{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:11:09Z","timestamp":1782364269568,"version":"3.54.5"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2010,3,24]],"date-time":"2010-03-24T00:00:00Z","timestamp":1269388800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1007\/s00259-010-1411-7","type":"journal-article","created":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T07:36:59Z","timestamp":1269329819000},"page":"1499-1506","source":"Crossref","is-referenced-by-count":23,"title":["Biodistribution and dosimetry in humans of two inverse agonists to image cannabinoid CB1 receptors using positron emission tomography"],"prefix":"10.1007","volume":"37","author":[{"given":"Garth E.","family":"Terry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Hirvonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeih-San","family":"Liow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Seneca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes T.","family":"Tauscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Schaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Phebus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian C.","family":"Felder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl L.","family":"Morse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor W.","family":"Pike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Halldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Innis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,3,24]]},"reference":[{"key":"1411_CR1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nrn1247","volume":"4","author":"D Piomelli","year":"2003","unstructured":"Piomelli D. The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 2003;4:873\u201384.","journal-title":"Nat Rev Neurosci"},{"key":"1411_CR2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.tins.2005.05.001","volume":"28","author":"LL Glickfeld","year":"2005","unstructured":"Glickfeld LL, Scanziani M. Self-administering cannabinoids. Trends Neurosci 2005;28:341\u20133.","journal-title":"Trends Neurosci"},{"key":"1411_CR3","doi-asserted-by":"crossref","first-page":"769","DOI":"10.2174\/138955707781387920","volume":"7","author":"BS Basavarajappa","year":"2007","unstructured":"Basavarajappa BS. The endocannabinoid signaling system: a potential target for next-generation therapeutics for alcoholism. Mini Rev Med Chem 2007;7:769\u201379.","journal-title":"Mini Rev Med Chem"},{"key":"1411_CR4","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1001\/archpsyc.65.7.772","volume":"65","author":"SM Eggan","year":"2008","unstructured":"Eggan SM, Hashimoto T, Lewis DA. Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia. Arch Gen Psychiatry 2008;65:772\u201384.","journal-title":"Arch Gen Psychiatry"},{"key":"1411_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tips.2008.10.001","volume":"30","author":"G Kunos","year":"2009","unstructured":"Kunos G, Osei-Hyiaman D, Batkai S, Sharkey KA, Makriyannis A. Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain? Trends Pharmacol Sci 2009;30:1\u20137.","journal-title":"Trends Pharmacol Sci"},{"key":"1411_CR6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.beem.2008.10.009","volume":"23","author":"P Caraceni","year":"2009","unstructured":"Caraceni P, Domenicali M, Giannone F, Bernardi M. The role of the endocannabinoid system in liver diseases. Best Pract Res Clin Endocrinol Metab 2009;23:65\u201377.","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"1411_CR7","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1751-7133.2008.00016.x","volume":"14","author":"P Mukhopadhyay","year":"2008","unstructured":"Mukhopadhyay P, Mohanraj R, B\u00e1tkai S, Pacher P. CB1 cannabinoid receptor inhibition: promising approach for heart failure? Congest Heart Fail 2008;14:330\u20134.","journal-title":"Congest Heart Fail"},{"key":"1411_CR8","doi-asserted-by":"crossref","first-page":"5833","DOI":"10.1021\/jm800416m","volume":"51","author":"SR Donohue","year":"2008","unstructured":"Donohue SR, Krushinski JH, Pike VW, Chernet E, Phebus L, Chesterfield AK, et al. Synthesis, ex vivo evaluation, and radiolabeling of potent 1, 5-diphenylpyrrolidin-2-one cannabinoid subtype-1 receptor ligands as candidates for in vivo imaging. J Med Chem 2008;51:5833\u201342.","journal-title":"J Med Chem"},{"key":"1411_CR9","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.neuroimage.2009.06.059","volume":"48","author":"GE Terry","year":"2009","unstructured":"Terry GE, Liow J-S, Zoghbi SS, Hirvonen J, Farris AG, Lerner A, et al. Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand. Neuroimage 2009;48:362\u201370.","journal-title":"Neuroimage"},{"key":"1411_CR10","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2967\/jnumed.109.067074","volume":"51","author":"GE Terry","year":"2010","unstructured":"Terry GE, Hirvonen J, Liow J-S, Zoghbi SS, Gladding R, Tauscher JT, et al. Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using (18)F-labeled inverse agonist radioligands. J Nucl Med 2010;51:112\u201320.","journal-title":"J Nucl Med"},{"key":"1411_CR11","first-page":"100","volume":"48","author":"DR Sprague","year":"2007","unstructured":"Sprague DR, Chin FT, Liow JS, Fujita M, Burns HD, Hargreaves R, et al. Human biodistribution and radiation dosimetry of the tachykinin NK1 antagonist radioligand [18F]SPA-RQ: comparison of thin-slice, bisected, and 2-dimensional planar image analysis. J Nucl Med 2007;48:100\u20137.","journal-title":"J Nucl Med"},{"key":"1411_CR12","volume-title":"ICRP publication 89: Basic anatomical and physiological data for use in radiological protection: reference values. A report of age- and gender-related differences in the anatomical and physiological characteristics of reference individuals","author":"ICRP","year":"2002","unstructured":"ICRP. ICRP publication 89: Basic anatomical and physiological data for use in radiological protection: reference values. A report of age- and gender-related differences in the anatomical and physiological characteristics of reference individuals. Oxford: Pergamon; 2002."},{"key":"1411_CR13","volume-title":"ICRP publication 23: Report of the Task Group on Reference Man","author":"ICRP","year":"1975","unstructured":"ICRP. ICRP publication 23: Report of the Task Group on Reference Man. Oxford: Pergamon; 1975."},{"key":"1411_CR14","volume-title":"ICRP publication 30 part 1: Limits for intakes of radionuclides by workers","author":"ICRP","year":"1979","unstructured":"ICRP. ICRP publication 30 part 1: Limits for intakes of radionuclides by workers. Oxford: Pergamon; 1979."},{"key":"1411_CR15","first-page":"1023","volume":"46","author":"MG Stabin","year":"2005","unstructured":"Stabin MG, Sparks RB, Crowe E. OLINDA\/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine. J Nucl Med 2005;46:1023\u20137.","journal-title":"J Nucl Med"},{"key":"1411_CR16","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.2967\/jnumed.107.044842","volume":"48","author":"AK Brown","year":"2007","unstructured":"Brown AK, Fujita M, Fujimura Y, Liow JS, Stabin M, Ryu YH, et al. Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammation. J Nucl Med 2007;48:2072\u20139.","journal-title":"J Nucl Med"},{"key":"1411_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2008.05.002","volume":"595","author":"D Patinkin","year":"2008","unstructured":"Patinkin D, Milman G, Breuer A, Fride E, Mechoulam R. Endocannabinoids as positive or negative factors in hematopoietic cell migration and differentiation. Eur J Pharmacol 2008;595:1\u20136.","journal-title":"Eur J Pharmacol"},{"key":"1411_CR18","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1432-1033.1995.tb20780.x","volume":"232","author":"S Galiegue","year":"1995","unstructured":"Galiegue S, Mary S, Marchand J, Dussossoy D, Carriere D, Carayon P, et al. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem 1995;232:54\u201361.","journal-title":"Eur J Biochem"},{"key":"1411_CR19","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.4049\/jimmunol.173.4.2373","volume":"173","author":"Y Do","year":"2004","unstructured":"Do Y, McKallip RJ, Nagarkatti M, Nagarkatti PS. Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation. J Immunol 2004;173:2373\u201382.","journal-title":"J Immunol"},{"key":"1411_CR20","first-page":"1482","volume":"44","author":"H Vesselle","year":"2003","unstructured":"Vesselle H, Grierson J, Peterson LM, Muzi M, Mankoff DA, Krohn KA. 18F-Fluorothymidine radiation dosimetry in human PET imaging studies. J Nucl Med 2003;44:1482\u20138.","journal-title":"J Nucl Med"},{"key":"1411_CR21","first-page":"1884","volume":"39","author":"WD Brown","year":"1998","unstructured":"Brown WD, Oakes TR, DeJesus OT, Taylor MD, Roberts AD, Nickles RJ, et al. Fluorine-18-fluoro-L-DOPA dosimetry with carbidopa pretreatment. J Nucl Med 1998;39:1884\u201391.","journal-title":"J Nucl Med"},{"key":"1411_CR22","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/89953","volume":"7","author":"S B\u00e1tkai","year":"2001","unstructured":"B\u00e1tkai S, Jarai Z, Wagner JA, Goparaju SK, Varga K, Liu J, et al. Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis. Nat Med 2001;7:827\u201332.","journal-title":"Nat Med"},{"key":"1411_CR23","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nm1421","volume":"12","author":"F Teixeira-Clerc","year":"2006","unstructured":"Teixeira-Clerc F, Julien B, Grenard P, Tran Van Nhieu J, Deveaux V, Li L, et al. CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Nat Med 2006;12:671\u20136.","journal-title":"Nat Med"},{"key":"1411_CR24","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1158\/1535-7163.MCT-08-1147","volume":"8","author":"S Oesch","year":"2009","unstructured":"Oesch S, Walter D, Wachtel M, Pretre K, Salazar M, Guzm\u00e1n M, et al. Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma. Mol Cancer Ther 2009;8:1838\u201345.","journal-title":"Mol Cancer Ther"},{"key":"1411_CR25","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2967\/jnumed.107.047290","volume":"49","author":"K Laere Van","year":"2008","unstructured":"Van Laere K, Koole M, Sanabria Bohorquez SM, Goffin K, Guenther I, Belanger MJ, et al. Whole-body biodistribution and radiation dosimetry of the human cannabinoid type-1 receptor ligand 18F-MK-9470 in healthy subjects. J Nucl Med 2008;49:439\u201345.","journal-title":"J Nucl Med"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-010-1411-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00259-010-1411-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-010-1411-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T12:01:53Z","timestamp":1558699313000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00259-010-1411-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,24]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["1411"],"URL":"https:\/\/doi.org\/10.1007\/s00259-010-1411-7","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,24]]}}}