{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:16:00Z","timestamp":1780107360087,"version":"3.54.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T00:00:00Z","timestamp":1267056000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1007\/s00259-010-1383-7","type":"journal-article","created":{"date-parts":[[2010,2,24]],"date-time":"2010-02-24T11:51:39Z","timestamp":1267012299000},"page":"1164-1173","source":"Crossref","is-referenced-by-count":25,"title":["The effect of anaesthesia on [18F]MK-9470 binding to the type 1 cannabinoid receptor in the rat brain"],"prefix":"10.1007","volume":"37","author":[{"given":"Cindy","family":"Casteels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Bormans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Van Laere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,2,25]]},"reference":[{"key":"1383_CR1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0166-2236(98)01283-1","volume":"21","author":"V Marzo Di","year":"1998","unstructured":"Di Marzo V, Melck D, Bisogno T, De Petrocellis L. Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action. Trends Neurosci 1998;21:521\u20138.","journal-title":"Trends Neurosci"},{"key":"1383_CR2","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1007\/s00259-007-0505-3","volume":"34","author":"K Laere Van","year":"2007","unstructured":"Van Laere K. In vivo imaging of the endocannabinoid system: a novel window to a central modulatory mechanism in humans. Eur J Nucl Med Mol Imaging 2007;34:1719\u201326.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1383_CR3","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.1063545","volume":"296","author":"RI Wilson","year":"2002","unstructured":"Wilson RI, Nicoll RA. Endocannabinoid signaling in the brain. Science 2002;296:678\u201382.","journal-title":"Science"},{"key":"1383_CR4","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1517\/13543784.15.4.351","volume":"15","author":"BA Bahr","year":"2006","unstructured":"Bahr BA, Karanian DA, Makanji SS, Makriyannis A. Targeting the endocannabinoid system in treating brain disorders. Expert Opin Investig Drugs 2006;15:351\u201365.","journal-title":"Expert Opin Investig Drugs"},{"key":"1383_CR5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/ilar.42.3.219","volume":"42","author":"SR Cherry","year":"2001","unstructured":"Cherry SR, Gambhir SS. Use of positron emission tomography in animal research. ILAR J 2001;42:219\u201332.","journal-title":"ILAR J"},{"key":"1383_CR6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/syn.20083","volume":"54","author":"S Momosaki","year":"2004","unstructured":"Momosaki S, Hatano K, Kawasumi Y, Kato T, Hosoi R, Kobayashi K, et al. Rat-PET study without anesthesia: anesthetics modify the dopamine D1 receptor binding in rat brain. Synapse 2004;54:207\u201313.","journal-title":"Synapse"},{"key":"1383_CR7","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1097\/00000542-200411000-00012","volume":"101","author":"JR Votaw","year":"2004","unstructured":"Votaw JR, Byas-Smith MG, Voll R, Halkar R, Goodman MM. Isoflurane alters the amount of dopamine transporter expressed on the plasma membrane in humans. Anesthesiology 2004;101:1128\u201335.","journal-title":"Anesthesiology"},{"key":"1383_CR8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF01271537","volume":"100","author":"K Kobayashi","year":"1995","unstructured":"Kobayashi K, Inoue O, Watanabe Y, Onoe H, L\u00e5ngstr\u00f6m B. Difference in response of D2 receptor binding between 11C-N-methylspiperone and 11C-raclopride against anesthetics in rhesus monkey brain. J Neural Transm Gen Sect\u00a01995;100:147\u201351.","journal-title":"J Neural Transm Gen Sect"},{"key":"1383_CR9","first-page":"1398","volume":"45","author":"H Toyama","year":"2004","unstructured":"Toyama H, Ichise M, Liow JS, Modell KJ, Vines DC, Esaki T, et al. Absolute quantification of regional cerebral glucose utilization in mice by 18F-FDG small animal PET scanning and 2-14C-DG autoradiography. J Nucl Med 2004;45:1398\u2013405.","journal-title":"J Nucl Med"},{"key":"1383_CR10","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1124\/mol.106.030049","volume":"71","author":"A Zeller","year":"2007","unstructured":"Zeller A, Arras M, Jurd R, Rudolph U. Identification of a molecular target mediating the general anesthetic actions of pentobarbital. Mol Pharmacol 2007;71:852\u20139.","journal-title":"Mol