{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:18:03Z","timestamp":1786979883070,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2009,12,3]],"date-time":"2009-12-03T00:00:00Z","timestamp":1259798400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1007\/s00259-009-1316-5","type":"journal-article","created":{"date-parts":[[2009,12,2]],"date-time":"2009-12-02T04:49:33Z","timestamp":1259729373000},"page":"357-367","source":"Crossref","is-referenced-by-count":18,"title":["Optimization of flow reserve measurement using SPECT technology to evaluate the determinants of coronary microvascular dysfunction in diabetes"],"prefix":"10.1007","volume":"37","author":[{"given":"Cecilia","family":"Marini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GianPaolo","family":"Bezante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Gandolfo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Modonesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia D.","family":"Morbelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"DePascale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Rollando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Maggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Albertelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Armonino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manrico","family":"Balbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Brunelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Cordera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmario","family":"Sambuceti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,12,3]]},"reference":[{"key":"1316_CR1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/path.1711660308","volume":"166","author":"R Yaron","year":"1992","unstructured":"Yaron R, Zirkin H, St\u00e4mmler G, Rose AG. Human coronary microvessels in diabetes and ischaemia: morphometric study of autopsy material. J Pathol 1992;166:265\u201372.","journal-title":"J Pathol"},{"key":"1316_CR2","first-page":"375","volume":"110","author":"S Sunni","year":"1986","unstructured":"Sunni S, Bishop SP, Kent SP, Geer JC. Diabetic cardiomyopathy. A morphological study of intramyocardial arteries. Arch Pathol Lab Med 1986;110:375\u201381.","journal-title":"Arch Pathol Lab Med"},{"key":"1316_CR3","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.2337\/diab.42.7.1017","volume":"42","author":"A Nitenberg","year":"1993","unstructured":"Nitenberg A, Valensi P, Sachs R, Dali M, Aptecar E, Attali JR. Impairment of coronary vascular reserve and ACh-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function. Diabetes 1993;42:1017\u201325.","journal-title":"Diabetes"},{"key":"1316_CR4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1042\/CS20050025","volume":"109","author":"CG Schalkwijk","year":"2005","unstructured":"Schalkwijk CG, Stehouwer CD. Vascular complications in diabetes mellitus: the role of endothelial dysfunction. Clin Sci (Lond) 2005;109:143\u201359.","journal-title":"Clin Sci (Lond)"},{"key":"1316_CR5","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1016\/j.jacc.2004.09.033","volume":"44","author":"R Pop-Busui","year":"2004","unstructured":"Pop-Busui R, Kirkwood I, Schmid H, Marinescu V, Schroeder J, Larkin D, et al. Sympathetic dysfunction in type 1 diabetes: association with impaired myocardial blood flow reserve and diastolic dysfunction. J Am Coll Cardiol 2004;44:2368\u201374.","journal-title":"J Am Coll Cardiol"},{"key":"1316_CR6","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1161\/01.CIR.100.10.1134","volume":"100","author":"SM Grundy","year":"1999","unstructured":"Grundy SM, Benjamin IJ, Burke GL, Chait A, Eckel RH, Howard BV, et al. Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation 1999;100:1134\u201346.","journal-title":"Circulation"},{"key":"1316_CR7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.7326\/0003-4819-124-1_Part_2-199601011-00009","volume":"124","author":"M Laakso","year":"1996","unstructured":"Laakso M. Glycemic control and the risk for coronary heart disease in patients with non-insulin-dependent diabetes mellitus. The Finnish studies. Ann Intern Med 1996;124:127\u201330.","journal-title":"Ann Intern Med"},{"key":"1316_CR8","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/S0735-1097(03)00166-9","volume":"41","author":"MF Carli Di","year":"2003","unstructured":"Di Carli MF, Janisse J, Grunberger