{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:28:48Z","timestamp":1762079328660},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1007\/s00259-011-2015-6","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T10:42:58Z","timestamp":1323340978000},"page":"642-650","source":"Crossref","is-referenced-by-count":7,"title":["The dopaminergic system in patients with functional dyspepsia analysed by single photon emission computed tomography (SPECT) and an alpha-methyl-para-tyrosine (AMPT) challenge test"],"prefix":"10.1007","volume":"39","author":[{"given":"Breg","family":"Braak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Booij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamira K.","family":"Klooker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene M. J.","family":"van den Wijngaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy E. E.","family":"Boeckxstaens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,12,9]]},"reference":[{"key":"2015_CR1","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1053\/j.gastro.2005.11.059","volume":"130","author":"J Tack","year":"2006","unstructured":"Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, et al. Functional gastroduodenal disorders. Gastroenterology. 2006;130:1466\u201379.","journal-title":"Gastroenterology"},{"key":"2015_CR2","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/0016-5085(94)90536-3","volume":"107","author":"B Coffin","year":"1994","unstructured":"Coffin B, Azpiroz F, Guarner F, Malagelada JR. Selective gastric hypersensitivity and reflex hyporeactivity in functional dyspepsia. Gastroenterology. 1994;107:1345\u201351.","journal-title":"Gastroenterology"},{"key":"2015_CR3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3109\/00365529709000193","volume":"32","author":"A Berstad","year":"1997","unstructured":"Berstad A, Hauksen T, Gilja OH, Hveem K, Undeland KA, Wilhelmsen I, et al. Gastric accommodation in functional dyspepsia. Scand J Gastroenterol. 1997;32:193\u20137.","journal-title":"Scand J Gastroenterol"},{"key":"2015_CR4","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1136\/gut.2008.158162","volume":"57","author":"L Oudenhove Van","year":"2008","unstructured":"Van Oudenhove L, Vandenberghe J, Geeraerts B, Vos R, Persoons P, Fischler B, et al. Determinants of symptoms in functional dyspepsia: gastric sensorimotor function, psychosocial factors or somatisation? Gut. 2008;57:1666\u201373.","journal-title":"Gut"},{"key":"2015_CR5","doi-asserted-by":"crossref","first-page":"G42","DOI":"10.1152\/ajpgi.00500.2004","volume":"289","author":"S Bradesi","year":"2005","unstructured":"Bradesi S, Schwetz I, Ennes HS, Lamy CM, Ohning G, Fanselow M, et al. Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia. Am J Physiol Gastrointest Liver Physiol. 2005;289:G42\u201353.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2015_CR6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0891-0618(01)00122-3","volume":"22","author":"YL Hurd","year":"2001","unstructured":"Hurd YL, Suzuki M, Sedvall GC. D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain. J Chem Neuroanat. 2001;22:127\u201337.","journal-title":"J Chem Neuroanat"},{"key":"2015_CR7","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/ajg.2010.39","volume":"105","author":"L Oudenhove Van","year":"2010","unstructured":"Van Oudenhove L, Vandenberghe J, Dupont P, Geeraerts B, Vos R, Dirix S, et al. Abnormal regional brain activity during rest and (anticipated) gastric distension in functional dyspepsia and the role of anxiety: a H(2)(15)O-PET study. Am J Gastroenterol. 2010;105:913\u201324.","journal-title":"Am J Gastroenterol"},{"key":"2015_CR8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/sj.mp.4000589","volume":"5","author":"L Pani","year":"2000","unstructured":"Pani L, Porcella A, Gessa GL. The role of stress in the pathophysiology of the dopaminergic system. Mol Psychiatry. 