{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T01:39:56Z","timestamp":1779154796340,"version":"3.51.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2008,5,29]],"date-time":"2008-05-29T00:00:00Z","timestamp":1212019200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1007\/s00259-008-0803-4","type":"journal-article","created":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T12:26:36Z","timestamp":1211977596000},"page":"1868-1877","source":"Crossref","is-referenced-by-count":84,"title":["Macrocyclic chelator-coupled gastrin-based radiopharmaceuticals for targeting of gastrin receptor-expressing tumours"],"prefix":"10.1007","volume":"35","author":[{"given":"Stephan","family":"Good","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin A.","family":"Walter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Waser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"M\u00fcller-Brand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin P.","family":"B\u00e9h\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Reubi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut R.","family":"Maecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,5,29]]},"reference":[{"key":"803_CR1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1749-6632.1994.tb44052.x","volume":"713","author":"SA Wank","year":"1994","unstructured":"Wank SA, Pisegna JR, de Weerth A. Cholecystokinin receptor family. Molecular cloning, structure, and functional expression in rat, guinea pig, and human. Ann N Y Acad Sci 1994;713:49\u201366.","journal-title":"Ann N Y Acad Sci"},{"key":"803_CR2","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s00109-006-0055-3","volume":"84","author":"JF Rehfeld","year":"2006","unstructured":"Rehfeld JF. The endoproteolytic maturation of progastrin and procholecystokinin. J Mol Med 2006;84:544\u201350.","journal-title":"J Mol Med"},{"key":"803_CR3","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0031-6997(24)01427-3","volume":"51","author":"F Noble","year":"1999","unstructured":"Noble F, Wank SA, Crawley JN, Bradwejn J, Seroogy KB, Hamon M, et al. International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol Rev 1999;51:745\u201381.","journal-title":"Pharmacol Rev"},{"key":"803_CR4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1210\/er.2002-0007","volume":"24","author":"JC Reubi","year":"2003","unstructured":"Reubi JC. Peptide receptors as molecular targets for cancer diagnosis and therapy. Endocr Rev 2003;24:389\u2013427.","journal-title":"Endocr Rev"},{"key":"803_CR5","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0016-5085(97)70131-8","volume":"112","author":"JC Reubi","year":"1997","unstructured":"Reubi JC, Waser B, Laderach U, Stettler C, Friess H, Halter F, et al. Localization of cholecystokinin A and cholecystokinin B-gastrin receptors in the human stomach. Gastroenterology 1997;112:1197\u2013205.","journal-title":"Gastroenterology"},{"key":"803_CR6","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/(SICI)1097-0215(19960904)67:5<644::AID-IJC9>3.0.CO;2-U","volume":"67","author":"J Reubi","year":"1996","unstructured":"Reubi J, Waser B. Unexpected high incidence of cholecystokinin B\/gastrin receptors in human medullary thyroid carcinomas. Int J Cancer 1996;67:644\u20137.","journal-title":"Int J Cancer"},{"key":"803_CR7","first-page":"1377","volume":"57","author":"JC Reubi","year":"1997","unstructured":"Reubi JC, Schaer JC, Waser B. Cholecystokinin(CCK)-A and CCK-B\/gastrin receptors in human tumors. Cancer Res 1997;57:1377\u201386.","journal-title":"Cancer Res"},{"key":"803_CR8","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s00259-003-1184-3","volume":"30","author":"JC Reubi","year":"2003","unstructured":"Reubi JC, Waser B. Concomitant expression of several peptide receptors in neuroendocrine tumours: molecular basis for in vivo multireceptor tumour targeting. Eur J Nucl Med Mol Imaging 2003;30:781\u201393.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"803_CR9","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s00259-006-0157-8","volume":"33","author":"M Gotthardt","year":"2006","unstructured":"Gotthardt M, Behe MP, Beuter D, Battmann A, Bauhofer A, Schurrat T, et al. Improved tumour detection by gastrin receptor scintigraphy in patients with metastasised medullary thyroid carcinoma. Eur J Nucl Med Mol Imaging 2006;33:1273\u20139.