{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:44:44Z","timestamp":1791481484360,"version":"4.3.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2011,3,2]],"date-time":"2011-03-02T00:00:00Z","timestamp":1299024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1007\/s00259-011-1757-5","type":"journal-article","created":{"date-parts":[[2011,3,2]],"date-time":"2011-03-02T19:32:12Z","timestamp":1299094332000},"page":"1344-1352","source":"Crossref","is-referenced-by-count":64,"title":["Ventilation\/perfusion SPECT in chronic obstructive pulmonary disease: an evaluation by reference to symptoms, spirometric lung function and emphysema, as assessed with HRCT"],"prefix":"10.1007","volume":"38","author":[{"given":"Jonas","family":"J\u00f6gi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Ekberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Jonson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gracijela","family":"Bozovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Bajc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,3,2]]},"reference":[{"key":"1757_CR1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1183\/09031936.04.00014304","volume":"23","author":"BR Celli","year":"2004","unstructured":"Celli BR, MacNee W, ATS\/ERS Task Force. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS\/ERS position paper. Eur Respir J 2004;23:932\u201346.","journal-title":"Eur Respir J"},{"key":"1757_CR2","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1164\/rccm.200703-456SO","volume":"176","author":"KF Rabe","year":"2007","unstructured":"Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2007;176:532\u201355.","journal-title":"Am J Respir Crit Care Med"},{"key":"1757_CR3","doi-asserted-by":"crossref","first-page":"121S","DOI":"10.1378\/chest.121.5_suppl.121S","volume":"121","author":"DM Mannino","year":"2002","unstructured":"Mannino DM. COPD: epidemiology, prevalence, morbidity and mortality, and disease heterogeneity. Chest 2002;121:121S\u20136S.","journal-title":"Chest"},{"key":"1757_CR4","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1056\/NEJMoa032158","volume":"350","author":"JC Hogg","year":"2004","unstructured":"Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004;350:2645\u201353. doi: 10.1056\/NEJMoa032158 .","journal-title":"N Engl J Med"},{"key":"1757_CR5","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1378\/chest.128.4.2005","volume":"128","author":"F Holguin","year":"2005","unstructured":"Holguin F, Folch E, Redd SC, Mannino DM. Comorbidity and mortality in COPD-related hospitalizations in the United States, 1979 to 2001. Chest 2005;128:2005\u201311. doi: 10.1378\/chest.128.4.2005 .","journal-title":"Chest"},{"key":"1757_CR6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2459\/01.JCM.0000263509.35573.2c","volume":"8","author":"PD Stein","year":"2007","unstructured":"Stein PD, Beemath A, Meyers FA, Olson RE. Pulmonary embolism and deep venous thrombosis in hospitalized adults with chronic obstructive pulmonary disease. J Cardiovasc Med (Hagerstown) 2007;8:253\u20137.","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"1757_CR7","doi-asserted-by":"crossref","first-page":"28s","DOI":"10.1183\/09031936.03.00000503","volume":"46","author":"NF Voelkel","year":"2003","unstructured":"Voelkel NF, Cool CD. Pulmonary vascular involvement in chronic obstructive pulmonary disease. Eur Respir J Suppl 2003;46:28s\u201332s.","journal-title":"Eur Respir J Suppl"},{"key":"1757_CR8","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1183\/09031936.06.00145104","volume":"27","author":"PW Jones","year":"2006","unstructured":"Jones PW, Agusti AG. Outcomes and markers in the assessment of chronic obstructive pulmonary disease. Eur Respir J 2006;27:822\u201332.","journal-title":"Eur Respir J"},{"key":"1757_CR9","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1378\/chest.125.5.1714","volume":"125","author":"I