{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:44:44Z","timestamp":1782391484499,"version":"3.54.5"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"European Society for Musculoskeletal Radiology","award":["Arthritis Subcommittee 2024 - travel grant (poster)"],"award-info":[{"award-number":["Arthritis Subcommittee 2024 - travel grant (poster)"]}]},{"name":"New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research Development and Innovation Fund, Hungary","award":["\u00daNKP-23-5"],"award-info":[{"award-number":["\u00daNKP-23-5"]}]},{"name":"Bolyai Research Scholarship, Hungary","award":["BO\/00270\/22\/5"],"award-info":[{"award-number":["BO\/00270\/22\/5"]}]},{"DOI":"10.13039\/501100002332","name":"Semmelweis University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Skeletal Radiol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>Photon-counting detector CT (PCD-CT) allows for iodine mapping of inflamed tissues in peripheral immune-mediated arthritis, supporting diagnosis and disease activity assessment. This study aims to identify the optimal timing for image acquisition after intravenous iodinated contrast administration to maximize enhancement and contrast with surrounding tissues.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>High-resolution PCD-CT scans of bilateral wrist\u2013hand regions were obtained from 26 patients with peripheral arthritis, both native and post-contrast (1\u00a0ml\/kg intravenous iodinated contrast at 2.5\u00a0ml\/sec flow) at 120-, 180-, and 240-s delay phases. Iodine maps were constructed from spectral data. Phases were compared based on densities and iodine concentrations measured in synovial, tenosynovial, and periungual tissues, with muscle, fat, and vessels as controls. We used descriptive statistics and mixed-effects linear regression inferential models for the comparisons. Synovitis and tenosynovitis were verified by ultrasound measurements.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>No significant differences (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) were found in iodine concentration or density across the 120-, 180-, and 240-s post-contrast phases in inflamed synovial, tenosynovial, and periungual soft tissues. Inflamed tissues showed significant and consistent differences in iodine concentration from muscle and fat (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) across all phases, while the greatest differentiation from vessels was in the 120-s phase. The effective dose was identical across all post-contrast phases (0.028\u2009\u00b1\u20090.0035\u00a0mSv).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Iodine uptake in inflamed tissues was identical across all three post-contrast phases. However, the 120-s phase offered the highest contrast between inflammation and surrounding vascular structures while minimizing scan time, supporting its use for standardized follow-up imaging.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00256-025-04993-4","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T14:21:31Z","timestamp":1754662891000},"page":"2565-2578","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Optimizing contrast timing in photon-counting detector CT for the assessment of peripheral arthritis"],"prefix":"10.1007","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2855-9709","authenticated-orcid":false,"given":"Akos","family":"Horvath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Csercsik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janos Norbert","family":"Gyebnar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Sandor","family":"Veres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pal","family":"Maurovich-Horvat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akos","family":"Menyhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Gyergyoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Vince","family":"Balint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7351-6361","authenticated-orcid":false,"given":"Nikolett","family":"Marton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"issue":"12","key":"4993_CR1","doi-asserted-by":"publisher","first-page":"2174","DOI":"10.3390\/jcm8122174","volume":"8","author":"L Hirtler","year":"2019","unstructured":"Hirtler L, Rath C, Platzgummer H, Aletaha D, Kainberger F. 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This work was carried out in accordance with the Helsinki Declaration (JAMA 2000; 284:3043\u20133049). Informed consent was obtained from all individual participants included in the study. Human Ethics and Consent to Participate declarations were collected and could be provided if necessary (the documents are in Hungarian).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Akos Horvath received the ESSR (European Society for Musculoskeletal Radiology) Arthritis Subcommittee Grant 2024 for his poster \u201cOptimization of photon-counting detector CT protocol for determining disease activity in peripheral inflammatory arthritides\u201d (Vienna, June 2024). This ESSR grant is supposed to be utilized as a travel grant for future ESSR meetings. The project was supported by the New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research Development and Innovation Fund (2023\u20132024 Nikolett Marton\u2019s scholarship number: \u00daNKP-23\u20135) and Bolyai Research Scholarship (2022\u20132024 Nikolett Marton\u2019s scholarship, number: BO\/00270\/22\/5). No further support in 2025. The other authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}