{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:07:07Z","timestamp":1789380427343,"version":"build-2803163510"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Skeletal Radiol"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s00256-026-05317-w","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T21:25:32Z","timestamp":1785619532000},"page":"2883-2896","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary bone lymphoma: a radiologic\u2013pathologic series of 72 cases uncovering the diagnostic complexity of a rare and heterogeneous\u00a0entity"],"prefix":"10.1007","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-045X","authenticated-orcid":false,"given":"Eva Manuela","family":"Pena-Burgos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Ib\u00e1\u00f1ez Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Tapia-Vi\u00f1e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Diego","family":"De la Morena Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Olmedilla-Arregui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Eugenia","family":"Garc\u00eda Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Manuel","family":"Cordero-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Jos\u00e9","family":"Ortiz-Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Juan","family":"Pozo-Kreilinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,1]]},"reference":[{"key":"5317_CR1","first-page":"182","volume-title":"WHO Classification of Tumours of Soft Tissue and Bone","author":"T Mentzel","year":"2020","unstructured":"Mentzel T, Agaram NP. Myopericytoma, including myofibroma. In: WHO Classification of Tumours of Soft Tissue and Bone. 5th ed. IARC Press; 2020. p. 182\u20135.","edition":"5th ed"},{"key":"5317_CR2","first-page":"201","volume-title":"Dorfman and Czerniak\u2019s bone tumors","author":"HD Dorfman","year":"2016","unstructured":"Dorfman HD, Czerniak B. Malignant lymphoma of bone. In: Dorfman and Czerniak\u2019s bone tumors. Second. Elsevier; 2016. p. 201.","edition":"Second"},{"issue":"1","key":"5317_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/diseases11010042","volume":"11","author":"T Kanavos","year":"2023","unstructured":"Kanavos T, Birbas E, Papoudou-Bai A, et al. Primary bone lymphoma: a review of the literature with emphasis on histopathology and histogenesis. Diseases. 2023;11(1):42. https:\/\/doi.org\/10.3390\/diseases11010042.","journal-title":"Diseases"},{"key":"5317_CR4","doi-asserted-by":"publisher","unstructured":"Abeyakoon C, Ting E, Khan S, et al. Clinical characteristics and disease outcomes of primary bone lymphoma in the rituximab era: a retrospective study from the Princess Margaret Cancer Center, Toronto, Canada. Leukemia & Lymphoma. Published online February 21, 2025:1\u20135. https:\/\/doi.org\/10.1080\/10428194.2025.2467801","DOI":"10.1080\/10428194.2025.2467801"},{"issue":"27","key":"5317_CR5","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1200\/JCO.2013.54.8800","volume":"32","author":"BD Cheson","year":"2014","unstructured":"Cheson BD, Fisher RI, Barrington SF, et al. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 2014;32(27):3059\u201368. https:\/\/doi.org\/10.1200\/JCO.2013.54.8800.","journal-title":"J Clin Oncol"},{"issue":"6","key":"5317_CR6","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.2214\/ajr.173.6.10584821","volume":"173","author":"ME Mulligan","year":"1999","unstructured":"Mulligan ME, McRae GA, Murphey MD. Imaging features of primary lymphoma of bone. AJR Am J Roentgenol. 1999;173(6):1691\u20137. https:\/\/doi.org\/10.2214\/ajr.173.6.10584821.","journal-title":"AJR Am J Roentgenol"},{"issue":"4","key":"5317_CR7","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.rcl.2016.03.008","volume":"54","author":"MD Murphey","year":"2016","unstructured":"Murphey MD, Kransdorf MJ. Primary musculoskeletal lymphoma. Radiol Clin North Am. 2016;54(4):785\u201395. https:\/\/doi.org\/10.1016\/j.rcl.2016.03.008.","journal-title":"Radiol Clin North Am"},{"issue":"11","key":"5317_CR8","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1007\/s00247-024-06012-5","volume":"54","author":"G Tuzzato","year":"2024","unstructured":"Tuzzato G, Spinnato P, Vara G, Ostetto F, Bianchi G. Spectrum of imaging findings of primary bone lymphoma in pediatric patients. Pediatr Radiol. 2024;54(11):1809\u201317. https:\/\/doi.org\/10.1007\/s00247-024-06012-5.","journal-title":"Pediatr Radiol"},{"issue":"01","key":"5317_CR9","doi-asserted-by":"publisher","first-page":"036","DOI":"10.1055\/s-0038-1676125","volume":"23","author":"MA Weber","year":"2019","unstructured":"Weber MA, Papakonstantinou O, Nikodinovska V, Vanhoenacker F. Ewing\u2019s sarcoma and primary osseous lymphoma: spectrum of imaging appearances. Semin Musculoskelet Radiol. 2019;23(01):036\u201357. https:\/\/doi.org\/10.1055\/s-0038-1676125.","journal-title":"Semin Musculoskelet Radiol"},{"issue":"12","key":"5317_CR10","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1038\/sj.leu.2401582","volume":"13","author":"F Heyning","year":"1999","unstructured":"Heyning F, Hogendoorn P, Kramer M, et al. Primary non-Hodgkin\u2019s lymphoma of bone: a clinicopathological investigation of 60 cases. Leukemia. 1999;13(12):2094\u20138. https:\/\/doi.org\/10.1038\/sj.leu.2401582.","journal-title":"Leukemia"},{"issue":"6","key":"5317_CR11","doi-asserted-by":"publisher","DOI":"10.1148\/rg.240175","volume":"45","author":"CD Sleeth","year":"2025","unstructured":"Sleeth CD, Moeller AR, Gaskin CM, Symanski JS, Davis KW, Kresse ME. Musculoskeletal lymphoma: imaging features, diagnosis, and assessment of treatment response. Radiographics. 