Pharmacol"},{"key":"1383_CR11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1113\/jphysiol.1992.sp019086","volume":"449","author":"MV Jones","year":"1992","unstructured":"Jones MV, Brooks PA, Harrison NL. Enhancement of gamma-aminobutyric acid-activated Cl- currents in cultured rat hippocampal neurones by three volatile anaesthetics. J Physiol 1992;449:279\u201393.","journal-title":"J Physiol"},{"key":"1383_CR12","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1749-6632.1991.tb33851.x","volume":"625","author":"J Yang","year":"1991","unstructured":"Yang J, Zorumski CF. Effects of isoflurane on N-methyl-D-aspartate gated ion channels in cultured rat hippocampal neurons. Ann N Y Acad Sci 1991;625:287\u20139.","journal-title":"Ann N Y Acad Sci"},{"key":"1383_CR13","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1097\/00000542-200302000-00021","volume":"98","author":"J Votaw","year":"2003","unstructured":"Votaw J, Byas-Smith M, Hua J, Voll R, Martarello L, Levey AI, et al. Interaction of isoflurane with the dopamine transporter. Anesthesiology 2003;98:404\u201311.","journal-title":"Anesthesiology"},{"key":"1383_CR14","doi-asserted-by":"crossref","first-page":"9800","DOI":"10.1073\/pnas.0703472104","volume":"104","author":"HD Burns","year":"2007","unstructured":"Burns HD, Van Laere K, Sanabria-Boh\u00f3rquez S, Hamill TG, Bormans G, Eng WS, et al. [18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor. Proc Natl Acad Sci U S A 2007;104:9800\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1383_CR15","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.neuropharm.2008.02.018","volume":"54","author":"K Goffin","year":"2008","unstructured":"Goffin K, Bormans G, Casteels C, Bosier B, Lambert DM, Grachev ID, et al. An in vivo [(18)F]MK-9470 microPET study of type 1 cannabinoid receptor binding in Wistar rats after chronic administration of valproate and levetiracetam. Neuropharmacology 2008;54:1103\u20136.","journal-title":"Neuropharmacology"},{"key":"1383_CR16","first-page":"1858","volume":"47","author":"C Casteels","year":"2006","unstructured":"Casteels C, Vermaelen P, Nuyts J, Van Der Linden A, Baekelandt V, Mortelmans L, et al. Construction and evaluation of multitracer small-animal PET probabilistic atlases for voxel-based functional mapping of the rat brain. J Nucl Med 2006;47:1858\u201366.","journal-title":"J Nucl Med"},{"key":"1383_CR17","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.neuroimage.2006.12.009","volume":"35","author":"K Kuyck van","year":"2007","unstructured":"van Kuyck K, Casteels C, Vermaelen P, Bormans G, Nuttin B, Van Laere K. Motor- and food-related metabolic cerebral changes in the activity-based rat model for anorexia nervosa: a voxel-based microPET study. Neuroimage 2007;35:214\u201321.","journal-title":"Neuroimage"},{"key":"1383_CR18","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1073\/pnas.87.5.1932","volume":"87","author":"M Herkenham","year":"1990","unstructured":"Herkenham M, Lynn AB, Little MD, Johnson MR, Melvin LS, de Costa BR, et al. Cannabinoid receptor localization in brain. Proc Natl Acad Sci U S A 1990;87:1932\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1383_CR19","unstructured":"Paxinos G, Watson C. The rat brain in stereotaxic coordinates. New York: Academic; 1998."},{"key":"1383_CR20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/ilar.49.1.17","volume":"49","author":"IJ Hildebrandt","year":"2008","unstructured":"Hildebrandt IJ, Su H, Weber WA. Anesthesia and other considerations for in vivo imaging of small animals. ILAR J 2008;49:17\u201326.","journal-title":"ILAR J"},{"key":"1383_CR21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1213\/00000539-200301000-00021","volume":"96","author":"Y Zhang","year":"2003","unstructured":"Zhang Y, Laster MJ, Hara K, Harris RA, Eger EI 2nd, Stabernack CR, et al. Glycine receptors mediate part of the immobility produced by inhaled anesthetics. Anesth Analg 2003;96:97\u2013101.","journal-title":"Anesth Analg"},{"key":"1383_CR22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0304-3940(92)90162-Z","volume":"146","author":"V Carl\u00e0","year":"1992","unstructured":"Carl\u00e0 V, Moroni F. General anaesthetics inhibit the responses induced by glutamate receptor agonists in the mouse cortex. Neurosci Lett 1992;146:21\u20134.","journal-title":"Neurosci Lett"},{"key":"1383_CR23","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1097\/00000542-200003000-00024","volume":"92","author":"JR Kimbro","year":"2000","unstructured":"Kimbro JR, Kelly