner TJ, Rubello D, Basu S, Alavi A. Increased 18F-FDG uptake suggests synovial inflammatory reaction with osteoarthritis: preliminary in-vivo results in humans. Nucl Med Commun. 2015;36(12):1215\u20139.","journal-title":"Nucl Med Commun"},{"issue":"14","key":"4908_CR48","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/1471-2474-14-141","volume":"22","author":"YH Hong","year":"2013","unstructured":"Hong YH, Kong EJ. (18F)Fluoro-deoxy-D-glucose uptake of knee joints in the aspect of age-related osteoarthritis: a case-control study. BMC Musculoskelet Disord. 2013;22(14):141.","journal-title":"BMC Musculoskelet Disord"},{"key":"4908_CR49","doi-asserted-by":"publisher","first-page":"101569","DOI":"10.1016\/j.jcot.2021.101569","volume":"22","author":"A Jena","year":"2021","unstructured":"Jena A, Goyal N, Vaishya R. 18F-NaF simultaneous PET\/MRI in osteoarthritis: initial observations with case illustration. J Clin Orthop Trauma. 2021;22:101569.","journal-title":"J Clin Orthop Trauma"},{"issue":"8","key":"4908_CR50","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.joca.2021.04.014","volume":"29","author":"JW MacKay","year":"2021","unstructured":"MacKay JW, Watkins L, Gold G, Kogan F. [18F]NaF PET-MRI provides direct in-vivo evidence of the association between bone metabolic activity and adjacent synovitis in knee osteoarthritis: a cross-sectional study. Osteoarthr Cartil. 2021;29(8):1155\u201362.","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"4908_CR51","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s13550-020-00736-9","volume":"10","author":"Y Helo","year":"2020","unstructured":"Helo Y, Searle GE, Borghese F, Abraham S, Saleem A. Specificity of translocator protein-targeted positron emission tomography in inflammatory joint disease. EJNMMI Res. 2020;10(1):147.","journal-title":"EJNMMI Res"},{"issue":"7","key":"4908_CR52","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1002\/art.30363","volume":"63","author":"TM Piscaer","year":"2011","unstructured":"Piscaer TM, M\u00fcller C, Mindt TL, Lubberts E, Verhaar JA, Krenning EP, Schibli R, De Jong M, Weinans H. Imaging of activated macrophages in experimental osteoarthritis using folate-targeted animal single-photon-emission computed tomography\/computed tomography. Arthritis Rheum. 2011;63(7):1898\u2013907.","journal-title":"Arthritis Rheum"},{"issue":"9","key":"4908_CR53","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1016\/j.joca.2016.04.010","volume":"24","author":"VB Kraus","year":"2016","unstructured":"Kraus VB, McDaniel G, Huebner JL, Stabler TV, Pieper CF, Shipes SW, Petry NA, Low PS, Shen J, McNearney TA, Mitchell P. Direct in vivo evidence of activated macrophages in human osteoarthritis. Osteoarthr Cartil. 2016;24(9):1613\u201321.","journal-title":"Osteoarthr Cartil"},{"issue":"6","key":"4908_CR54","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1136\/annrheumdis-2013-204820","volume":"73","author":"Z Zhu","year":"2014","unstructured":"Zhu Z, Yin Y, Zheng K, Li F, Chen X, Zhang F, Zhang X. Evaluation of synovial angiogenesis in patients with rheumatoid arthritis using \u2076\u2078Ga-PRGD2 PET\/CT: a prospective proof-of-concept cohort study. Ann Rheum Dis. 2014;73(6):1269\u201372.","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"4908_CR55","doi-asserted-by":"publisher","first-page":"e144","DOI":"10.1097\/RLU.0000000000003854","volume":"47","author":"\u00d6 Erol Fenercio\u011flu","year":"2022","unstructured":"Erol Fenercio\u011flu \u00d6, Beyhan E, Erg\u00fcl N, Arslan E, \u00c7ermik TF. 18F-FDG PET\/CT and 68Ga-FAPI-4 PET\/CT findings of bilateral knee osteoarthritis in a patient with uveal malignant melanoma. Clin Nucl Med. 2022;47(2):e144\u20136.","journal-title":"Clin Nucl Med"},{"issue":"10","key":"4908_CR56","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1007\/s12149-015-1011-5","volume":"29","author":"N