2025;45(6):e240175. https:\/\/doi.org\/10.1148\/rg.240175.","journal-title":"Radiographics"},{"issue":"1","key":"5317_CR12","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1093\/annonc\/mdl329","volume":"18","author":"KM Ramadan","year":"2007","unstructured":"Ramadan KM, Shenkier T, Sehn LH, Gascoyne RD, Connors JM. A clinicopathological retrospective study of 131 patients with primary bone lymphoma: a population-based study of successively treated cohorts from the British Columbia Cancer Agency. Ann Oncol. 2007;18(1):129\u201335. https:\/\/doi.org\/10.1093\/annonc\/mdl329.","journal-title":"Ann Oncol"},{"issue":"4","key":"5317_CR13","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1097\/MNM.0000000000001668","volume":"44","author":"Y Pu","year":"2023","unstructured":"Pu Y, Wang C, Xie R, et al. Role of 18F-fluorodeoxyglucose PET\/computed tomography in the diagnosis and treatment response assessment of primary bone lymphoma. Nucl Med Commun. 2023;44(4):318\u201329. https:\/\/doi.org\/10.1097\/MNM.0000000000001668.","journal-title":"Nucl Med Commun"},{"issue":"1","key":"5317_CR14","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1148\/rg.2020190089","volume":"40","author":"RD Meek","year":"2020","unstructured":"Meek RD, Mills MK, Hanrahan CJ, et al. Pearls and pitfalls for soft-tissue and bone biopsies: a cross-institutional review. Radiographics. 2020;40(1):266\u201390. https:\/\/doi.org\/10.1148\/rg.2020190089.","journal-title":"Radiographics"},{"issue":"8","key":"5317_CR15","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1177\/1753193411420033","volume":"36","author":"D Jafari","year":"2011","unstructured":"Jafari D, Jamshidi K, Najdmazhar F, Shariatzade H, Liaghat O. Expansile aneurysmal bone cyst in the tubular bones of the hand treated with en bloc excision and autograft reconstruction: a report of 12 cases. J Hand Surg Eur. 2011;36(8):648\u201355. https:\/\/doi.org\/10.1177\/1753193411420033.","journal-title":"J Hand Surg Eur"},{"key":"5317_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fnume.2024.1402552","volume":"4","author":"A Jaafari","year":"2024","unstructured":"Jaafari A, Rizzo O, Mansour S, et al. Case report: when infection lurks behind malignancy: a unique case of primary bone lymphoma mimicking infectious process in the spine. Front Nucl Med. 2024;4:1402552. https:\/\/doi.org\/10.3389\/fnume.2024.1402552.","journal-title":"Front Nucl Med"},{"issue":"5","key":"5317_CR17","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1309\/CMPGPYTMFRM6RVQR","volume":"129","author":"FP Lima","year":"2008","unstructured":"Lima FP, Bousquet M, Gomez-Brouchet A, et al. Primary diffuse large B-cell lymphoma of bone displays preferential rearrangements of the c-MYC or BCL2 gene. Am J Clin Pathol. 2008;129(5):723\u20136. https:\/\/doi.org\/10.1309\/CMPGPYTMFRM6RVQR.","journal-title":"Am J Clin Pathol"},{"issue":"10","key":"5317_CR18","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1097\/PAS.0b013e3181b314ce","volume":"33","author":"S Bhagavathi","year":"2009","unstructured":"Bhagavathi S, Micale MA, Les K, Wilson JD, Wiggins ML, Fu K. Primary bone diffuse large B-cell lymphoma: clinicopathologic study of 21 cases and review of literature. Am J Surg Pathol. 2009;33(10):1463\u20139. https:\/\/doi.org\/10.1097\/PAS.0b013e3181b314ce.","journal-title":"Am J Surg Pathol"},{"key":"5317_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbo.2020.100326","volume":"25","author":"A M\u00fcller","year":"2020","unstructured":"M\u00fcller A, Dreyling M, Roeder F, et al. Primary bone lymphoma: clinical presentation and therapeutic considerations. J Bone Oncol. 2020;25:100326. https:\/\/doi.org\/10.1016\/j.jbo.2020.100326.","journal-title":"J Bone Oncol"},{"key":"5317_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-900","volume":"14","author":"H Wu","year":"2014","unstructured":"Wu H, Bui MM, Leston DG, et al. Clinical characteristics and prognostic factors of bone lymphomas: focus on the clinical significance of multifocal bone involvement by primary bone large B-cell lymphomas. BMC Cancer. 2014;14:900. https:\/\/doi.org\/10.1186\/1471-2407-14-900.","journal-title":"BMC Cancer"},{"key":"5317_CR21","doi-asserted-by":"publisher","DOI":"10.1177\/2040620720958538","volume":"11","author":"CX Liu","year":"2020","unstructured":"Liu CX, Xu TQ, Xu L, et al. Primary lymphoma of bone: a population-based study of 2558 patients. Ther Adv Hematol. 2020;11:2040620720958538. https:\/\/doi.org\/10.1177\/2040620720958538.","journal-title":"Ther Adv Hematol"}],"container-title":["Skeletal Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00256-026-05317-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00256-026-05317-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00256-026-05317-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:41:21Z","timestamp":1789378881000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00256-026-05317-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,1]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["5317"],"URL":"https:\/\/doi.org\/10.1007\/s00256-026-05317-w","relation":{},"ISSN":["0364-2348","1432-2161"],"issn-type":[{"value":"0364-2348","type":"print"},{"value":"1432-2161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,1]]},"assertion":[{"value":"12 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Verbal consent for publication was obtained from the patient.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}