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"803_CR10","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1677\/erc.1.01245","volume":"13","author":"M Gotthardt","year":"2006","unstructured":"Gotthardt M, Behe MP, Grass J, Bauhofer A, Rinke A, Schipper ML, et al. Added value of gastrin receptor scintigraphy in comparison to somatostatin receptor scintigraphy in patients with carcinoids and other neuroendocrine tumours. Endocr Relat Cancer 2006;13:1203\u201311.","journal-title":"Endocr Relat Cancer"},{"key":"803_CR11","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s002590050241","volume":"25","author":"TM Behr","year":"1998","unstructured":"Behr TM, Jenner N, Radetzky S, Behe M, Gratz S, Yucekent S, et al. Targeting of cholecystokinin-B\/gastrin receptors in vivo: preclinical and initial clinical evaluation of the diagnostic and therapeutic potential of radiolabelled gastrin. Eur J Nucl Med 1998;25:424\u201330.","journal-title":"Eur J Nucl Med"},{"key":"803_CR12","first-page":"2081","volume":"40","author":"M Jong de","year":"1999","unstructured":"de Jong M, Bakker W, Bernard B, Valkema R, Kwekkeboom D, Reubi J, et al. Preclinical and initial clinical evaluation of 111In-labeled nonsulfated CCK8 analog: a peptide for CCK-B receptor targeted scintigraphy and radionuclide therapy. J Nucl Med 1999;40:2081\u20137.","journal-title":"J Nucl Med"},{"key":"803_CR13","first-page":"1029","volume":"40","author":"TM Behr","year":"1999","unstructured":"Behr TM, Jenner N, Behe M, Angerstein C, Gratz S, Raue F, et al. Radiolabeled peptides for targeting cholecystokinin-B\/gastrin receptor-expressing tumors. J Nucl Med 1999;40:1029\u201344.","journal-title":"J Nucl Med"},{"key":"803_CR14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/clb.61.234.101.104","volume":"234","author":"JC Reubi","year":"2001","unstructured":"Reubi JC. CCK receptors in human neuroendocrine tumors: clinical implications. Scand J Clin Lab Invest Suppl 2001;234:101\u20134.","journal-title":"Scand J Clin Lab Invest Suppl"},{"key":"803_CR15","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1007\/s002590000296","volume":"27","author":"DJ Kwekkeboom","year":"2000","unstructured":"Kwekkeboom DJ, Bakker WH, Kooij PP, Erion J, Srinivasan A, de Jong M, et al. Cholecystokinin receptor imaging using an octapeptide DTPA-CCK analogue in patients with medullary thyroid carcinoma. Eur J Nucl Med 2000;27:1312\u20137.","journal-title":"Eur J Nucl Med"},{"key":"803_CR16","first-page":"67S","volume":"46","author":"JC Reubi","year":"2005","unstructured":"Reubi JC, Maecke HR, Krenning EP. Candidates for peptide receptor radiotherapy today and in the future. J Nucl Med 2005;46:67S\u201375S.","journal-title":"J Nucl Med"},{"key":"803_CR17","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1021\/bc0300807","volume":"15","author":"E Guggenberg von","year":"2004","unstructured":"von Guggenberg E, Behe M, Behr TM, Saurer M, Seppi T, Decristoforo C. 99mTc-labeling and in vitro and in vivo evaluation of HYNIC- and (Na-His)acetic acid-modified [d-Glu1]-minigastrin. Bioconjug Chem 2004;15:864\u201371.","journal-title":"Bioconjug Chem"},{"key":"803_CR18","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1007\/s00259-003-1178-1","volume":"30","author":"M Behe","year":"2003","unstructured":"Behe M, Becker W, Gotthardt M, Angerstein C, Behr TM. Improved kinetic stability of DTPA-dGlu as compared with conventional monofunctional DTPA in chelating indium and yttrium: preclinical and initial clinical evaluation of radiometal labelled minigastrin derivatives. Eur J Nucl Med Mol Imaging 2003;30:1140\u20136.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"803_CR19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/bip.10356","volume":"66","author":"M Behe","year":"2002","unstructured":"Behe M, Behr TM. Cholecystokinin-B (CCK-B)\/gastrin receptor targeting peptides for staging and therapy of medullary thyroid cancer and other CCK-B receptor expressing malignancies. Biopolymers 2002;66:399\u2013418.","journal-title":"Biopolymers"},{"key":"803_CR20","first-page":"1727","volume":"46","author":"BA Nock","year":"2005","unstructured":"Nock BA, Maina T, Behe M, Nikolopoulou A, Gotthardt M, Schmitt JS, et al. CCK-2\/Gastrin receptor-targeted tumor imaging with 99mTc-labeled minigastrin analogs. J Nucl Med 2005;46:1727\u201336.","journal-title":"J Nucl Med"},{"key":"803_CR21","first-page":"485","volume":"45","author":"L Aloj","year":"2004","unstructured":"Aloj L, Caraco C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, et