Cerveri","year":"2004","unstructured":"Cerveri I, Dore R, Corsico A, Zoia MC, Pellegrino R, Brusasco V, et al. Assessment of emphysema in COPD: a functional and radiologic study. Chest 2004;125:1714\u20138.","journal-title":"Chest"},{"key":"1757_CR10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1378\/chest.109.2.353","volume":"109","author":"AF Gelb","year":"1996","unstructured":"Gelb AF, Hogg JC, M\u00fcller NL, Schein MJ, Kuei J, Tashkin DP, et al. Contribution of emphysema and small airways in COPD. Chest 1996;109:353\u20139.","journal-title":"Chest"},{"key":"1757_CR11","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1136\/thx.54.7.581","volume":"54","author":"JC Bestall","year":"1999","unstructured":"Bestall JC, Paul EA, Garrod R, Garnham R, Jones PW, Wedzicha JA. Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease. Thorax 1999;54:581\u20136.","journal-title":"Thorax"},{"key":"1757_CR12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1136\/bmj.2.5147.257","volume":"2","author":"CM Fletcher","year":"1959","unstructured":"Fletcher CM, Elmes PC, Fairbairn A, Wood CH. The significance of respiratory symptoms and the diagnosis of chronic bronchitis in a working population. Br Med J 1959;2:257\u201366.","journal-title":"Br Med J"},{"key":"1757_CR13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1477-7525-1-13","volume":"1","author":"T Molen van der","year":"2003","unstructured":"van der Molen T, Willemse BW, Schokker S, ten Hacken NH, Postma DS, Juniper EF. Development, validity and responsiveness of the Clinical COPD Questionnaire. Health Qual Life Outcomes 2003;1:13.","journal-title":"Health Qual Life Outcomes"},{"key":"1757_CR14","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1378\/chest.121.5.1434","volume":"121","author":"K Nishimura","year":"2002","unstructured":"Nishimura K, Izumi T, Tsukino M, Oga T. Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD. Chest 2002;121:1434\u201340.","journal-title":"Chest"},{"key":"1757_CR15","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1378\/chest.96.6.1247","volume":"96","author":"N Wolkove","year":"1989","unstructured":"Wolkove N, Dajczman E, Colacone A, Kreisman H. The relationship between pulmonary function and dyspnea in obstructive lung disease. Chest 1989;96:1247\u201351.","journal-title":"Chest"},{"key":"1757_CR16","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1183\/09031936.06.00024605","volume":"27","author":"DM Mannino","year":"2006","unstructured":"Mannino DM, Watt G, Hole D, Gillis C, Hart C, McConnachie A, et al. The natural history of chronic obstructive pulmonary disease. Eur Respir J 2006;27:627\u201343. doi: 10.1183\/09031936.06.00024605 .","journal-title":"Eur Respir J"},{"key":"1757_CR17","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1007\/s00259-009-1170-5","volume":"36","author":"M Bajc","year":"2009","unstructured":"Bajc M, Neilly JB, Miniati M, Schuemichen C, Meignan M, Jonson B, et al. EANM guidelines for ventilation\/perfusion scintigraphy: part 1. Pulmonary imaging with ventilation\/perfusion single photon emission tomography. Eur J Nucl Med Mol Imaging 2009;36:1356\u201370.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1757_CR18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1053\/snuc.2001.21273","volume":"31","author":"LM Freeman","year":"2001","unstructured":"Freeman LM, Krynyckyi B, Zuckier LS. Enhanced lung scan diagnosis of pulmonary embolism with the use of ancillary scintigraphic findings and clinical correlation. Semin Nucl Med 2001;31:143\u201357.","journal-title":"Semin Nucl Med"},{"key":"1757_CR19","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1097\/MNM.0b013e328302cd26","volume":"29","author":"J J\u00f6gi","year":"2008","unstructured":"J\u00f6gi J, Palmer J, Jonson B, Bajc M. Heart failure diagnostics based on ventilation\/perfusion single photon emission computed tomography pattern and quantitative perfusion gradients. Nucl