Withofs","year":"2015","unstructured":"Withofs N, Charlier E, Simoni P, Alvarez-Miezentseva V, Mievis F, Giacomelli F, Mella C, Gambhir SS, Malaise O, de Seny D, Malaise M, Hustinx R. 1\u2078F-FPRGD\u2082 PET\/CT imaging of musculoskeletal disorders. Ann Nucl Med. 2015;29(10):839\u201347.","journal-title":"Ann Nucl Med"},{"issue":"4","key":"4908_CR57","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1177\/1947603519855776","volume":"12","author":"D Zarringam","year":"2019","unstructured":"Zarringam D, Saris DBF, Bekkers JEJ. The value of SPECT\/CT for knee osteoarthritis: a systematic review. Cartilage. 2019;12(4):431\u20137.","journal-title":"Cartilage"},{"issue":"11","key":"4908_CR58","doi-asserted-by":"publisher","first-page":"e480","DOI":"10.1097\/RLU.0000000000001839","volume":"42","author":"YG Abdelhafez","year":"2017","unstructured":"Abdelhafez YG, Hagge RJ, Badawi RD, Raychaudhuri SP, Chaudhari AJ. Early and delayed 99mTc-MDP SPECT\/CT findings in rheumatoid arthritis and osteoarthritis. Clin Nucl Med. 2017;42(11):e480-1.","journal-title":"Clin Nucl Med"},{"issue":"1","key":"4908_CR59","doi-asserted-by":"publisher","first-page":"14705","DOI":"10.1038\/s41598-024-65613-0","volume":"14","author":"Z Zhao","year":"2024","unstructured":"Zhao Z, Zhao M, Yang T, Li J, Qin C, Wang B, Wang L, Li B, Liu J. Identifying significant structural factors associated with knee pain severity in patients with osteoarthritis using machine learning. Sci Rep. 2024;14(1):14705.","journal-title":"Sci Rep"},{"key":"4908_CR60","doi-asserted-by":"crossref","unstructured":"Chang GH, Felson DT, Qiu S, Guermazi A, Capellini TD, Kolachalama VB. Assessment of knee pain from MR imaging using a convolutional Siamese network. Eur Radiol. 2020;30(6):3538\u20133548. Erratum in: Eur Radiol. 2020c;30(12):6968.","DOI":"10.1007\/s00330-020-06658-3"},{"issue":"1","key":"4908_CR61","doi-asserted-by":"publisher","first-page":"3155","DOI":"10.1038\/s41598-022-07092-9","volume":"12","author":"S Raman","year":"2022","unstructured":"Raman S, Gold GE, Rosen MS, Sveinsson B. Automatic estimation of knee effusion from limited MRI data. Sci Rep. 2022;12(1):3155.","journal-title":"Sci Rep"},{"issue":"3","key":"4908_CR62","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1148\/radiol.212009","volume":"304","author":"J Li","year":"2022","unstructured":"Li J, Fu S, Gong Z, Zhu Z, Zeng D, Cao P, Lin T, Chen T, Wang X, Lartey R, Kwoh CK, Guermazi A, Roemer FW, Hunter DJ, Ma J, Ding C. MRI-based texture analysis of infrapatellar fat pad to predict knee osteoarthritis incidence. Radiology. 2022;304(3):611\u201321.","journal-title":"Radiology"}],"container-title":["Skeletal Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00256-025-04908-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00256-025-04908-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00256-025-04908-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:02:53Z","timestamp":1758708173000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00256-025-04908-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,22]]},"references-count":62,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["4908"],"URL":"https:\/\/doi.org\/10.1007\/s00256-025-04908-3","relation":{},"ISSN":["0364-2348","1432-2161"],"issn-type":[{"value":"0364-2348","type":"print"},{"value":"1432-2161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,22]]},"assertion":[{"value":"2 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"DH received publication royalties from Wolters Kluwer. KT has nothing to disclose. FWR is a shareholder of Boston Imaging Core Lab, LLC. AG is the President and shareholder of Boston Imaging Core Lab, LLC. He is a consultant to ICM, Levicept, Paradigm, Novartis, TissueGene, Scarcell, 4Moving, Peptinov, Coval, Pacira, Medipost, and Formation Bio.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}