2000;5:14\u201321.","journal-title":"Mol Psychiatry"},{"key":"2015_CR9","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1046\/j.1365-2036.2001.01090.x","volume":"15","author":"TG Dinan","year":"2001","unstructured":"Dinan TG, Mahmud N, Rathore O, Thakore J, Scott LV, Carr E, et al. A double-blind placebo-controlled study of buspirone-stimulated prolactin release in non-ulcer dyspepsia \u2013 are central serotoninergic responses enhanced? Aliment Pharmacol Ther. 2001;15:1613\u20138.","journal-title":"Aliment Pharmacol Ther"},{"key":"2015_CR10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0165-0327(02)00025-3","volume":"75","author":"EA Malt","year":"2003","unstructured":"Malt EA, Olafsson S, Aakvaag A, Lund A, Ursin H. Altered dopamine D2 receptor function in fibromyalgia patients: a neuroendocrine study with buspirone in women with fibromyalgia compared to female population based controls. J Affect Disord. 2003;75:77\u201382.","journal-title":"J Affect Disord"},{"key":"2015_CR11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jpain.2006.05.014","volume":"8","author":"PB Wood","year":"2007","unstructured":"Wood PB, Patterson JC, Sunderland JJ, Tainter KH, Glabus MF, Lilien DL. Reduced presynaptic dopamine activity in fibromyalgia syndrome demonstrated with positron emission tomography: a pilot study. J Pain. 2007;8:51\u20138.","journal-title":"J Pain"},{"key":"2015_CR12","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0022-3999(02)00470-1","volume":"54","author":"EA Malt","year":"2003","unstructured":"Malt EA, Ursin H. Mutilation anxiety differs among females with fibromyalgia and functional dyspepsia and population controls. J Psychosom Res. 2003;54:523\u201331.","journal-title":"J Psychosom Res"},{"key":"2015_CR13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1053\/j.gastro.2010.04.015","volume":"139","author":"L Oudenhove Van","year":"2010","unstructured":"Van Oudenhove L, Vandenberghe J, Dupont P, Geeraerts B, Vos R, Dirix S, et al. Regional brain activity in functional dyspepsia: a H(2)(15)O-PET study on the role of gastric sensitivity and abuse history. Gastroenterology. 2010;139:36\u201347.","journal-title":"Gastroenterology"},{"key":"2015_CR14","first-page":"674","volume":"24","author":"J Booij","year":"1997","unstructured":"Booij J, Korn P, Linszen DH, van Royen EA. Assessment of endogenous dopamine release by methylphenidate challenge using iodine-123 iodobenzamide single-photon emission tomography. Eur J Nucl Med. 1997;24:674\u20137.","journal-title":"Eur J Nucl Med"},{"key":"2015_CR15","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1007\/s00259-008-0739-8","volume":"35","author":"E Boot","year":"2008","unstructured":"Boot E, Booij J, Hasler G, Zinkstok JR, de Haan L, Linszen DH, et al. AMPT-induced monoamine depletion in humans: evaluation of two alternative [123I]IBZM SPECT procedures. Eur J Nucl Med Mol Imaging. 2008;35:1350\u20136.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2015_CR16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1365-2036.1999.00445.x","volume":"13","author":"NJ Talley","year":"1999","unstructured":"Talley NJ, Haque M, Wyeth JW, Stace NH, Tytgat GN, Stanghellini V, et al. Development of a new dyspepsia impact scale: the Nepean Dyspepsia Index. Aliment Pharmacol Ther. 1999;13:225\u201335.","journal-title":"Aliment Pharmacol Ther"},{"key":"2015_CR17","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1053\/gast.2001.28656","volume":"121","author":"GE Boeckxstaens","year":"2001","unstructured":"Boeckxstaens GE, Hirsch DP, van den Elzen BD, Heisterkamp SH, Tytgat GN. Impaired drinking capacity in patients with functional dyspepsia: relationship with proximal stomach function. Gastroenterology. 2001;121:1054\u201363.","journal-title":"Gastroenterology"},{"key":"2015_CR18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/archpsyc.1965.01720310065008","volume":"12","author":"WW Zung","year":"1965","unstructured":"Zung WW. A self-rating depression scale. Arch Gen Psychiatry. 