Med Commun 2008;29:666\u201373.","journal-title":"Nucl Med Commun"},{"key":"1757_CR20","first-page":"640","volume":"43","author":"M Bajc","year":"2002","unstructured":"Bajc M, Bitz\u00e9n U, Olsson B, Perez de S\u00e1 V, Palmer J, Jonson B. Lung ventilation\/perfusion SPECT in the artificially embolized pig. J Nucl Med 2002;43:640\u20137.","journal-title":"J Nucl Med"},{"key":"1757_CR21","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1365-2796.2008.01980.x","volume":"264","author":"M Bajc","year":"2008","unstructured":"Bajc M, Olsson B, Palmer J, Jonson B. Ventilation\/perfusion SPECT for diagnostics of pulmonary embolism in clinical practice. J Intern Med 2008;264:379\u201387.","journal-title":"J Intern Med"},{"key":"1757_CR22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1475-097X.2004.00546.x","volume":"24","author":"M Bajc","year":"2004","unstructured":"Bajc M, Olsson CG, Olsson B, Palmer J, Jonson B. Diagnostic evaluation of planar and tomographic ventilation\/perfusion lung images in patients with suspected pulmonary emboli. Clin Physiol Funct Imaging 2004;24:249\u201356.","journal-title":"Clin Physiol Funct Imaging"},{"key":"1757_CR23","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/MNM.0b013e3283336747","volume":"31","author":"H Gutte","year":"2010","unstructured":"Gutte H, Mortensen J, Jensen CV, von der Recke P, Petersen CL, Kristoffersen US, et al. Comparison of V\/Q SPECT and planar V\/Q lung scintigraphy in diagnosing acute pulmonary embolism. Nucl Med Commun 2010;31:82\u20136. doi: 10.1097\/MNM.0b013e3283336747 .","journal-title":"Nucl Med Commun"},{"key":"1757_CR24","first-page":"1501","volume":"45","author":"P Reinartz","year":"2004","unstructured":"Reinartz P, Wildberger JE, Schaefer W, Nowak B, Mahnken AH, Buell U. Tomographic imaging in the diagnosis of pulmonary embolism: a comparison between V\/Q lung scintigraphy in SPECT technique and multislice spiral CT. J Nucl Med 2004;45:1501\u20138.","journal-title":"J Nucl Med"},{"key":"1757_CR25","doi-asserted-by":"crossref","first-page":"735","DOI":"10.2967\/jnumed.109.073957","volume":"51","author":"J J\u00f6gi","year":"2010","unstructured":"J\u00f6gi J, Jonson B, Ekberg M, Bajc M. Ventilation-perfusion SPECT with 99mTc-DTPA versus Technegas: a head-to-head study in obstructive and nonobstructive disease. J Nucl Med 2010;51:735\u201341. doi: 10.2967\/jnumed.109.073957 .","journal-title":"J Nucl Med"},{"key":"1757_CR26","unstructured":"Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med 1995;152:1107\u201336."},{"key":"1757_CR27","first-page":"1288","volume":"42","author":"J Palmer","year":"2001","unstructured":"Palmer J, Bitz\u00e9n U, Jonson B, Bajc M. Comprehensive ventilation\/perfusion SPECT. J Nucl Med 2001;42:1288\u201394.","journal-title":"J Nucl Med"},{"key":"1757_CR28","first-page":"PI9","volume":"12","author":"CG Olsson","year":"2006","unstructured":"Olsson CG, Bitz\u00e9n U, Olsson B, Magnusson P, Carlsson MS, Jonson B, et al. Outpatient tinzaparin therapy in pulmonary embolism quantified with ventilation\/perfusion scintigraphy. Med Sci Monit 2006;12:PI9\u201313.","journal-title":"Med Sci Monit"},{"key":"1757_CR29","doi-asserted-by":"crossref","unstructured":"Value of the ventilation\/perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). The PIOPED Investigators. JAMA 1990;263:2753\u20139.","DOI":"10.1001\/jama.263.20.2753"},{"key":"1757_CR30","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1007\/s00259-009-1169-y","volume":"36","author":"M Bajc","year":"2009","unstructured":"Bajc M, Neilly JB, Miniati M, Schuemichen C, Meignan M, Jonson B. EANM guidelines for ventilation\/perfusion scintigraphy: part 2. Algorithms and clinical considerations for diagnosis of pulmonary emboli with V\/P(SPECT) and MDCT. Eur J Nucl Med Mol Imaging 2009;36:1528\u201338.