PJ, Drummond JC, Cole DJ, Patel PM. Isoflurane and pentobarbital reduce AMPA toxicity in vivo in the rat cerebral cortex. Anesthesiology 2000;92:806\u201312.","journal-title":"Anesthesiology"},{"key":"1383_CR24","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1111\/j.1471-4159.1988.tb01102.x","volume":"51","author":"EJ Moody","year":"1988","unstructured":"Moody EJ, Suzdak PD, Paul SM, Skolnick P. Modulation of the benzodiazepine\/gamma-aminobutyric acid receptor chloride channel complex by inhalation anesthetics. J Neurochem 1988;51:1386\u201393.","journal-title":"J Neurochem"},{"key":"1383_CR25","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0022-3565(25)39199-8","volume":"242","author":"JP Huidobro-Toro","year":"1987","unstructured":"Huidobro-Toro JP, Bleck V, Allan AM, Harris RA. Neurochemical actions of anesthetic drugs on the gamma-aminobutyric acid receptor-chloride channel complex. J Pharmacol Exp Ther 1987;242:963\u20139.","journal-title":"J Pharmacol Exp Ther"},{"key":"1383_CR26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0022-3565(25)38288-1","volume":"266","author":"B Longoni","year":"1993","unstructured":"Longoni B, Demontis GC, Olsen RW. Enhancement of gamma-aminobutyric acidA receptor function and binding by the volatile anesthetic halothane. J Pharmacol Exp Ther 1993;266:153\u20139.","journal-title":"J Pharmacol Exp Ther"},{"key":"1383_CR27","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0006-8993(91)90447-4","volume":"538","author":"I Mody","year":"1991","unstructured":"Mody I, Tanelian DL, MacIver MB. Halothane enhances tonic neuronal inhibition by elevating intracellular calcium. Brain Res 1991;538:319\u201323.","journal-title":"Brain Res"},{"key":"1383_CR28","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1476-5381.1985.tb10563.x","volume":"85","author":"PW Gage","year":"1985","unstructured":"Gage PW, Robertson B. Prolongation of inhibitory postsynaptic currents by pentobarbitone, halothane and ketamine in CA1 pyramidal cells in rat hippocampus. Br J Pharmacol 1985;85:675\u201381.","journal-title":"Br J Pharmacol"},{"key":"1383_CR29","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1096\/fasebj.3.7.2541038","volume":"3","author":"M Nakahiro","year":"1989","unstructured":"Nakahiro M, Yeh JZ, Brunner E, Narahashi T. General anesthetics modulate GABA receptor channel complex in rat dorsal root ganglion neurons. FASEB J 1989;3:1850\u20134.","journal-title":"FASEB J"},{"key":"1383_CR30","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1152\/jn.1991.66.6.2014","volume":"66","author":"M Wakamori","year":"1991","unstructured":"Wakamori M, Ikemoto Y, Akaike N. Effects of two volatile anesthetics and a volatile convulsant on the excitatory and inhibitory amino acid responses in dissociated CNS neurons of the rat. J Neurophysiol 1991;66:2014\u201321.","journal-title":"J Neurophysiol"},{"key":"1383_CR31","doi-asserted-by":"crossref","first-page":"7168","DOI":"10.1523\/JNEUROSCI.14-11-07168.1994","volume":"14","author":"A Guti\u00e9rrez","year":"1994","unstructured":"Guti\u00e9rrez A, Khan ZU, De Blas AL. Immunocytochemical localization of gamma 2 short and gamma 2 long subunits of the GABAA receptor in the rat brain. J Neurosci 1994;14:7168\u201379.","journal-title":"J Neurosci"},{"key":"1383_CR32","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/cne.903180309","volume":"318","author":"RS Petralia","year":"1992","unstructured":"Petralia RS, Wenthold RJ. Light and electron immunocytochemical localization of AMPA-selective glutamate receptors in the rat brain. J Comp Neurol 1992;318:329\u201354.","journal-title":"J Comp Neurol"},{"key":"1383_CR33","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0896-6273(92)90165-A","volume":"9","author":"LJ Martin","year":"1992","unstructured":"Martin LJ, Blackstone CD, Huganir RL, Price DL. Cellular localization of a metabotropic glutamate receptor in rat brain. Neuron 1992;9:259\u201370.","journal-title":"Neuron"},{"key":"1383_CR34","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/S0196-9781(00)00324-7","volume":"21","author":"G Moldrich","year":"2000","unstructured":"Moldrich G, Wenger T. Localization of the CB1 cannabinoid receptor in the rat brain. An immunohistochemical study. Peptides 2000;21:1735\u201342.","journal-title":"Peptides"},{"key":"1383_CR35","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/ACO.0b013e32830edbf3","volume":"21","author":"R Ramani","year":"2008","unstructured":"Ramani R, Wardhan