G, Ager J. Role of chronic hyperglycemia in the pathogenesis of coronary microvascular dysfunction in diabetes. J Am Coll Cardiol 2003;41:1387\u201393.","journal-title":"J Am Coll Cardiol"},{"key":"1316_CR9","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/S0735-1097(97)00327-6","volume":"30","author":"I Yokoyama","year":"1997","unstructured":"Yokoyama I, Momomura S, Ohtake T, Yonekura K, Nishikawa J, Sasaki Y, et al. Reduced myocardial flow reserve in non-insulin-dependent diabetes mellitus. J Am Coll Cardiol 1997;30:1472\u20137.","journal-title":"J Am Coll Cardiol"},{"key":"1316_CR10","doi-asserted-by":"crossref","first-page":"700","DOI":"10.7326\/0003-4819-140-9-200405040-00009","volume":"140","author":"MJ Qui\u00f1ones","year":"2004","unstructured":"Qui\u00f1ones MJ, Hernandez-Pampaloni M, Schelbert H, Bulnes-Enriquez I, Jimenez X, Hernandez G, et al. Coronary vasomotor abnormalities in insulin-resistant individuals. Ann Intern Med 2004;140:700\u20138.","journal-title":"Ann Intern Med"},{"key":"1316_CR11","first-page":"978","volume":"41","author":"I Yokoyama","year":"2000","unstructured":"Yokoyama I, Yonekura K, Ohtake T, Yang W, Shin WS, Yarnada N, et al. Coronary microangiopathy in type 2 diabetic patients: relation to glycemic control, sex, and microvascular angina rather than to coronary artery disease. J Nucl Med 2000;41:978\u201385.","journal-title":"J Nucl Med"},{"key":"1316_CR12","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/01.CIR.63.6.1259","volume":"63","author":"HR Schelbert","year":"1981","unstructured":"Schelbert HR, Phelps ME, Huang SC, MacDonald NS, Hansen H, Selin C, et al. N-13 ammonia as an indicator of myocardial blood flow. Circulation 1981;63:1259\u201372.","journal-title":"Circulation"},{"key":"1316_CR13","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/01.CIR.70.4.724","volume":"70","author":"SR Bergmann","year":"1984","unstructured":"Bergmann SR, Fox KA, Rand AL, McElvany KD, Welch MJ, Markham J, et al. Quantification of regional myocardial blood flow in vivo with H215O. Circulation 1984;70:724\u201333.","journal-title":"Circulation"},{"key":"1316_CR14","first-page":"1426","volume":"41","author":"RA deKemp","year":"2000","unstructured":"deKemp RA, Ruddy TD, Hewitt T, Dalipaj MM, Beanlands RSB. Detection of serial changes in absolute myocardial perfusion with 82Rb PET. J Nucl Med 2000;41:1426\u201335.","journal-title":"J Nucl Med"},{"key":"1316_CR15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0033-0620(88)90010-2","volume":"31","author":"ML Marcus","year":"1988","unstructured":"Marcus ML, Harrison DG, White CW, McPherson DD, Wilson RF, Kerber RE. Assessing the physiologic significance of coronary obstructions in patients: importance of diffuse undetected atherosclerosis. Prog Cardiovasc Dis 1988;31:39\u201356.","journal-title":"Prog Cardiovasc Dis"},{"key":"1316_CR16","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1161\/01.CIR.91.9.2345","volume":"91","author":"AM Zeiher","year":"1995","unstructured":"Zeiher AM, Krause T, Sch\u00e4chinger V, Minners J, Moser E. Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia. Circulation 1995;91:2345\u201352.","journal-title":"Circulation"},{"key":"1316_CR17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00259-002-1031-y","volume":"30","author":"Y Ito","year":"2003","unstructured":"Ito Y, Katoh C, Noriyasu K, Kuge Y, Furuyama H, Morita K, et al. Estimation of myocardial blood flow and myocardial flow reserve by 99mTc-sestamibi imaging: comparison with the results of [15O]H2O PET. Eur J Nucl Med Mol Imaging 2003;30:281\u20137.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1316_CR18","first-page":"1457","volume":"42","author":"J Taki","year":"2001","unstructured":"Taki J, Fujino S, Nakajima K, Matsunari I, Okazaki H, Saga T, et al. (99m)Tc-sestamibi retention characteristics during pharmacologic hyperemia in human myocardium: comparison with coronary flow reserve measured by Doppler flowire. J Nucl Med 2001;42:1457\u201363.","journal-title":"J Nucl Med"},{"key":"1316_CR19","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.nuclcard.2004.08.007","volume":"11","author":"G Storto","year":"2004","unstructured":"Storto G, Cirillo P, Vicario ML, Pellegrino T, Sorrentino AR, Petretta M, et al. Estimation of coronary flow reserve by Tc-99m sestamibi imaging in patients with coronary artery disease: comparison with the results of