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1757_CR31","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/MNM.0b013e32827a8e99","volume":"28","author":"M Leblanc","year":"2007","unstructured":"Leblanc M, Leveill\u00e9e F, Turcotte E. Prospective evaluation of the negative predictive value of V\/Q SPECT using 99mTc-Technegas. Nucl Med Commun 2007;28:667\u201372.","journal-title":"Nucl Med Commun"},{"key":"1757_CR32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/ntr\/ntp170","volume":"12","author":"BM Sundblad","year":"2010","unstructured":"Sundblad BM, Larsson K, Nathell L. Lung function testing influences the attitude toward smoking cessation. Nicotine Tob Res 2010;12:37\u201342. doi: 10.1093\/ntr\/ntp170 .","journal-title":"Nicotine Tob Res"},{"key":"1757_CR33","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1378\/chest.71.5.567","volume":"71","author":"GV Taplin","year":"1977","unstructured":"Taplin GV, Tashkin DP, Chopra SK, Anselmi OE, Elam D, Calvarese B, et al. Early detection of chronic obstructive pulmonary disease using radionuclide lung-imaging procedures. Chest 1977;71:567\u201375.","journal-title":"Chest"},{"key":"1757_CR34","first-page":"277","volume":"15","author":"K Satoh","year":"1997","unstructured":"Satoh K, Nakano S, Tanabe M, Nishiyama Y, Takahashi K, Kobayashi T, et al. A clinical comparison between Technegas SPECT, CT, and pulmonary function tests in patients with emphysema. Radiat Med 1997;15:277\u201382.","journal-title":"Radiat Med"},{"key":"1757_CR35","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1097\/01.mnm.0000239484.76651.6f","volume":"27","author":"K Yokoe","year":"2006","unstructured":"Yokoe K, Satoh K, Yamamoto Y, Nishiyama Y, Asakura H, Haba R, et al. Usefulness of 99mTc-Technegas and 133Xe dynamic SPECT in ventilatory impairment. Nucl Med Commun 2006;27:887\u201392.","journal-title":"Nucl Med Commun"},{"key":"1757_CR36","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/00005382-198603000-00006","volume":"1","author":"A Santolicandro","year":"1986","unstructured":"Santolicandro A, Ruschi S, Fornai E, Giuntini C. Imaging of ventilation in chronic obstructive pulmonary disease. J Thorac Imaging 1986;1:36\u201353.","journal-title":"J Thorac Imaging"},{"key":"1757_CR37","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1152\/japplphysiol.00085.2009","volume":"106","author":"R Rodr\u00edguez-Roisin","year":"2009","unstructured":"Rodr\u00edguez-Roisin R, Drakulovic M, Rodr\u00edguez DA, Roca J, Barber\u00e0 JA, Wagner PD. Ventilation-perfusion imbalance and chronic obstructive pulmonary disease staging severity. J Appl Physiol 2009;106:1902\u20138. doi: 10.1152\/japplphysiol.00085.2009 .","journal-title":"J Appl Physiol"},{"key":"1757_CR38","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/00003072-198401000-00003","volume":"9","author":"JC Palmaz","year":"1984","unstructured":"Palmaz JC, Barnett CA, Reich SB, Krumpe PE, Farrer PA. Reverse ventilation\u2013perfusion mismatch. Clin Nucl Med 1984;9:6\u20139.","journal-title":"Clin Nucl Med"},{"key":"1757_CR39","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.ejheart.2006.01.010","volume":"8","author":"FH Rutten","year":"2006","unstructured":"Rutten FH, Cramer MJ, Lammers JW, Grobbee DE, Hoes AW. Heart failure and chronic obstructive pulmonary disease: an ignored combination? Eur J Heart Fail 2006;8:706\u201311. doi: 10.1016\/j.ejheart.2006.01.010 .","journal-title":"Eur J Heart Fail"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-011-1757-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00259-011-1757-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-011-1757-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T19:30:30Z","timestamp":1560022230000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00259-011-1757-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,2]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["1757"],"URL":"https:\/\/doi.org\/10.1007\/s00259-011-1757-5","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,2]]}}}