R. Understanding anesthesia through functional imaging. Curr Opin Anaesthesiol 2008;21:530\u20136.","journal-title":"Curr Opin Anaesthesiol"},{"key":"1383_CR36","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1399-6576.2006.00954.x","volume":"50","author":"L Schl\u00fcnzen","year":"2006","unstructured":"Schl\u00fcnzen L, Cold GE, Rasmussen M, Vafaee MS. Effects of dose-dependent levels of isoflurane on cerebral blood flow in healthy subjects studied using positron emission tomography. Acta Anaesthesiol Scand 2006;50:306\u201312.","journal-title":"Acta Anaesthesiol Scand"},{"key":"1383_CR37","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/00000542-198809000-00008","volume":"69","author":"TD Hansen","year":"1988","unstructured":"Hansen TD, Warner DS, Todd MM, Vust LJ, Trawick DC. Distribution of cerebral blood flow during halothane versus isoflurane anesthesia in rats. Anesthesiology 1988;69:332\u20137.","journal-title":"Anesthesiology"},{"key":"1383_CR38","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/00000542-199909000-00019","volume":"91","author":"BF Matta","year":"1999","unstructured":"Matta BF, Heath KJ, Tipping K, Summors AC. Direct cerebral vasodilatory effects of sevoflurane and isoflurane. Anesthesiology 1999;91:677\u201380.","journal-title":"Anesthesiology"},{"key":"1383_CR39","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/mrm.1178","volume":"46","author":"KS Hendrich","year":"2001","unstructured":"Hendrich KS, Kochanek PM, Melick JA, Schiding JK, Statler KD, Williams DS, et al. Cerebral perfusion during anesthesia with fentanyl, isoflurane, or pentobarbital in normal rats studied by arterial spin-labeled MRI. Magn Reson Med 2001;46:202\u20136.","journal-title":"Magn Reson Med"},{"key":"1383_CR40","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/00008506-199610000-00007","volume":"8","author":"MM Todd","year":"1996","unstructured":"Todd MM, Weeks J. Comparative effects of propofol, pentobarbital, and isoflurane on cerebral blood flow and blood volume. J Neurosurg Anesthesiol 1996;8:296\u2013303.","journal-title":"J Neurosurg Anesthesiol"},{"key":"1383_CR41","doi-asserted-by":"crossref","unstructured":"Sanabria-Boh\u00f3rquez SM, Hamill TG, Goffin K, De Lepeleire I, Bormans G, Burns HD, et al. Kinetic analysis of the cannabinoid-1 receptor PET tracer [(18)F]MK-9470 in human brain. Eur J Nucl Med Mol Imaging, in press. 2009.","DOI":"10.1007\/s00259-009-1340-5"},{"key":"1383_CR42","first-page":"317","volume":"40","author":"M Sugiura","year":"1999","unstructured":"Sugiura M, Kawashima R, Sadato N, Senda M, Kanno I, Oda K, et al. Anatomic validation of spatial normalization methods for PET. J Nucl Med 1999;40:317\u201322.","journal-title":"J Nucl Med"},{"key":"1383_CR43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0024-3205(94)00585-0","volume":"54","author":"F Rodr\u00edguez de Fonseca","year":"1994","unstructured":"Rodr\u00edguez de Fonseca F, Cebeira M, Ramos JA, Mart\u00edn M, Fern\u00e1ndez-Ruiz JJ. Cannabinoid receptors in rat brain areas: sexual differences, fluctuations during estrous cycle and changes after gonadectomy and sex steroid replacement. Life Sci 1994;54:159\u201370.","journal-title":"Life Sci"},{"key":"1383_CR44","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1111\/j.1476-5381.1991.tb09830.x","volume":"103","author":"P Westerling","year":"1991","unstructured":"Westerling P, Lindgren S, Meyerson B. Functional changes in GABAA receptor stimulation during the oestrous cycle of the rat. Br J Pharmacol 1991;103:1580\u20134.","journal-title":"Br J Pharmacol"},{"key":"1383_CR45","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/00000542-200308000-00031","volume":"99","author":"P Flood","year":"2003","unstructured":"Flood P, Daniel D. Pronociceptive actions of isoflurane: a protective role for estrogen. Anesthesiology 2003;99:476\u20139.","journal-title":"Anesthesiology"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-010-1383-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00259-010-1383-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-010-1383-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T21:41:41Z","timestamp":1739914901000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00259-010-1383-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,25]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["1383"],"URL":"https:\/\/doi.org\/10.1007\/s00259-010-1383-7","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,25]]}}}