1965;12:63\u201370.","journal-title":"Arch Gen Psychiatry"},{"key":"2015_CR19","first-page":"1182","volume":"36","author":"M Laruelle","year":"1995","unstructured":"Laruelle M, Abi-Dargham A, van Dyck CH, Rosenblatt W, Zea-Ponce Y, Zoghbi SS, et al. SPECT imaging of striatal dopamine release after amphetamine challenge. J Nucl Med. 1995;36:1182\u201390.","journal-title":"J Nucl Med"},{"key":"2015_CR20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00001756-200402090-00014","volume":"15","author":"V Kaasinen","year":"2004","unstructured":"Kaasinen V, Aalto S, Nagren K, Rinne JO. Dopaminergic effects of caffeine in the human striatum and thalamus. Neuroreport. 2004;15:281\u20135.","journal-title":"Neuroreport"},{"key":"2015_CR21","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0197-0186(94)00139-L","volume":"26","author":"I Nevo","year":"1995","unstructured":"Nevo I, Hamon M. Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism. Neurochem Int. 1995;26:305\u201336.","journal-title":"Neurochem Int"},{"key":"2015_CR22","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/jnnp.62.2.133","volume":"62","author":"J Booij","year":"1997","unstructured":"Booij J, Tissingh G, Boer GJ, Speelman JD, Stoof JC, Janssen AG, et al. [123I]FP-CIT SPECT shows a pronounced decline of striatal dopamine transporter labelling in early and advanced Parkinson's disease. J Neurol Neurosurg Psychiatry. 1997;62:133\u201340.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2015_CR23","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/sj.jcbfm.9600493","volume":"27","author":"RB Innis","year":"2007","unstructured":"Innis RB, Cunningham VJ, Delforge J, Fujita M, Gjedde A, Gunn RN, et al. Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab. 2007;27:1533\u20139.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2015_CR24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0893-133X(01)00231-7","volume":"25","author":"NP Verhoeff","year":"2001","unstructured":"Verhoeff NP, Kapur S, Hussey D, Lee M, Christensen B, Papatheodorou G, et al. A simple method to measure baseline occupancy of neostriatal dopamine D2 receptors by dopamine in vivo in healthy subjects. Neuropsychopharmacology. 2001;25:213\u201323.","journal-title":"Neuropsychopharmacology"},{"key":"2015_CR25","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nn798","volume":"5","author":"D Morgan","year":"2002","unstructured":"Morgan D, Grant KA, Gage HD, Mach RH, Kaplan JR, Prioleau O, et al. Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nat Neurosci. 2002;5:169\u201374.","journal-title":"Nat Neurosci"},{"key":"2015_CR26","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0893-133X(97)00043-2","volume":"17","author":"M Laruelle","year":"1997","unstructured":"Laruelle M, D'Souza CD, Baldwin RM, Abi-Dargham A, Kanes SJ, Fingado CL, et al. Imaging D2 receptor occupancy by endogenous dopamine in humans. Neuropsychopharmacology. 1997;17:162\u201374.","journal-title":"Neuropsychopharmacology"},{"key":"2015_CR27","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1053\/gast.2001.21201","volume":"120","author":"U Ladabaum","year":"2001","unstructured":"Ladabaum U, Minoshima S, Hasler WL, Cross D, Chey WD, Owyang C. Gastric distention correlates with activation of multiple cortical and subcortical regions. Gastroenterology. 2001;120:369\u201376.","journal-title":"Gastroenterology"},{"key":"2015_CR28","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1136\/gut.52.9.1271","volume":"52","author":"J Tack","year":"2003","unstructured":"Tack J, Caenepeel P, Piessevaux H, Cuomo R, Janssens J. Assessment of meal induced gastric accommodation by a satiety drinking test in health and in severe functional dyspepsia. Gut. 2003;52:1271\u20137.","journal-title":"Gut"},{"key":"2015_CR29","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1440-1746.2006.04493.x","volume":"22","author":"T Hiyama","year":"2007","unstructured":"Hiyama T, Yoshihara M, Matsuo K, Kusunoki H, Kamada T, Ito M, et al. Meta-analysis of the effects of prokinetic agents in patients with functional dyspepsia. J Gastroenterol Hepatol. 2007;22:304\u201310.","journal-title":"J Gastroenterol Hepatol"},{"key":"2015_CR30","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1176\/appi.ajp.2009.08121801","volume":"166","author":"D Martinez","year":"2009","unstructured":"Martinez D, Greene K, Broft A, Kumar D, Liu F, Narendran R, et al. Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)\/D(3) receptors following acute dopamine depletion. Am J Psychiatry. 2009;166:1170\u20137.","journal-title":"Am J Psychiatry"},{"key":"2015_CR31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1755-5949.2010.00135.x","volume":"16","author":"G Giovanni Di","year":"2010","unstructured":"Di Giovanni G, Esposito E, Di Matteo V. Role of serotonin in central dopamine dysfunction. CNS Neurosci Ther. 2010;16:179\u201394.","journal-title":"CNS Neurosci Ther"},{"key":"2015_CR32","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00213-010-2029-y","volume":"213","author":"S Navailles","year":"2011","unstructured":"Navailles S, De Deurwaerdere P. Presynaptic control of serotonin on striatal dopamine function. Psychopharmacology (Berl). 2011;213:213\u201342.","journal-title":"Psychopharmacology (Berl)"},{"key":"2015_CR33","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3748\/wjg.v12.i9.1329","volume":"12","author":"AS Chua","year":"2006","unstructured":"Chua AS, Keeling PW, Dinan TG. Role of cholecystokinin and central serotonergic receptors in functional dyspepsia. World J Gastroenterol. 2006;12:1329\u201335.","journal-title":"World J Gastroenterol"},{"key":"2015_CR34","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.neuroimage.2008.05.009","volume":"42","author":"BN Frey","year":"2008","unstructured":"Frey BN, Rosa-Neto P, Lubarsky S, Diksic M. Correlation between serotonin synthesis and 5-HT1A receptor binding in the living human brain: a combined alpha-[11C]MT and [18F]MPPF positron emission tomography study. Neuroimage. 2008;42:850\u20137.","journal-title":"Neuroimage"},{"key":"2015_CR35","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-230X-9-6","volume":"9","author":"G Clarke","year":"2009","unstructured":"Clarke G, Fitzgerald P, Cryan JF, Cassidy EM, Quigley EM, Dinan TG. Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort. BMC Gastroenterol. 2009;9:6.","journal-title":"BMC Gastroenterol"},{"key":"2015_CR36","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1136\/gut.2004.041657","volume":"53","author":"TO Kilkens","year":"2004","unstructured":"Kilkens TO, Honig A, van Nieuwenhoven MA, Riedel WJ, Brummer RJ. Acute tryptophan depletion affects brain-gut responses in irritable bowel syndrome patients and controls. Gut. 2004;53:1794\u2013800.","journal-title":"Gut"},{"key":"2015_CR37","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/gut.2004.047423","volume":"54","author":"V Morgan","year":"2005","unstructured":"Morgan V, Pickens D, Gautam S, Kessler R, Mertz H. Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome. Gut. 2005;54:601\u20137.","journal-title":"Gut"},{"key":"2015_CR38","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1053\/j.gastro.2004.11.054","volume":"128","author":"J Vandenbergh","year":"2005","unstructured":"Vandenbergh J, Dupont P, Fischler B, Bormans G, Persoons P, Janssens J, et al. Regional brain activation during proximal stomach distention in humans: a positron emission tomography study. Gastroenterology. 2005;128:564\u201373.","journal-title":"Gastroenterology"},{"key":"2015_CR39","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00259-008-0924-9","volume":"36","author":"RJ Beukers","year":"2009","unstructured":"Beukers RJ, Booij J, Weisscher N, Zijlstra F, van Amelsvoort TA, Tijssen MA. Reduced striatal D2 receptor binding in myoclonus-dystonia. Eur J Nucl Med Mol Imaging. 2009;36:269\u201374.","journal-title":"Eur J Nucl Med Mol Imaging"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-011-2015-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T07:01:17Z","timestamp":1497942077000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00259-011-2015-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,9]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["2015"],"URL":"https:\/\/doi.org\/10.1007\/s00259-011-2015-6","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,9]]}}}