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Around the age of 78\u00a0years, mean LS (lumbar spine) QCT BMD is around 68\u00a0mg\/mL and 100\u00a0mg\/mL for East Asian men and Caucasian men, respectively. For East Asian men, LS QCT BMD &lt;68\u00a0mg\/mL offers a sensitivity of 77% for detecting vertebral FFx cases, which is consistent with LS QCT BMD &lt;80\u00a0mg\/mL and\u2009&lt;\u200950\u00a0mg\/mL offering a vertebral FFx detection sensitivity of around 77% for Caucasian women and East Asian women, respectively. For Chinese men,\n                    <jats:italic>T<\/jats:italic>\n                    -score\u2009\u2264\u2009\u22122.5 predicts hip FFx risk better than other\n                    <jats:italic>T<\/jats:italic>\n                    -score values, and LS DXA\n                    <jats:italic>T<\/jats:italic>\n                    -score\u2009\u2212\u20092.5 corresponds to QCT BMD 68\u00a0mg\/mL. Hip FFx occur at approximately 0.5 LS\n                    <jats:italic>T<\/jats:italic>\n                    -score higher in Caucasian men than in Caucasian women. Among older Caucasian populations, for the separation of patients with FFx and without FFx, QCT BMD &lt;100\u00a0mg\/mL in older men is approximately comparable to &lt;80\u00a0mg\/mL in older women. For FFx risk prediction, we propose osteofrailia threshold LS DXA\n                    <jats:italic>T<\/jats:italic>\n                    -score to be \u2264\u2009\u2212\u20092.5 and\u2009\u2264\u2009\u22122.0, and QCT BMD to be &lt;68\u00a0mg\/mL and\u2009&lt;\u2009100\u00a0mg\/mL, respectively, for East Asian men and Caucasian men. The relationship between LS QCT BMD and hip FFx risk should be better investigated in the future.\n                  <\/jats:p>","DOI":"10.1007\/s00256-026-05133-2","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T03:36:28Z","timestamp":1769139388000},"page":"915-929","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lumbar spine DXA T-score and QCT BMD cutpoint values for defining osteofrailia among older men: a framework for further refinement"],"prefix":"10.1007","volume":"55","author":[{"given":"Y\u00ec Xi\u00e1ng J.","family":"W\u00e1ng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C. 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