intracoronary Doppler technique. J Nucl Cardiol 2004;11:682\u20138.","journal-title":"J Nucl Cardiol"},{"key":"1316_CR20","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.nuclcard.2006.12.327","volume":"14","author":"G Storto","year":"2007","unstructured":"Storto G, Pellegrino T, Sorrentino AR, Luongo L, Petretta M, Cuocolo A. Estimation of coronary flow reserve by sestamibi imaging in type 2 diabetic patients with normal coronary arteries. J Nucl Cardiol 2007;14:194\u20139.","journal-title":"J Nucl Cardiol"},{"key":"1316_CR21","doi-asserted-by":"crossref","unstructured":"Storto G, Soricelli A, Pellegrino T, Petretta M, Cuocolo A. Assessment of the arterial input function for estimation of coronary flow reserve by single photon emission computed tomography: comparison of two different approaches. Eur J Nucl Med Mol Imaging 2009; Epub ahead of print.","DOI":"10.1007\/s00259-009-1186-x"},{"key":"1316_CR22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jacc.2008.09.006","volume":"53","author":"RC Hendel","year":"2009","unstructured":"Hendel RC, Budoff MJ, Cardella JF, Chambers CE, Dent JM, Fitzgerald DM, et al. ACC\/AHA\/ACR\/ASE\/ASNC\/HRS\/NASCI\/RSNA\/SAIP\/SCAI\/SCCT\/SCMR\/SIR 2008 key data elements and definitions for cardiac imaging: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Clinical Data Standards for Cardiac Imaging). J Am Coll Cardiol 2009;53:91\u2013124.","journal-title":"J Am Coll Cardiol"},{"issue":"Suppl 1","key":"1316_CR23","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.2337\/diacare.27.2007.S5","volume":"27","author":"American Diabetes Association","year":"2004","unstructured":"American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2004;27(Suppl 1):S5\u201310.","journal-title":"Diabetes Care"},{"key":"1316_CR24","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/ki.1995.356","volume":"48","author":"T Kawagishi","year":"1995","unstructured":"Kawagishi T, Nishizawa Y, Konishi T, Kawasaki K, Emoto M, Shoji T, et al. High-resolution B-mode ultrasonography in evaluation of atherosclerosis in uremia. Kidney Int 1995;48:820\u20136.","journal-title":"Kidney Int"},{"key":"1316_CR25","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1161\/01.ATV.13.10.1404","volume":"13","author":"I Weldelhag","year":"1993","unstructured":"Weldelhag I, Wiklund O, Wikstrand J. Atherosclerotic changes in the femoral and carotid arteries in familial hypercholesterolemia. Ultrasonographic assessment of intima-media thickness and plaque occurrence. Arterioscler Thromb 1993;13:1404\u201311.","journal-title":"Arterioscler Thromb"},{"key":"1316_CR26","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ajh.2008.351","volume":"22","author":"GP Bezante","year":"2009","unstructured":"Bezante GP, Viazzi F, Leoncini G, Ratto E, Conti N, Balbi M, et al. Coronary flow reserve is impaired in hypertensive patients with subclinical renal damage. Am J Hypertens 2009;22:191\u20136.","journal-title":"Am J Hypertens"},{"key":"1316_CR27","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","volume":"1","author":"JM Bland","year":"1986","unstructured":"Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986;1:307\u201310.","journal-title":"Lancet"},{"key":"1316_CR28","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/S0735-1097(98)00389-1","volume":"32","author":"T Hozumi","year":"1998","unstructured":"Hozumi T, Yoshida K, Akasaka T, Asami Y, Ogata Y, Takagi T, et al. Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique. J Am Coll Cardiol 1998;32:1251\u20139.","journal-title":"J Am Coll Cardiol"},{"key":"1316_CR29","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1161\/01.CIR.99.6.771","volume":"99","author":"C Caiati","year":"1999","unstructured":"Caiati C, Montaldo C, Zedda N, Bina A, Iliceto S. New noninvasive method for coronary flow reserve assessment: contrast-enhanced transthoracic second harmonic echo Doppler. Circulation 1999;99:771\u20138.","journal-title":"Circulation"},{"key":"1316_CR30","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0894-7317(03)00281-5","volume":"16","author":"J Lowenstein","year":"2003","unstructured":"Lowenstein J, Tiano C, Marquez C, Presti C, Quiroz C. Simultaneous analysis of wall motion and coronary flow reserve of the left anterior descending coronary artery by transthoracic doppler echocardiography during dipyridamole stress echocardiography. J Am Soc Echocardiogr 