al. In vitro and in vivo evaluation of 111In-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging. J Nucl Med 2004;45:485\u201394.","journal-title":"J Nucl Med"},{"key":"803_CR22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1053\/snuc.2002.31028","volume":"32","author":"TM Behr","year":"2002","unstructured":"Behr TM, Behe MP. Cholecystokinin-B\/Gastrin receptor-targeting peptides for staging and therapy of medullary thyroid cancer and other cholecystokinin-B receptor-expressing malignancies. Semin Nucl Med 2002;32:97\u2013109.","journal-title":"Semin Nucl Med"},{"key":"803_CR23","first-page":"469","volume":"18","author":"A Harrison","year":"1991","unstructured":"Harrison A, Walker C, Parker D. The in vivo release of 90Y from cyclic and acyclic ligand-antibody conjugates. Nucl Med & Biol 1991;18:469\u201376.","journal-title":"Nucl Med & Biol"},{"key":"803_CR24","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/S0960-894X(00)00413-3","volume":"10","author":"KP Eisenwiener","year":"2000","unstructured":"Eisenwiener KP, Powell P, Maecke HR. A convenient synthesis of novel bifunctional prochelators for coupling to bioactive peptides for radiometal labelling. Bioorg Med Chem Lett 2000;10:2133\u20135.","journal-title":"Bioorg Med Chem Lett"},{"issue":"Suppl 2","key":"803_CR25","first-page":"S319","volume":"30","author":"S Good","year":"2003","unstructured":"Good S, Maecke H. Kinetics of formation and dissociation of two DOTA-based chelator conjugates with 177Lu. Eur J Nucl Med Mol Imaging 2003;30(Suppl 2):S319.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"803_CR26","first-page":"A11","volume":"43","author":"S Good","year":"2004","unstructured":"Good S, Maecke H. Stability and kinetics of formation of two macrocyclic chelator-conjugates. Nuklearmedizin 2004;43:A11.","journal-title":"Nuklearmedizin"},{"key":"803_CR27","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/(SICI)1521-3765(19990702)5:7<1974::AID-CHEM1974>3.0.CO;2-X","volume":"5","author":"A Heppeler","year":"1999","unstructured":"Heppeler A, Froidevaux S, M\u00e4cke HR, Jermann E, B\u00e9h\u00e9 M, Powell P, et al. Radiometal-labelled macrocyclic chelator-derivatised somatostatin analogue with superb tumour-targeting properties and potential for receptor-mediated internal radiotherapy. Chemistry A European Journal 1999;5:1016\u201323.","journal-title":"Chemistry A European Journal"},{"key":"803_CR28","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1021\/bc010074f","volume":"13","author":"KP Eisenwiener","year":"2002","unstructured":"Eisenwiener KP, Prata MI, Buschmann I, Zhang HW, Santos AC, Wenger S, et al. NODAGATOC, a new chelator-coupled somatostatin analogue labeled with [67\/68Ga] and [111In] for SPECT, PET, and targeted therapeutic applications of somatostatin receptor (hsst2) expressing tumors. Bioconjug Chem 2002;13:530\u201341.","journal-title":"Bioconjug Chem"},{"key":"803_CR29","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s002590050247","volume":"25","author":"J Reubi","year":"1998","unstructured":"Reubi J, Waser B, Schaer J, Laederach U, Erion J, Srinivasan A, et al. Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo. Eur J Nucl Med 1998;25:481\u201390.","journal-title":"Eur J Nucl Med"},{"key":"803_CR30","first-page":"5969","volume":"50","author":"JC Reubi","year":"1990","unstructured":"Reubi JC, Kvols LK, Waser B, Nagorney DM, Heitz PU, Charboneau JW, et al. Detection of somatostatin receptors in surgical and percutaneous needle biopsy samples of carcinoids and islet cell carcinomas. Cancer Res 1990;50:5969\u201377.","journal-title":"Cancer Res"},{"key":"803_CR31","first-page":"G963","volume":"266","author":"J Christophe","year":"1994","unstructured":"Christophe J. Pancreatic tumoral cell line AR42J: an amphicrine model. Am J Physiol 1994;266:G963\u2013G71.","journal-title":"Am J Physiol"},{"key":"803_CR32","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1007\/s00259-003-1255-5","volume":"30","author":"D Wild","year":"2003","unstructured":"Wild D, Schmitt JS, Ginj M, Maecke HR, Bernard BF, Krenning E, et al. DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labelling with various radiometals. Eur J Nucl Med Mol Imaging 2003;30:1338\u201347.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"803_CR33","first-page":"1561","volume":"46","author":"D Storch","year":"2005","unstructured":"Storch D, Behe M, Walter MA, Chen J, Powell P, Mikolajczak R, et al. Evaluation of [99mTc\/EDDA\/HYNIC0]octreotide derivatives compared with [111In-DOTA0,Tyr3, Thr8]octreotide and [111In-DTPA0]octreotide: does tumor or pancreas uptake correlate with the rate of internalization? J Nucl Med 2005;46:1561\u20139.","journal-title":"J Nucl Med"},{"key":"803_CR34","unstructured":"Maecke H, Good S. Radiometals (non-Tc, non-Re) and bifunctional labeling chemistry. In: Vertes A, Nagy S, Klencsar Z, editors. Handbook of nuclear chemistry. Vol. 4. Netherlands; 2003, p. 279\u2013314."},{"key":"803_CR35","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1023\/A:1023964712999","volume":"256","author":"A Bogni","year":"2003","unstructured":"Bogni A, Bombardieri E, Iwata R, Cadini L, Pascali C. Stability of l-[S-methyl-11C]methionine solutions. J Radioanal Nucl Chem 2003;256:199\u2013203.","journal-title":"J Radioanal Nucl Chem"},{"key":"803_CR36","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1021\/bc000145v","volume":"12","author":"S Liu","year":"2001","unstructured":"Liu S, Edwards DS. Stabilization of 90Y-labeled DOTA-biomolecule conjugates using gentisic acid and ascorbic acid. Bioconjug Chem 2001;12:554\u20138.","journal-title":"Bioconjug Chem"},{"key":"803_CR37","first-page":"A7","volume":"43","author":"S Good","year":"2004","unstructured":"Good S, Maecke H, Merlo A, Reubi JC. Development of NK-1 receptor mediated radiopharmaceuticals. Nuklearmedizin 2004;43:A7.","journal-title":"Nuklearmedizin"},{"key":"803_CR38","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s002590100502","volume":"28","author":"WA Breeman","year":"2001","unstructured":"Breeman WA, de Jong M, Kwekkeboom DJ, Valkema R, Bakker WH, Kooij PP, et al. Somatostatin receptor-mediated imaging and therapy: basic science, current knowledge, limitations and future perspectives. Eur J Nucl Med 2001;28:1421\u20139.","journal-title":"Eur J Nucl Med"},{"key":"803_CR39","first-page":"181","volume":"46","author":"F Trejtnar","year":"2002","unstructured":"Trejtnar F, Laznicek M. Analysis of renal handling of radiopharmaceuticals. Q J Nucl Med 2002;46:181\u201394.","journal-title":"Q J Nucl Med"},{"key":"803_CR40","first-page":"1696","volume":"46","author":"M Jong de","year":"2005","unstructured":"de Jong M, Barone R, Krenning E, Bernard B, Melis M, Visser T, et al. Megalin is essential for renal proximal tubule reabsorption of 111In-DTPA-octreotide. J Nucl Med 2005;46:1696\u2013700.","journal-title":"J Nucl Med"},{"key":"803_CR41","first-page":"1012","volume":"46","author":"M Behe","year":"2005","unstructured":"Behe M, Kluge G, Becker W, Gotthardt M, Behr TM. Use of polyglutamic acids to reduce uptake of radiometal-labeled minigastrin in the kidneys. J Nucl Med 2005;46:1012\u20135.","journal-title":"J Nucl Med"},{"issue":"Suppl 1","key":"803_CR42","first-page":"S35","volume":"32","author":"E Guggenberg von","year":"2005","unstructured":"von Guggenberg E, Rupprich M, Virgolini I, Decristoforo C. 99mTc-HYNIC-Minigastrin: improved in vitro and in vivo properties of a short chain analogue. Eur J Nucl Med Mol Imaging 2005;32(Suppl 1):S35.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"Suppl 1","key":"803_CR43","first-page":"S78","volume":"32","author":"M Behe","year":"2005","unstructured":"Behe M, Reubi JC, Nock B. Evaluation of a DOTA-minigastrin derivative for therapy and diagnosis for CCK-2 receptor positive tumours. Eur J Nucl Med Mol Imaging 2005;32(Suppl 1):S78.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"803_CR44","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s002590050216","volume":"25","author":"TM Behr","year":"1998","unstructured":"Behr TM, Goldenberg DM, Becker W. Reducing the renal uptake of radiolabeled antibody fragments and peptides for diagnosis and therapy: present status, future prospects and limitations. Eur J Nucl Med 1998;25:201\u201312.","journal-title":"Eur J Nucl Med"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-008-0803-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00259-008-0803-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-008-0803-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T13:02:53Z","timestamp":1738242173000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00259-008-0803-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,29]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["803"],"URL":"https:\/\/doi.org\/10.1007\/s00259-008-0803-4","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,29]]}}}