2003;16:607\u201313.","journal-title":"J Am Soc Echocardiogr"},{"key":"1316_CR31","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.amjhyper.2007.08.005","volume":"20","author":"M Galderisi","year":"2007","unstructured":"Galderisi M, Capaldo B, Sidiropulos M, D\u2019Errico A, Ferrara L, Turco A, et al. Determinants of reduction of coronary flow reserve in patients with type 2 diabetes mellitus or arterial hypertension without angiographically determined epicardial coronary stenosis. Am J Hypertens 2007;20:1283\u201390.","journal-title":"Am J Hypertens"},{"key":"1316_CR32","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.amjcard.2008.02.055","volume":"101","author":"SA Ahmari","year":"2008","unstructured":"Ahmari SA, Bunch TJ, Modesto K, Stussy V, Dichak A, Seward JB, et al. Impact of individual and cumulative coronary risk factors on coronary flow reserve assessed by dobutamine stress echocardiography. Am J Cardiol 2008;101:1694\u20139.","journal-title":"Am J Cardiol"},{"key":"1316_CR33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1291\/hypres.23.233","volume":"23","author":"M Hashimoto","year":"2000","unstructured":"Hashimoto M, Kozaki K, Eto M, Akishita M, Ako J, Iijima K, et al. Association of coronary risk factors and endothelium-dependent flow-mediated dilatation of the brachial artery. Hypertens Res 2000;23:233\u20138.","journal-title":"Hypertens Res"},{"key":"1316_CR34","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1291\/hypres.26.945","volume":"26","author":"S Takiuchi","year":"2003","unstructured":"Takiuchi S, Rakugi H, Fujii H, Kamide K, Horio T, Nakatani S, et al. Carotid intima-media thickness is correlated with impairment of coronary flow reserve in hypertensive patients without coronary artery disease. Hypertens Res 2003;26:945\u201351.","journal-title":"Hypertens Res"},{"key":"1316_CR35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2337\/diab.47.1.119","volume":"47","author":"I Yokoyama","year":"1998","unstructured":"Yokoyama I, Ohtake T, Momomura S, Yonekura K, Woo-Soo S, Nishikawa J, et al. Hyperglycemia rather than insulin resistance is related to reduced coronary flow reserve in NIDDM. Diabetes 1998;47:119\u201324.","journal-title":"Diabetes"},{"key":"1316_CR36","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1161\/01.CIR.90.2.808","volume":"90","author":"F Dayanikli","year":"1994","unstructured":"Dayanikli F, Grambow D, Muzik O, Mosca L, Rubenfire M, Schwaiger M. Early detection of abnormal coronary flow reserve in asymptomatic men at high risk for coronary artery disease using positron emission tomography. Circulation 1994;90:808\u201317.","journal-title":"Circulation"},{"key":"1316_CR37","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1161\/01.CIR.90.4.1696","volume":"90","author":"G Sambuceti","year":"1994","unstructured":"Sambuceti G, Marzullo P, Giorgetti A, Neglia D, Marzilli M, Salvadori P, et al. Global alteration in perfusion response to increasing oxygen consumption in patients with single-vessel coronary artery disease. Circulation 1994;90:1696\u2013705.","journal-title":"Circulation"},{"key":"1316_CR38","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1161\/01.CIR.81.2.628","volume":"81","author":"DK Glover","year":"1990","unstructured":"Glover DK, Okada RD. Myocardial kinetics of Tc-MIBI in canine myocardium after dipyridamole. Circulation 1990;81:628\u201337.","journal-title":"Circulation"},{"key":"1316_CR39","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/0735-1097(92)90388-4","volume":"20","author":"PG Melon","year":"1992","unstructured":"Melon PG, Beanlands RS, DeGrado TR, Nguyen N, Petry NA, Schwaiger M. Comparison of technetium-99m sestamibi and thallium-201 retention characteristics in canine myocardium. J Am Coll Cardiol 1992;20:1277\u201383.","journal-title":"J Am Coll Cardiol"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-009-1316-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00259-009-1316-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-009-1316-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T15:10:35Z","timestamp":1685200235000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00259-009-1316-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,3]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["1316"],"URL":"https:\/\/doi.org\/10.1007\/s00259-009-1316-5","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,3]]}}}